Sec20-domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Sec20, putative

Species:

Leishmania mexicana

UniProt:

E9ANH6_LEIMU

TriTrypDb:

LmxM.11.0300

Length:

274

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005783	endoplasmic reticulum	5	1
GO:0031201	SNARE complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098796	membrane protein complex	2	1

Expansion

Sequence features

E9ANH6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANH6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	10
GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	6	10
GO:0016192	vesicle-mediated transport	4	10
GO:0048193	Golgi vesicle transport	5	10
GO:0051179	localization	1	10
GO:0051234	establishment of localization	2	10

Molecular functions
Term	Name	Level	Count
GO:0005484	SNAP receptor activity	3	10
GO:0030674	protein-macromolecule adaptor activity	2	10
GO:0060090	molecular adaptor activity	1	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	238	244	PF00089	0.368
CLV_NRD_NRD_1	138	140	PF00675	0.349
CLV_NRD_NRD_1	35	37	PF00675	0.304
CLV_PCSK_KEX2_1	138	140	PF00082	0.349
CLV_PCSK_KEX2_1	35	37	PF00082	0.280
CLV_PCSK_PC7_1	134	140	PF00082	0.335
CLV_PCSK_SKI1_1	138	142	PF00082	0.363
CLV_PCSK_SKI1_1	143	147	PF00082	0.368
CLV_PCSK_SKI1_1	175	179	PF00082	0.249
CLV_PCSK_SKI1_1	181	185	PF00082	0.249
CLV_PCSK_SKI1_1	227	231	PF00082	0.264
DEG_APCC_DBOX_1	133	141	PF00400	0.614
DEG_Nend_UBRbox_2	1	3	PF02207	0.655
DEG_SPOP_SBC_1	159	163	PF00917	0.672
DOC_CYCLIN_RxL_1	172	182	PF00134	0.447
DOC_CYCLIN_RxL_1	224	234	PF00134	0.449
DOC_CYCLIN_RxL_1	255	266	PF00134	0.389
DOC_MAPK_gen_1	224	232	PF00069	0.486
DOC_MAPK_gen_1	23	31	PF00069	0.501
DOC_MAPK_gen_1	55	65	PF00069	0.635
DOC_MAPK_MEF2A_6	181	188	PF00069	0.427
DOC_MAPK_MEF2A_6	235	242	PF00069	0.461
DOC_MAPK_MEF2A_6	25	33	PF00069	0.591
DOC_MAPK_MEF2A_6	58	67	PF00069	0.504
DOC_MAPK_NFAT4_5	235	243	PF00069	0.473
DOC_USP7_MATH_1	110	114	PF00917	0.693
DOC_USP7_MATH_1	173	177	PF00917	0.464
DOC_USP7_MATH_1	199	203	PF00917	0.473
DOC_WW_Pin1_4	10	15	PF00397	0.742
DOC_WW_Pin1_4	101	106	PF00397	0.721
DOC_WW_Pin1_4	108	113	PF00397	0.750
DOC_WW_Pin1_4	17	22	PF00397	0.746
LIG_14-3-3_CanoR_1	181	187	PF00244	0.569
LIG_14-3-3_CanoR_1	224	230	PF00244	0.459
LIG_14-3-3_CanoR_1	23	31	PF00244	0.534
LIG_14-3-3_CanoR_1	241	249	PF00244	0.236
LIG_Actin_WH2_2	123	140	PF00022	0.628
LIG_Actin_WH2_2	225	243	PF00022	0.449
LIG_FHA_1	149	155	PF00498	0.653
LIG_FHA_1	2	8	PF00498	0.654
LIG_FHA_1	24	30	PF00498	0.666
LIG_FHA_1	264	270	PF00498	0.465
LIG_FHA_1	45	51	PF00498	0.629
