Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ANI5_LEIMU

TriTrypDb:

LmxM.11.0390

Length:

498

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ANI5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANI5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	314	318	PF00656	0.626
CLV_C14_Caspase3-7	64	68	PF00656	0.529
CLV_NRD_NRD_1	103	105	PF00675	0.756
CLV_NRD_NRD_1	107	109	PF00675	0.761
CLV_NRD_NRD_1	227	229	PF00675	0.530
CLV_NRD_NRD_1	5	7	PF00675	0.746
CLV_PCSK_KEX2_1	103	105	PF00082	0.650
CLV_PCSK_KEX2_1	107	109	PF00082	0.581
CLV_PCSK_KEX2_1	148	150	PF00082	0.547
CLV_PCSK_KEX2_1	227	229	PF00082	0.530
CLV_PCSK_KEX2_1	356	358	PF00082	0.543
CLV_PCSK_KEX2_1	5	7	PF00082	0.815
CLV_PCSK_KEX2_1	89	91	PF00082	0.720
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.547
CLV_PCSK_PC1ET2_1	356	358	PF00082	0.520
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.698
CLV_PCSK_PC7_1	103	109	PF00082	0.734
CLV_PCSK_SKI1_1	155	159	PF00082	0.524
CLV_PCSK_SKI1_1	212	216	PF00082	0.669
CLV_PCSK_SKI1_1	227	231	PF00082	0.270
CLV_PCSK_SKI1_1	34	38	PF00082	0.725
DEG_Nend_Nbox_1	1	3	PF02207	0.664
DEG_SPOP_SBC_1	214	218	PF00917	0.710
DEG_SPOP_SBC_1	22	26	PF00917	0.695
DEG_SPOP_SBC_1	311	315	PF00917	0.639
DOC_CKS1_1	264	269	PF01111	0.799
DOC_MAPK_DCC_7	425	433	PF00069	0.384
DOC_MAPK_gen_1	148	156	PF00069	0.566
DOC_MAPK_gen_1	227	235	PF00069	0.501
DOC_MAPK_gen_1	356	364	PF00069	0.628
DOC_MAPK_gen_1	437	447	PF00069	0.546
DOC_MAPK_JIP1_4	466	472	PF00069	0.506
DOC_MAPK_MEF2A_6	227	235	PF00069	0.522
DOC_MAPK_MEF2A_6	440	447	PF00069	0.626
DOC_PP2B_LxvP_1	470	473	PF13499	0.478
DOC_SPAK_OSR1_1	228	232	PF12202	0.514
DOC_USP7_MATH_1	122	126	PF00917	0.798
DOC_USP7_MATH_1	260	264	PF00917	0.518
DOC_USP7_MATH_1	311	315	PF00917	0.655
DOC_USP7_MATH_1	324	328	PF00917	0.571
DOC_USP7_MATH_1	351	355	PF00917	0.414
DOC_USP7_MATH_1	382	386	PF00917	0.755
DOC_USP7_MATH_1	47	51	PF00917	0.690
DOC_USP7_MATH_1	74	78	PF00917	0.558
DOC_USP7_UBL2_3	206	210	PF12436	0.604
DOC_USP7_UBL2_3	437	441	PF12436	0.583
DOC_WW_Pin1_4	222	227	PF00397	0.575
DOC_WW_Pin1_4	240	245	PF00397	0.555
DOC_WW_Pin1_4	263	268	PF00397	0.805
DOC_WW_Pin1_4	367	372	PF00397	0.705
DOC_WW_Pin1_4	384	389	PF00397	0.656
DOC_WW_Pin1_4	426	431	PF00397	0.678
LIG_14-3-3_CanoR_1	103	109	PF00244	0.676
LIG_14-3-3_CanoR_1	212	220	PF00244	0.527
LIG_14-3-3_CanoR_1	227	232	PF00244	0.265
LIG_14-3-3_CanoR_1	295	300	PF00244	0.545
LIG_14-3-3_CanoR_1	5	9	PF00244	0.718
LIG_14-3-3_CanoR_1	90	98	PF00244	0.710
LIG_BIR_III_2	115	119	PF00653	0.518
LIG_BIR_III_2	67	71	PF00653	0.517
LIG_BIR_III_4	338	342	PF00653	0.701
LIG_BRCT_BRCA1_1	360	364	PF00533	0.557
LIG_Clathr_ClatBox_1	444	448	PF01394	0.541
LIG_FHA_1	165	171	PF00498	0.524
LIG_FHA_1	22	28	PF00498	0.564
LIG_FHA_1	228	234	PF00498	0.561
LIG_FHA_1	259	265	PF00498	0.808
LIG_FHA_1	304	310	PF00498	0.531
LIG_FHA_1	430	436	PF00498	0.480
LIG_FHA_2	130	136	PF00498	0.823
LIG_FHA_2	320	326	PF00498	0.720
LIG_FHA_2	62	68	PF00498	0.607
LIG_LIR_Apic_2	238	244	PF02991	0.440
LIG_LIR_Gen_1	306	311	PF02991	0.523
LIG_LIR_Nem_3	197	202	PF02991	0.429
LIG_LIR_Nem_3	306	310	PF02991	0.522
LIG_LIR_Nem_3	354	358	PF02991	0.509
