Putative chromatin binding protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

regulator of chromatin condensation, putative

Species:

Leishmania mexicana

UniProt:

E9ANI8_LEIMU

TriTrypDb:

LmxM.11.0420

Length:

774

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ANI8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANI8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.462
CLV_C14_Caspase3-7	338	342	PF00656	0.517
CLV_C14_Caspase3-7	705	709	PF00656	0.504
CLV_NRD_NRD_1	364	366	PF00675	0.481
CLV_NRD_NRD_1	465	467	PF00675	0.619
CLV_NRD_NRD_1	717	719	PF00675	0.613
CLV_PCSK_KEX2_1	364	366	PF00082	0.481
CLV_PCSK_KEX2_1	464	466	PF00082	0.636
CLV_PCSK_KEX2_1	717	719	PF00082	0.549
CLV_PCSK_SKI1_1	131	135	PF00082	0.309
CLV_PCSK_SKI1_1	265	269	PF00082	0.406
CLV_PCSK_SKI1_1	398	402	PF00082	0.539
CLV_PCSK_SKI1_1	422	426	PF00082	0.547
CLV_PCSK_SKI1_1	496	500	PF00082	0.598
CLV_PCSK_SKI1_1	687	691	PF00082	0.530
CLV_PCSK_SKI1_1	697	701	PF00082	0.495
DEG_MDM2_SWIB_1	590	597	PF02201	0.593
DEG_SPOP_SBC_1	650	654	PF00917	0.586
DEG_SPOP_SBC_1	76	80	PF00917	0.313
DEG_SPOP_SBC_1	769	773	PF00917	0.749
DOC_CDC14_PxL_1	287	295	PF14671	0.454
DOC_MAPK_RevD_3	450	465	PF00069	0.427
DOC_PP1_RVXF_1	129	135	PF00149	0.332
DOC_PP4_FxxP_1	230	233	PF00568	0.172
DOC_PP4_FxxP_1	599	602	PF00568	0.338
DOC_USP7_MATH_1	13	17	PF00917	0.550
DOC_USP7_MATH_1	158	162	PF00917	0.407
DOC_USP7_MATH_1	207	211	PF00917	0.388
DOC_USP7_MATH_1	219	223	PF00917	0.328
DOC_USP7_MATH_1	278	282	PF00917	0.676
DOC_USP7_MATH_1	325	329	PF00917	0.679
DOC_USP7_MATH_1	335	339	PF00917	0.556
DOC_USP7_MATH_1	367	371	PF00917	0.518
DOC_USP7_MATH_1	390	394	PF00917	0.368
DOC_USP7_MATH_1	432	436	PF00917	0.643
DOC_USP7_MATH_1	490	494	PF00917	0.582
DOC_USP7_MATH_1	56	60	PF00917	0.613
DOC_USP7_MATH_1	628	632	PF00917	0.604
DOC_USP7_MATH_1	651	655	PF00917	0.566
DOC_USP7_MATH_1	727	731	PF00917	0.547
DOC_USP7_MATH_1	748	752	PF00917	0.455
DOC_USP7_MATH_1	770	774	PF00917	0.728
DOC_USP7_UBL2_3	352	356	PF12436	0.669
DOC_WW_Pin1_4	215	220	PF00397	0.374
DOC_WW_Pin1_4	265	270	PF00397	0.533
DOC_WW_Pin1_4	274	279	PF00397	0.595
DOC_WW_Pin1_4	428	433	PF00397	0.447
DOC_WW_Pin1_4	537	542	PF00397	0.625
DOC_WW_Pin1_4	558	563	PF00397	0.678
DOC_WW_Pin1_4	564	569	PF00397	0.651
