Putative 14-3-3 protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

14-3-3 protein 2, putative

Species:

Leishmania mexicana

UniProt:

E9ANI1_LEIMU

TriTrypDb:

LmxM.11.0350

Length:

253

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 1
Forrest at al. (procyclic)	no	yes: 1
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 4

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0016281	eukaryotic translation initiation factor 4F complex	2	1
GO:0020016	ciliary pocket	2	1
GO:0032991	protein-containing complex	1	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

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Expansion

Sequence features

E9ANI1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANI1

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006897	endocytosis	5	1
GO:0007165	signal transduction	2	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0010564	regulation of cell cycle process	5	1
GO:0016192	vesicle-mediated transport	4	1
GO:0032465	regulation of cytokinesis	5	1
GO:0033036	macromolecule localization	2	1
GO:0050789	regulation of biological process	2	1

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	63	65	PF00675	0.309
CLV_PCSK_KEX2_1	10	12	PF00082	0.431
CLV_PCSK_KEX2_1	35	37	PF00082	0.323
CLV_PCSK_KEX2_1	63	65	PF00082	0.309
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.431
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.323
CLV_PCSK_SKI1_1	199	203	PF00082	0.323
CLV_PCSK_SKI1_1	36	40	PF00082	0.309
CLV_PCSK_SKI1_1	49	53	PF00082	0.309
CLV_Separin_Metazoa	186	190	PF03568	0.452

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P443	Leptomonas seymouri	94%	100%
A0A0N1IJ96	Leptomonas seymouri	52%	98%
A0A0S4IUJ3	Bodo saltans	70%	91%
A0A0S4JJB7	Bodo saltans	56%	97%
A0A1X0NVF8	Trypanosomatidae	75%	100%
A0A1X0P3Q3	Trypanosomatidae	53%	96%
A0A3R7KVM5	Trypanosoma rangeli	72%	100%
A0A3S7WRH0	Leishmania donovani	98%	100%
A0A3S7XB66	Leishmania donovani	52%	98%
A0A422NKL2	Trypanosoma rangeli	53%	97%

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