ATP-dependent DNA helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PIF1 helicase-like protein, putative

Species:

Leishmania mexicana

UniProt:

E9ANH8_LEIMU

TriTrypDb:

LmxM.11.0320

Length:

1223

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

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Cellular components
Term	Name	Level	Count
GO:0005657	replication fork	2	1
GO:0005737	cytoplasm	2	8
GO:0110165	cellular anatomical entity	1	8

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Expansion

Sequence features

E9ANH8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANH8

Function

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Biological processes
Term	Name	Level	Count
GO:0000723	telomere maintenance	5	8
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006259	DNA metabolic process	4	8
GO:0006260	DNA replication	5	1
GO:0006281	DNA repair	5	8
GO:0006310	DNA recombination	5	8
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0006950	response to stress	2	8
GO:0006974	DNA damage response	4	8

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003678	DNA helicase activity	3	8
GO:0003824	catalytic activity	1	8
GO:0004386	helicase activity	2	8
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	8
GO:0008094	ATP-dependent activity, acting on DNA	2	8
GO:0016462	pyrophosphatase activity	5	8
GO:0016787	hydrolase activity	2	8
GO:0016817	hydrolase activity, acting on acid anhydrides	3	8

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	290	294	PF00656	0.826
CLV_C14_Caspase3-7	766	770	PF00656	0.453
CLV_C14_Caspase3-7	80	84	PF00656	0.649
CLV_C14_Caspase3-7	856	860	PF00656	0.424
CLV_C14_Caspase3-7	913	917	PF00656	0.628
CLV_NRD_NRD_1	1147	1149	PF00675	0.546
CLV_NRD_NRD_1	1152	1154	PF00675	0.572
CLV_NRD_NRD_1	1158	1160	PF00675	0.553
CLV_NRD_NRD_1	1168	1170	PF00675	0.521
CLV_NRD_NRD_1	1207	1209	PF00675	0.677

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIS5	Leptomonas seymouri	63%	90%
A0A3R7MZY3	Trypanosoma rangeli	44%	100%
A0A3S7WRJ2	Leishmania donovani	90%	100%
A4H6E9	Leishmania braziliensis	79%	97%
A4HUU3	Leishmania infantum	90%	81%
Q4QH48	Leishmania major	89%	100%

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