Putative pumilio-repeat, RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pumilio-repeat, RNA-binding protein, putative

Species:

Leishmania mexicana

UniProt:

E9ANJ3_LEIMU

TriTrypDb:

LmxM.11.0470

Length:

745

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ANJ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANJ3

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.386
CLV_C14_Caspase3-7	155	159	PF00656	0.714
CLV_C14_Caspase3-7	474	478	PF00656	0.440
CLV_NRD_NRD_1	115	117	PF00675	0.650
CLV_NRD_NRD_1	184	186	PF00675	0.498
CLV_NRD_NRD_1	306	308	PF00675	0.602
CLV_NRD_NRD_1	32	34	PF00675	0.587
CLV_NRD_NRD_1	355	357	PF00675	0.484
CLV_NRD_NRD_1	40	42	PF00675	0.553
CLV_NRD_NRD_1	515	517	PF00675	0.331
CLV_NRD_NRD_1	522	524	PF00675	0.381
CLV_PCSK_FUR_1	16	20	PF00082	0.602
CLV_PCSK_FUR_1	30	34	PF00082	0.625
CLV_PCSK_KEX2_1	115	117	PF00082	0.625
CLV_PCSK_KEX2_1	18	20	PF00082	0.549
CLV_PCSK_KEX2_1	184	186	PF00082	0.498
CLV_PCSK_KEX2_1	32	34	PF00082	0.507
CLV_PCSK_KEX2_1	355	357	PF00082	0.435
CLV_PCSK_KEX2_1	360	362	PF00082	0.388
CLV_PCSK_KEX2_1	371	373	PF00082	0.262
CLV_PCSK_KEX2_1	422	424	PF00082	0.491
CLV_PCSK_KEX2_1	515	517	PF00082	0.465
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.625
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.547
CLV_PCSK_PC1ET2_1	360	362	PF00082	0.406
CLV_PCSK_PC1ET2_1	371	373	PF00082	0.299
CLV_PCSK_PC1ET2_1	422	424	PF00082	0.491
CLV_PCSK_PC7_1	356	362	PF00082	0.482
CLV_PCSK_SKI1_1	110	114	PF00082	0.496
CLV_PCSK_SKI1_1	207	211	PF00082	0.431
CLV_PCSK_SKI1_1	310	314	PF00082	0.723
CLV_PCSK_SKI1_1	356	360	PF00082	0.463
CLV_PCSK_SKI1_1	643	647	PF00082	0.515
DEG_APCC_DBOX_1	355	363	PF00400	0.483
DEG_SCF_FBW7_1	292	298	PF00400	0.501
DEG_SPOP_SBC_1	295	299	PF00917	0.503
DOC_CKS1_1	292	297	PF01111	0.488
DOC_CYCLIN_yCln2_LP_2	434	440	PF00134	0.337
DOC_MAPK_gen_1	38	48	PF00069	0.682
DOC_PP2B_LxvP_1	480	483	PF13499	0.296
DOC_PP2B_LxvP_1	71	74	PF13499	0.516
DOC_SPAK_OSR1_1	624	628	PF12202	0.320
DOC_USP7_MATH_1	152	156	PF00917	0.640
DOC_USP7_MATH_1	196	200	PF00917	0.513
DOC_USP7_MATH_1	295	299	PF00917	0.503
DOC_USP7_MATH_1	483	487	PF00917	0.438
DOC_USP7_MATH_1	585	589	PF00917	0.382
DOC_USP7_UBL2_3	309	313	PF12436	0.602
DOC_USP7_UBL2_3	38	42	PF12436	0.616
