LeishMANIAdb
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Nucleobase transporter

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Nucleobase transporter
Gene product:
nucleobase transporter
Species:
Leishmania mexicana
UniProt:
E9ANK1_LEIMU
TriTrypDb:
LmxM.11.0550
Length:
549

Annotations

LeishMANIAdb annotations

An expanded family of eukaryotic equlibrative nuceloside transporters.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 0
Pissara et al. no yes: 45
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 10
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 34
NetGPI no yes: 0, no: 34
Cellular components
Term Name Level Count
GO:0016020 membrane 2 35
GO:0110165 cellular anatomical entity 1 35
GO:0005886 plasma membrane 3 5

Expansion

Sequence features

E9ANK1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANK1

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 2
GO:0015851 nucleobase transport 5 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0071702 organic substance transport 4 2
GO:0071705 nitrogen compound transport 4 2
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 35
GO:0005337 nucleoside transmembrane transporter activity 4 35
GO:0015932 nucleobase-containing compound transmembrane transporter activity 3 35
GO:0022857 transmembrane transporter activity 2 35
GO:1901505 carbohydrate derivative transmembrane transporter activity 3 35
GO:0015205 nucleobase transmembrane transporter activity 3 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 420 424 PF00656 0.309
CLV_NRD_NRD_1 216 218 PF00675 0.247
CLV_NRD_NRD_1 225 227 PF00675 0.402
CLV_NRD_NRD_1 235 237 PF00675 0.418
CLV_NRD_NRD_1 453 455 PF00675 0.274
CLV_PCSK_FUR_1 223 227 PF00082 0.333
CLV_PCSK_KEX2_1 216 218 PF00082 0.289
CLV_PCSK_KEX2_1 225 227 PF00082 0.425
CLV_PCSK_KEX2_1 448 450 PF00082 0.260
CLV_PCSK_PC1ET2_1 448 450 PF00082 0.195
CLV_PCSK_SKI1_1 237 241 PF00082 0.483
CLV_PCSK_SKI1_1 374 378 PF00082 0.373
CLV_PCSK_SKI1_1 442 446 PF00082 0.373
CLV_PCSK_SKI1_1 455 459 PF00082 0.278
CLV_PCSK_SKI1_1 464 468 PF00082 0.346
CLV_PCSK_SKI1_1 56 60 PF00082 0.485
DEG_SCF_FBW7_1 508 514 PF00400 0.418
DEG_SPOP_SBC_1 342 346 PF00917 0.734
DOC_CDC14_PxL_1 465 473 PF14671 0.409
DOC_CKS1_1 508 513 PF01111 0.457
DOC_CYCLIN_yClb1_LxF_4 56 62 PF00134 0.313
DOC_MAPK_DCC_7 464 473 PF00069 0.333
DOC_MAPK_gen_1 272 278 PF00069 0.625
DOC_MAPK_gen_1 392 399 PF00069 0.526
DOC_MAPK_MEF2A_6 464 473 PF00069 0.339
DOC_MIT_MIM_1 436 446 PF04212 0.235
DOC_PP1_RVXF_1 462 468 PF00149 0.410
DOC_PP2B_LxvP_1 106 109 PF13499 0.401
DOC_PP2B_PxIxI_1 412 418 PF00149 0.317
DOC_USP7_MATH_1 164 168 PF00917 0.277
DOC_USP7_MATH_1 26 30 PF00917 0.376
DOC_USP7_MATH_1 418 422 PF00917 0.359
DOC_USP7_MATH_1 535 539 PF00917 0.409
DOC_USP7_UBL2_3 478 482 PF12436 0.218
DOC_WW_Pin1_4 110 115 PF00397 0.253
DOC_WW_Pin1_4 256 261 PF00397 0.583
DOC_WW_Pin1_4 315 320 PF00397 0.629
DOC_WW_Pin1_4 48 53 PF00397 0.423
DOC_WW_Pin1_4 504 509 PF00397 0.250
