Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ANI9_LEIMU

TriTrypDb:

LmxM.11.0430

Length:

644

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ANI9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANI9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	602	606	PF00656	0.545
CLV_MEL_PAP_1	253	259	PF00089	0.516
CLV_NRD_NRD_1	255	257	PF00675	0.563
CLV_NRD_NRD_1	314	316	PF00675	0.530
CLV_NRD_NRD_1	427	429	PF00675	0.395
CLV_NRD_NRD_1	456	458	PF00675	0.518
CLV_NRD_NRD_1	560	562	PF00675	0.453
CLV_PCSK_KEX2_1	255	257	PF00082	0.563
CLV_PCSK_KEX2_1	427	429	PF00082	0.392
CLV_PCSK_KEX2_1	456	458	PF00082	0.498
CLV_PCSK_KEX2_1	467	469	PF00082	0.442
CLV_PCSK_KEX2_1	480	482	PF00082	0.347
CLV_PCSK_KEX2_1	559	561	PF00082	0.460
CLV_PCSK_PC1ET2_1	467	469	PF00082	0.526
CLV_PCSK_PC1ET2_1	480	482	PF00082	0.532
CLV_PCSK_SKI1_1	282	286	PF00082	0.462
CLV_PCSK_SKI1_1	378	382	PF00082	0.476
CLV_PCSK_SKI1_1	412	416	PF00082	0.536
CLV_PCSK_SKI1_1	429	433	PF00082	0.419
CLV_PCSK_SKI1_1	463	467	PF00082	0.400
CLV_PCSK_SKI1_1	483	487	PF00082	0.491
CLV_PCSK_SKI1_1	51	55	PF00082	0.745
CLV_Separin_Metazoa	252	256	PF03568	0.406
DEG_SPOP_SBC_1	37	41	PF00917	0.499
DOC_AGCK_PIF_2	493	498	PF00069	0.351
DOC_CKS1_1	385	390	PF01111	0.543
DOC_CKS1_1	83	88	PF01111	0.760
DOC_MAPK_gen_1	225	232	PF00069	0.492
DOC_MAPK_gen_1	399	407	PF00069	0.440
DOC_MAPK_gen_1	424	432	PF00069	0.387
DOC_MAPK_gen_1	456	462	PF00069	0.374
DOC_MAPK_gen_1	559	567	PF00069	0.513
DOC_MAPK_HePTP_8	4	16	PF00069	0.663
DOC_MAPK_MEF2A_6	225	232	PF00069	0.507
DOC_MAPK_MEF2A_6	7	16	PF00069	0.552
DOC_PP1_RVXF_1	376	383	PF00149	0.538
DOC_PP1_RVXF_1	426	433	PF00149	0.449
DOC_PP4_FxxP_1	163	166	PF00568	0.311
DOC_PP4_FxxP_1	381	384	PF00568	0.498
DOC_USP7_MATH_1	104	108	PF00917	0.694
DOC_USP7_MATH_1	132	136	PF00917	0.697
DOC_USP7_MATH_1	335	339	PF00917	0.382
DOC_USP7_MATH_1	37	41	PF00917	0.746
DOC_USP7_UBL2_3	448	452	PF12436	0.469
DOC_USP7_UBL2_3	463	467	PF12436	0.288
DOC_USP7_UBL2_3	584	588	PF12436	0.373
DOC_WW_Pin1_4	100	105	PF00397	0.729
DOC_WW_Pin1_4	130	135	PF00397	0.642
DOC_WW_Pin1_4	300	305	PF00397	0.684
DOC_WW_Pin1_4	324	329	PF00397	0.356
DOC_WW_Pin1_4	384	389	PF00397	0.542
DOC_WW_Pin1_4	56	61	PF00397	0.671
DOC_WW_Pin1_4	82	87	PF00397	0.733
LIG_14-3-3_CanoR_1	105	112	PF00244	0.496
LIG_14-3-3_CanoR_1	397	406	PF00244	0.551
LIG_14-3-3_CanoR_1	422	427	PF00244	0.453
LIG_14-3-3_CanoR_1	519	528	PF00244	0.453
LIG_14-3-3_CanoR_1	541	547	PF00244	0.484
LIG_APCC_ABBA_1	112	117	PF00400	0.431
LIG_BIR_II_1	1	5	PF00653	0.567
LIG_BIR_III_2	131	135	PF00653	0.442
LIG_BRCT_BRCA1_1	302	306	PF00533	0.551
LIG_CtBP_PxDLS_1	443	447	PF00389	0.554
LIG_EVH1_2	126	130	PF00568	0.670
LIG_FHA_1	134	140	PF00498	0.514
LIG_FHA_1	166	172	PF00498	0.448
LIG_FHA_1	260	266	PF00498	0.486
LIG_FHA_1	31	37	PF00498	0.697
LIG_FHA_1	354	360	PF00498	0.488
LIG_FHA_1	385	391	PF00498	0.496
