Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ANH2_LEIMU

TriTrypDb:

LmxM.11.0260

Length:

594

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ANH2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANH2

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	11
GO:0005996	monosaccharide metabolic process	3	11
GO:0006006	glucose metabolic process	5	11
GO:0006094	gluconeogenesis	6	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0016051	carbohydrate biosynthetic process	4	11
GO:0019318	hexose metabolic process	4	11
GO:0019319	hexose biosynthetic process	5	11
GO:0044238	primary metabolic process	2	11
GO:0044281	small molecule metabolic process	2	11
GO:0044283	small molecule biosynthetic process	3	11
GO:0046364	monosaccharide biosynthetic process	4	11
GO:0071704	organic substance metabolic process	2	11
GO:1901576	organic substance biosynthetic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004611	phosphoenolpyruvate carboxykinase activity	5	11
GO:0005488	binding	1	11
GO:0016829	lyase activity	2	11
GO:0016830	carbon-carbon lyase activity	3	11
GO:0016831	carboxy-lyase activity	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0036094	small molecule binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	400	404	PF00656	0.502
CLV_C14_Caspase3-7	537	541	PF00656	0.527
CLV_NRD_NRD_1	161	163	PF00675	0.414
CLV_NRD_NRD_1	296	298	PF00675	0.427
CLV_NRD_NRD_1	478	480	PF00675	0.561
CLV_NRD_NRD_1	64	66	PF00675	0.596
CLV_PCSK_KEX2_1	176	178	PF00082	0.605
CLV_PCSK_KEX2_1	217	219	PF00082	0.475
CLV_PCSK_KEX2_1	283	285	PF00082	0.534
CLV_PCSK_KEX2_1	296	298	PF00082	0.427
CLV_PCSK_KEX2_1	478	480	PF00082	0.560
CLV_PCSK_KEX2_1	64	66	PF00082	0.596
CLV_PCSK_PC1ET2_1	176	178	PF00082	0.621
CLV_PCSK_PC1ET2_1	217	219	PF00082	0.403
CLV_PCSK_PC1ET2_1	283	285	PF00082	0.534
CLV_PCSK_PC7_1	474	480	PF00082	0.540
CLV_PCSK_SKI1_1	206	210	PF00082	0.440
CLV_PCSK_SKI1_1	217	221	PF00082	0.451
CLV_PCSK_SKI1_1	251	255	PF00082	0.367
CLV_PCSK_SKI1_1	391	395	PF00082	0.504
CLV_PCSK_SKI1_1	552	556	PF00082	0.389
CLV_PCSK_SKI1_1	571	575	PF00082	0.384
CLV_PCSK_SKI1_1	585	589	PF00082	0.349
CLV_PCSK_SKI1_1	66	70	PF00082	0.637
DEG_SPOP_SBC_1	15	19	PF00917	0.634
DOC_MAPK_FxFP_2	186	189	PF00069	0.291
DOC_MAPK_gen_1	162	172	PF00069	0.395
DOC_MAPK_gen_1	296	302	PF00069	0.372
DOC_MAPK_gen_1	388	397	PF00069	0.507
DOC_MAPK_HePTP_8	385	397	PF00069	0.442
DOC_MAPK_MEF2A_6	388	397	PF00069	0.505
DOC_PP2B_LxvP_1	378	381	PF13499	0.457
DOC_PP4_FxxP_1	186	189	PF00568	0.285
DOC_PP4_FxxP_1	310	313	PF00568	0.464
DOC_PP4_FxxP_1	319	322	PF00568	0.485
DOC_PP4_FxxP_1	486	489	PF00568	0.632
DOC_PP4_FxxP_1	507	510	PF00568	0.499
DOC_USP7_MATH_1	114	118	PF00917	0.564
DOC_USP7_MATH_1	13	17	PF00917	0.620
DOC_USP7_MATH_1	381	385	PF00917	0.405
