Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ANI3_LEIMU

TriTrypDb:

LmxM.11.0370

Length:

615

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9ANI3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANI3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	414	418	PF00656	0.625
CLV_C14_Caspase3-7	508	512	PF00656	0.712
CLV_NRD_NRD_1	105	107	PF00675	0.395
CLV_NRD_NRD_1	16	18	PF00675	0.359
CLV_NRD_NRD_1	457	459	PF00675	0.486
CLV_NRD_NRD_1	506	508	PF00675	0.504
CLV_NRD_NRD_1	563	565	PF00675	0.422
CLV_NRD_NRD_1	588	590	PF00675	0.555
CLV_NRD_NRD_1	591	593	PF00675	0.465
CLV_PCSK_FUR_1	589	593	PF00082	0.513
CLV_PCSK_KEX2_1	104	106	PF00082	0.407
CLV_PCSK_KEX2_1	325	327	PF00082	0.406
CLV_PCSK_KEX2_1	362	364	PF00082	0.446
CLV_PCSK_KEX2_1	506	508	PF00082	0.536
CLV_PCSK_KEX2_1	562	564	PF00082	0.420
CLV_PCSK_KEX2_1	588	590	PF00082	0.555
CLV_PCSK_KEX2_1	591	593	PF00082	0.465
CLV_PCSK_PC1ET2_1	104	106	PF00082	0.442
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.406
CLV_PCSK_PC1ET2_1	362	364	PF00082	0.446
CLV_PCSK_SKI1_1	292	296	PF00082	0.422
CLV_PCSK_SKI1_1	362	366	PF00082	0.376
CLV_PCSK_SKI1_1	459	463	PF00082	0.406
CLV_PCSK_SKI1_1	592	596	PF00082	0.362
DEG_APCC_DBOX_1	22	30	PF00400	0.599
DEG_APCC_DBOX_1	55	63	PF00400	0.551
DEG_APCC_DBOX_1	591	599	PF00400	0.362
DEG_APCC_DBOX_1	87	95	PF00400	0.637
DEG_SCF_TRCP1_1	511	516	PF00400	0.633
DOC_CYCLIN_RxL_1	250	263	PF00134	0.625
DOC_CYCLIN_RxL_1	560	570	PF00134	0.646
DOC_CYCLIN_yCln2_LP_2	551	557	PF00134	0.499
DOC_MAPK_gen_1	112	119	PF00069	0.531
DOC_MAPK_gen_1	17	28	PF00069	0.657
DOC_MAPK_gen_1	362	368	PF00069	0.633
DOC_MAPK_gen_1	588	598	PF00069	0.513
DOC_MAPK_gen_1	88	97	PF00069	0.642
DOC_MAPK_MEF2A_6	90	99	PF00069	0.637
DOC_MAPK_NFAT4_5	92	100	PF00069	0.630
DOC_PP2B_LxvP_1	565	568	PF13499	0.679
DOC_USP7_MATH_1	189	193	PF00917	0.668
DOC_USP7_MATH_1	201	205	PF00917	0.562
DOC_USP7_MATH_1	301	305	PF00917	0.583
DOC_USP7_MATH_1	351	355	PF00917	0.566
DOC_USP7_MATH_1	401	405	PF00917	0.827
DOC_USP7_MATH_1	410	414	PF00917	0.773
DOC_USP7_MATH_1	494	498	PF00917	0.738
DOC_WW_Pin1_4	182	187	PF00397	0.664
DOC_WW_Pin1_4	406	411	PF00397	0.698
DOC_WW_Pin1_4	431	436	PF00397	0.668
DOC_WW_Pin1_4	534	539	PF00397	0.674
LIG_14-3-3_CanoR_1	313	322	PF00244	0.662
LIG_14-3-3_CanoR_1	332	338	PF00244	0.645
LIG_14-3-3_CanoR_1	363	367	PF00244	0.575
LIG_14-3-3_CanoR_1	474	478	PF00244	0.647
LIG_Actin_WH2_2	250	267	PF00022	0.623
LIG_BRCT_BRCA1_1	195	199	PF00533	0.619
LIG_BRCT_BRCA1_1	353	357	PF00533	0.585
