Putative DNA ligase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative DNA ligase

Gene product:

DNA ligase, putative

Species:

Leishmania mexicana

UniProt:

E9ANJ1_LEIMU

TriTrypDb:

LmxM.11.0450

Length:

746

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ANJ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANJ1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0003909	DNA ligase activity	4	8
GO:0003910	DNA ligase (ATP) activity	5	8
GO:0016874	ligase activity	2	11
GO:0016886	ligase activity, forming phosphoric ester bonds	3	8
GO:0140097	catalytic activity, acting on DNA	3	8
GO:0140640	catalytic activity, acting on a nucleic acid	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.594
CLV_C14_Caspase3-7	164	168	PF00656	0.702
CLV_C14_Caspase3-7	181	185	PF00656	0.706
CLV_C14_Caspase3-7	268	272	PF00656	0.440
CLV_C14_Caspase3-7	285	289	PF00656	0.303
CLV_C14_Caspase3-7	54	58	PF00656	0.553
CLV_NRD_NRD_1	168	170	PF00675	0.772
CLV_NRD_NRD_1	175	177	PF00675	0.806
CLV_NRD_NRD_1	353	355	PF00675	0.708
CLV_NRD_NRD_1	445	447	PF00675	0.755
CLV_NRD_NRD_1	463	465	PF00675	0.624
CLV_NRD_NRD_1	527	529	PF00675	0.595
CLV_NRD_NRD_1	618	620	PF00675	0.586
CLV_PCSK_KEX2_1	175	177	PF00082	0.808
CLV_PCSK_KEX2_1	445	447	PF00082	0.755
CLV_PCSK_KEX2_1	463	465	PF00082	0.579
CLV_PCSK_KEX2_1	527	529	PF00082	0.575
CLV_PCSK_KEX2_1	618	620	PF00082	0.538
CLV_PCSK_PC1ET2_1	618	620	PF00082	0.538
CLV_PCSK_SKI1_1	175	179	PF00082	0.687
CLV_PCSK_SKI1_1	478	482	PF00082	0.648
CLV_PCSK_SKI1_1	528	532	PF00082	0.558
CLV_PCSK_SKI1_1	539	543	PF00082	0.519
CLV_PCSK_SKI1_1	545	549	PF00082	0.459
CLV_PCSK_SKI1_1	558	562	PF00082	0.309
CLV_PCSK_SKI1_1	614	618	PF00082	0.784
CLV_PCSK_SKI1_1	659	663	PF00082	0.418
DEG_SCF_FBW7_2	607	613	PF00400	0.578
DEG_SPOP_SBC_1	89	93	PF00917	0.757
DOC_CDC14_PxL_1	217	225	PF14671	0.498
DOC_CKS1_1	607	612	PF01111	0.682
DOC_CYCLIN_RxL_1	552	565	PF00134	0.518
DOC_CYCLIN_yCln2_LP_2	584	590	PF00134	0.481
DOC_MAPK_gen_1	463	473	PF00069	0.657
DOC_MAPK_gen_1	566	576	PF00069	0.538
DOC_MAPK_MEF2A_6	466	475	PF00069	0.701
DOC_MAPK_NFAT4_5	468	476	PF00069	0.698
DOC_PP2B_LxvP_1	241	244	PF13499	0.632
DOC_PP2B_LxvP_1	431	434	PF13499	0.634
DOC_PP4_FxxP_1	229	232	PF00568	0.494
DOC_PP4_FxxP_1	61	64	PF00568	0.380
DOC_SPAK_OSR1_1	225	229	PF12202	0.261
DOC_USP7_MATH_1	155	159	PF00917	0.504
DOC_USP7_MATH_1	177	181	PF00917	0.713
DOC_USP7_MATH_1	262	266	PF00917	0.459