DOC_WW_Pin1_4	6	11	PF00397	0.504
DOC_WW_Pin1_4	629	634	PF00397	0.692
LIG_14-3-3_CanoR_1	388	397	PF00244	0.471
LIG_14-3-3_CanoR_1	404	411	PF00244	0.528
LIG_14-3-3_CanoR_1	534	544	PF00244	0.598
LIG_14-3-3_CanoR_1	592	598	PF00244	0.474
LIG_14-3-3_CanoR_1	629	633	PF00244	0.595
LIG_14-3-3_CanoR_1	647	651	PF00244	0.592
LIG_14-3-3_CanoR_1	697	706	PF00244	0.478
LIG_14-3-3_CanoR_1	749	753	PF00244	0.369
LIG_BRCT_BRCA1_1	369	373	PF00533	0.417
LIG_BRCT_BRCA1_1	595	599	PF00533	0.460
LIG_BRCT_BRCA1_1	653	657	PF00533	0.451
LIG_FHA_1	164	170	PF00498	0.414
LIG_FHA_1	183	189	PF00498	0.175
LIG_FHA_1	431	437	PF00498	0.611
LIG_FHA_1	438	444	PF00498	0.484
LIG_FHA_1	72	78	PF00498	0.321
LIG_FHA_2	104	110	PF00498	0.433
LIG_FHA_2	122	128	PF00498	0.557
LIG_FHA_2	199	205	PF00498	0.441
LIG_FHA_2	39	45	PF00498	0.537
LIG_FHA_2	390	396	PF00498	0.627
LIG_FHA_2	405	411	PF00498	0.563
LIG_FHA_2	58	64	PF00498	0.413
LIG_Integrin_RGD_1	299	301	PF01839	0.560
LIG_LIR_Apic_2	229	233	PF02991	0.172
LIG_LIR_Apic_2	596	602	PF02991	0.332
LIG_LIR_Gen_1	16	23	PF02991	0.309
LIG_LIR_Gen_1	190	199	PF02991	0.291
LIG_LIR_Gen_1	310	319	PF02991	0.507
LIG_LIR_Gen_1	370	379	PF02991	0.482
LIG_LIR_Gen_1	445	455	PF02991	0.283
LIG_LIR_Gen_1	497	506	PF02991	0.598
LIG_LIR_Gen_1	591	602	PF02991	0.544
LIG_LIR_Gen_1	733	744	PF02991	0.411
LIG_LIR_Nem_3	16	21	PF02991	0.320
LIG_LIR_Nem_3	190	194	PF02991	0.300
LIG_LIR_Nem_3	301	305	PF02991	0.446
LIG_LIR_Nem_3	310	315	PF02991	0.546
LIG_LIR_Nem_3	370	376	PF02991	0.421
LIG_LIR_Nem_3	445	450	PF02991	0.392
LIG_LIR_Nem_3	591	597	PF02991	0.463
LIG_LIR_Nem_3	724	728	PF02991	0.464
LIG_LIR_Nem_3	733	739	PF02991	0.367
LIG_LYPXL_yS_3	290	293	PF13949	0.425
LIG_MLH1_MIPbox_1	369	373	PF16413	0.491
LIG_PCNA_yPIPBox_3	609	618	PF02747	0.478
LIG_Pex14_1	479	483	PF04695	0.413
LIG_Pex14_2	368	372	PF04695	0.551
LIG_Pex14_2	51	55	PF04695	0.480
LIG_Pex14_2	590	594	PF04695	0.535
LIG_SH2_CRK	18	22	PF00017	0.363
LIG_SH2_CRK	241	245	PF00017	0.389
LIG_SH2_CRK	72	76	PF00017	0.377
LIG_SH2_NCK_1	18	22	PF00017	0.363
LIG_SH2_NCK_1	736	740	PF00017	0.399
LIG_SH2_STAP1	18	22	PF00017	0.363
LIG_SH2_STAT5	170	173	PF00017	0.424
LIG_SH2_STAT5	18	21	PF00017	0.367
LIG_SH2_STAT5	189	192	PF00017	0.424
LIG_SH2_STAT5	483	486	PF00017	0.476
LIG_SH2_STAT5	621	624	PF00017	0.412