LIG_BRCT_BRCA1_1	511	515	PF00533	0.774
LIG_FHA_1	164	170	PF00498	0.757
LIG_FHA_1	233	239	PF00498	0.587
LIG_FHA_1	249	255	PF00498	0.602
LIG_FHA_1	32	38	PF00498	0.447
LIG_FHA_1	363	369	PF00498	0.679
LIG_FHA_1	480	486	PF00498	0.650
LIG_FHA_1	534	540	PF00498	0.630
LIG_FHA_1	568	574	PF00498	0.687
LIG_FHA_1	581	587	PF00498	0.733
LIG_FHA_1	64	70	PF00498	0.626
LIG_FHA_1	7	13	PF00498	0.592
LIG_FHA_2	145	151	PF00498	0.568
LIG_FHA_2	338	344	PF00498	0.609
LIG_FHA_2	412	418	PF00498	0.668
LIG_FHA_2	76	82	PF00498	0.526
LIG_LIR_Gen_1	147	156	PF02991	0.647
LIG_LIR_Gen_1	349	357	PF02991	0.558
LIG_LIR_Nem_3	147	152	PF02991	0.548
LIG_LIR_Nem_3	349	355	PF02991	0.554
LIG_LIR_Nem_3	610	614	PF02991	0.464
LIG_NRBOX	151	157	PF00104	0.661
LIG_Pex14_1	382	386	PF04695	0.556
LIG_PTB_Apo_2	275	282	PF02174	0.547
LIG_PTB_Phospho_1	275	281	PF10480	0.545
LIG_RPA_C_Fungi	453	465	PF08784	0.490
LIG_SH2_CRK	387	391	PF00017	0.545
LIG_SH2_NCK_1	387	391	PF00017	0.545
LIG_SH2_STAP1	149	153	PF00017	0.571
LIG_SH2_STAP1	299	303	PF00017	0.557
LIG_SH3_3	497	503	PF00018	0.673
LIG_TRAF2_1	242	245	PF00917	0.628
LIG_TRAF2_1	340	343	PF00917	0.458
LIG_UBA3_1	603	612	PF00899	0.247
LIG_WRC_WIRS_1	608	613	PF05994	0.536
MOD_CDC14_SPxK_1	409	412	PF00782	0.621
MOD_CDK_SPxK_1	406	412	PF00069	0.627
MOD_CK1_1	304	310	PF00069	0.480
MOD_CK1_1	358	364	PF00069	0.573
MOD_CK1_1	476	482	PF00069	0.447
MOD_CK2_1	201	207	PF00069	0.689
MOD_CK2_1	337	343	PF00069	0.447
MOD_CK2_1	75	81	PF00069	0.533
MOD_Cter_Amidation	504	507	PF01082	0.729
MOD_GlcNHglycan	191	194	PF01048	0.693
MOD_GlcNHglycan	195	198	PF01048	0.675
MOD_GlcNHglycan	303	306	PF01048	0.579
MOD_GlcNHglycan	396	399	PF01048	0.693
MOD_GlcNHglycan	427	430	PF01048	0.792
MOD_GlcNHglycan	497	500	PF01048	0.588
MOD_GlcNHglycan	511	514	PF01048	0.598
MOD_GlcNHglycan	578	581	PF01048	0.634
MOD_GSK3_1	140	147	PF00069	0.366
MOD_GSK3_1	189	196	PF00069	0.516
MOD_GSK3_1	283	290	PF00069	0.495
MOD_GSK3_1	31	38	PF00069	0.286
MOD_GSK3_1	351	358	PF00069	0.456
MOD_GSK3_1	386	393	PF00069	0.542
MOD_GSK3_1	396	403	PF00069	0.670
MOD_GSK3_1	406	413	PF00069	0.685
MOD_GSK3_1	421	428	PF00069	0.628
MOD_GSK3_1	472	479	PF00069	0.565
MOD_GSK3_1	509	516	PF00069	0.632
MOD_GSK3_1	534	541	PF00069	0.648
MOD_GSK3_1	542	549	PF00069	0.596
MOD_GSK3_1	576	583	PF00069	0.671
MOD_NEK2_1	140	145	PF00069	0.433
MOD_NEK2_1	331	336	PF00069	0.603
MOD_NEK2_1	473	478	PF00069	0.430
MOD_NEK2_1	485	490	PF00069	0.649
MOD_NEK2_1	533	538	PF00069	0.679
MOD_NEK2_1	539	544	PF00069	0.668
MOD_NEK2_1	607	612	PF00069	0.439
