Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ANH2_LEIMU

TriTrypDb:

LmxM.11.0260

Length:

594

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ANH2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANH2

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	11
GO:0005996	monosaccharide metabolic process	3	11
GO:0006006	glucose metabolic process	5	11
GO:0006094	gluconeogenesis	6	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0016051	carbohydrate biosynthetic process	4	11
GO:0019318	hexose metabolic process	4	11
GO:0019319	hexose biosynthetic process	5	11
GO:0044238	primary metabolic process	2	11

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004611	phosphoenolpyruvate carboxykinase activity	5	11
GO:0005488	binding	1	11
GO:0016829	lyase activity	2	11
GO:0016830	carbon-carbon lyase activity	3	11
GO:0016831	carboxy-lyase activity	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0036094	small molecule binding	2	11
GO:0097159	organic cyclic compound binding	2	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	400	404	PF00656	0.502
CLV_C14_Caspase3-7	537	541	PF00656	0.527
CLV_NRD_NRD_1	161	163	PF00675	0.414
CLV_NRD_NRD_1	296	298	PF00675	0.427
CLV_NRD_NRD_1	478	480	PF00675	0.561
CLV_NRD_NRD_1	64	66	PF00675	0.596
CLV_PCSK_KEX2_1	176	178	PF00082	0.605
CLV_PCSK_KEX2_1	217	219	PF00082	0.475
CLV_PCSK_KEX2_1	283	285	PF00082	0.534
CLV_PCSK_KEX2_1	296	298	PF00082	0.427

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2F9	Leptomonas seymouri	81%	99%
A0A0S4IUG4	Bodo saltans	54%	100%
A0A1X0NVG4	Trypanosomatidae	66%	97%
A0A3S5H6I1	Leishmania donovani	95%	100%
A4H9T2	Leishmania braziliensis	88%	100%
A4HUT8	Leishmania infantum	96%	100%
D0A7M0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	98%
Q4QH54	Leishmania major	95%	100%
V5BB32	Trypanosoma cruzi	64%	100%

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