LIG_FHA_1	53	59	PF00498	0.710
LIG_FHA_2	342	348	PF00498	0.517
LIG_FHA_2	492	498	PF00498	0.475
LIG_FHA_2	95	101	PF00498	0.794
LIG_LIR_Gen_1	183	193	PF02991	0.551
LIG_LIR_Gen_1	199	208	PF02991	0.209
LIG_LIR_Gen_1	274	284	PF02991	0.516
LIG_LIR_Gen_1	332	341	PF02991	0.547
LIG_LIR_LC3C_4	135	139	PF02991	0.562
LIG_LIR_Nem_3	183	188	PF02991	0.495
LIG_LIR_Nem_3	199	204	PF02991	0.194
LIG_LIR_Nem_3	207	211	PF02991	0.406
LIG_LIR_Nem_3	220	226	PF02991	0.274
LIG_LIR_Nem_3	237	243	PF02991	0.377
LIG_LIR_Nem_3	245	250	PF02991	0.362
LIG_LIR_Nem_3	332	336	PF02991	0.529
LIG_LIR_Nem_3	364	370	PF02991	0.421
LIG_Pex14_2	236	240	PF04695	0.349
LIG_REV1ctd_RIR_1	565	572	PF16727	0.483
LIG_SH2_CRK	267	271	PF00017	0.425
LIG_SH2_CRK	562	566	PF00017	0.382
LIG_SH2_GRB2like	185	188	PF00017	0.447
LIG_SH2_PTP2	201	204	PF00017	0.361
LIG_SH2_SRC	185	188	PF00017	0.447
LIG_SH2_STAP1	244	248	PF00017	0.530
LIG_SH2_STAT3	275	278	PF00017	0.329
LIG_SH2_STAT3	492	495	PF00017	0.477
LIG_SH2_STAT5	177	180	PF00017	0.527
LIG_SH2_STAT5	185	188	PF00017	0.375
LIG_SH2_STAT5	201	204	PF00017	0.182
LIG_SH2_STAT5	275	278	PF00017	0.338
LIG_SH2_STAT5	492	495	PF00017	0.370
LIG_SH2_STAT5	566	569	PF00017	0.336
LIG_SH2_STAT5	575	578	PF00017	0.298
LIG_SH3_1	433	439	PF00018	0.475
LIG_SH3_3	121	127	PF00018	0.611
LIG_SH3_3	298	304	PF00018	0.544
LIG_SH3_3	382	388	PF00018	0.542
LIG_SH3_3	433	439	PF00018	0.415
LIG_SH3_3	506	512	PF00018	0.377
LIG_SH3_3	615	621	PF00018	0.658
LIG_SH3_3	80	86	PF00018	0.709
LIG_SUMO_SIM_anti_2	190	195	PF11976	0.381
LIG_SUMO_SIM_anti_2	229	234	PF11976	0.349
LIG_SUMO_SIM_anti_2	347	352	PF11976	0.422
LIG_SUMO_SIM_par_1	135	140	PF11976	0.620
LIG_SUMO_SIM_par_1	149	155	PF11976	0.444
LIG_TRAF2_1	406	409	PF00917	0.401
LIG_TRAF2_1	599	602	PF00917	0.652
LIG_TRAF2_1	60	63	PF00917	0.442
LIG_UBA3_1	474	480	PF00899	0.497
LIG_WRC_WIRS_1	205	210	PF05994	0.436
LIG_WRC_WIRS_1	462	467	PF05994	0.307
LIG_WW_3	125	129	PF00397	0.617
MOD_CDK_SPK_2	100	105	PF00069	0.473
MOD_CDK_SPK_2	326	331	PF00069	0.408
MOD_CDK_SPxxK_3	324	331	PF00069	0.418
MOD_CK1_1	103	109	PF00069	0.679
MOD_CK1_1	216	222	PF00069	0.382
MOD_CK1_1	326	332	PF00069	0.459
MOD_CK1_1	41	47	PF00069	0.662
MOD_CK1_1	604	610	PF00069	0.555
MOD_CK1_1	611	617	PF00069	0.535
MOD_CK1_1	87	93	PF00069	0.662
MOD_CK2_1	211	217	PF00069	0.434
MOD_CK2_1	317	323	PF00069	0.417
MOD_CK2_1	37	43	PF00069	0.655
MOD_CK2_1	491	497	PF00069	0.480
MOD_CK2_1	56	62	PF00069	0.587
MOD_CK2_1	87	93	PF00069	0.692
MOD_GlcNHglycan	106	109	PF01048	0.623
MOD_GlcNHglycan	144	147	PF01048	0.412
MOD_GlcNHglycan	213	216	PF01048	0.524
MOD_GlcNHglycan	319	322	PF01048	0.552
MOD_GlcNHglycan	356	359	PF01048	0.464
MOD_GlcNHglycan	40	43	PF01048	0.695
MOD_GlcNHglycan	47	50	PF01048	0.719
MOD_GlcNHglycan	499	502	PF01048	0.386
MOD_GlcNHglycan	589	592	PF01048	0.457
MOD_GlcNHglycan	610	613	PF01048	0.653
