Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9ANI0_LEIMU

TriTrypDb:

LmxM.11.0340

Length:

503

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ANI0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANI0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	288	292	PF00656	0.608
CLV_NRD_NRD_1	13	15	PF00675	0.704
CLV_NRD_NRD_1	17	19	PF00675	0.681
CLV_NRD_NRD_1	340	342	PF00675	0.556
CLV_NRD_NRD_1	4	6	PF00675	0.649
CLV_PCSK_KEX2_1	13	15	PF00082	0.665
CLV_PCSK_KEX2_1	340	342	PF00082	0.556
CLV_PCSK_KEX2_1	4	6	PF00082	0.649
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.649
CLV_PCSK_SKI1_1	432	436	PF00082	0.608
DEG_SCF_FBW7_2	359	364	PF00400	0.535
DEG_SIAH_1	474	482	PF03145	0.638
DOC_CDC14_PxL_1	161	169	PF14671	0.481
DOC_CKS1_1	134	139	PF01111	0.724
DOC_CYCLIN_yClb1_LxF_4	430	435	PF00134	0.550
DOC_PP1_RVXF_1	299	306	PF00149	0.450
DOC_PP1_RVXF_1	430	436	PF00149	0.548
DOC_PP2B_LxvP_1	386	389	PF13499	0.665
DOC_USP7_MATH_1	115	119	PF00917	0.772
DOC_USP7_MATH_1	284	288	PF00917	0.676
DOC_USP7_MATH_1	297	301	PF00917	0.555
DOC_USP7_MATH_1	372	376	PF00917	0.656
DOC_USP7_UBL2_3	104	108	PF12436	0.618
DOC_USP7_UBL2_3	390	394	PF12436	0.601
DOC_USP7_UBL2_3	4	8	PF12436	0.677
DOC_WW_Pin1_4	133	138	PF00397	0.729
DOC_WW_Pin1_4	168	173	PF00397	0.738
DOC_WW_Pin1_4	220	225	PF00397	0.650
DOC_WW_Pin1_4	236	241	PF00397	0.556
DOC_WW_Pin1_4	279	284	PF00397	0.663
DOC_WW_Pin1_4	357	362	PF00397	0.755
DOC_WW_Pin1_4	375	380	PF00397	0.639
DOC_WW_Pin1_4	399	404	PF00397	0.751
DOC_WW_Pin1_4	417	422	PF00397	0.548
DOC_WW_Pin1_4	426	431	PF00397	0.657
DOC_WW_Pin1_4	477	482	PF00397	0.660
LIG_14-3-3_CanoR_1	142	146	PF00244	0.735
LIG_14-3-3_CanoR_1	355	360	PF00244	0.640
LIG_Actin_WH2_2	196	212	PF00022	0.628
LIG_Actin_WH2_2	311	328	PF00022	0.611
LIG_APCC_ABBA_1	251	256	PF00400	0.413
LIG_BIR_III_2	437	441	PF00653	0.567
LIG_Clathr_ClatBox_1	269	273	PF01394	0.675
LIG_EVH1_2	440	444	PF00568	0.492
LIG_FHA_1	124	130	PF00498	0.687
LIG_FHA_1	246	252	PF00498	0.649
LIG_FHA_1	337	343	PF00498	0.527
LIG_FHA_1	358	364	PF00498	0.680
LIG_FHA_1	478	484	PF00498	0.666
LIG_FHA_2	134	140	PF00498	0.716
LIG_GBD_Chelix_1	185	193	PF00786	0.619
LIG_HP1_1	481	485	PF01393	0.680
LIG_LIR_Apic_2	128	134	PF02991	0.512
LIG_LIR_Apic_2	302	308	PF02991	0.601
LIG_LIR_Gen_1	313	321	PF02991	0.592
LIG_LIR_Gen_1	354	363	PF02991	0.659
LIG_LIR_Nem_3	181	187	PF02991	0.628
LIG_LIR_Nem_3	201	207	PF02991	0.715
LIG_LIR_Nem_3	302	307	PF02991	0.605
LIG_LIR_Nem_3	313	319	PF02991	0.470
LIG_LIR_Nem_3	354	359	PF02991	0.684
LIG_LYPXL_SIV_4	449	457	PF13949	0.453
LIG_SH2_CRK	131	135	PF00017	0.691
LIG_SH2_CRK	446	450	PF00017	0.613
LIG_SH2_NCK_1	131	135	PF00017	0.691
LIG_SH2_STAT5	184	187	PF00017	0.622
LIG_SH2_STAT5	450	453	PF00017	0.605
LIG_SH3_1	131	137	PF00018	0.686
LIG_SH3_3	131	137	PF00018	0.783
LIG_SH3_3	159	165	PF00018	0.652
