Membrane-associated protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9ANH4_LEIMU

TriTrypDb:

LmxM.11.0280

Length:

976

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E9ANH4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANH4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.664
CLV_C14_Caspase3-7	267	271	PF00656	0.499
CLV_C14_Caspase3-7	704	708	PF00656	0.454
CLV_NRD_NRD_1	109	111	PF00675	0.678
CLV_NRD_NRD_1	60	62	PF00675	0.592
CLV_NRD_NRD_1	67	69	PF00675	0.343
CLV_NRD_NRD_1	721	723	PF00675	0.673
CLV_NRD_NRD_1	768	770	PF00675	0.694
CLV_NRD_NRD_1	858	860	PF00675	0.632
CLV_NRD_NRD_1	878	880	PF00675	0.699
CLV_PCSK_FUR_1	876	880	PF00082	0.726
CLV_PCSK_KEX2_1	146	148	PF00082	0.676
CLV_PCSK_KEX2_1	327	329	PF00082	0.625
CLV_PCSK_KEX2_1	60	62	PF00082	0.592
CLV_PCSK_KEX2_1	67	69	PF00082	0.343
CLV_PCSK_KEX2_1	770	772	PF00082	0.661
CLV_PCSK_KEX2_1	858	860	PF00082	0.632
CLV_PCSK_KEX2_1	878	880	PF00082	0.699
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.676
CLV_PCSK_PC1ET2_1	327	329	PF00082	0.609
CLV_PCSK_PC1ET2_1	770	772	PF00082	0.631
CLV_PCSK_PC7_1	63	69	PF00082	0.533
CLV_PCSK_SKI1_1	115	119	PF00082	0.691
CLV_PCSK_SKI1_1	291	295	PF00082	0.652
CLV_PCSK_SKI1_1	324	328	PF00082	0.606
CLV_PCSK_SKI1_1	387	391	PF00082	0.654
CLV_PCSK_SKI1_1	416	420	PF00082	0.747
CLV_PCSK_SKI1_1	484	488	PF00082	0.783
CLV_PCSK_SKI1_1	51	55	PF00082	0.482
CLV_PCSK_SKI1_1	878	882	PF00082	0.732
CLV_PCSK_SKI1_1	90	94	PF00082	0.787
DEG_APCC_DBOX_1	89	97	PF00400	0.423
DEG_SPOP_SBC_1	116	120	PF00917	0.488
DEG_SPOP_SBC_1	235	239	PF00917	0.499
DEG_SPOP_SBC_1	474	478	PF00917	0.472
DOC_ANK_TNKS_1	638	645	PF00023	0.486
DOC_CKS1_1	305	310	PF01111	0.632
DOC_CKS1_1	696	701	PF01111	0.616
DOC_CYCLIN_yCln2_LP_2	154	157	PF00134	0.453
DOC_MAPK_gen_1	324	333	PF00069	0.403
DOC_MAPK_gen_1	67	74	PF00069	0.616
DOC_MAPK_HePTP_8	64	76	PF00069	0.449
DOC_MAPK_MEF2A_6	67	76	PF00069	0.616
DOC_PP1_RVXF_1	414	420	PF00149	0.577
DOC_PP2B_LxvP_1	154	157	PF13499	0.486
DOC_PP2B_PxIxI_1	501	507	PF00149	0.428
DOC_USP7_MATH_1	105	109	PF00917	0.532
DOC_USP7_MATH_1	116	120	PF00917	0.413
DOC_USP7_MATH_1	131	135	PF00917	0.567
DOC_USP7_MATH_1	226	230	PF00917	0.580
DOC_USP7_MATH_1	235	239	PF00917	0.458
DOC_USP7_MATH_1	32	36	PF00917	0.780
DOC_USP7_MATH_1	359	363	PF00917	0.470
DOC_USP7_MATH_1	382	386	PF00917	0.547
DOC_USP7_MATH_1	405	409	PF00917	0.613
DOC_USP7_MATH_1	45	49	PF00917	0.661
DOC_USP7_MATH_1	475	479	PF00917	0.546
DOC_USP7_MATH_1	556	560	PF00917	0.482
