Protein phosphatase 1 regulatory subunit 22

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ANJ0_LEIMU

TriTrypDb:

LmxM.11.0440

Length:

587

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	7
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9ANJ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANJ0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0019900	kinase binding	4	1
GO:0019901	protein kinase binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	180	182	PF00675	0.454
CLV_NRD_NRD_1	280	282	PF00675	0.559
CLV_NRD_NRD_1	341	343	PF00675	0.632
CLV_NRD_NRD_1	439	441	PF00675	0.467
CLV_NRD_NRD_1	446	448	PF00675	0.459
CLV_NRD_NRD_1	453	455	PF00675	0.509
CLV_NRD_NRD_1	496	498	PF00675	0.743
CLV_NRD_NRD_1	547	549	PF00675	0.556
CLV_NRD_NRD_1	568	570	PF00675	0.716
CLV_NRD_NRD_1	7	9	PF00675	0.439
CLV_PCSK_KEX2_1	182	184	PF00082	0.444
CLV_PCSK_KEX2_1	280	282	PF00082	0.559
CLV_PCSK_KEX2_1	341	343	PF00082	0.626
CLV_PCSK_KEX2_1	439	441	PF00082	0.473
CLV_PCSK_KEX2_1	446	448	PF00082	0.460
CLV_PCSK_KEX2_1	453	455	PF00082	0.509
CLV_PCSK_KEX2_1	512	514	PF00082	0.566
CLV_PCSK_KEX2_1	547	549	PF00082	0.558
CLV_PCSK_KEX2_1	568	570	PF00082	0.580
CLV_PCSK_KEX2_1	6	8	PF00082	0.430
CLV_PCSK_PC1ET2_1	182	184	PF00082	0.444
CLV_PCSK_PC1ET2_1	512	514	PF00082	0.537
CLV_PCSK_PC7_1	435	441	PF00082	0.464
CLV_PCSK_SKI1_1	182	186	PF00082	0.440
CLV_PCSK_SKI1_1	341	345	PF00082	0.591
CLV_Separin_Metazoa	418	422	PF03568	0.490
DEG_APCC_DBOX_1	445	453	PF00400	0.525
DEG_Nend_UBRbox_3	1	3	PF02207	0.411
DEG_SPOP_SBC_1	210	214	PF00917	0.622
DEG_SPOP_SBC_1	221	225	PF00917	0.637
DEG_SPOP_SBC_1	286	290	PF00917	0.554
DEG_SPOP_SBC_1	317	321	PF00917	0.665
DOC_CYCLIN_RxL_1	179	186	PF00134	0.448
DOC_CYCLIN_RxL_1	26	40	PF00134	0.317
DOC_MAPK_gen_1	127	137	PF00069	0.434
DOC_MAPK_gen_1	181	190	PF00069	0.442
DOC_MAPK_gen_1	439	445	PF00069	0.495
DOC_MAPK_gen_1	512	519	PF00069	0.584
DOC_MAPK_HePTP_8	180	192	PF00069	0.443
DOC_MAPK_MEF2A_6	183	192	PF00069	0.439
DOC_MAPK_MEF2A_6	512	519	PF00069	0.584
DOC_PP2B_LxvP_1	190	193	PF13499	0.466
DOC_USP7_MATH_1	221	225	PF00917	0.620
DOC_USP7_MATH_1	286	290	PF00917	0.574
DOC_USP7_MATH_1	333	337	PF00917	0.610
DOC_USP7_MATH_1	374	378	PF00917	0.644
DOC_USP7_MATH_1	526	530	PF00917	0.721
DOC_USP7_MATH_1	551	555	PF00917	0.605
DOC_USP7_MATH_1	94	98	PF00917	0.329
DOC_WW_Pin1_4	350	355	PF00397	0.642
DOC_WW_Pin1_4	359	364	PF00397	0.656
DOC_WW_Pin1_4	368	373	PF00397	0.702
DOC_WW_Pin1_4	392	397	PF00397	0.684
DOC_WW_Pin1_4	511	516	PF00397	0.680
DOC_WW_Pin1_4	536	541	PF00397	0.702
LIG_14-3-3_CanoR_1	130	135	PF00244	0.309
LIG_14-3-3_CanoR_1	183	192	PF00244	0.507
LIG_14-3-3_CanoR_1	211	220	PF00244	0.630