LIG_FHA_1	54	60	PF00498	0.657
LIG_FHA_2	118	124	PF00498	0.700
LIG_FHA_2	144	150	PF00498	0.535
LIG_FHA_2	153	159	PF00498	0.659
LIG_FHA_2	268	274	PF00498	0.408
LIG_FHA_2	77	83	PF00498	0.547
LIG_LIR_Gen_1	265	274	PF02991	0.448
LIG_LIR_Nem_3	265	271	PF02991	0.487
LIG_NRBOX	173	179	PF00104	0.449
LIG_PCNA_yPIPBox_3	220	230	PF02747	0.448
LIG_PDZ_Class_3	269	274	PF00595	0.418
LIG_SH2_CRK	92	96	PF00017	0.522
LIG_SH2_PTP2	268	271	PF00017	0.459
LIG_SH2_STAT5	253	256	PF00017	0.287
LIG_SH2_STAT5	268	271	PF00017	0.386
LIG_SH3_3	11	17	PF00018	0.761
LIG_SUMO_SIM_par_1	182	187	PF11976	0.508
LIG_SUMO_SIM_par_1	228	234	PF11976	0.434
LIG_SUMO_SIM_par_1	28	34	PF11976	0.475
LIG_TRAF2_1	120	123	PF00917	0.635
MOD_CDC14_SPxK_1	20	23	PF00782	0.555
MOD_CDK_SPxK_1	17	23	PF00069	0.567
MOD_CDK_SPxxK_3	101	108	PF00069	0.682
MOD_CK1_1	15	21	PF00069	0.714
MOD_CK1_1	163	169	PF00069	0.695
MOD_CK1_1	182	188	PF00069	0.492
MOD_CK1_1	201	207	PF00069	0.381
MOD_CK1_1	53	59	PF00069	0.593
MOD_CK1_1	99	105	PF00069	0.740
MOD_CK2_1	117	123	PF00069	0.692
MOD_CK2_1	143	149	PF00069	0.513
MOD_CK2_1	267	273	PF00069	0.402
MOD_CK2_1	76	82	PF00069	0.559
MOD_GlcNHglycan	162	165	PF01048	0.507
MOD_GlcNHglycan	17	20	PF01048	0.489
MOD_GlcNHglycan	242	245	PF01048	0.413
MOD_GlcNHglycan	98	101	PF01048	0.565
MOD_GSK3_1	104	111	PF00069	0.780
MOD_GSK3_1	148	155	PF00069	0.716
MOD_GSK3_1	159	166	PF00069	0.686
MOD_GSK3_1	173	180	PF00069	0.398
MOD_GSK3_1	263	270	PF00069	0.419
MOD_N-GLC_1	152	157	PF02516	0.448
MOD_N-GLC_1	53	58	PF02516	0.469
MOD_NEK2_1	1	6	PF00069	0.724
MOD_NEK2_1	177	182	PF00069	0.465
MOD_NEK2_1	208	213	PF00069	0.467
MOD_NEK2_1	225	230	PF00069	0.455
MOD_NEK2_1	240	245	PF00069	0.201
MOD_NEK2_1	44	49	PF00069	0.581
MOD_NEK2_1	7	12	PF00069	0.654
MOD_PIKK_1	53	59	PF00454	0.583
MOD_PKA_2	240	246	PF00069	0.287
MOD_Plk_4	263	269	PF00069	0.427
MOD_ProDKin_1	10	16	PF00069	0.741
MOD_ProDKin_1	101	107	PF00069	0.723
MOD_ProDKin_1	108	114	PF00069	0.748
MOD_ProDKin_1	17	23	PF00069	0.740
MOD_SUMO_rev_2	182	191	PF00179	0.532
TRG_DiLeu_BaLyEn_6	255	260	PF01217	0.180
TRG_ENDOCYTIC_2	127	130	PF00928	0.632
TRG_ENDOCYTIC_2	268	271	PF00928	0.484
TRG_ENDOCYTIC_2	92	95	PF00928	0.519
TRG_ER_diArg_1	137	139	PF00400	0.541
TRG_ER_diArg_1	22	25	PF00400	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1V7	Leptomonas seymouri	59%	100%
A0A1X0NV60	Trypanosomatidae	42%	100%
A0A3S5ISC5	Trypanosoma rangeli	39%	100%
A0A3S7WRJ0	Leishmania donovani	90%	100%
A4H9S8	Leishmania braziliensis	81%	100%
A4HUU1	Leishmania infantum	90%	100%
Q4QH50	Leishmania major	91%	100%
V5BBG4	Trypanosoma cruzi	44%	100%