DOC_USP7_MATH_1	32	36	PF00917	0.796
DOC_USP7_MATH_1	537	541	PF00917	0.599
DOC_USP7_MATH_1	623	627	PF00917	0.766
DOC_USP7_MATH_1	704	708	PF00917	0.620
DOC_USP7_UBL2_3	263	267	PF12436	0.635
DOC_USP7_UBL2_3	421	425	PF12436	0.626
DOC_USP7_UBL2_3	562	566	PF12436	0.511
DOC_USP7_UBL2_3	614	618	PF12436	0.700
DOC_USP7_UBL2_3	691	695	PF12436	0.652
DOC_WW_Pin1_4	100	105	PF00397	0.612
DOC_WW_Pin1_4	232	237	PF00397	0.581
DOC_WW_Pin1_4	24	29	PF00397	0.776
DOC_WW_Pin1_4	302	307	PF00397	0.554
DOC_WW_Pin1_4	324	329	PF00397	0.507
DOC_WW_Pin1_4	482	487	PF00397	0.766
DOC_WW_Pin1_4	503	508	PF00397	0.713
DOC_WW_Pin1_4	60	65	PF00397	0.393
DOC_WW_Pin1_4	603	608	PF00397	0.728
DOC_WW_Pin1_4	678	683	PF00397	0.725
DOC_WW_Pin1_4	76	81	PF00397	0.587
DOC_WW_Pin1_4	82	87	PF00397	0.694
LIG_14-3-3_CanoR_1	281	290	PF00244	0.501
LIG_14-3-3_CanoR_1	310	315	PF00244	0.516
LIG_14-3-3_CanoR_1	539	547	PF00244	0.558
LIG_14-3-3_CanoR_1	70	75	PF00244	0.436
LIG_Actin_WH2_2	424	439	PF00022	0.651
LIG_APCC_ABBA_1	398	403	PF00400	0.474
LIG_BIR_II_1	1	5	PF00653	0.555
LIG_BIR_III_4	182	186	PF00653	0.628
LIG_BRCT_BRCA1_1	629	633	PF00533	0.482
LIG_Clathr_ClatBox_1	120	124	PF01394	0.470
LIG_FHA_1	189	195	PF00498	0.440
LIG_FHA_1	285	291	PF00498	0.480
LIG_FHA_1	3	9	PF00498	0.637
LIG_FHA_1	345	351	PF00498	0.643
LIG_FHA_1	392	398	PF00498	0.480
LIG_FHA_1	475	481	PF00498	0.626
LIG_FHA_1	568	574	PF00498	0.638
LIG_FHA_2	148	154	PF00498	0.609
LIG_FHA_2	511	517	PF00498	0.735
LIG_FHA_2	546	552	PF00498	0.619
LIG_FHA_2	623	629	PF00498	0.609
LIG_FHA_2	721	727	PF00498	0.575
LIG_FHA_2	97	103	PF00498	0.486
LIG_GSK3_LRP6_1	76	81	PF00069	0.466
LIG_LIR_Apic_2	111	116	PF02991	0.439
LIG_LIR_Apic_2	73	77	PF02991	0.599
LIG_LIR_Gen_1	191	200	PF02991	0.423
LIG_LIR_Gen_1	713	724	PF02991	0.442
LIG_LIR_Nem_3	108	113	PF02991	0.416
LIG_LIR_Nem_3	191	196	PF02991	0.417
LIG_LIR_Nem_3	551	557	PF02991	0.448
LIG_LIR_Nem_3	630	636	PF02991	0.513
LIG_LIR_Nem_3	713	719	PF02991	0.423
LIG_LYPXL_yS_3	554	557	PF13949	0.547
LIG_MYND_1	555	559	PF01753	0.572
LIG_NRBOX	316	322	PF00104	0.374
LIG_NRBOX	661	667	PF00104	0.443
LIG_PCNA_PIPBox_1	658	667	PF02747	0.444
LIG_Pex14_2	189	193	PF04695	0.579
LIG_SH2_CRK	113	117	PF00017	0.552
LIG_SH2_CRK	384	388	PF00017	0.457
LIG_SH2_CRK	716	720	PF00017	0.414
LIG_SH2_NCK_1	40	44	PF00017	0.606
LIG_SH2_PTP2	74	77	PF00017	0.586
LIG_SH2_SRC	219	222	PF00017	0.498
LIG_SH2_SRC	401	404	PF00017	0.547
LIG_SH2_SRC	74	77	PF00017	0.557
LIG_SH2_STAT3	146	149	PF00017	0.518