DOC_USP7_MATH_1	520	524	PF00917	0.506
DOC_USP7_MATH_1	544	548	PF00917	0.517
DOC_USP7_MATH_1	580	584	PF00917	0.385
DOC_WW_Pin1_4	245	250	PF00397	0.412
DOC_WW_Pin1_4	285	290	PF00397	0.564
DOC_WW_Pin1_4	309	314	PF00397	0.533
DOC_WW_Pin1_4	407	412	PF00397	0.405
LIG_14-3-3_CanoR_1	140	144	PF00244	0.481
LIG_14-3-3_CanoR_1	177	183	PF00244	0.601
LIG_14-3-3_CanoR_1	284	290	PF00244	0.589
LIG_14-3-3_CanoR_1	333	339	PF00244	0.480
LIG_14-3-3_CanoR_1	391	396	PF00244	0.416
LIG_14-3-3_CanoR_1	456	462	PF00244	0.495
LIG_14-3-3_CanoR_1	478	488	PF00244	0.638
LIG_APCC_ABBAyCdc20_2	552	558	PF00400	0.365
LIG_BRCT_BRCA1_1	306	310	PF00533	0.428
LIG_DCNL_PONY_1	1	4	PF03556	0.661
LIG_deltaCOP1_diTrp_1	291	295	PF00928	0.488
LIG_eIF4E_1	501	507	PF01652	0.585
LIG_eIF4E_1	95	101	PF01652	0.597
LIG_FHA_1	140	146	PF00498	0.486
LIG_FHA_1	165	171	PF00498	0.523
LIG_FHA_1	359	365	PF00498	0.329
LIG_FHA_1	392	398	PF00498	0.352
LIG_FHA_1	445	451	PF00498	0.493
LIG_FHA_1	491	497	PF00498	0.542
LIG_FHA_1	510	516	PF00498	0.469
LIG_FHA_2	102	108	PF00498	0.561
LIG_FHA_2	396	402	PF00498	0.461
LIG_FHA_2	546	552	PF00498	0.566
LIG_LIR_Apic_2	292	298	PF02991	0.454
LIG_LIR_Apic_2	307	313	PF02991	0.434
LIG_LIR_Apic_2	317	322	PF02991	0.501
LIG_LIR_Apic_2	337	343	PF02991	0.233
LIG_LIR_Apic_2	483	489	PF02991	0.653
LIG_LIR_Gen_1	121	130	PF02991	0.506
LIG_LIR_Gen_1	270	279	PF02991	0.540
LIG_LIR_Gen_1	374	385	PF02991	0.392
LIG_LIR_Gen_1	427	437	PF02991	0.353
LIG_LIR_Nem_3	121	126	PF02991	0.518
LIG_LIR_Nem_3	248	253	PF02991	0.374
LIG_LIR_Nem_3	270	274	PF02991	0.518
LIG_LIR_Nem_3	374	380	PF02991	0.404
LIG_LIR_Nem_3	427	433	PF02991	0.346
LIG_MAD2	314	322	PF02301	0.514
LIG_Pex14_1	139	143	PF04695	0.478
LIG_Pex14_1	488	492	PF04695	0.597
LIG_RPA_C_Fungi	1	13	PF08784	0.554
LIG_SH2_CRK	250	254	PF00017	0.364
LIG_SH2_CRK	30	34	PF00017	0.616
LIG_SH2_CRK	303	307	PF00017	0.346
LIG_SH2_CRK	340	344	PF00017	0.382
LIG_SH2_CRK	95	99	PF00017	0.591
LIG_SH2_GRB2like	129	132	PF00017	0.502
LIG_SH2_GRB2like	30	33	PF00017	0.581
LIG_SH2_NCK_1	129	133	PF00017	0.493
LIG_SH2_NCK_1	30	34	PF00017	0.616
LIG_SH2_SRC	129	132	PF00017	0.502
LIG_SH2_SRC	30	33	PF00017	0.616
LIG_SH2_STAP1	492	496	PF00017	0.442
LIG_SH2_STAP1	556	560	PF00017	0.492
LIG_SH2_STAT5	141	144	PF00017	0.474
LIG_SH2_STAT5	234	237	PF00017	0.352
LIG_SH2_STAT5	261	264	PF00017	0.327
LIG_SH2_STAT5	273	276	PF00017	0.452
LIG_SH2_STAT5	377	380	PF00017	0.511
LIG_SH2_STAT5	492	495	PF00017	0.420
LIG_SH2_STAT5	86	89	PF00017	0.509
LIG_SH3_3	430	436	PF00018	0.376
LIG_SUMO_SIM_anti_2	278	283	PF11976	0.640
LIG_SUMO_SIM_anti_2	392	398	PF11976	0.427
LIG_SUMO_SIM_anti_2	529	534	PF11976	0.348
LIG_SUMO_SIM_par_1	392	398	PF11976	0.393
LIG_SUMO_SIM_par_1	531	537	PF11976	0.420
LIG_TRAF2_1	275	278	PF00917	0.483
