Putative amino acid permease/transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amino acid permease/transporter, putative

Species:

Leishmania mexicana

UniProt:

E9ANJ8_LEIMU

TriTrypDb:

LmxM.11.0520

Length:

465

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	23
GO:0110165	cellular anatomical entity	1	23
GO:0000323	lytic vacuole	6	1
GO:0005764	lysosome	7	1
GO:0005773	vacuole	5	1
GO:0020022	acidocalcisome	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9ANJ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANJ8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	23
GO:0015203	polyamine transmembrane transporter activity	3	23
GO:0022857	transmembrane transporter activity	2	23
GO:0003824	catalytic activity	1	5
GO:0016787	hydrolase activity	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	301	303	PF00675	0.200
CLV_PCSK_FUR_1	302	306	PF00082	0.264
CLV_PCSK_KEX2_1	301	303	PF00082	0.297
CLV_PCSK_KEX2_1	304	306	PF00082	0.298
CLV_PCSK_PC1ET2_1	304	306	PF00082	0.293
CLV_PCSK_SKI1_1	256	260	PF00082	0.397
CLV_PCSK_SKI1_1	429	433	PF00082	0.360
DEG_Nend_Nbox_1	1	3	PF02207	0.236
DOC_CYCLIN_yCln2_LP_2	361	367	PF00134	0.425
DOC_MAPK_gen_1	107	116	PF00069	0.289
DOC_MAPK_MEF2A_6	343	351	PF00069	0.318
DOC_MAPK_MEF2A_6	397	406	PF00069	0.314
DOC_MAPK_MEF2A_6	429	438	PF00069	0.486
DOC_PP1_RVXF_1	427	434	PF00149	0.493
DOC_PP1_RVXF_1	59	65	PF00149	0.309
DOC_PP4_FxxP_1	365	368	PF00568	0.436
DOC_USP7_MATH_1	226	230	PF00917	0.284
DOC_USP7_MATH_1	244	248	PF00917	0.313
DOC_USP7_MATH_1	381	385	PF00917	0.328
DOC_USP7_MATH_1	49	53	PF00917	0.429
DOC_USP7_MATH_1	73	77	PF00917	0.383
DOC_WW_Pin1_4	453	458	PF00397	0.688
LIG_14-3-3_CanoR_1	397	401	PF00244	0.133
LIG_14-3-3_CanoR_1	429	434	PF00244	0.597
LIG_APCC_ABBA_1	391	396	PF00400	0.289
LIG_BRCT_BRCA1_1	152	156	PF00533	0.445
LIG_Clathr_ClatBox_1	332	336	PF01394	0.325
LIG_CtBP_PxDLS_1	232	236	PF00389	0.200
LIG_deltaCOP1_diTrp_1	171	175	PF00928	0.452
LIG_FHA_1	1	7	PF00498	0.304
LIG_FHA_1	115	121	PF00498	0.245
LIG_FHA_1	171	177	PF00498	0.529
LIG_FHA_1	276	282	PF00498	0.403
LIG_FHA_1	397	403	PF00498	0.269
LIG_FHA_1	433	439	PF00498	0.547
LIG_FHA_1	450	456	PF00498	0.688
LIG_FHA_1	72	78	PF00498	0.238
LIG_FHA_2	189	195	PF00498	0.484
LIG_LIR_Apic_2	217	221	PF02991	0.290
LIG_LIR_Gen_1	169	179	PF02991	0.469
LIG_LIR_Gen_1	240	250	PF02991	0.277
LIG_LIR_Gen_1	312	323	PF02991	0.373
LIG_LIR_Gen_1	414	421	PF02991	0.376
LIG_LIR_Gen_1	432	438	PF02991	0.536
LIG_LIR_Gen_1	76	87	PF02991	0.280
LIG_LIR_Nem_3	169	175	PF02991	0.436
LIG_LIR_Nem_3	240	246	PF02991	0.264
LIG_LIR_Nem_3	312	318	PF02991	0.334
LIG_LIR_Nem_3	320	326	PF02991	0.256
LIG_LIR_Nem_3	350	354	PF02991	0.348
LIG_LIR_Nem_3	414	420	PF02991	0.281
LIG_LIR_Nem_3	432	436	PF02991	0.639
LIG_LIR_Nem_3	76	82	PF02991	0.317
LIG_LIR_Nem_3	89	94	PF02991	0.255
LIG_LYPXL_S_1	357	361	PF13949	0.303
LIG_LYPXL_S_1	86	90	PF13949	0.457
LIG_LYPXL_yS_3	358	361	PF13949	0.422
LIG_LYPXL_yS_3	87	90	PF13949	0.241
LIG_MAD2	429	437	PF02301	0.496
LIG_NRBOX	110	116	PF00104	0.329
LIG_NRBOX	144	150	PF00104	0.350
LIG_Pex14_1	238	242	PF04695	0.237
LIG_Pex14_1	311	315	PF04695	0.232
LIG_Pex14_2	156	160	PF04695	0.444
LIG_Pex14_2	365	369	PF04695	0.469
LIG_PTB_Apo_2	81	88	PF02174	0.229
LIG_PTB_Phospho_1	81	87	PF10480	0.241
LIG_SH2_GRB2like	157	160	PF00017	0.448
LIG_SH2_PTP2	218	221	PF00017	0.290