LIG_SH2_STAT3	634	637	PF00017	0.388
LIG_SH2_STAT5	146	149	PF00017	0.409
LIG_SH2_STAT5	219	222	PF00017	0.380
LIG_SH2_STAT5	316	319	PF00017	0.473
LIG_SH2_STAT5	401	404	PF00017	0.448
LIG_SH2_STAT5	74	77	PF00017	0.579
LIG_SH3_1	218	224	PF00018	0.431
LIG_SH3_1	74	80	PF00018	0.428
LIG_SH3_3	160	166	PF00018	0.568
LIG_SH3_3	218	224	PF00018	0.502
LIG_SH3_3	237	243	PF00018	0.665
LIG_SH3_3	498	504	PF00018	0.737
LIG_SH3_3	53	59	PF00018	0.558
LIG_SH3_3	571	577	PF00018	0.484
LIG_SH3_3	584	590	PF00018	0.498
LIG_SH3_3	604	610	PF00018	0.624
LIG_SH3_3	645	651	PF00018	0.409
LIG_SH3_3	74	80	PF00018	0.548
LIG_SUMO_SIM_anti_2	4	10	PF11976	0.577
LIG_SUMO_SIM_anti_2	516	521	PF11976	0.642
LIG_SUMO_SIM_par_1	4	10	PF11976	0.581
LIG_SUMO_SIM_par_1	471	477	PF11976	0.600
LIG_SUMO_SIM_par_1	707	713	PF11976	0.526
LIG_SxIP_EBH_1	375	388	PF03271	0.524
LIG_TRAF2_1	211	214	PF00917	0.414
LIG_TYR_ITIM	382	387	PF00017	0.412
LIG_UBA3_1	556	562	PF00899	0.438
MOD_CDK_SPK_2	24	29	PF00069	0.674
MOD_CDK_SPK_2	60	65	PF00069	0.384
MOD_CDK_SPxxK_3	24	31	PF00069	0.502
MOD_CDK_SPxxK_3	324	331	PF00069	0.436
MOD_CK1_1	253	259	PF00069	0.657
MOD_CK1_1	284	290	PF00069	0.412
MOD_CK1_1	474	480	PF00069	0.664
MOD_CK1_1	591	597	PF00069	0.706
MOD_CK1_1	722	728	PF00069	0.551
MOD_CK1_1	90	96	PF00069	0.784
MOD_CK2_1	510	516	PF00069	0.727
MOD_CK2_1	622	628	PF00069	0.579
MOD_CK2_1	720	726	PF00069	0.485
MOD_CK2_1	76	82	PF00069	0.569
MOD_CK2_1	96	102	PF00069	0.498
MOD_Cter_Amidation	167	170	PF01082	0.587
MOD_Cter_Amidation	461	464	PF01082	0.706
MOD_Cter_Amidation	525	528	PF01082	0.668
MOD_GlcNHglycan	196	199	PF01048	0.412
MOD_GlcNHglycan	236	239	PF01048	0.477
MOD_GlcNHglycan	252	255	PF01048	0.604
MOD_GlcNHglycan	337	340	PF01048	0.406
MOD_GlcNHglycan	34	37	PF01048	0.766
MOD_GlcNHglycan	367	370	PF01048	0.677
MOD_GlcNHglycan	40	43	PF01048	0.550
MOD_GlcNHglycan	459	463	PF01048	0.791
MOD_GlcNHglycan	590	593	PF01048	0.580
MOD_GlcNHglycan	625	628	PF01048	0.684
MOD_GlcNHglycan	666	669	PF01048	0.613
MOD_GSK3_1	20	27	PF00069	0.683
MOD_GSK3_1	230	237	PF00069	0.338
MOD_GSK3_1	34	41	PF00069	0.767
MOD_GSK3_1	386	393	PF00069	0.470
MOD_GSK3_1	572	579	PF00069	0.513
MOD_GSK3_1	623	630	PF00069	0.703
MOD_GSK3_1	704	711	PF00069	0.601
MOD_GSK3_1	715	722	PF00069	0.405
MOD_GSK3_1	78	85	PF00069	0.627
MOD_GSK3_1	89	96	PF00069	0.615
MOD_N-GLC_1	302	307	PF02516	0.388
MOD_N-GLC_1	38	43	PF02516	0.622
MOD_N-GLC_1	646	651	PF02516	0.468