LIG_14-3-3_CanoR_1 374 382 PF00244 0.562
LIG_14-3-3_CanoR_1 442 447 PF00244 0.331
LIG_14-3-3_CanoR_1 56 62 PF00244 0.178
LIG_14-3-3_CanoR_1 84 88 PF00244 0.496
LIG_14-3-3_CanoR_1 90 100 PF00244 0.305
LIG_Actin_WH2_2 158 176 PF00022 0.401
LIG_BIR_II_1 1 5 PF00653 0.575
LIG_BRCT_BRCA1_1 201 205 PF00533 0.239
LIG_BRCT_BRCA1_1 494 498 PF00533 0.329
LIG_BRCT_BRCA1_1 50 54 PF00533 0.375
LIG_BRCT_BRCA1_1 85 89 PF00533 0.546
LIG_EH1_1 61 69 PF00400 0.389
LIG_eIF4E_1 434 440 PF01652 0.312
LIG_FHA_1 10 16 PF00498 0.384
LIG_FHA_1 151 157 PF00498 0.506
LIG_FHA_1 184 190 PF00498 0.283
LIG_FHA_1 376 382 PF00498 0.512
LIG_FHA_1 389 395 PF00498 0.459
LIG_FHA_1 398 404 PF00498 0.307
LIG_FHA_1 406 412 PF00498 0.324
LIG_FHA_1 425 431 PF00498 0.364
LIG_FHA_1 461 467 PF00498 0.384
LIG_FHA_1 489 495 PF00498 0.230
LIG_FHA_1 508 514 PF00498 0.457
LIG_FHA_2 240 246 PF00498 0.754
LIG_FHA_2 303 309 PF00498 0.801
LIG_FHA_2 343 349 PF00498 0.793
LIG_FHA_2 375 381 PF00498 0.510
LIG_FHA_2 513 519 PF00498 0.502
LIG_GBD_Chelix_1 165 173 PF00786 0.389
LIG_GBD_Chelix_1 484 492 PF00786 0.378
LIG_IBAR_NPY_1 212 214 PF08397 0.464
LIG_Integrin_RGD_1 282 284 PF01839 0.405
LIG_LIR_Gen_1 139 149 PF02991 0.491
LIG_LIR_Gen_1 178 189 PF02991 0.359
LIG_LIR_Gen_1 202 213 PF02991 0.400
LIG_LIR_Gen_1 400 410 PF02991 0.295
LIG_LIR_Gen_1 423 434 PF02991 0.331
LIG_LIR_Gen_1 60 69 PF02991 0.350
LIG_LIR_LC3C_4 12 16 PF02991 0.235
LIG_LIR_Nem_3 113 119 PF02991 0.376
LIG_LIR_Nem_3 139 144 PF02991 0.499
LIG_LIR_Nem_3 178 184 PF02991 0.325
LIG_LIR_Nem_3 188 194 PF02991 0.246
LIG_LIR_Nem_3 202 208 PF02991 0.365
LIG_LIR_Nem_3 36 41 PF02991 0.353
LIG_LIR_Nem_3 400 405 PF02991 0.308
LIG_LIR_Nem_3 408 412 PF02991 0.330
LIG_LIR_Nem_3 423 429 PF02991 0.308
LIG_LIR_Nem_3 445 450 PF02991 0.448
LIG_LIR_Nem_3 60 65 PF02991 0.315
LIG_LYPXL_S_1 394 398 PF13949 0.402
LIG_LYPXL_S_1 411 415 PF13949 0.207
LIG_LYPXL_yS_3 395 398 PF13949 0.402
LIG_LYPXL_yS_3 412 415 PF13949 0.207
LIG_PALB2_WD40_1 421 429 PF16756 0.218
LIG_Pex14_1 229 233 PF04695 0.587
LIG_Pex14_2 81 85 PF04695 0.539
LIG_PTB_Apo_2 135 142 PF02174 0.329
LIG_PTB_Phospho_1 135 141 PF10480 0.329
LIG_SH2_CRK 116 120 PF00017 0.316
LIG_SH2_CRK 181 185 PF00017 0.313
LIG_SH2_CRK 38 42 PF00017 0.324
LIG_SH2_CRK 62 66 PF00017 0.453
LIG_SH2_NCK_1 62 66 PF00017 0.399
LIG_SH2_SRC 300 303 PF00017 0.633
LIG_SH2_STAP1 181 185 PF00017 0.357
LIG_SH2_STAP1 214 218 PF00017 0.447
LIG_SH2_STAP1 300 304 PF00017 0.632
LIG_SH2_STAT5 127 130 PF00017 0.387
LIG_SH2_STAT5 135 138 PF00017 0.388
LIG_SH2_STAT5 191 194 PF00017 0.318
LIG_SH2_STAT5 218 221 PF00017 0.530
LIG_SH2_STAT5 233 236 PF00017 0.615
LIG_SH2_STAT5 264 267 PF00017 0.681
LIG_SH2_STAT5 40 43 PF00017 0.344
LIG_SH2_STAT5 409 412 PF00017 0.359
LIG_SH2_STAT5 486 489 PF00017 0.356
LIG_SH2_STAT5 62 65 PF00017 0.334
LIG_SH3_3 143 149 PF00018 0.485
LIG_SH3_3 18 24 PF00018 0.229
LIG_SH3_3 207 213 PF00018 0.348
LIG_SH3_3 505 511 PF00018 0.424
LIG_Sin3_3 528 535 PF02671 0.224