LIG_SH2_PTP2	79	82	PF00017	0.200
LIG_SH2_SRC	165	168	PF00017	0.480
LIG_SH2_SRC	218	221	PF00017	0.290
LIG_SH2_STAP1	2	6	PF00017	0.289
LIG_SH2_STAT3	147	150	PF00017	0.377
LIG_SH2_STAT5	147	150	PF00017	0.448
LIG_SH2_STAT5	157	160	PF00017	0.430
LIG_SH2_STAT5	165	168	PF00017	0.437
LIG_SH2_STAT5	2	5	PF00017	0.275
LIG_SH2_STAT5	218	221	PF00017	0.270
LIG_SH2_STAT5	360	363	PF00017	0.516
LIG_SH2_STAT5	417	420	PF00017	0.344
LIG_SH2_STAT5	69	72	PF00017	0.269
LIG_SH2_STAT5	79	82	PF00017	0.228
LIG_SH2_STAT5	94	97	PF00017	0.215
LIG_SH3_1	454	460	PF00018	0.558
LIG_SH3_3	155	161	PF00018	0.496
LIG_SH3_3	356	362	PF00018	0.439
LIG_SH3_3	431	437	PF00018	0.649
LIG_SH3_3	454	460	PF00018	0.746
LIG_SUMO_SIM_anti_2	24	30	PF11976	0.395
LIG_SUMO_SIM_anti_2	331	336	PF11976	0.416
LIG_SUMO_SIM_anti_2	396	402	PF11976	0.292
LIG_SUMO_SIM_par_1	132	139	PF11976	0.347
LIG_SUMO_SIM_par_1	21	27	PF11976	0.318
LIG_SUMO_SIM_par_1	231	236	PF11976	0.366
LIG_SUMO_SIM_par_1	331	336	PF11976	0.378
LIG_SUMO_SIM_par_1	344	350	PF11976	0.405
LIG_SUMO_SIM_par_1	384	392	PF11976	0.233
LIG_SUMO_SIM_par_1	39	45	PF11976	0.372
LIG_SxIP_EBH_1	201	214	PF03271	0.377
LIG_TYR_ITIM	77	82	PF00017	0.232
LIG_UBA3_1	57	61	PF00899	0.518
LIG_WRC_WIRS_1	1	6	PF05994	0.355
LIG_WRC_WIRS_1	348	353	PF05994	0.379
LIG_WRC_WIRS_1	412	417	PF05994	0.409
LIG_WRC_WIRS_1	430	435	PF05994	0.515
MOD_CK1_1	177	183	PF00069	0.450
MOD_CK1_1	199	205	PF00069	0.417
MOD_CK1_1	439	445	PF00069	0.682
MOD_CK1_1	71	77	PF00069	0.378
MOD_CK2_1	181	187	PF00069	0.443
MOD_CK2_1	188	194	PF00069	0.412
MOD_CK2_1	459	465	PF00069	0.567
MOD_GlcNHglycan	183	186	PF01048	0.280
MOD_GlcNHglycan	265	268	PF01048	0.288
MOD_GlcNHglycan	272	275	PF01048	0.269
MOD_GlcNHglycan	6	9	PF01048	0.446
MOD_GSK3_1	129	136	PF00069	0.296
MOD_GSK3_1	166	173	PF00069	0.453
MOD_GSK3_1	177	184	PF00069	0.435
MOD_GSK3_1	199	206	PF00069	0.475
MOD_GSK3_1	233	240	PF00069	0.303
MOD_GSK3_1	270	277	PF00069	0.271
MOD_GSK3_1	305	312	PF00069	0.424
MOD_GSK3_1	317	324	PF00069	0.312
MOD_GSK3_1	382	389	PF00069	0.308
MOD_GSK3_1	407	414	PF00069	0.330
MOD_GSK3_1	432	439	PF00069	0.631
MOD_GSK3_1	449	456	PF00069	0.755
MOD_GSK3_1	95	102	PF00069	0.223
MOD_NEK2_1	114	119	PF00069	0.223
MOD_NEK2_1	175	180	PF00069	0.443
MOD_NEK2_1	233	238	PF00069	0.364
MOD_NEK2_1	268	273	PF00069	0.263
MOD_NEK2_1	275	280	PF00069	0.421
MOD_NEK2_1	322	327	PF00069	0.315
MOD_NEK2_1	382	387	PF00069	0.337
MOD_NEK2_1	4	9	PF00069	0.274
MOD_NEK2_1	68	73	PF00069	0.306
MOD_NEK2_1	95	100	PF00069	0.312
MOD_NEK2_2	449	454	PF00069	0.660
MOD_OFUCOSY	96	101	PF10250	0.332
MOD_PIKK_1	196	202	PF00454	0.366
MOD_PKA_2	396	402	PF00069	0.149
MOD_Plk_1	244	250	PF00069	0.299
MOD_Plk_4	129	135	PF00069	0.298
MOD_Plk_4	188	194	PF00069	0.479
MOD_Plk_4	203	209	PF00069	0.419
MOD_Plk_4	21	27	PF00069	0.274
MOD_Plk_4	314	320	PF00069	0.257
MOD_Plk_4	322	328	PF00069	0.294
MOD_Plk_4	382	388	PF00069	0.250
MOD_Plk_4	389	395	PF00069	0.277
MOD_Plk_4	396	402	PF00069	0.240
MOD_Plk_4	407	413	PF00069	0.234
MOD_Plk_4	429	435	PF00069	0.604
MOD_Plk_4	73	79	PF00069	0.263
MOD_Plk_4	86	92	PF00069	0.263
MOD_ProDKin_1	453	459	PF00069	0.685
TRG_DiLeu_BaLyEn_6	206	211	PF01217	0.287
TRG_ENDOCYTIC_2	358	361	PF00928	0.445
TRG_ENDOCYTIC_2	417	420	PF00928	0.361
TRG_ENDOCYTIC_2	69	72	PF00928	0.275
TRG_ENDOCYTIC_2	79	82	PF00928	0.231
TRG_ENDOCYTIC_2	87	90	PF00928	0.234

