Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF563), putative

Species:

Leishmania mexicana

UniProt:

E9ANK0_LEIMU

TriTrypDb:

LmxM.11.0540

Length:

646

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9ANK0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANK0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016740	transferase activity	2	10
GO:0016757	glycosyltransferase activity	3	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	301	305	PF00656	0.391
CLV_MEL_PAP_1	584	590	PF00089	0.656
CLV_NRD_NRD_1	100	102	PF00675	0.736
CLV_NRD_NRD_1	327	329	PF00675	0.523
CLV_NRD_NRD_1	333	335	PF00675	0.506
CLV_NRD_NRD_1	47	49	PF00675	0.514
CLV_NRD_NRD_1	6	8	PF00675	0.564
CLV_PCSK_FUR_1	45	49	PF00082	0.526
CLV_PCSK_FUR_1	628	632	PF00082	0.570
CLV_PCSK_KEX2_1	115	117	PF00082	0.712
CLV_PCSK_KEX2_1	327	329	PF00082	0.536
CLV_PCSK_KEX2_1	333	335	PF00082	0.481
CLV_PCSK_KEX2_1	47	49	PF00082	0.473
CLV_PCSK_KEX2_1	630	632	PF00082	0.598
CLV_PCSK_KEX2_1	8	10	PF00082	0.537
CLV_PCSK_KEX2_1	99	101	PF00082	0.729
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.762
CLV_PCSK_PC1ET2_1	630	632	PF00082	0.575
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.560
CLV_PCSK_SKI1_1	414	418	PF00082	0.591
CLV_PCSK_SKI1_1	476	480	PF00082	0.518
CLV_PCSK_SKI1_1	599	603	PF00082	0.648
DEG_APCC_DBOX_1	413	421	PF00400	0.391
DOC_CDC14_PxL_1	452	460	PF14671	0.183
DOC_MAPK_FxFP_2	612	615	PF00069	0.452
DOC_MAPK_gen_1	47	58	PF00069	0.535
DOC_MAPK_gen_1	547	554	PF00069	0.413
DOC_MAPK_JIP1_4	474	480	PF00069	0.290
DOC_MAPK_MEF2A_6	266	275	PF00069	0.420
DOC_MAPK_MEF2A_6	522	530	PF00069	0.361
DOC_PP2B_LxvP_1	308	311	PF13499	0.391
DOC_PP2B_LxvP_1	453	456	PF13499	0.214
DOC_PP4_FxxP_1	102	105	PF00568	0.525
DOC_PP4_FxxP_1	345	348	PF00568	0.290
DOC_PP4_FxxP_1	612	615	PF00568	0.452
DOC_USP7_MATH_1	11	15	PF00917	0.694
DOC_USP7_MATH_1	127	131	PF00917	0.540
DOC_USP7_MATH_1	188	192	PF00917	0.488
DOC_USP7_MATH_1	206	210	PF00917	0.313
DOC_USP7_MATH_1	294	298	PF00917	0.369
DOC_USP7_MATH_1	355	359	PF00917	0.391
DOC_USP7_MATH_1	391	395	PF00917	0.342
DOC_USP7_MATH_1	488	492	PF00917	0.391
DOC_WW_Pin1_4	110	115	PF00397	0.366
DOC_WW_Pin1_4	12	17	PF00397	0.741
DOC_WW_Pin1_4	212	217	PF00397	0.381
DOC_WW_Pin1_4	32	37	PF00397	0.618
DOC_WW_Pin1_4	344	349	PF00397	0.361
DOC_WW_Pin1_4	351	356	PF00397	0.361
DOC_WW_Pin1_4	379	384	PF00397	0.394
DOC_WW_Pin1_4	386	391	PF00397	0.269
DOC_WW_Pin1_4	428	433	PF00397	0.342
DOC_WW_Pin1_4	541	546	PF00397	0.490
LIG_14-3-3_CanoR_1	103	112	PF00244	0.547
LIG_14-3-3_CanoR_1	181	186	PF00244	0.481
LIG_14-3-3_CanoR_1	223	231	PF00244	0.440
LIG_14-3-3_CanoR_1	259	267	PF00244	0.383
LIG_14-3-3_CanoR_1	296	300	PF00244	0.300
