Optic atrophy 3 protein-domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Optic atrophy 3 protein (OPA3), putative

Species:

Leishmania mexicana

UniProt:

E9ANI2_LEIMU

TriTrypDb:

LmxM.11.0360

Length:

401

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ANI2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANI2

Function

Biological processes
Term	Name	Level	Count
GO:0019216	regulation of lipid metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	324	326	PF00675	0.808
CLV_NRD_NRD_1	355	357	PF00675	0.732
CLV_PCSK_KEX2_1	32	34	PF00082	0.350
CLV_PCSK_KEX2_1	399	401	PF00082	0.667
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.350
CLV_PCSK_PC1ET2_1	399	401	PF00082	0.667
CLV_PCSK_PC7_1	28	34	PF00082	0.410
CLV_PCSK_SKI1_1	15	19	PF00082	0.348
CLV_PCSK_SKI1_1	155	159	PF00082	0.376
CLV_PCSK_SKI1_1	33	37	PF00082	0.320
CLV_PCSK_SKI1_1	66	70	PF00082	0.327
CLV_PCSK_SKI1_1	71	75	PF00082	0.303
CLV_PCSK_SKI1_1	8	12	PF00082	0.395
DEG_APCC_DBOX_1	154	162	PF00400	0.430
DEG_SPOP_SBC_1	101	105	PF00917	0.375
DEG_SPOP_SBC_1	133	137	PF00917	0.210
DOC_CYCLIN_RxL_1	152	160	PF00134	0.430
DOC_MAPK_gen_1	373	383	PF00069	0.630
DOC_PP4_FxxP_1	210	213	PF00568	0.430
DOC_USP7_MATH_1	101	105	PF00917	0.472
DOC_USP7_MATH_1	132	136	PF00917	0.466
DOC_USP7_MATH_1	198	202	PF00917	0.392
DOC_USP7_MATH_1	264	268	PF00917	0.430
DOC_USP7_MATH_1	306	310	PF00917	0.381
DOC_USP7_MATH_1	330	334	PF00917	0.613
DOC_WW_Pin1_4	143	148	PF00397	0.498
DOC_WW_Pin1_4	279	284	PF00397	0.598
LIG_14-3-3_CanoR_1	153	158	PF00244	0.376
LIG_14-3-3_CanoR_1	207	211	PF00244	0.455
LIG_14-3-3_CanoR_1	278	283	PF00244	0.585
LIG_14-3-3_CanoR_1	299	307	PF00244	0.580
LIG_14-3-3_CanoR_1	33	38	PF00244	0.361
LIG_14-3-3_CanoR_1	45	49	PF00244	0.300
LIG_Actin_WH2_2	281	297	PF00022	0.671
LIG_APCC_ABBA_1	211	216	PF00400	0.430
LIG_BRCT_BRCA1_1	176	180	PF00533	0.430
LIG_Clathr_ClatBox_1	239	243	PF01394	0.430
LIG_DLG_GKlike_1	153	161	PF00625	0.430
LIG_eIF4E_1	377	383	PF01652	0.399
LIG_FHA_1	16	22	PF00498	0.405
LIG_FHA_1	176	182	PF00498	0.390
LIG_FHA_1	236	242	PF00498	0.430
LIG_FHA_1	295	301	PF00498	0.693
LIG_FHA_1	306	312	PF00498	0.554
LIG_FHA_1	34	40	PF00498	0.327
LIG_FHA_1	378	384	PF00498	0.632
LIG_FHA_1	73	79	PF00498	0.210
LIG_FHA_2	184	190	PF00498	0.430
LIG_FHA_2	56	62	PF00498	0.430
LIG_LIR_Apic_2	209	213	PF02991	0.430
LIG_LIR_Gen_1	177	187	PF02991	0.424
LIG_LIR_Gen_1	201	211	PF02991	0.430
LIG_LIR_LC3C_4	238	242	PF02991	0.430
LIG_LIR_Nem_3	177	183	PF02991	0.426
LIG_LIR_Nem_3	201	206	PF02991	0.376
LIG_LIR_Nem_3	301	307	PF02991	0.604
LIG_NRBOX	235	241	PF00104	0.397
LIG_PCNA_yPIPBox_3	384	396	PF02747	0.552
LIG_Pex14_2	206	210	PF04695	0.430
LIG_Pex14_2	7	11	PF04695	0.430
LIG_SH2_CRK	233	237	PF00017	0.376
LIG_SH2_CRK	364	368	PF00017	0.766
LIG_SH2_SRC	364	367	PF00017	0.746
LIG_SH2_STAP1	175	179	PF00017	0.404
LIG_SH2_STAP1	377	381	PF00017	0.409
LIG_SH2_STAT3	163	166	PF00017	0.430
LIG_SH2_STAT5	233	236	PF00017	0.395
LIG_SH2_STAT5	37	40	PF00017	0.424