LIG_PDZ_Class_2	493	498	PF00595	0.538
LIG_SH2_SRC	358	361	PF00017	0.514
LIG_SH2_STAT5	2	5	PF00017	0.612
LIG_SH2_STAT5	203	206	PF00017	0.525
LIG_SH2_STAT5	288	291	PF00017	0.533
LIG_SH2_STAT5	29	32	PF00017	0.641
LIG_SH2_STAT5	35	38	PF00017	0.622
LIG_SH2_STAT5	358	361	PF00017	0.480
LIG_SH2_STAT5	42	45	PF00017	0.625
LIG_SH3_3	138	144	PF00018	0.685
LIG_SH3_3	230	236	PF00018	0.521
LIG_SH3_3	265	271	PF00018	0.767
LIG_SH3_3	372	378	PF00018	0.680
LIG_SH3_3	450	456	PF00018	0.535
LIG_SH3_3	92	98	PF00018	0.517
LIG_Sin3_3	150	157	PF02671	0.632
LIG_SUMO_SIM_anti_2	468	473	PF11976	0.472
LIG_SUMO_SIM_par_1	138	145	PF11976	0.676
LIG_SUMO_SIM_par_1	191	197	PF11976	0.467
LIG_SUMO_SIM_par_1	443	450	PF11976	0.546
LIG_WW_2	379	382	PF00397	0.506
MOD_CDK_SPK_2	222	227	PF00069	0.623
MOD_CDK_SPxK_1	222	228	PF00069	0.620
MOD_CK1_1	125	131	PF00069	0.704
MOD_CK1_1	218	224	PF00069	0.599
MOD_CK1_1	263	269	PF00069	0.709
MOD_CK1_1	384	390	PF00069	0.569
MOD_CK1_1	4	10	PF00069	0.719
MOD_CK1_1	429	435	PF00069	0.474
MOD_CK1_1	446	452	PF00069	0.537
MOD_CK1_1	61	67	PF00069	0.671
MOD_CK2_1	129	135	PF00069	0.823
MOD_CK2_1	139	145	PF00069	0.512
MOD_CK2_1	248	254	PF00069	0.747
MOD_CK2_1	317	323	PF00069	0.656
MOD_CK2_1	446	452	PF00069	0.547
MOD_GlcNHglycan	119	123	PF01048	0.782
MOD_GlcNHglycan	217	220	PF01048	0.489
MOD_GlcNHglycan	250	253	PF01048	0.695
MOD_GlcNHglycan	297	300	PF01048	0.576
MOD_GlcNHglycan	338	342	PF01048	0.738
MOD_GlcNHglycan	344	348	PF01048	0.534
MOD_GlcNHglycan	416	419	PF01048	0.757
MOD_GlcNHglycan	71	74	PF01048	0.599
MOD_GlcNHglycan	8	11	PF01048	0.768
MOD_GSK3_1	118	125	PF00069	0.724
MOD_GSK3_1	214	221	PF00069	0.684
MOD_GSK3_1	367	374	PF00069	0.533
MOD_GSK3_1	43	50	PF00069	0.685
MOD_N-GLC_1	125	130	PF02516	0.775
MOD_NEK2_1	1	6	PF00069	0.591
MOD_NEK2_1	215	220	PF00069	0.731
MOD_NEK2_1	23	28	PF00069	0.567
MOD_NEK2_1	337	342	PF00069	0.618
MOD_NEK2_1	436	441	PF00069	0.515
MOD_NEK2_1	485	490	PF00069	0.461
MOD_PIKK_1	107	113	PF00454	0.730
MOD_PIKK_1	312	318	PF00454	0.692
MOD_PIKK_1	74	80	PF00454	0.716
MOD_PKA_1	107	113	PF00069	0.680
MOD_PKA_1	227	233	PF00069	0.501
MOD_PKA_1	89	95	PF00069	0.795
MOD_PKA_2	102	108	PF00069	0.665
MOD_PKA_2	227	233	PF00069	0.520
MOD_PKA_2	4	10	PF00069	0.738
MOD_PKA_2	89	95	PF00069	0.727
MOD_Plk_1	58	64	PF00069	0.721
MOD_Plk_2-3	317	323	PF00069	0.712
MOD_Plk_4	472	478	PF00069	0.498
MOD_Plk_4	48	54	PF00069	0.711
MOD_Plk_4	58	64	PF00069	0.763
MOD_ProDKin_1	222	228	PF00069	0.564
MOD_ProDKin_1	240	246	PF00069	0.561
MOD_ProDKin_1	263	269	PF00069	0.801
MOD_ProDKin_1	367	373	PF00069	0.709
MOD_ProDKin_1	384	390	PF00069	0.656
MOD_ProDKin_1	426	432	PF00069	0.671
MOD_SUMO_for_1	465	468	PF00179	0.514
MOD_SUMO_rev_2	360	370	PF00179	0.613
TRG_DiLeu_BaEn_2	359	365	PF01217	0.556
TRG_DiLeu_BaLyEn_6	440	445	PF01217	0.559
TRG_ER_diArg_1	107	109	PF00400	0.709
TRG_ER_diArg_1	226	228	PF00400	0.566

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IH30	Leptomonas seymouri	33%	100%
A0A3Q8I7W7	Leishmania donovani	87%	98%
A0A3R7P0A0	Trypanosoma rangeli	24%	100%
A4H6K7	Leishmania braziliensis	64%	100%
A4HUV0	Leishmania infantum	87%	98%
Q4QH41	Leishmania major	83%	99%