DOC_USP7_MATH_1	660	664	PF00917	0.588
DOC_USP7_MATH_1	866	870	PF00917	0.553
DOC_USP7_MATH_1	98	102	PF00917	0.602
DOC_WW_Pin1_4	164	169	PF00397	0.546
DOC_WW_Pin1_4	252	257	PF00397	0.631
DOC_WW_Pin1_4	268	273	PF00397	0.437
DOC_WW_Pin1_4	304	309	PF00397	0.628
DOC_WW_Pin1_4	408	413	PF00397	0.512
DOC_WW_Pin1_4	470	475	PF00397	0.477
DOC_WW_Pin1_4	549	554	PF00397	0.556
DOC_WW_Pin1_4	646	651	PF00397	0.642
DOC_WW_Pin1_4	692	697	PF00397	0.508
DOC_WW_Pin1_4	793	798	PF00397	0.505
DOC_WW_Pin1_4	815	820	PF00397	0.550
LIG_14-3-3_CanoR_1	115	125	PF00244	0.652
LIG_14-3-3_CanoR_1	181	186	PF00244	0.488
LIG_14-3-3_CanoR_1	38	47	PF00244	0.773
LIG_14-3-3_CanoR_1	387	397	PF00244	0.472
LIG_14-3-3_CanoR_1	426	435	PF00244	0.589
LIG_14-3-3_CanoR_1	510	520	PF00244	0.479
LIG_14-3-3_CanoR_1	551	561	PF00244	0.454
LIG_14-3-3_CanoR_1	645	650	PF00244	0.480
LIG_14-3-3_CanoR_1	722	726	PF00244	0.532
LIG_14-3-3_CanoR_1	779	789	PF00244	0.608
LIG_14-3-3_CanoR_1	808	812	PF00244	0.446
LIG_14-3-3_CanoR_1	858	862	PF00244	0.487
LIG_14-3-3_CanoR_1	878	884	PF00244	0.532
LIG_14-3-3_CanoR_1	945	953	PF00244	0.516
LIG_14-3-3_CanoR_1	959	968	PF00244	0.501
LIG_Actin_WH2_2	743	759	PF00022	0.480
LIG_Actin_WH2_2	79	96	PF00022	0.283
LIG_APCC_ABBA_1	1	6	PF00400	0.780
LIG_BIR_III_4	455	459	PF00653	0.444
LIG_BRCT_BRCA1_1	602	606	PF00533	0.526
LIG_CaM_NSCaTE_8	752	759	PF13499	0.471
LIG_deltaCOP1_diTrp_1	686	690	PF00928	0.472
LIG_FHA_1	156	162	PF00498	0.622
LIG_FHA_1	305	311	PF00498	0.632
LIG_FHA_1	313	319	PF00498	0.516
LIG_FHA_1	412	418	PF00498	0.536
LIG_FHA_1	428	434	PF00498	0.486
LIG_FHA_1	485	491	PF00498	0.489
LIG_FHA_1	501	507	PF00498	0.511
LIG_FHA_1	512	518	PF00498	0.470
LIG_FHA_1	52	58	PF00498	0.764
LIG_FHA_1	614	620	PF00498	0.442
LIG_FHA_1	78	84	PF00498	0.504
LIG_FHA_1	784	790	PF00498	0.448
LIG_FHA_1	831	837	PF00498	0.573
LIG_FHA_1	97	103	PF00498	0.379
LIG_FHA_2	207	213	PF00498	0.485
LIG_FHA_2	214	220	PF00498	0.448
LIG_FHA_2	364	370	PF00498	0.525
LIG_FHA_2	654	660	PF00498	0.512
LIG_FHA_2	702	708	PF00498	0.587
LIG_FHA_2	858	864	PF00498	0.485
LIG_FHA_2	885	891	PF00498	0.459
LIG_LIR_Apic_2	527	533	PF02991	0.601
LIG_LIR_Apic_2	637	643	PF02991	0.485
LIG_LIR_Gen_1	346	355	PF02991	0.479
LIG_LIR_Gen_1	430	438	PF02991	0.557
LIG_LIR_Gen_1	677	683	PF02991	0.500
LIG_LIR_Gen_1	686	694	PF02991	0.475
LIG_LIR_Gen_1	842	850	PF02991	0.491
LIG_LIR_Gen_1	877	886	PF02991	0.540
LIG_LIR_Nem_3	346	350	PF02991	0.567
LIG_LIR_Nem_3	369	373	PF02991	0.435