MOD_GlcNHglycan	629	632	PF01048	0.792
MOD_GSK3_1	12	19	PF00069	0.599
MOD_GSK3_1	165	172	PF00069	0.372
MOD_GSK3_1	209	216	PF00069	0.435
MOD_GSK3_1	300	307	PF00069	0.586
MOD_GSK3_1	32	39	PF00069	0.618
MOD_GSK3_1	41	48	PF00069	0.652
MOD_GSK3_1	52	59	PF00069	0.658
MOD_GSK3_1	541	548	PF00069	0.556
MOD_GSK3_1	597	604	PF00069	0.531
MOD_GSK3_1	70	77	PF00069	0.449
MOD_GSK3_1	94	101	PF00069	0.661
MOD_N-GLC_1	16	21	PF02516	0.549
MOD_N-GLC_1	520	525	PF02516	0.427
MOD_N-GLC_1	94	99	PF02516	0.778
MOD_NEK2_1	12	17	PF00069	0.568
MOD_NEK2_1	204	209	PF00069	0.474
MOD_NEK2_1	211	216	PF00069	0.341
MOD_NEK2_1	45	50	PF00069	0.520
MOD_NEK2_1	608	613	PF00069	0.628
MOD_NEK2_1	99	104	PF00069	0.658
MOD_NEK2_2	542	547	PF00069	0.459
MOD_PIKK_1	341	347	PF00454	0.542
MOD_PIKK_1	397	403	PF00454	0.452
MOD_PIKK_1	491	497	PF00454	0.480
MOD_PIKK_1	597	603	PF00454	0.499
MOD_PKA_2	104	110	PF00069	0.584
MOD_PKA_2	30	36	PF00069	0.632
MOD_PKB_1	395	403	PF00069	0.455
MOD_Plk_1	209	215	PF00069	0.538
MOD_Plk_1	361	367	PF00069	0.545
MOD_Plk_1	604	610	PF00069	0.581
MOD_Plk_4	133	139	PF00069	0.533
MOD_Plk_4	335	341	PF00069	0.490
MOD_Plk_4	386	392	PF00069	0.425
MOD_Plk_4	461	467	PF00069	0.350
MOD_ProDKin_1	100	106	PF00069	0.727
MOD_ProDKin_1	130	136	PF00069	0.642
MOD_ProDKin_1	300	306	PF00069	0.675
MOD_ProDKin_1	324	330	PF00069	0.353
MOD_ProDKin_1	384	390	PF00069	0.535
MOD_ProDKin_1	56	62	PF00069	0.670
MOD_ProDKin_1	82	88	PF00069	0.732
TRG_DiLeu_BaEn_1	309	314	PF01217	0.508
TRG_DiLeu_BaEn_3	472	478	PF01217	0.367
TRG_DiLeu_BaLyEn_6	526	531	PF01217	0.490
TRG_ENDOCYTIC_2	185	188	PF00928	0.447
TRG_ENDOCYTIC_2	201	204	PF00928	0.182
TRG_ENDOCYTIC_2	205	208	PF00928	0.410
TRG_ENDOCYTIC_2	319	322	PF00928	0.428
TRG_ENDOCYTIC_2	367	370	PF00928	0.339
TRG_ENDOCYTIC_2	562	565	PF00928	0.384
TRG_ENDOCYTIC_2	566	569	PF00928	0.388
TRG_ENDOCYTIC_2	575	578	PF00928	0.401
TRG_ER_diArg_1	254	256	PF00400	0.559
TRG_ER_diArg_1	392	395	PF00400	0.413
TRG_ER_diArg_1	396	399	PF00400	0.404
TRG_ER_diArg_1	426	428	PF00400	0.366
TRG_ER_diArg_1	455	457	PF00400	0.478
TRG_ER_diArg_1	558	561	PF00400	0.436
TRG_NLS_Bipartite_1	467	484	PF00514	0.368
TRG_NLS_MonoExtN_4	479	484	PF00514	0.371
TRG_Pf-PMV_PEXEL_1	529	533	PF00026	0.438

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU37	Leptomonas seymouri	54%	80%
A0A0S4IU07	Bodo saltans	40%	89%
A0A0S4J638	Bodo saltans	33%	88%
A0A1X0NQ80	Trypanosomatidae	31%	84%
A0A1X0NVF1	Trypanosomatidae	45%	97%
A0A3S5H6I4	Leishmania donovani	92%	100%
A0A422N1P2	Trypanosoma rangeli	31%	89%
A0A422NYN8	Trypanosoma rangeli	46%	93%
A4H6F9	Leishmania braziliensis	82%	100%
A4HUV4	Leishmania infantum	93%	100%
C9ZT00	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	85%
D0A7K0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	98%
Q4QH37	Leishmania major	91%	100%
V5BNE0	Trypanosoma cruzi	31%	90%
V5DSY4	Trypanosoma cruzi	52%	95%