LIG_14-3-3_CanoR_1	301	310	PF00244	0.692
LIG_14-3-3_CanoR_1	365	371	PF00244	0.653
LIG_14-3-3_CanoR_1	381	390	PF00244	0.639
LIG_14-3-3_CanoR_1	414	420	PF00244	0.494
LIG_14-3-3_CanoR_1	430	438	PF00244	0.516
LIG_14-3-3_CanoR_1	453	457	PF00244	0.376
LIG_14-3-3_CanoR_1	8	14	PF00244	0.423
LIG_Actin_WH2_2	139	156	PF00022	0.359
LIG_Actin_WH2_2	438	455	PF00022	0.415
LIG_BRCT_BRCA1_1	168	172	PF00533	0.434
LIG_Clathr_ClatBox_1	134	138	PF01394	0.445
LIG_CtBP_PxDLS_1	468	472	PF00389	0.497
LIG_FHA_1	116	122	PF00498	0.426
LIG_FHA_1	221	227	PF00498	0.619
LIG_FHA_1	266	272	PF00498	0.702
LIG_FHA_1	319	325	PF00498	0.627
LIG_FHA_1	383	389	PF00498	0.628
LIG_FHA_2	120	126	PF00498	0.437
LIG_FHA_2	71	77	PF00498	0.401
LIG_Integrin_isoDGR_2	379	381	PF01839	0.640
LIG_IRF3_LxIS_1	53	59	PF10401	0.240
LIG_LIR_Gen_1	104	111	PF02991	0.307
LIG_LIR_Gen_1	122	131	PF02991	0.359
LIG_LIR_Nem_3	104	108	PF02991	0.307
LIG_LIR_Nem_3	122	126	PF02991	0.358
LIG_NRBOX	24	30	PF00104	0.427
LIG_SH2_SRC	123	126	PF00017	0.349
LIG_SH2_STAT5	123	126	PF00017	0.349
LIG_SH3_3	215	221	PF00018	0.551
LIG_SH3_3	537	543	PF00018	0.569
LIG_SUMO_SIM_anti_2	51	57	PF11976	0.307
LIG_SUMO_SIM_par_1	518	523	PF11976	0.619
LIG_SUMO_SIM_par_1	70	76	PF11976	0.403
LIG_TRAF2_1	502	505	PF00917	0.542
LIG_TRAF2_1	73	76	PF00917	0.302
LIG_TYR_ITIM	121	126	PF00017	0.381
LIG_WRC_WIRS_1	10	15	PF05994	0.416
MOD_CDC14_SPxK_1	362	365	PF00782	0.593
MOD_CDK_SPxK_1	359	365	PF00069	0.604
MOD_CDK_SPxxK_3	511	518	PF00069	0.836
MOD_CK1_1	166	172	PF00069	0.388
MOD_CK1_1	209	215	PF00069	0.632
MOD_CK1_1	225	231	PF00069	0.615
MOD_CK1_1	274	280	PF00069	0.660
MOD_CK1_1	288	294	PF00069	0.610
MOD_CK1_1	323	329	PF00069	0.703
MOD_CK1_1	358	364	PF00069	0.696
MOD_CK1_1	37	43	PF00069	0.307
MOD_CK1_1	392	398	PF00069	0.609
MOD_CK1_1	475	481	PF00069	0.650
MOD_CK1_1	525	531	PF00069	0.636
MOD_CK1_1	560	566	PF00069	0.707
MOD_CK1_1	97	103	PF00069	0.341
MOD_CK2_1	191	197	PF00069	0.563
MOD_CK2_1	233	239	PF00069	0.671
MOD_CK2_1	70	76	PF00069	0.403
MOD_GlcNHglycan	168	171	PF01048	0.435
MOD_GlcNHglycan	173	176	PF01048	0.397
MOD_GlcNHglycan	247	250	PF01048	0.790
MOD_GlcNHglycan	255	258	PF01048	0.583
MOD_GlcNHglycan	273	277	PF01048	0.616
MOD_GlcNHglycan	305	308	PF01048	0.655
MOD_GlcNHglycan	312	315	PF01048	0.597
MOD_GlcNHglycan	355	358	PF01048	0.634
MOD_GlcNHglycan	391	394	PF01048	0.568
MOD_GlcNHglycan	477	480	PF01048	0.627
MOD_GlcNHglycan	491	495	PF01048	0.745
MOD_GlcNHglycan	523	527	PF01048	0.613
MOD_GlcNHglycan	553	556	PF01048	0.647
MOD_GSK3_1	115	122	PF00069	0.429
MOD_GSK3_1	138	145	PF00069	0.373
MOD_GSK3_1	201	208	PF00069	0.599
MOD_GSK3_1	216	223	PF00069	0.527
MOD_GSK3_1	225	232	PF00069	0.667
MOD_GSK3_1	245	252	PF00069	0.550
