Methylcrotonoyl-CoA carboxylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3-methylcrotonoyl-CoA carboxylase beta subunit, putative

Species:

Leishmania mexicana

UniProt:

E9ANK4_LEIMU

TriTrypDb:

LmxM.11.0590

Length:

534

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1
GO:1905202	methylcrotonoyl-CoA carboxylase complex	3	1

Expansion

Sequence features

E9ANK4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANK4

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	12
GO:0006520	amino acid metabolic process	3	12
GO:0006551	leucine metabolic process	5	12
GO:0006552	leucine catabolic process	6	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009063	amino acid catabolic process	4	12
GO:0009081	branched-chain amino acid metabolic process	4	12
GO:0009083	branched-chain amino acid catabolic process	5	12
GO:0009987	cellular process	1	12
GO:0016054	organic acid catabolic process	4	12
GO:0019752	carboxylic acid metabolic process	5	12
GO:0043436	oxoacid metabolic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044248	cellular catabolic process	3	12
GO:0044281	small molecule metabolic process	2	12
GO:0044282	small molecule catabolic process	3	12
GO:0046395	carboxylic acid catabolic process	5	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901565	organonitrogen compound catabolic process	4	12
GO:1901575	organic substance catabolic process	3	12
GO:1901605	alpha-amino acid metabolic process	4	12
GO:1901606	alpha-amino acid catabolic process	5	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004485	methylcrotonoyl-CoA carboxylase activity	5	8
GO:0016421	CoA carboxylase activity	4	8
GO:0016874	ligase activity	2	12
GO:0016885	ligase activity, forming carbon-carbon bonds	3	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	265	267	PF00675	0.271
CLV_NRD_NRD_1	376	378	PF00675	0.308
CLV_NRD_NRD_1	42	44	PF00675	0.465
CLV_PCSK_KEX2_1	265	267	PF00082	0.273
CLV_PCSK_SKI1_1	107	111	PF00082	0.404
CLV_PCSK_SKI1_1	443	447	PF00082	0.242
CLV_PCSK_SKI1_1	470	474	PF00082	0.387
DEG_Nend_UBRbox_2	1	3	PF02207	0.492
DOC_CDC14_PxL_1	285	293	PF14671	0.142
DOC_CYCLIN_RxL_1	40	48	PF00134	0.493
DOC_MAPK_gen_1	265	273	PF00069	0.311
DOC_MAPK_gen_1	377	384	PF00069	0.311
DOC_MAPK_MEF2A_6	181	190	PF00069	0.324
DOC_MAPK_MEF2A_6	344	352	PF00069	0.257
DOC_MAPK_MEF2A_6	377	384	PF00069	0.259
DOC_PP2B_PxIxI_1	417	423	PF00149	0.242
DOC_PP4_FxxP_1	446	449	PF00568	0.242
DOC_USP7_MATH_1	176	180	PF00917	0.257
DOC_USP7_MATH_1	29	33	PF00917	0.615
DOC_USP7_UBL2_3	484	488	PF12436	0.257
LIG_14-3-3_CanoR_1	177	183	PF00244	0.262
LIG_14-3-3_CanoR_1	452	456	PF00244	0.257
LIG_Actin_WH2_2	460	475	PF00022	0.387
LIG_EH1_1	311	319	PF00400	0.367
LIG_EVH1_2	221	225	PF00568	0.276
LIG_FHA_1	213	219	PF00498	0.244
LIG_FHA_1	253	259	PF00498	0.255
LIG_FHA_1	412	418	PF00498	0.242
LIG_FHA_1	419	425	PF00498	0.242
LIG_FHA_1	499	505	PF00498	0.242
LIG_FHA_1	513	519	PF00498	0.242
LIG_FHA_1	64	70	PF00498	0.300
LIG_FHA_2	524	530	PF00498	0.347
LIG_LIR_Gen_1	325	334	PF02991	0.286
LIG_LIR_Gen_1	441	451	PF02991	0.317
LIG_LIR_Gen_1	66	75	PF02991	0.242
LIG_LIR_Nem_3	121	125	PF02991	0.242
LIG_LIR_Nem_3	165	171	PF02991	0.277
LIG_LIR_Nem_3	325	330	PF02991	0.286
LIG_LIR_Nem_3	66	71	PF02991	0.287
LIG_Pex14_2	168	172	PF04695	0.242
LIG_Pex14_2	440	444	PF04695	0.242
LIG_Rb_pABgroove_1	286	294	PF01858	0.387
LIG_SH2_SRC	199	202	PF00017	0.242
LIG_SH2_SRC	396	399	PF00017	0.276
LIG_SH2_STAP1	360	364	PF00017	0.242
LIG_SH2_STAP1	88	92	PF00017	0.406
LIG_SH2_STAT5	14	17	PF00017	0.617
LIG_SH2_STAT5	146	149	PF00017	0.242
LIG_SH2_STAT5	199	202	PF00017	0.242
LIG_SH2_STAT5	262	265	PF00017	0.345
LIG_SH3_3	284	290	PF00018	0.387
LIG_SH3_3	506	512	PF00018	0.242
LIG_SUMO_SIM_anti_2	184	190	PF11976	0.367
LIG_SUMO_SIM_par_1	463	468	PF11976	0.242
LIG_WRC_WIRS_1	309	314	PF05994	0.252
LIG_WW_1	289	292	PF00397	0.336
MOD_CK1_1	179	185	PF00069	0.311
MOD_CK1_1	32	38	PF00069	0.464
MOD_CK2_1	473	479	PF00069	0.374