MOD_N-GLC_2	201	203	PF02516	0.290
MOD_NEK2_1	1	6	PF00069	0.470
MOD_NEK2_1	18	23	PF00069	0.694
MOD_NEK2_1	194	199	PF00069	0.407
MOD_NEK2_1	390	395	PF00069	0.533
MOD_NEK2_1	450	455	PF00069	0.681
MOD_NEK2_1	471	476	PF00069	0.679
MOD_NEK2_1	646	651	PF00069	0.481
MOD_NEK2_1	715	720	PF00069	0.424
MOD_NEK2_2	105	110	PF00069	0.563
MOD_NEK2_2	262	267	PF00069	0.460
MOD_OFUCOSY	203	208	PF10250	0.327
MOD_PIKK_1	269	275	PF00454	0.585
MOD_PIKK_1	305	311	PF00454	0.389
MOD_PIKK_1	391	397	PF00454	0.565
MOD_PK_1	731	737	PF00069	0.570
MOD_PKA_1	354	360	PF00069	0.495
MOD_PKA_1	614	620	PF00069	0.770
MOD_PKA_2	155	161	PF00069	0.495
MOD_PKA_2	203	209	PF00069	0.569
MOD_PKA_2	450	456	PF00069	0.779
MOD_PKB_1	202	210	PF00069	0.554
MOD_Plk_1	135	141	PF00069	0.539
MOD_Plk_1	646	652	PF00069	0.480
MOD_Plk_4	135	141	PF00069	0.474
MOD_Plk_4	628	634	PF00069	0.362
MOD_Plk_4	657	663	PF00069	0.500
MOD_ProDKin_1	100	106	PF00069	0.601
MOD_ProDKin_1	232	238	PF00069	0.603
MOD_ProDKin_1	24	30	PF00069	0.776
MOD_ProDKin_1	302	308	PF00069	0.553
MOD_ProDKin_1	324	330	PF00069	0.505
MOD_ProDKin_1	482	488	PF00069	0.767
MOD_ProDKin_1	503	509	PF00069	0.713
MOD_ProDKin_1	60	66	PF00069	0.392
MOD_ProDKin_1	603	609	PF00069	0.730
MOD_ProDKin_1	678	684	PF00069	0.725
MOD_ProDKin_1	76	82	PF00069	0.594
TRG_DiLeu_BaEn_1	125	130	PF01217	0.358
TRG_DiLeu_BaEn_4	125	131	PF01217	0.342
TRG_DiLeu_BaLyEn_6	431	436	PF01217	0.539
TRG_DiLeu_BaLyEn_6	556	561	PF01217	0.432
TRG_DiLeu_BaLyEn_6	67	72	PF01217	0.544
TRG_DiLeu_LyEn_5	125	130	PF01217	0.418
TRG_ENDOCYTIC_2	118	121	PF00928	0.494
TRG_ENDOCYTIC_2	384	387	PF00928	0.462
TRG_ENDOCYTIC_2	554	557	PF00928	0.430
TRG_ENDOCYTIC_2	716	719	PF00928	0.403
TRG_ER_diArg_1	445	448	PF00400	0.699
TRG_ER_diArg_1	463	466	PF00400	0.715
TRG_ER_diArg_1	568	571	PF00400	0.589
TRG_NLS_MonoExtC_3	168	173	PF00514	0.678
TRG_NLS_MonoExtN_4	166	173	PF00514	0.629
TRG_NLS_MonoExtN_4	615	622	PF00514	0.593
TRG_Pf-PMV_PEXEL_1	131	136	PF00026	0.363
TRG_Pf-PMV_PEXEL_1	528	532	PF00026	0.668
TRG_Pf-PMV_PEXEL_1	558	563	PF00026	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZN9	Leptomonas seymouri	52%	97%
A0A1X0NVK9	Trypanosomatidae	36%	100%
A0A3R7NRR1	Trypanosoma rangeli	37%	100%
A0A3S7WRI1	Leishmania donovani	88%	100%
A4H6G1	Leishmania braziliensis	74%	100%
A4HUV6	Leishmania infantum	89%	100%
D0A7J8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
Q4QH35	Leishmania major	86%	100%
V5BB55	Trypanosoma cruzi	35%	100%