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2T0	Leptomonas seymouri	68%	80%
A0A0N1PGN1	Leptomonas seymouri	34%	89%
A0A0S4IJF6	Bodo saltans	25%	80%
A0A0S4ISA5	Bodo saltans	23%	80%
A0A0S4JBT0	Bodo saltans	25%	90%
A0A1X0NNQ0	Trypanosomatidae	32%	73%
A0A1X0NV66	Trypanosomatidae	51%	89%
A0A1X0P501	Trypanosomatidae	35%	85%
A0A3R7M6P3	Trypanosoma rangeli	32%	76%
A0A3R7N0T9	Trypanosoma rangeli	53%	92%
A0A3S5IRV3	Trypanosoma rangeli	36%	92%
A0A3S7WRN2	Leishmania donovani	94%	100%
A0A3S7XA01	Leishmania donovani	36%	90%
A2X8M8	Oryza sativa subsp. indica	28%	88%
A4H6H7	Leishmania braziliensis	83%	100%
A4HNB0	Leishmania braziliensis	36%	100%
A4HUW5	Leishmania infantum	94%	100%
A4IBY1	Leishmania infantum	36%	90%
C9ZYM5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	95%
D0A7J0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	92%
E9AFR8	Leishmania major	36%	100%
E9B6X1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	90%
Q4QH28	Leishmania major	91%	100%
Q6Z8D0	Oryza sativa subsp. japonica	28%	88%
Q9C6S4	Arabidopsis thaliana	25%	96%
Q9C6S5	Arabidopsis thaliana	25%	94%
Q9FFL1	Arabidopsis thaliana	30%	95%
Q9LH39	Arabidopsis thaliana	28%	97%
Q9LHN7	Arabidopsis thaliana	27%	97%
V5BCQ1	Trypanosoma cruzi	38%	100%
V5DDZ5	Trypanosoma cruzi	30%	74%