LIG_14-3-3_CanoR_1	464	471	PF00244	0.352
LIG_14-3-3_CanoR_1	48	54	PF00244	0.673
LIG_Actin_WH2_2	280	298	PF00022	0.336
LIG_APCC_ABBA_1	621	626	PF00400	0.407
LIG_BRCT_BRCA1_1	358	362	PF00533	0.330
LIG_CtBP_PxDLS_1	468	474	PF00389	0.183
LIG_deltaCOP1_diTrp_1	422	428	PF00928	0.361
LIG_eIF4E_1	356	362	PF01652	0.361
LIG_eIF4E_1	473	479	PF01652	0.308
LIG_FHA_1	105	111	PF00498	0.545
LIG_FHA_1	247	253	PF00498	0.405
LIG_FHA_1	287	293	PF00498	0.354
LIG_FHA_1	310	316	PF00498	0.361
LIG_FHA_1	404	410	PF00498	0.363
LIG_FHA_1	464	470	PF00498	0.272
LIG_FHA_1	562	568	PF00498	0.498
LIG_FHA_1	616	622	PF00498	0.411
LIG_FHA_2	299	305	PF00498	0.351
LIG_FHA_2	548	554	PF00498	0.308
LIG_KLC1_Yacidic_2	505	510	PF13176	0.391
LIG_LIR_Gen_1	123	133	PF02991	0.545
LIG_LIR_Gen_1	282	292	PF02991	0.361
LIG_LIR_Gen_1	575	586	PF02991	0.297
LIG_LIR_Nem_3	282	288	PF02991	0.340
LIG_LIR_Nem_3	575	581	PF02991	0.231
LIG_MYND_3	409	413	PF01753	0.336
LIG_PTB_Apo_2	204	211	PF02174	0.487
LIG_PTB_Phospho_1	204	210	PF10480	0.490
LIG_SH2_CRK	142	146	PF00017	0.363
LIG_SH2_CRK	576	580	PF00017	0.438
LIG_SH2_SRC	523	526	PF00017	0.331
LIG_SH2_STAP1	523	527	PF00017	0.353
LIG_SH2_STAT3	418	421	PF00017	0.361
LIG_SH2_STAT5	169	172	PF00017	0.474
LIG_SH2_STAT5	204	207	PF00017	0.499
LIG_SH2_STAT5	225	228	PF00017	0.381
LIG_SH2_STAT5	508	511	PF00017	0.354
LIG_SH3_3	108	114	PF00018	0.402
LIG_SH3_3	133	139	PF00018	0.573
LIG_SH3_3	382	388	PF00018	0.375
LIG_SH3_3	560	566	PF00018	0.478
LIG_SH3_3	576	582	PF00018	0.404
LIG_SH3_3	589	595	PF00018	0.399
LIG_SUMO_SIM_anti_2	242	247	PF11976	0.366
LIG_SUMO_SIM_par_1	564	571	PF11976	0.489
LIG_TRAF2_1	595	598	PF00917	0.460
LIG_WRC_WIRS_1	614	619	PF05994	0.407
LIG_WRPW_2	554	557	PF00400	0.399
MOD_CDC14_SPxK_1	113	116	PF00782	0.365
MOD_CDC14_SPxK_1	544	547	PF00782	0.491
MOD_CDK_SPK_2	110	115	PF00069	0.366
MOD_CDK_SPK_2	32	37	PF00069	0.553
MOD_CDK_SPxK_1	110	116	PF00069	0.366
MOD_CDK_SPxK_1	541	547	PF00069	0.485
MOD_CDK_SPxxK_3	32	39	PF00069	0.620
MOD_CK1_1	179	185	PF00069	0.486
MOD_CK1_1	191	197	PF00069	0.447
MOD_CK1_1	254	260	PF00069	0.527
MOD_CK1_1	32	38	PF00069	0.665
MOD_CK1_1	389	395	PF00069	0.369
MOD_CK1_1	467	473	PF00069	0.354
MOD_CK1_1	561	567	PF00069	0.493
MOD_CK2_1	343	349	PF00069	0.391
MOD_CK2_1	547	553	PF00069	0.318
MOD_Cter_Amidation	325	328	PF01082	0.383
MOD_Cter_Amidation	45	48	PF01082	0.353
MOD_GlcNHglycan	166	169	PF01048	0.662
MOD_GlcNHglycan	188	191	PF01048	0.700
MOD_GlcNHglycan	23	26	PF01048	0.440
MOD_GlcNHglycan	336	340	PF01048	0.561
MOD_GlcNHglycan	466	469	PF01048	0.442
MOD_GlcNHglycan	604	607	PF01048	0.693
MOD_GSK3_1	127	134	PF00069	0.479
MOD_GSK3_1	206	213	PF00069	0.431
MOD_GSK3_1	251	258	PF00069	0.499