DOC_WW_Pin1_4	291	296	PF00397	0.529
DOC_WW_Pin1_4	581	586	PF00397	0.466
LIG_14-3-3_CanoR_1	185	191	PF00244	0.443
LIG_14-3-3_CanoR_1	227	235	PF00244	0.455
LIG_14-3-3_CanoR_1	249	258	PF00244	0.498
LIG_14-3-3_CanoR_1	265	271	PF00244	0.294
LIG_14-3-3_CanoR_1	327	336	PF00244	0.416
LIG_14-3-3_CanoR_1	498	506	PF00244	0.469
LIG_14-3-3_CanoR_1	643	649	PF00244	0.452
LIG_14-3-3_CanoR_1	710	719	PF00244	0.511
LIG_Actin_RPEL_3	349	368	PF02755	0.491
LIG_APCC_ABBA_1	401	406	PF00400	0.469
LIG_BIR_III_4	666	670	PF00653	0.439
LIG_BRCT_BRCA1_1	641	645	PF00533	0.483
LIG_EH1_1	425	433	PF00400	0.364
LIG_EH1_1	469	477	PF00400	0.332
LIG_EH1_1	498	506	PF00400	0.365
LIG_EH1_1	624	632	PF00400	0.414
LIG_FHA_1	168	174	PF00498	0.519
LIG_FHA_1	328	334	PF00498	0.479
LIG_FHA_1	372	378	PF00498	0.489
LIG_FHA_1	382	388	PF00498	0.599
LIG_FHA_1	500	506	PF00498	0.507
LIG_FHA_1	552	558	PF00498	0.446
LIG_FHA_1	600	606	PF00498	0.441
LIG_FHA_1	652	658	PF00498	0.341
LIG_FHA_1	97	103	PF00498	0.764
LIG_FHA_2	132	138	PF00498	0.392
LIG_FHA_2	251	257	PF00498	0.546
LIG_FHA_2	26	32	PF00498	0.474
LIG_FHA_2	591	597	PF00498	0.390
LIG_GBD_Chelix_1	186	194	PF00786	0.364
LIG_GBD_Chelix_1	427	435	PF00786	0.442
LIG_Integrin_isoDGR_2	622	624	PF01839	0.308
LIG_LIR_Gen_1	537	548	PF02991	0.392
LIG_LIR_Gen_1	593	600	PF02991	0.360
LIG_LIR_Gen_1	642	649	PF02991	0.400
LIG_LIR_LC3C_4	511	514	PF02991	0.298
LIG_LIR_Nem_3	10	15	PF02991	0.518
LIG_LIR_Nem_3	537	543	PF02991	0.399
LIG_LIR_Nem_3	593	598	PF02991	0.352
LIG_LIR_Nem_3	642	648	PF02991	0.443
LIG_MAD2	45	53	PF02301	0.615
LIG_NRBOX	345	351	PF00104	0.558
LIG_NRBOX	376	382	PF00104	0.420
LIG_NRBOX	657	663	PF00104	0.415
LIG_PCNA_PIPBox_1	78	87	PF02747	0.511
LIG_PCNA_yPIPBox_3	422	432	PF02747	0.412
LIG_PCNA_yPIPBox_3	550	562	PF02747	0.346
LIG_PCNA_yPIPBox_3	652	662	PF02747	0.356
LIG_Pex14_2	727	731	PF04695	0.356
LIG_PTB_Apo_2	539	546	PF02174	0.469
LIG_PTB_Phospho_1	539	545	PF10480	0.469
LIG_Rb_pABgroove_1	589	597	PF01858	0.222
LIG_REV1ctd_RIR_1	725	734	PF16727	0.376
LIG_RPA_C_Fungi	659	671	PF08784	0.424
LIG_SH2_CRK	85	89	PF00017	0.468
LIG_SH2_NCK_1	545	549	PF00017	0.339
LIG_SH2_NCK_1	85	89	PF00017	0.468
LIG_SH2_STAP1	586	590	PF00017	0.324
LIG_SH2_STAP1	85	89	PF00017	0.600
LIG_SH2_STAT5	545	548	PF00017	0.400