LIG_SUMO_SIM_anti_2 101 107 PF11976 0.345
LIG_SUMO_SIM_par_1 415 421 PF11976 0.294
LIG_SUMO_SIM_par_1 455 461 PF11976 0.449
LIG_SUMO_SIM_par_1 486 491 PF11976 0.192
LIG_TRAF2_1 305 308 PF00917 0.607
LIG_TRAF2_1 313 316 PF00917 0.662
LIG_TYR_ITIM 189 194 PF00017 0.402
LIG_TYR_ITIM 410 415 PF00017 0.260
LIG_UBA3_1 439 448 PF00899 0.379
LIG_UBA3_1 470 478 PF00899 0.297
LIG_WRC_WIRS_1 402 407 PF05994 0.301
LIG_WRC_WIRS_1 58 63 PF05994 0.347
LIG_WRC_WIRS_1 78 83 PF05994 0.434
MOD_CDK_SPxxK_3 256 263 PF00069 0.579
MOD_CK1_1 159 165 PF00069 0.343
MOD_CK1_1 29 35 PF00069 0.307
MOD_CK1_1 507 513 PF00069 0.464
MOD_CK1_1 60 66 PF00069 0.313
MOD_CK2_1 265 271 PF00069 0.709
MOD_CK2_1 302 308 PF00069 0.737
MOD_CK2_1 342 348 PF00069 0.735
MOD_CK2_1 358 364 PF00069 0.778
MOD_CK2_1 374 380 PF00069 0.531
MOD_CK2_1 512 518 PF00069 0.444
MOD_GlcNHglycan 158 161 PF01048 0.342
MOD_GlcNHglycan 201 204 PF01048 0.321
MOD_GlcNHglycan 250 253 PF01048 0.552
MOD_GlcNHglycan 267 270 PF01048 0.462
MOD_GlcNHglycan 28 31 PF01048 0.568
MOD_GlcNHglycan 287 290 PF01048 0.483
MOD_GlcNHglycan 345 348 PF01048 0.587
MOD_GlcNHglycan 420 423 PF01048 0.563
MOD_GSK3_1 173 180 PF00069 0.312
MOD_GSK3_1 343 350 PF00069 0.779
MOD_GSK3_1 354 361 PF00069 0.772
MOD_GSK3_1 397 404 PF00069 0.349
MOD_GSK3_1 488 495 PF00069 0.182
MOD_GSK3_1 500 507 PF00069 0.376
MOD_GSK3_1 73 80 PF00069 0.325
MOD_N-GLC_1 329 334 PF02516 0.546
MOD_N-GLC_1 76 81 PF02516 0.403
MOD_NEK2_1 136 141 PF00069 0.333
MOD_NEK2_1 156 161 PF00069 0.359
MOD_NEK2_1 173 178 PF00069 0.298
MOD_NEK2_1 185 190 PF00069 0.269
MOD_NEK2_1 265 270 PF00069 0.779
MOD_NEK2_1 397 402 PF00069 0.287
MOD_NEK2_1 405 410 PF00069 0.359
MOD_NEK2_1 458 463 PF00069 0.314
MOD_NEK2_1 488 493 PF00069 0.337
MOD_NEK2_1 9 14 PF00069 0.335
MOD_NEK2_1 91 96 PF00069 0.329
MOD_PIKK_1 183 189 PF00454 0.251
MOD_PIKK_1 329 335 PF00454 0.623
MOD_PKA_2 83 89 PF00069 0.486
MOD_Plk_1 76 82 PF00069 0.401
MOD_Plk_2-3 358 364 PF00069 0.683
MOD_Plk_4 10 16 PF00069 0.281
MOD_Plk_4 164 170 PF00069 0.315
MOD_Plk_4 180 186 PF00069 0.328
MOD_Plk_4 29 35 PF00069 0.326
MOD_Plk_4 425 431 PF00069 0.310
MOD_Plk_4 442 448 PF00069 0.299
MOD_Plk_4 500 506 PF00069 0.422
MOD_Plk_4 535 541 PF00069 0.333
MOD_Plk_4 57 63 PF00069 0.308
MOD_Plk_4 77 83 PF00069 0.312
MOD_ProDKin_1 110 116 PF00069 0.254
MOD_ProDKin_1 256 262 PF00069 0.584
MOD_ProDKin_1 315 321 PF00069 0.626
MOD_ProDKin_1 48 54 PF00069 0.418
MOD_ProDKin_1 504 510 PF00069 0.250
MOD_SUMO_rev_2 268 274 PF00179 0.611
MOD_SUMO_rev_2 380 387 PF00179 0.566
TRG_DiLeu_BaLyEn_6 439 444 PF01217 0.406
TRG_DiLeu_BaLyEn_6 466 471 PF01217 0.386
TRG_ENDOCYTIC_2 116 119 PF00928 0.316
TRG_ENDOCYTIC_2 141 144 PF00928 0.506
TRG_ENDOCYTIC_2 181 184 PF00928 0.324
TRG_ENDOCYTIC_2 191 194 PF00928 0.311
TRG_ENDOCYTIC_2 38 41 PF00928 0.318
TRG_ENDOCYTIC_2 395 398 PF00928 0.420
TRG_ENDOCYTIC_2 412 415 PF00928 0.218
TRG_ENDOCYTIC_2 62 65 PF00928 0.334
TRG_ER_diArg_1 216 218 PF00400 0.505
TRG_ER_diArg_1 222 225 PF00400 0.607