LIG_SH3_1	193	199	PF00018	0.172
LIG_SH3_3	123	129	PF00018	0.565
LIG_SH3_3	193	199	PF00018	0.353
LIG_SH3_3	266	272	PF00018	0.621
LIG_SH3_3	285	291	PF00018	0.344
LIG_SH3_3	384	390	PF00018	0.510
LIG_SH3_3	538	544	PF00018	0.625
LIG_SH3_3	556	562	PF00018	0.477
LIG_SH3_3	680	686	PF00018	0.538
LIG_SUMO_SIM_anti_2	43	50	PF11976	0.424
LIG_SUMO_SIM_par_1	73	80	PF11976	0.424
LIG_TRAF2_1	393	396	PF00917	0.423
LIG_TRAF2_1	527	530	PF00917	0.491
LIG_TYR_ITIM	239	244	PF00017	0.427
LIG_TYR_ITIM	288	293	PF00017	0.508
LIG_TYR_ITIM	734	739	PF00017	0.342
LIG_WRC_WIRS_1	52	57	PF05994	0.509
MOD_CK1_1	121	127	PF00069	0.492
MOD_CK1_1	16	22	PF00069	0.487
MOD_CK1_1	248	254	PF00069	0.263
MOD_CK1_1	281	287	PF00069	0.597
MOD_CK1_1	40	46	PF00069	0.444
MOD_CK1_1	459	465	PF00069	0.495
MOD_CK1_1	543	549	PF00069	0.634
MOD_CK1_1	57	63	PF00069	0.323
MOD_CK1_1	637	643	PF00069	0.760
MOD_CK2_1	38	44	PF00069	0.418
MOD_CK2_1	389	395	PF00069	0.614
MOD_CK2_1	404	410	PF00069	0.575
MOD_CK2_1	442	448	PF00069	0.648
MOD_CK2_1	482	488	PF00069	0.599
MOD_CK2_1	57	63	PF00069	0.391
MOD_CK2_1	727	733	PF00069	0.594
MOD_DYRK1A_RPxSP_1	215	219	PF00069	0.374
MOD_DYRK1A_RPxSP_1	265	269	PF00069	0.346
MOD_DYRK1A_RPxSP_1	629	633	PF00069	0.561
MOD_GlcNHglycan	221	224	PF01048	0.421
MOD_GlcNHglycan	225	228	PF01048	0.394
MOD_GlcNHglycan	337	340	PF01048	0.557
MOD_GlcNHglycan	344	347	PF01048	0.510
MOD_GlcNHglycan	369	372	PF01048	0.592
MOD_GlcNHglycan	383	387	PF01048	0.598
MOD_GlcNHglycan	392	395	PF01048	0.609
MOD_GlcNHglycan	440	443	PF01048	0.654
MOD_GlcNHglycan	458	461	PF01048	0.274
MOD_GlcNHglycan	545	548	PF01048	0.775
MOD_GlcNHglycan	56	59	PF01048	0.487
MOD_GlcNHglycan	578	581	PF01048	0.535
MOD_GlcNHglycan	729	732	PF01048	0.585
MOD_GSK3_1	158	165	PF00069	0.316
MOD_GSK3_1	207	214	PF00069	0.449
MOD_GSK3_1	215	222	PF00069	0.378
MOD_GSK3_1	274	281	PF00069	0.681
MOD_GSK3_1	428	435	PF00069	0.710
MOD_GSK3_1	438	445	PF00069	0.637
MOD_GSK3_1	535	542	PF00069	0.590
MOD_GSK3_1	582	589	PF00069	0.528
MOD_GSK3_1	593	600	PF00069	0.478
MOD_GSK3_1	634	641	PF00069	0.767
MOD_GSK3_1	645	652	PF00069	0.500
MOD_GSK3_1	71	78	PF00069	0.377
MOD_GSK3_1	764	771	PF00069	0.579
MOD_GSK3_1	96	103	PF00069	0.566
MOD_LATS_1	420	426	PF00433	0.538
MOD_N-GLC_1	281	286	PF02516	0.541
MOD_N-GLC_2	175	177	PF02516	0.424