LIG_SH2_STAT5	556	559	PF00017	0.273
LIG_SH3_3	334	340	PF00018	0.406
LIG_SH3_3	45	51	PF00018	0.666
LIG_Sin3_3	145	152	PF02671	0.512
LIG_SUMO_SIM_anti_2	164	176	PF11976	0.525
LIG_SUMO_SIM_par_1	288	294	PF11976	0.497
LIG_SUMO_SIM_par_1	378	384	PF11976	0.474
LIG_SUMO_SIM_par_1	471	477	PF11976	0.395
LIG_TRAF2_1	318	321	PF00917	0.712
LIG_UBA3_1	517	524	PF00899	0.351
LIG_UBA3_1	661	670	PF00899	0.384
MOD_CK1_1	105	111	PF00069	0.695
MOD_CK1_1	237	243	PF00069	0.514
MOD_CK1_1	291	297	PF00069	0.486
MOD_CK1_1	386	392	PF00069	0.669
MOD_CK1_1	563	569	PF00069	0.472
MOD_CK1_1	714	720	PF00069	0.512
MOD_CK1_1	96	102	PF00069	0.729
MOD_CK2_1	197	203	PF00069	0.491
MOD_CK2_1	23	29	PF00069	0.591
MOD_CK2_1	250	256	PF00069	0.544
MOD_CK2_1	297	303	PF00069	0.691
MOD_CK2_1	483	489	PF00069	0.422
MOD_CK2_1	570	576	PF00069	0.328
MOD_Cter_Amidation	1	4	PF01082	0.530
MOD_Cter_Amidation	182	185	PF01082	0.479
MOD_Cter_Amidation	305	308	PF01082	0.698
MOD_GlcNHglycan	104	107	PF01048	0.713
MOD_GlcNHglycan	154	157	PF01048	0.700
MOD_GlcNHglycan	180	184	PF01048	0.445
MOD_GlcNHglycan	229	232	PF01048	0.461
MOD_GlcNHglycan	299	302	PF01048	0.714
MOD_GlcNHglycan	323	326	PF01048	0.748
MOD_GlcNHglycan	341	344	PF01048	0.278
MOD_GlcNHglycan	441	444	PF01048	0.573
MOD_GlcNHglycan	459	462	PF01048	0.468
MOD_GlcNHglycan	485	488	PF01048	0.423
MOD_GlcNHglycan	562	565	PF01048	0.501
MOD_GlcNHglycan	572	575	PF01048	0.545
MOD_GlcNHglycan	631	634	PF01048	0.229
MOD_GlcNHglycan	706	709	PF01048	0.412
MOD_GlcNHglycan	713	716	PF01048	0.366
MOD_GSK3_1	101	108	PF00069	0.738
MOD_GSK3_1	186	193	PF00069	0.403
MOD_GSK3_1	260	267	PF00069	0.500
MOD_GSK3_1	290	297	PF00069	0.467
MOD_GSK3_1	367	374	PF00069	0.467
MOD_GSK3_1	375	382	PF00069	0.453
MOD_GSK3_1	519	526	PF00069	0.442
MOD_GSK3_1	551	558	PF00069	0.469
MOD_GSK3_1	577	584	PF00069	0.473
MOD_GSK3_1	680	687	PF00069	0.376
MOD_GSK3_1	93	100	PF00069	0.703
MOD_N-GLC_1	499	504	PF02516	0.435
MOD_N-GLC_1	680	685	PF02516	0.534
MOD_NEK2_1	101	106	PF00069	0.809
MOD_NEK2_1	131	136	PF00069	0.494
MOD_NEK2_1	139	144	PF00069	0.514
MOD_NEK2_1	190	195	PF00069	0.451
MOD_NEK2_1	23	28	PF00069	0.612
MOD_NEK2_1	274	279	PF00069	0.479
MOD_NEK2_1	290	295	PF00069	0.314
MOD_NEK2_1	367	372	PF00069	0.440
MOD_NEK2_1	381	386	PF00069	0.533