MOD_NEK2_1	84	89	PF00069	0.472
MOD_PIKK_1	112	118	PF00454	0.583
MOD_PIKK_1	144	150	PF00454	0.464
MOD_PIKK_1	232	238	PF00454	0.502
MOD_PIKK_1	248	254	PF00454	0.521
MOD_PIKK_1	304	310	PF00454	0.520
MOD_PIKK_1	331	337	PF00454	0.599
MOD_PIKK_1	390	396	PF00454	0.573
MOD_PIKK_1	401	407	PF00454	0.596
MOD_PIKK_1	476	482	PF00454	0.419
MOD_PIKK_1	7	13	PF00454	0.490
MOD_PKA_1	362	368	PF00069	0.469
MOD_PKA_2	140	146	PF00069	0.477
MOD_PKA_2	283	289	PF00069	0.543
MOD_PKA_2	331	337	PF00069	0.500
MOD_PKA_2	362	368	PF00069	0.469
MOD_PKA_2	473	479	PF00069	0.439
MOD_Plk_1	112	118	PF00069	0.517
MOD_Plk_1	248	254	PF00069	0.501
MOD_Plk_1	276	282	PF00069	0.490
MOD_Plk_1	342	348	PF00069	0.496
MOD_Plk_1	49	55	PF00069	0.439
MOD_Plk_2-3	343	349	PF00069	0.517
MOD_Plk_4	151	157	PF00069	0.521
MOD_Plk_4	266	272	PF00069	0.416
MOD_Plk_4	351	357	PF00069	0.496
MOD_Plk_4	479	485	PF00069	0.534
MOD_Plk_4	542	548	PF00069	0.557
MOD_Plk_4	594	600	PF00069	0.351
MOD_ProDKin_1	182	188	PF00069	0.591
MOD_ProDKin_1	406	412	PF00069	0.642
MOD_ProDKin_1	431	437	PF00069	0.589
MOD_ProDKin_1	534	540	PF00069	0.602
MOD_SUMO_for_1	242	245	PF00179	0.499
MOD_SUMO_rev_2	25	34	PF00179	0.420
MOD_SUMO_rev_2	261	267	PF00179	0.538
MOD_SUMO_rev_2	354	364	PF00179	0.541
MOD_SUMO_rev_2	377	384	PF00179	0.551
MOD_SUMO_rev_2	71	76	PF00179	0.535
TRG_DiLeu_BaEn_1	24	29	PF01217	0.481
TRG_DiLeu_BaEn_1	249	254	PF01217	0.487
TRG_DiLeu_BaEn_4	24	30	PF01217	0.549
TRG_DiLeu_BaLyEn_6	164	169	PF01217	0.458
TRG_DiLeu_BaLyEn_6	535	540	PF01217	0.715
TRG_DiLeu_BaLyEn_6	553	558	PF01217	0.384
TRG_DiLeu_LyEn_5	24	29	PF01217	0.481
TRG_ENDOCYTIC_2	149	152	PF00928	0.444
TRG_ENDOCYTIC_2	387	390	PF00928	0.523
TRG_ER_diArg_1	208	211	PF00400	0.384
TRG_ER_diArg_1	562	564	PF00400	0.505
TRG_ER_diArg_1	587	589	PF00400	0.685
TRG_ER_diArg_1	590	592	PF00400	0.665
TRG_NLS_MonoExtC_3	16	21	PF00514	0.439
TRG_Pf-PMV_PEXEL_1	20	24	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.471
TRG_Pf-PMV_PEXEL_1	325	329	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	531	535	PF00026	0.626
TRG_Pf-PMV_PEXEL_1	556	561	PF00026	0.528

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHW2	Leptomonas seymouri	56%	96%
A0A0S4ITZ6	Bodo saltans	25%	100%
A0A1X0NWL4	Trypanosomatidae	35%	100%
A0A3R7KMY4	Trypanosoma rangeli	33%	100%
A0A3S5H6I2	Leishmania donovani	88%	99%
A4H6F4	Leishmania braziliensis	75%	100%
A4HUU8	Leishmania infantum	89%	100%
D0A7K7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
Q4QH43	Leishmania major	89%	100%
V5BB44	Trypanosoma cruzi	34%	100%