LIG_TRAF2_1	60	63	PF00917	0.577
LIG_TRAF2_1	80	83	PF00917	0.536
LIG_TRFH_1	148	152	PF08558	0.414
LIG_TYR_ITIM	28	33	PF00017	0.652
LIG_TYR_ITSM	246	253	PF00017	0.391
LIG_UBA3_1	562	571	PF00899	0.466
LIG_WRC_WIRS_1	268	273	PF05994	0.519
MOD_CDK_SPK_2	309	314	PF00069	0.507
MOD_CDK_SPxK_1	245	251	PF00069	0.401
MOD_CK1_1	121	127	PF00069	0.530
MOD_CK1_1	16	22	PF00069	0.604
MOD_CK1_1	384	390	PF00069	0.391
MOD_CK1_1	460	466	PF00069	0.538
MOD_CK2_1	395	401	PF00069	0.416
MOD_Cter_Amidation	160	163	PF01082	0.418
MOD_Cter_Amidation	174	177	PF01082	0.488
MOD_Cter_Amidation	215	218	PF01082	0.403
MOD_Cter_Amidation	476	479	PF01082	0.570
MOD_GlcNHglycan	135	138	PF01048	0.505
MOD_GlcNHglycan	18	21	PF01048	0.643
MOD_GlcNHglycan	210	214	PF01048	0.488
MOD_GSK3_1	114	121	PF00069	0.557
MOD_GSK3_1	239	246	PF00069	0.367
MOD_GSK3_1	251	258	PF00069	0.372
MOD_GSK3_1	334	341	PF00069	0.460
MOD_GSK3_1	391	398	PF00069	0.455
MOD_GSK3_1	7	14	PF00069	0.657
MOD_N-GLC_1	114	119	PF02516	0.564
MOD_N-GLC_1	121	126	PF02516	0.518
MOD_N-GLC_1	490	495	PF02516	0.510
MOD_NEK2_1	2	7	PF00069	0.629
MOD_NEK2_1	327	332	PF00069	0.465
MOD_NEK2_1	357	362	PF00069	0.343
MOD_NEK2_1	413	418	PF00069	0.419
MOD_NEK2_1	572	577	PF00069	0.436
MOD_NEK2_2	86	91	PF00069	0.525
MOD_PIKK_1	121	127	PF00454	0.530
MOD_PIKK_1	283	289	PF00454	0.582
MOD_PKA_1	176	182	PF00069	0.504
MOD_PKA_1	283	289	PF00069	0.542
MOD_PKA_2	139	145	PF00069	0.472
MOD_PKA_2	176	182	PF00069	0.504
MOD_PKA_2	2	8	PF00069	0.608
MOD_PKA_2	283	289	PF00069	0.544
MOD_PKA_2	520	526	PF00069	0.469
MOD_Plk_1	114	120	PF00069	0.560
MOD_Plk_1	121	127	PF00069	0.512
MOD_Plk_1	209	215	PF00069	0.466
MOD_Plk_1	277	283	PF00069	0.630
MOD_Plk_1	358	364	PF00069	0.331
MOD_Plk_4	277	283	PF00069	0.636
MOD_Plk_4	381	387	PF00069	0.351
MOD_Plk_4	391	397	PF00069	0.350
MOD_Plk_4	96	102	PF00069	0.537
MOD_ProDKin_1	245	251	PF00069	0.411
MOD_ProDKin_1	285	291	PF00069	0.565
MOD_ProDKin_1	309	315	PF00069	0.543
MOD_ProDKin_1	407	413	PF00069	0.401
TRG_DiLeu_BaEn_4	82	88	PF01217	0.537
TRG_ENDOCYTIC_2	250	253	PF00928	0.367
TRG_ENDOCYTIC_2	30	33	PF00928	0.581
TRG_ENDOCYTIC_2	377	380	PF00928	0.398
TRG_ENDOCYTIC_2	95	98	PF00928	0.588
TRG_ER_diArg_1	155	158	PF00400	0.469
TRG_ER_diArg_1	295	297	PF00400	0.456
TRG_Pf-PMV_PEXEL_1	218	222	PF00026	0.431
TRG_Pf-PMV_PEXEL_1	251	255	PF00026	0.367
TRG_Pf-PMV_PEXEL_1	524	529	PF00026	0.393

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2F9	Leptomonas seymouri	81%	99%
A0A0S4IUG4	Bodo saltans	54%	100%
A0A1X0NVG4	Trypanosomatidae	66%	97%
A0A3S5H6I1	Leishmania donovani	95%	100%
A4H9T2	Leishmania braziliensis	88%	100%
A4HUT8	Leishmania infantum	96%	100%
D0A7M0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	98%
Q4QH54	Leishmania major	95%	100%
V5BB32	Trypanosoma cruzi	64%	100%