MOD_NEK2_1	551	556	PF00069	0.381
MOD_NEK2_1	560	565	PF00069	0.438
MOD_NEK2_1	7	12	PF00069	0.640
MOD_PIKK_1	139	145	PF00454	0.449
MOD_PIKK_1	375	381	PF00454	0.401
MOD_PIKK_1	651	657	PF00454	0.336
MOD_PKA_1	371	377	PF00069	0.511
MOD_PKA_1	523	529	PF00069	0.415
MOD_PKA_2	250	256	PF00069	0.505
MOD_PKA_2	264	270	PF00069	0.321
MOD_PKA_2	279	285	PF00069	0.356
MOD_PKA_2	326	332	PF00069	0.559
MOD_PKA_2	371	377	PF00069	0.493
MOD_PKA_2	651	657	PF00069	0.453
MOD_PKA_2	711	717	PF00069	0.503
MOD_PKB_1	249	257	PF00069	0.517
MOD_Plk_1	167	173	PF00069	0.622
MOD_Plk_1	674	680	PF00069	0.429
MOD_Plk_4	169	175	PF00069	0.418
MOD_Plk_4	186	192	PF00069	0.463
MOD_Plk_4	471	477	PF00069	0.395
MOD_Plk_4	508	514	PF00069	0.340
MOD_Plk_4	563	569	PF00069	0.510
MOD_Plk_4	601	607	PF00069	0.497
MOD_Plk_4	674	680	PF00069	0.505
MOD_Plk_4	689	695	PF00069	0.270
MOD_Plk_4	714	720	PF00069	0.485
MOD_Plk_4	97	103	PF00069	0.612
MOD_ProDKin_1	291	297	PF00069	0.544
MOD_ProDKin_1	581	587	PF00069	0.460
MOD_SUMO_rev_2	37	43	PF00179	0.718
MOD_SUMO_rev_2	90	97	PF00179	0.498
TRG_DiLeu_BaEn_1	547	552	PF01217	0.455
TRG_DiLeu_BaLyEn_6	257	262	PF01217	0.451
TRG_DiLeu_BaLyEn_6	516	521	PF01217	0.445
TRG_DiLeu_BaLyEn_6	527	532	PF01217	0.454
TRG_ENDOCYTIC_2	85	88	PF00928	0.538
TRG_ER_diArg_1	184	186	PF00400	0.502
TRG_ER_diArg_1	248	251	PF00400	0.486
TRG_ER_diArg_1	514	516	PF00400	0.469
TRG_ER_diArg_1	709	712	PF00400	0.360
TRG_ER_diArg_1	9	12	PF00400	0.683
TRG_NES_CRM1_1	409	421	PF08389	0.466
TRG_NES_CRM1_1	722	737	PF08389	0.486
TRG_NLS_MonoCore_2	114	119	PF00514	0.750
TRG_NLS_MonoCore_2	306	311	PF00514	0.732
TRG_NLS_MonoExtC_3	114	120	PF00514	0.635
TRG_NLS_MonoExtN_4	307	312	PF00514	0.659
TRG_Pf-PMV_PEXEL_1	260	264	PF00026	0.467
TRG_Pf-PMV_PEXEL_1	50	55	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	624	628	PF00026	0.370

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3F3	Leptomonas seymouri	68%	100%
A0A0S4IWW4	Bodo saltans	34%	100%
A0A1X0NV47	Trypanosomatidae	37%	100%
A0A3Q8I8Y6	Leishmania donovani	92%	100%
A0A3R7MZX0	Trypanosoma rangeli	38%	100%
A4H6G3	Leishmania braziliensis	86%	100%
A4HUV8	Leishmania infantum	91%	100%
D0A7J7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
Q4QH33	Leishmania major	92%	100%
V5DSY9	Trypanosoma cruzi	37%	100%