LIG_SH3_1	364	370	PF00018	0.686
LIG_SH3_3	14	20	PF00018	0.430
LIG_SH3_3	159	165	PF00018	0.392
LIG_SH3_3	348	354	PF00018	0.671
LIG_SH3_3	360	366	PF00018	0.714
LIG_SH3_3	75	81	PF00018	0.210
LIG_SUMO_SIM_anti_2	238	243	PF11976	0.430
LIG_SUMO_SIM_par_1	237	243	PF11976	0.430
LIG_SUMO_SIM_par_1	378	386	PF11976	0.376
LIG_TRAF2_1	284	287	PF00917	0.648
LIG_TRAF2_1	338	341	PF00917	0.633
LIG_TYR_ITIM	231	236	PF00017	0.376
LIG_WW_3	365	369	PF00397	0.688
MOD_CDK_SPK_2	148	153	PF00069	0.410
MOD_CDK_SPxxK_3	148	155	PF00069	0.410
MOD_CK1_1	105	111	PF00069	0.462
MOD_CK1_1	115	121	PF00069	0.367
MOD_CK1_1	136	142	PF00069	0.446
MOD_CK1_1	143	149	PF00069	0.470
MOD_CK1_1	248	254	PF00069	0.411
MOD_CK1_1	319	325	PF00069	0.718
MOD_CK1_1	328	334	PF00069	0.735
MOD_CK2_1	100	106	PF00069	0.419
MOD_CK2_1	183	189	PF00069	0.430
MOD_CK2_1	55	61	PF00069	0.382
MOD_Cter_Amidation	323	326	PF01082	0.719
MOD_GlcNHglycan	112	115	PF01048	0.414
MOD_GlcNHglycan	122	125	PF01048	0.435
MOD_GlcNHglycan	142	145	PF01048	0.501
MOD_GlcNHglycan	200	203	PF01048	0.455
MOD_GlcNHglycan	250	253	PF01048	0.487
MOD_GlcNHglycan	300	303	PF01048	0.681
MOD_GlcNHglycan	308	311	PF01048	0.612
MOD_GlcNHglycan	327	330	PF01048	0.707
MOD_GlcNHglycan	332	335	PF01048	0.731
MOD_GlcNHglycan	50	53	PF01048	0.399
MOD_GlcNHglycan	81	84	PF01048	0.287
MOD_GSK3_1	106	113	PF00069	0.431
MOD_GSK3_1	115	122	PF00069	0.232
MOD_GSK3_1	132	139	PF00069	0.466
MOD_GSK3_1	153	160	PF00069	0.399
MOD_GSK3_1	171	178	PF00069	0.272
MOD_GSK3_1	231	238	PF00069	0.430
MOD_GSK3_1	24	31	PF00069	0.501
MOD_GSK3_1	294	301	PF00069	0.683
MOD_GSK3_1	325	332	PF00069	0.790
MOD_GSK3_1	44	51	PF00069	0.171
MOD_GSK3_1	72	79	PF00069	0.464
MOD_GSK3_1	96	103	PF00069	0.427
MOD_N-GLC_1	357	362	PF02516	0.652
MOD_NEK2_1	110	115	PF00069	0.210
MOD_NEK2_1	157	162	PF00069	0.430
MOD_NEK2_1	181	186	PF00069	0.473
MOD_NEK2_1	206	211	PF00069	0.430
MOD_NEK2_1	294	299	PF00069	0.718
MOD_NEK2_1	48	53	PF00069	0.397
MOD_NEK2_2	175	180	PF00069	0.404
MOD_PKA_1	325	331	PF00069	0.803
MOD_PKA_2	206	212	PF00069	0.455
MOD_PKA_2	248	254	PF00069	0.430
MOD_PKA_2	294	300	PF00069	0.700
MOD_PKA_2	44	50	PF00069	0.357
MOD_Plk_1	175	181	PF00069	0.387
MOD_Plk_1	377	383	PF00069	0.619
MOD_Plk_4	157	163	PF00069	0.420
MOD_Plk_4	175	181	PF00069	0.430
MOD_Plk_4	206	212	PF00069	0.430
MOD_Plk_4	231	237	PF00069	0.376
MOD_Plk_4	377	383	PF00069	0.622
MOD_ProDKin_1	143	149	PF00069	0.498
MOD_ProDKin_1	279	285	PF00069	0.606
MOD_SUMO_rev_2	263	269	PF00179	0.393
MOD_SUMO_rev_2	61	70	PF00179	0.326
TRG_DiLeu_BaEn_1	386	391	PF01217	0.544
TRG_DiLeu_BaEn_4	340	346	PF01217	0.641
TRG_ENDOCYTIC_2	233	236	PF00928	0.376
TRG_ER_diArg_1	152	155	PF00400	0.376
TRG_NES_CRM1_1	385	398	PF08389	0.580
TRG_Pf-PMV_PEXEL_1	155	159	PF00026	0.376

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2X1	Leptomonas seymouri	57%	93%
A0A3Q8I8X5	Leishmania donovani	92%	100%
A4H6F3	Leishmania braziliensis	74%	99%
A4HUU7	Leishmania infantum	92%	100%
Q4QH44	Leishmania major	87%	98%
V5BRK4	Trypanosoma cruzi	33%	100%