MOD_CK2_1	523	529	PF00069	0.347
MOD_Cter_Amidation	392	395	PF01082	0.301
MOD_GlcNHglycan	149	152	PF01048	0.242
MOD_GlcNHglycan	178	181	PF01048	0.261
MOD_GlcNHglycan	21	24	PF01048	0.582
MOD_GlcNHglycan	246	249	PF01048	0.242
MOD_GlcNHglycan	362	365	PF01048	0.275
MOD_GlcNHglycan	92	95	PF01048	0.276
MOD_GSK3_1	456	463	PF00069	0.426
MOD_GSK3_1	493	500	PF00069	0.278
MOD_N-GLC_1	153	158	PF02516	0.311
MOD_N-GLC_1	212	217	PF02516	0.257
MOD_N-GLC_1	385	390	PF02516	0.242
MOD_N-GLC_1	473	478	PF02516	0.311
MOD_NEK2_1	147	152	PF00069	0.265
MOD_NEK2_1	333	338	PF00069	0.402
MOD_NEK2_1	410	415	PF00069	0.299
MOD_NEK2_1	45	50	PF00069	0.363
MOD_NEK2_1	456	461	PF00069	0.319
MOD_NEK2_1	465	470	PF00069	0.203
MOD_NEK2_1	523	528	PF00069	0.304
MOD_NEK2_1	69	74	PF00069	0.253
MOD_PIKK_1	181	187	PF00454	0.367
MOD_PIKK_1	372	378	PF00454	0.336
MOD_PIKK_1	456	462	PF00454	0.311
MOD_PIKK_1	69	75	PF00454	0.242
MOD_PKA_2	176	182	PF00069	0.262
MOD_PKA_2	244	250	PF00069	0.227
MOD_PKA_2	451	457	PF00069	0.257
MOD_PKA_2	523	529	PF00069	0.336
MOD_Plk_1	113	119	PF00069	0.242
MOD_Plk_1	512	518	PF00069	0.401
MOD_Plk_1	69	75	PF00069	0.242
MOD_Plk_4	118	124	PF00069	0.242
MOD_Plk_4	212	218	PF00069	0.255
MOD_Plk_4	334	340	PF00069	0.271
MOD_Plk_4	460	466	PF00069	0.248
MOD_SUMO_rev_2	278	288	PF00179	0.362
MOD_SUMO_rev_2	323	333	PF00179	0.242
TRG_DiLeu_BaEn_2	295	301	PF01217	0.257
TRG_DiLeu_BaLyEn_6	377	382	PF01217	0.242
TRG_DiLeu_BaLyEn_6	57	62	PF01217	0.311
TRG_ENDOCYTIC_2	122	125	PF00928	0.242
TRG_ER_diArg_1	8	11	PF00400	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4K5	Leptomonas seymouri	31%	100%
A0A0N1IIF0	Leptomonas seymouri	84%	80%
A0A0S4IW40	Bodo saltans	67%	79%
A0A0S4J7G9	Bodo saltans	31%	100%
A0A1X0NV46	Trypanosomatidae	71%	86%
A0A3Q8I921	Leishmania donovani	98%	100%
A0A3R7M923	Trypanosoma rangeli	72%	86%
A0A3S7X171	Leishmania donovani	31%	100%
A4H6I5	Leishmania braziliensis	93%	100%
A4HG89	Leishmania braziliensis	32%	100%
A4HUX0	Leishmania infantum	98%	100%
D0A7I1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	87%
E9AZL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
I3R7F1	Haloferax mediterranei (strain ATCC 33500 / DSM 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4)	32%	100%
I6YDK7	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	59%	100%
O31825	Bacillus subtilis (strain 168)	36%	100%
O53578	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	29%	100%
O54028	Propionigenium modestum	33%	100%
O86318	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	48%	100%
P05166	Homo sapiens	31%	99%
P07633	Rattus norvegicus	31%	99%
P34385	Caenorhabditis elegans	58%	88%
P53002	Mycobacterium leprae (strain TN)	31%	97%
P53003	Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338)	33%	98%
P54541	Bacillus subtilis (strain 168)	32%	100%
P63408	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	32%	100%
P79384	Sus scrofa	31%	99%
P9WQH4	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	32%	100%
P9WQH5	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	32%	100%
P9WQH6	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	31%	97%
P9WQH7	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	31%	97%
Q06101	Rhodococcus erythropolis	32%	100%
Q06700	Acidaminococcus fermentans (strain ATCC 25085 / DSM 20731 / CCUG 9996 / CIP 106432 / VR4)	27%	91%
Q168G2	Roseobacter denitrificans (strain ATCC 33942 / OCh 114)	32%	100%
Q2TBR0	Bos taurus	30%	99%
Q3J4E3	Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.)	33%	100%
Q3ULD5	Mus musculus	61%	95%
Q4Q8M1	Leishmania major	31%	100%
Q4QH21	Leishmania major	97%	100%
Q57079	Veillonella parvula	31%	100%
Q5XIT9	Rattus norvegicus	61%	95%
Q8GBW6	Propionibacterium freudenreichii subsp. shermanii	34%	100%
Q8T2J9	Dictyostelium discoideum	60%	91%
Q99MN9	Mus musculus	30%	99%
Q9HCC0	Homo sapiens	59%	95%
Q9LDD8	Arabidopsis thaliana	56%	91%
Q9V9A7	Drosophila melanogaster	64%	92%
V5BWB7	Trypanosoma cruzi	70%	87%