MOD_GSK3_1	294	301	PF00069	0.369
MOD_GSK3_1	351	358	PF00069	0.348
MOD_GSK3_1	375	382	PF00069	0.300
MOD_GSK3_1	454	461	PF00069	0.350
MOD_GSK3_1	463	470	PF00069	0.282
MOD_GSK3_1	543	550	PF00069	0.306
MOD_N-GLC_1	191	196	PF02516	0.686
MOD_N-GLC_1	206	211	PF02516	0.705
MOD_N-GLC_1	356	361	PF02516	0.591
MOD_N-GLC_1	374	379	PF02516	0.379
MOD_N-GLC_1	435	440	PF02516	0.565
MOD_N-GLC_1	488	493	PF02516	0.591
MOD_NEK2_1	295	300	PF00069	0.311
MOD_NEK2_1	335	340	PF00069	0.346
MOD_NEK2_1	361	366	PF00069	0.385
MOD_NEK2_1	402	407	PF00069	0.340
MOD_NEK2_1	458	463	PF00069	0.375
MOD_NEK2_1	469	474	PF00069	0.329
MOD_NEK2_1	601	606	PF00069	0.497
MOD_NEK2_1	71	76	PF00069	0.584
MOD_PIKK_1	127	133	PF00454	0.509
MOD_PIKK_1	309	315	PF00454	0.308
MOD_PIKK_1	561	567	PF00454	0.503
MOD_PIKK_1	69	75	PF00454	0.613
MOD_PKA_2	176	182	PF00069	0.421
MOD_PKA_2	254	260	PF00069	0.543
MOD_PKA_2	295	301	PF00069	0.183
MOD_PKA_2	463	469	PF00069	0.327
MOD_Plk_1	191	197	PF00069	0.504
MOD_Plk_1	206	212	PF00069	0.339
MOD_Plk_1	241	247	PF00069	0.432
MOD_Plk_1	356	362	PF00069	0.391
MOD_Plk_1	435	441	PF00069	0.391
MOD_Plk_1	488	494	PF00069	0.391
MOD_Plk_2-3	147	153	PF00069	0.429
MOD_Plk_4	191	197	PF00069	0.411
MOD_Plk_4	241	247	PF00069	0.461
MOD_Plk_4	311	317	PF00069	0.342
MOD_Plk_4	356	362	PF00069	0.361
MOD_Plk_4	448	454	PF00069	0.325
MOD_ProDKin_1	110	116	PF00069	0.366
MOD_ProDKin_1	12	18	PF00069	0.740
MOD_ProDKin_1	212	218	PF00069	0.377
MOD_ProDKin_1	32	38	PF00069	0.618
MOD_ProDKin_1	344	350	PF00069	0.361
MOD_ProDKin_1	351	357	PF00069	0.361
MOD_ProDKin_1	379	385	PF00069	0.394
MOD_ProDKin_1	386	392	PF00069	0.269
MOD_ProDKin_1	428	434	PF00069	0.342
MOD_ProDKin_1	541	547	PF00069	0.494
TRG_DiLeu_BaEn_1	597	602	PF01217	0.446
TRG_ENDOCYTIC_2	126	129	PF00928	0.543
TRG_ENDOCYTIC_2	142	145	PF00928	0.380
TRG_ENDOCYTIC_2	523	526	PF00928	0.353
TRG_ENDOCYTIC_2	576	579	PF00928	0.376
TRG_ENDOCYTIC_2	614	617	PF00928	0.385
TRG_ER_diArg_1	327	329	PF00400	0.250
TRG_ER_diArg_1	333	335	PF00400	0.253
TRG_ER_diArg_1	36	39	PF00400	0.706
TRG_ER_diArg_1	444	447	PF00400	0.310
TRG_ER_diArg_1	45	48	PF00400	0.693
TRG_ER_diArg_1	473	476	PF00400	0.229
TRG_ER_diArg_1	6	9	PF00400	0.735
TRG_ER_diArg_1	99	101	PF00400	0.530
TRG_NLS_MonoExtC_3	6	12	PF00514	0.759
TRG_Pf-PMV_PEXEL_1	549	553	PF00026	0.424
TRG_Pf-PMV_PEXEL_1	631	635	PF00026	0.620

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBV1	Leptomonas seymouri	28%	100%
A0A0N1PD55	Leptomonas seymouri	45%	100%
A0A1X0NW39	Trypanosomatidae	24%	100%
A0A3Q8IHF7	Leishmania donovani	89%	100%
A4H6H9	Leishmania braziliensis	79%	100%
A4HUW3	Leishmania infantum	89%	100%
Q4QH26	Leishmania major	89%	100%
V5BJI5	Trypanosoma cruzi	22%	100%