LIG_LIR_Nem_3	430	435	PF02991	0.557
LIG_LIR_Nem_3	677	682	PF02991	0.477
LIG_LIR_Nem_3	686	690	PF02991	0.401
LIG_LIR_Nem_3	842	846	PF02991	0.476
LIG_LIR_Nem_3	877	883	PF02991	0.561
LIG_LIR_Nem_3	910	916	PF02991	0.408
LIG_NRBOX	82	88	PF00104	0.458
LIG_PCNA_yPIPBox_3	535	547	PF02747	0.491
LIG_PDZ_Class_3	971	976	PF00595	0.597
LIG_Pex14_1	912	916	PF04695	0.407
LIG_Pex14_2	679	683	PF04695	0.452
LIG_PTB_Apo_2	846	853	PF02174	0.572
LIG_PTB_Phospho_1	846	852	PF10480	0.574
LIG_RPA_C_Fungi	56	68	PF08784	0.537
LIG_SH2_CRK	640	644	PF00017	0.615
LIG_SH2_CRK	824	828	PF00017	0.607
LIG_SH2_GRB2like	820	823	PF00017	0.742
LIG_SH2_PTP2	432	435	PF00017	0.648
LIG_SH2_SRC	395	398	PF00017	0.562
LIG_SH2_STAP1	600	604	PF00017	0.743
LIG_SH2_STAP1	824	828	PF00017	0.607
LIG_SH2_STAT3	520	523	PF00017	0.605
LIG_SH2_STAT3	525	528	PF00017	0.655
LIG_SH2_STAT3	672	675	PF00017	0.765
LIG_SH2_STAT3	820	823	PF00017	0.625
LIG_SH2_STAT3	852	855	PF00017	0.725
LIG_SH2_STAT3	908	911	PF00017	0.635
LIG_SH2_STAT5	395	398	PF00017	0.562
LIG_SH2_STAT5	432	435	PF00017	0.648
LIG_SH2_STAT5	546	549	PF00017	0.631
LIG_SH2_STAT5	820	823	PF00017	0.586
LIG_SH2_STAT5	843	846	PF00017	0.625
LIG_SH2_STAT5	916	919	PF00017	0.499
LIG_SH2_STAT5	946	949	PF00017	0.640
LIG_SH2_STAT5	967	970	PF00017	0.635
LIG_SH3_1	269	275	PF00018	0.665
LIG_SH3_2	256	261	PF14604	0.620
LIG_SH3_2	272	277	PF14604	0.535
LIG_SH3_2	696	701	PF14604	0.796
LIG_SH3_3	167	173	PF00018	0.593
LIG_SH3_3	251	257	PF00018	0.786
LIG_SH3_3	269	275	PF00018	0.755
LIG_SH3_3	496	502	PF00018	0.769
LIG_SH3_3	561	567	PF00018	0.752
LIG_SH3_3	647	653	PF00018	0.823
LIG_SH3_3	693	699	PF00018	0.771
LIG_SH3_3	794	800	PF00018	0.567
LIG_SH3_3	880	886	PF00018	0.685
LIG_SH3_3	889	895	PF00018	0.739
LIG_SH3_3	89	95	PF00018	0.518
LIG_SH3_3	965	971	PF00018	0.771
LIG_SH3_CIN85_PxpxPR_1	272	277	PF14604	0.629
LIG_SH3_CIN85_PxpxPR_1	803	808	PF14604	0.580
LIG_SUMO_SIM_anti_2	295	301	PF11976	0.679
LIG_SUMO_SIM_par_1	485	492	PF11976	0.619
LIG_SUMO_SIM_par_1	502	507	PF11976	0.650
LIG_TRAF2_1	376	379	PF00917	0.738
LIG_TRAF2_1	526	529	PF00917	0.724
LIG_TRFH_1	690	694	PF08558	0.627
LIG_TYR_ITIM	914	919	PF00017	0.498
LIG_UBA3_1	717	723	PF00899	0.777
LIG_WW_3	274	278	PF00397	0.862
MOD_CDK_SPK_2	692	697	PF00069	0.551
MOD_CDK_SPxK_1	695	701	PF00069	0.792
MOD_CK1_1	119	125	PF00069	0.662
MOD_CK1_1	197	203	PF00069	0.689
MOD_CK1_1	225	231	PF00069	0.725
MOD_CK1_1	295	301	PF00069	0.679
MOD_CK1_1	391	397	PF00069	0.690
MOD_CK1_1	408	414	PF00069	0.665