MOD_GSK3_1	261	268	PF00069	0.753
MOD_GSK3_1	285	292	PF00069	0.679
MOD_GSK3_1	316	323	PF00069	0.587
MOD_GSK3_1	353	360	PF00069	0.767
MOD_GSK3_1	380	387	PF00069	0.620
MOD_GSK3_1	522	529	PF00069	0.611
MOD_GSK3_1	551	558	PF00069	0.675
MOD_GSK3_1	580	587	PF00069	0.693
MOD_GSK3_1	97	104	PF00069	0.311
MOD_N-GLC_1	101	106	PF02516	0.307
MOD_N-GLC_1	115	120	PF02516	0.440
MOD_N-GLC_1	56	61	PF02516	0.280
MOD_NEK2_1	101	106	PF00069	0.321
MOD_NEK2_1	229	234	PF00069	0.633
MOD_NEK2_1	265	270	PF00069	0.641
MOD_NEK2_1	310	315	PF00069	0.524
MOD_NEK2_1	34	39	PF00069	0.307
MOD_NEK2_1	375	380	PF00069	0.606
MOD_NEK2_1	384	389	PF00069	0.646
MOD_NEK2_1	452	457	PF00069	0.429
MOD_NEK2_1	557	562	PF00069	0.689
MOD_NEK2_1	56	61	PF00069	0.280
MOD_NEK2_1	574	579	PF00069	0.518
MOD_NEK2_1	77	82	PF00069	0.366
MOD_PIKK_1	138	144	PF00454	0.332
MOD_PIKK_1	183	189	PF00454	0.500
MOD_PIKK_1	458	464	PF00454	0.496
MOD_PIKK_1	469	475	PF00454	0.502
MOD_PIKK_1	529	535	PF00454	0.746
MOD_PK_1	513	519	PF00069	0.654
MOD_PKA_2	129	135	PF00069	0.281
MOD_PKA_2	210	216	PF00069	0.638
MOD_PKA_2	300	306	PF00069	0.665
MOD_PKA_2	348	354	PF00069	0.656
MOD_PKA_2	380	386	PF00069	0.678
MOD_PKA_2	413	419	PF00069	0.592
MOD_PKA_2	429	435	PF00069	0.502
MOD_PKA_2	452	458	PF00069	0.410
MOD_PKA_2	496	502	PF00069	0.548
MOD_PKB_1	181	189	PF00069	0.504
MOD_Plk_1	101	107	PF00069	0.307
MOD_Plk_1	221	227	PF00069	0.619
MOD_Plk_1	229	235	PF00069	0.603
MOD_Plk_4	119	125	PF00069	0.385
MOD_Plk_4	130	136	PF00069	0.378
MOD_Plk_4	163	169	PF00069	0.425
MOD_Plk_4	261	267	PF00069	0.632
MOD_Plk_4	384	390	PF00069	0.620
MOD_Plk_4	51	57	PF00069	0.357
MOD_ProDKin_1	350	356	PF00069	0.643
MOD_ProDKin_1	359	365	PF00069	0.656
MOD_ProDKin_1	368	374	PF00069	0.697
MOD_ProDKin_1	392	398	PF00069	0.684
MOD_ProDKin_1	511	517	PF00069	0.680
MOD_ProDKin_1	536	542	PF00069	0.699
TRG_DiLeu_BaEn_1	23	28	PF01217	0.436
TRG_DiLeu_BaLyEn_6	174	179	PF01217	0.370
TRG_DiLeu_BaLyEn_6	180	185	PF01217	0.420
TRG_ENDOCYTIC_2	123	126	PF00928	0.372
TRG_ER_diArg_1	180	183	PF00400	0.457
TRG_ER_diArg_1	340	342	PF00400	0.608
TRG_ER_diArg_1	438	440	PF00400	0.476
TRG_ER_diArg_1	445	447	PF00400	0.463
TRG_ER_diArg_1	452	454	PF00400	0.509
TRG_ER_diArg_1	5	8	PF00400	0.395
TRG_Pf-PMV_PEXEL_1	144	149	PF00026	0.381
TRG_Pf-PMV_PEXEL_1	183	187	PF00026	0.435
TRG_Pf-PMV_PEXEL_1	342	347	PF00026	0.614
TRG_Pf-PMV_PEXEL_1	447	451	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	518	523	PF00026	0.619

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBI0	Leptomonas seymouri	50%	93%
A0A3Q8I916	Leishmania donovani	88%	100%
A4H6G0	Leishmania braziliensis	70%	100%
A4HUV5	Leishmania infantum	88%	100%
Q4QH36	Leishmania major	88%	100%