LIG_SH3_3	327	333	PF00018	0.640
LIG_SH3_3	376	382	PF00018	0.609
LIG_SUMO_SIM_anti_2	480	486	PF11976	0.607
LIG_SUMO_SIM_par_1	267	273	PF11976	0.622
LIG_TRFH_1	262	266	PF08558	0.632
LIG_TRFH_1	304	308	PF08558	0.593
LIG_WW_3	328	332	PF00397	0.638
MOD_CDK_SPK_2	401	406	PF00069	0.750
MOD_CDK_SPxK_1	426	432	PF00069	0.547
MOD_CDK_SPxxK_3	399	406	PF00069	0.693
MOD_CK1_1	124	130	PF00069	0.784
MOD_CK1_1	144	150	PF00069	0.687
MOD_CK1_1	194	200	PF00069	0.711
MOD_CK1_1	208	214	PF00069	0.578
MOD_CK1_1	239	245	PF00069	0.655
MOD_CK1_1	268	274	PF00069	0.782
MOD_CK1_1	285	291	PF00069	0.546
MOD_CK1_1	362	368	PF00069	0.631
MOD_CK1_1	375	381	PF00069	0.690
MOD_CK1_1	54	60	PF00069	0.717
MOD_GlcNHglycan	117	120	PF01048	0.783
MOD_GlcNHglycan	131	134	PF01048	0.627
MOD_GlcNHglycan	146	149	PF01048	0.615
MOD_GlcNHglycan	461	464	PF01048	0.823
MOD_GlcNHglycan	56	59	PF01048	0.555
MOD_GlcNHglycan	93	96	PF01048	0.679
MOD_GSK3_1	129	136	PF00069	0.731
MOD_GSK3_1	187	194	PF00069	0.626
MOD_GSK3_1	195	202	PF00069	0.568
MOD_GSK3_1	264	271	PF00069	0.742
MOD_GSK3_1	332	339	PF00069	0.547
MOD_GSK3_1	351	358	PF00069	0.545
MOD_GSK3_1	359	366	PF00069	0.588
MOD_GSK3_1	422	429	PF00069	0.750
MOD_GSK3_1	50	57	PF00069	0.733
MOD_GSK3_1	66	73	PF00069	0.633
MOD_GSK3_1	81	88	PF00069	0.577
MOD_N-GLC_1	194	199	PF02516	0.654
MOD_N-GLC_1	70	75	PF02516	0.656
MOD_NEK2_1	129	134	PF00069	0.693
MOD_NEK2_1	311	316	PF00069	0.576
MOD_NEK2_1	457	462	PF00069	0.541
MOD_NEK2_1	52	57	PF00069	0.723
MOD_NEK2_2	205	210	PF00069	0.611
MOD_OFUCOSY	163	170	PF10250	0.621
MOD_PIKK_1	98	104	PF00454	0.609
MOD_PK_1	355	361	PF00069	0.592
MOD_PKA_2	141	147	PF00069	0.705
MOD_PKA_2	411	417	PF00069	0.562
MOD_Plk_1	194	200	PF00069	0.693
MOD_Plk_4	151	157	PF00069	0.763
MOD_Plk_4	199	205	PF00069	0.612
MOD_Plk_4	265	271	PF00069	0.673
MOD_Plk_4	306	312	PF00069	0.650
MOD_Plk_4	411	417	PF00069	0.618
MOD_Plk_4	439	445	PF00069	0.568
MOD_ProDKin_1	133	139	PF00069	0.727
MOD_ProDKin_1	168	174	PF00069	0.738
MOD_ProDKin_1	220	226	PF00069	0.654
MOD_ProDKin_1	236	242	PF00069	0.552
MOD_ProDKin_1	279	285	PF00069	0.662
MOD_ProDKin_1	357	363	PF00069	0.751
MOD_ProDKin_1	375	381	PF00069	0.636
MOD_ProDKin_1	399	405	PF00069	0.745
MOD_ProDKin_1	417	423	PF00069	0.546
MOD_ProDKin_1	426	432	PF00069	0.660
MOD_ProDKin_1	477	483	PF00069	0.659
TRG_ENDOCYTIC_2	304	307	PF00928	0.599
TRG_ER_diArg_1	13	15	PF00400	0.532
TRG_ER_diArg_1	340	342	PF00400	0.553
TRG_NLS_MonoCore_2	3	8	PF00514	0.651
TRG_NLS_MonoExtC_3	3	8	PF00514	0.611
TRG_NLS_MonoExtC_3	393	398	PF00514	0.594
TRG_NLS_MonoExtN_4	392	398	PF00514	0.643
TRG_NLS_MonoExtN_4	4	10	PF00514	0.691
TRG_Pf-PMV_PEXEL_1	340	345	PF00026	0.654

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8I8Z9	Leishmania donovani	78%	100%
A4H6F1	Leishmania braziliensis	65%	96%
A4HUU5	Leishmania infantum	76%	100%
Q4QH46	Leishmania major	78%	99%