MOD_CK1_1	467	473	PF00069	0.720
MOD_CK1_1	511	517	PF00069	0.654
MOD_CK1_1	552	558	PF00069	0.562
MOD_CK1_1	575	581	PF00069	0.810
MOD_CK1_1	635	641	PF00069	0.746
MOD_CK1_1	648	654	PF00069	0.570
MOD_CK1_1	695	701	PF00069	0.792
MOD_CK1_1	780	786	PF00069	0.733
MOD_CK1_1	796	802	PF00069	0.500
MOD_CK1_1	830	836	PF00069	0.668
MOD_CK1_1	896	902	PF00069	0.639
MOD_CK2_1	206	212	PF00069	0.757
MOD_CK2_1	213	219	PF00069	0.781
MOD_CK2_1	340	346	PF00069	0.733
MOD_CK2_1	363	369	PF00069	0.641
MOD_CK2_1	373	379	PF00069	0.708
MOD_CK2_1	653	659	PF00069	0.655
MOD_CK2_1	707	713	PF00069	0.737
MOD_CK2_1	884	890	PF00069	0.575
MOD_CK2_1	951	957	PF00069	0.653
MOD_Cter_Amidation	65	68	PF01082	0.503
MOD_GlcNHglycan	183	186	PF01048	0.698
MOD_GlcNHglycan	196	199	PF01048	0.564
MOD_GlcNHglycan	224	227	PF01048	0.805
MOD_GlcNHglycan	228	231	PF01048	0.787
MOD_GlcNHglycan	335	338	PF01048	0.627
MOD_GlcNHglycan	390	393	PF01048	0.744
MOD_GlcNHglycan	445	448	PF01048	0.767
MOD_GlcNHglycan	466	469	PF01048	0.714
MOD_GlcNHglycan	477	480	PF01048	0.715
MOD_GlcNHglycan	509	513	PF01048	0.773
MOD_GlcNHglycan	574	577	PF01048	0.667
MOD_GlcNHglycan	600	603	PF01048	0.794
MOD_GlcNHglycan	962	965	PF01048	0.654
MOD_GSK3_1	115	122	PF00069	0.715
MOD_GSK3_1	206	213	PF00069	0.802
MOD_GSK3_1	221	228	PF00069	0.631
MOD_GSK3_1	359	366	PF00069	0.521
MOD_GSK3_1	387	394	PF00069	0.597
MOD_GSK3_1	404	411	PF00069	0.660
MOD_GSK3_1	470	477	PF00069	0.649
MOD_GSK3_1	552	559	PF00069	0.799
MOD_GSK3_1	571	578	PF00069	0.475
MOD_GSK3_1	648	655	PF00069	0.635
MOD_GSK3_1	713	720	PF00069	0.685
MOD_GSK3_1	77	84	PF00069	0.283
MOD_GSK3_1	775	782	PF00069	0.691
MOD_GSK3_1	823	830	PF00069	0.707
MOD_GSK3_1	874	881	PF00069	0.777
MOD_GSK3_1	932	939	PF00069	0.720
MOD_GSK3_1	947	954	PF00069	0.647
MOD_N-GLC_1	164	169	PF02516	0.593
MOD_N-GLC_1	194	199	PF02516	0.624
MOD_N-GLC_1	470	475	PF02516	0.753
MOD_N-GLC_1	645	650	PF02516	0.807
MOD_N-GLC_1	775	780	PF02516	0.665
MOD_N-GLC_2	27	29	PF02516	0.587
MOD_N-GLC_2	496	498	PF02516	0.519
MOD_NEK2_1	15	20	PF00069	0.585
MOD_NEK2_1	221	226	PF00069	0.638
MOD_NEK2_1	236	241	PF00069	0.637
MOD_NEK2_1	333	338	PF00069	0.624
MOD_NEK2_1	438	443	PF00069	0.707
MOD_NEK2_1	572	577	PF00069	0.574
MOD_NEK2_1	613	618	PF00069	0.693
MOD_NEK2_1	634	639	PF00069	0.742
MOD_NEK2_1	661	666	PF00069	0.650
MOD_NEK2_1	717	722	PF00069	0.537
MOD_NEK2_1	777	782	PF00069	0.742
MOD_NEK2_1	809	814	PF00069	0.778
MOD_NEK2_1	907	912	PF00069	0.653
MOD_NEK2_1	947	952	PF00069	0.646
MOD_NEK2_2	284	289	PF00069	0.713
MOD_NEK2_2	53	58	PF00069	0.578
MOD_NEK2_2	866	871	PF00069	0.749
MOD_NEK2_2	9	14	PF00069	0.583
MOD_OFUCOSY	921	928	PF10250	0.531
MOD_PIKK_1	105	111	PF00454	0.603
MOD_PIKK_1	236	242	PF00454	0.847
MOD_PIKK_1	39	45	PF00454	0.604
MOD_PIKK_1	524	530	PF00454	0.760
MOD_PIKK_1	661	667	PF00454	0.765
MOD_PIKK_1	721	727	PF00454	0.767
MOD_PIKK_1	907	913	PF00454	0.634
MOD_PK_1	68	74	PF00069	0.283
MOD_PK_1	864	870	PF00069	0.503
MOD_PK_1	879	885	PF00069	0.557
MOD_PKA_1	878	884	PF00069	0.792
MOD_PKA_2	39	45	PF00069	0.604
MOD_PKA_2	624	630	PF00069	0.687
MOD_PKA_2	721	727	PF00069	0.594
MOD_PKA_2	778	784	PF00069	0.776
MOD_PKA_2	807	813	PF00069	0.558
MOD_PKA_2	857	863	PF00069	0.619
MOD_PKA_2	878	884	PF00069	0.739
MOD_PKB_1	876	884	PF00069	0.787
MOD_Plk_1	194	200	PF00069	0.695
MOD_Plk_1	363	369	PF00069	0.677
MOD_Plk_1	484	490	PF00069	0.623
MOD_Plk_1	936	942	PF00069	0.755
MOD_Plk_2-3	363	369	PF00069	0.524
MOD_Plk_2-3	707	713	PF00069	0.527
MOD_Plk_4	156	162	PF00069	0.631
MOD_Plk_4	213	219	PF00069	0.675
MOD_Plk_4	295	301	PF00069	0.679
MOD_Plk_4	391	397	PF00069	0.557
MOD_Plk_4	500	506	PF00069	0.766
MOD_Plk_4	556	562	PF00069	0.584
MOD_Plk_4	713	719	PF00069	0.519
MOD_Plk_4	77	83	PF00069	0.504
MOD_Plk_4	823	829	PF00069	0.725
MOD_Plk_4	839	845	PF00069	0.615
MOD_Plk_4	912	918	PF00069	0.502
MOD_ProDKin_1	164	170	PF00069	0.700
MOD_ProDKin_1	252	258	PF00069	0.819
MOD_ProDKin_1	268	274	PF00069	0.542
MOD_ProDKin_1	304	310	PF00069	0.816
MOD_ProDKin_1	408	414	PF00069	0.648
MOD_ProDKin_1	470	476	PF00069	0.601
MOD_ProDKin_1	549	555	PF00069	0.717
MOD_ProDKin_1	646	652	PF00069	0.831
MOD_ProDKin_1	692	698	PF00069	0.648
MOD_ProDKin_1	793	799	PF00069	0.641
MOD_ProDKin_1	815	821	PF00069	0.702
TRG_DiLeu_BaEn_1	713	718	PF01217	0.751
TRG_DiLeu_BaLyEn_6	321	326	PF01217	0.736
TRG_ENDOCYTIC_2	432	435	PF00928	0.713
TRG_ENDOCYTIC_2	69	72	PF00928	0.516
TRG_ENDOCYTIC_2	763	766	PF00928	0.682
TRG_ENDOCYTIC_2	824	827	PF00928	0.581
TRG_ENDOCYTIC_2	843	846	PF00928	0.601
TRG_ENDOCYTIC_2	916	919	PF00928	0.499
TRG_ER_diArg_1	288	291	PF00400	0.577
TRG_ER_diArg_1	37	40	PF00400	0.603
TRG_ER_diArg_1	60	63	PF00400	0.761
TRG_ER_diArg_1	67	69	PF00400	0.411
TRG_ER_diArg_1	769	772	PF00400	0.575
TRG_ER_diArg_1	857	859	PF00400	0.534
TRG_ER_diArg_1	876	879	PF00400	0.667
TRG_NLS_MonoExtC_3	769	775	PF00514	0.533
TRG_NLS_MonoExtN_4	769	774	PF00514	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAK7	Leptomonas seymouri	47%	100%
A4H9T0	Leishmania braziliensis	68%	99%