MOD_NEK2_1	162	167	PF00069	0.374
MOD_NEK2_1	326	331	PF00069	0.615
MOD_NEK2_1	382	387	PF00069	0.571
MOD_NEK2_1	402	407	PF00069	0.397
MOD_NEK2_1	437	442	PF00069	0.724
MOD_NEK2_1	590	595	PF00069	0.469
MOD_NEK2_1	75	80	PF00069	0.332
MOD_NEK2_2	13	18	PF00069	0.399
MOD_NEK2_2	608	613	PF00069	0.442
MOD_NEK2_2	748	753	PF00069	0.497
MOD_PIKK_1	326	332	PF00454	0.643
MOD_PKA_2	207	213	PF00069	0.423
MOD_PKA_2	242	248	PF00069	0.374
MOD_PKA_2	326	332	PF00069	0.698
MOD_PKA_2	535	541	PF00069	0.574
MOD_PKA_2	628	634	PF00069	0.560
MOD_PKA_2	646	652	PF00069	0.412
MOD_PKA_2	748	754	PF00069	0.369
MOD_PKA_2	96	102	PF00069	0.541
MOD_Plk_1	158	164	PF00069	0.450
MOD_Plk_1	347	353	PF00069	0.657
MOD_Plk_1	382	388	PF00069	0.489
MOD_Plk_1	528	534	PF00069	0.431
MOD_Plk_1	555	561	PF00069	0.472
MOD_Plk_1	586	592	PF00069	0.571
MOD_Plk_4	13	19	PF00069	0.519
MOD_Plk_4	147	153	PF00069	0.562
MOD_Plk_4	158	164	PF00069	0.437
MOD_Plk_4	251	257	PF00069	0.313
MOD_Plk_4	289	295	PF00069	0.564
MOD_Plk_4	432	438	PF00069	0.441
MOD_Plk_4	528	534	PF00069	0.423
MOD_Plk_4	611	617	PF00069	0.479
MOD_Plk_4	71	77	PF00069	0.381
MOD_Plk_4	748	754	PF00069	0.393
MOD_ProDKin_1	215	221	PF00069	0.374
MOD_ProDKin_1	265	271	PF00069	0.540
MOD_ProDKin_1	274	280	PF00069	0.598
MOD_ProDKin_1	428	434	PF00069	0.448
MOD_ProDKin_1	537	543	PF00069	0.630
MOD_ProDKin_1	558	564	PF00069	0.678
MOD_ProDKin_1	6	12	PF00069	0.490
MOD_ProDKin_1	629	635	PF00069	0.699
TRG_DiLeu_BaEn_1	471	476	PF01217	0.341
TRG_DiLeu_BaLyEn_6	235	240	PF01217	0.317
TRG_DiLeu_BaLyEn_6	569	574	PF01217	0.529
TRG_ENDOCYTIC_2	18	21	PF00928	0.367
TRG_ENDOCYTIC_2	241	244	PF00928	0.396
TRG_ENDOCYTIC_2	290	293	PF00928	0.400
TRG_ENDOCYTIC_2	72	75	PF00928	0.283
TRG_ENDOCYTIC_2	736	739	PF00928	0.448
TRG_ER_diArg_1	364	366	PF00400	0.524
TRG_ER_diArg_1	463	466	PF00400	0.636
TRG_ER_diArg_1	717	719	PF00400	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0Q9	Leptomonas seymouri	44%	100%
A0A0S4IQ49	Bodo saltans	28%	100%
A0A1X0NV79	Trypanosomatidae	28%	100%
A0A3Q8IHE4	Leishmania donovani	88%	100%
A0A3S5ISC4	Trypanosoma rangeli	30%	100%
A4H6F8	Leishmania braziliensis	76%	100%
A4HUV3	Leishmania infantum	88%	100%
D0A7K1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
Q4QH38	Leishmania major	87%	100%
V5BB49	Trypanosoma cruzi	29%	100%