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P486 Leptomonas seymouri 46% 100%
A0A0N0P6Z5 Leptomonas seymouri 31% 100%
A0A0N1I1J0 Leptomonas seymouri 59% 100%
A0A0N1I8E8 Leptomonas seymouri 23% 100%
A0A0N1PBQ1 Leptomonas seymouri 36% 100%
A0A0S4JBS4 Bodo saltans 32% 100%
A0A3Q8ICX7 Leishmania donovani 35% 100%
A0A3S7WTL0 Leishmania donovani 28% 100%
A0A3S7XAS5 Leishmania donovani 32% 100%
A0A422N8M2 Trypanosoma rangeli 30% 100%
A4H6I0 Leishmania braziliensis 73% 100%
A4H7A5 Leishmania braziliensis 37% 91%
A4HG96 Leishmania braziliensis 23% 92%
A4HP60 Leishmania braziliensis 34% 93%
A4HUW2 Leishmania infantum 87% 100%
A4HVP9 Leishmania infantum 35% 100%
A4HWK9 Leishmania infantum 28% 100%
A4IDG6 Leishmania infantum 32% 100%
C9ZN88 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
C9ZZR9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 24% 100%
E9AGM5 Leishmania infantum 28% 100%
E9AGM6 Leishmania infantum 28% 100%
E9AGM7 Leishmania infantum 28% 100%
E9APE5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E9AQB5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9AQB6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9ASW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
O76343 Leishmania donovani 28% 100%
Q4Q1M9 Leishmania major 33% 93%
Q4QF58 Leishmania major 27% 91%
Q4QF59 Leishmania major 27% 100%
Q4QG33 Leishmania major 36% 91%
Q4QH25 Leishmania major 86% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS