RECA_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Rad51, putative

Species:

Leishmania mexicana

UniProt:

E9ANG9_LEIMU

TriTrypDb:

LmxM.11.0230

Length:

520

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ANG9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANG9

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006259	DNA metabolic process	4	7
GO:0006281	DNA repair	5	6
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0006950	response to stress	2	6
GO:0006974	DNA damage response	4	6
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0033554	cellular response to stress	3	6
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0046483	heterocycle metabolic process	3	7
GO:0050896	response to stimulus	1	6
GO:0051716	cellular response to stimulus	2	6
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:0000730	DNA recombinase assembly	7	1
GO:0006310	DNA recombination	5	1
GO:0006312	mitotic recombination	6	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0042148	strand invasion	5	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0065004	protein-DNA complex assembly	6	1
GO:0071824	protein-DNA complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090735	DNA repair complex assembly	6	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003676	nucleic acid binding	3	7
GO:0003677	DNA binding	4	7
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0008094	ATP-dependent activity, acting on DNA	2	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140097	catalytic activity, acting on DNA	3	7
GO:0140299	small molecule sensor activity	1	7
GO:0140612	DNA damage sensor activity	2	7
GO:0140640	catalytic activity, acting on a nucleic acid	2	7
GO:0140657	ATP-dependent activity	1	7
GO:0140664	ATP-dependent DNA damage sensor activity	3	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0000150	DNA strand exchange activity	4	1
GO:0003690	double-stranded DNA binding	5	1
GO:0003697	single-stranded DNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.742
CLV_C14_Caspase3-7	221	225	PF00656	0.538
CLV_C14_Caspase3-7	241	245	PF00656	0.472
CLV_C14_Caspase3-7	3	7	PF00656	0.728
CLV_C14_Caspase3-7	348	352	PF00656	0.544
CLV_C14_Caspase3-7	460	464	PF00656	0.664
CLV_C14_Caspase3-7	476	480	PF00656	0.539
CLV_NRD_NRD_1	163	165	PF00675	0.346
CLV_NRD_NRD_1	19	21	PF00675	0.752
CLV_NRD_NRD_1	279	281	PF00675	0.334
CLV_PCSK_KEX2_1	163	165	PF00082	0.346
CLV_PCSK_KEX2_1	19	21	PF00082	0.752
CLV_PCSK_KEX2_1	279	281	PF00082	0.363
CLV_PCSK_KEX2_1	304	306	PF00082	0.346
CLV_PCSK_PC1ET2_1	304	306	PF00082	0.346
CLV_PCSK_SKI1_1	389	393	PF00082	0.567
CLV_PCSK_SKI1_1	427	431	PF00082	0.633
DEG_APCC_DBOX_1	432	440	PF00400	0.592
DEG_COP1_1	507	517	PF00400	0.612
DEG_ODPH_VHL_1	491	503	PF01847	0.783
DEG_SPOP_SBC_1	139	143	PF00917	0.563
DOC_CKS1_1	414	419	PF01111	0.512
DOC_CKS1_1	455	460	PF01111	0.548
DOC_CYCLIN_yCln2_LP_2	439	445	PF00134	0.516
DOC_MAPK_gen_1	431	438	PF00069	0.609
DOC_PP1_RVXF_1	387	393	PF00149	0.566
DOC_PP2B_LxvP_1	145	148	PF13499	0.619
DOC_PP2B_LxvP_1	28	31	PF13499	0.439
DOC_PP2B_LxvP_1	443	446	PF13499	0.535
DOC_PP2B_LxvP_1	453	456	PF13499	0.553
DOC_USP7_MATH_1	115	119	PF00917	0.743
DOC_USP7_MATH_1	139	143	PF00917	0.556
DOC_USP7_MATH_1	210	214	PF00917	0.609
DOC_USP7_MATH_1	22	26	PF00917	0.612
DOC_USP7_MATH_1	354	358	PF00917	0.714
DOC_USP7_MATH_1	68	72	PF00917	0.817
DOC_WW_Pin1_4	108	113	PF00397	0.643
DOC_WW_Pin1_4	258	263	PF00397	0.619
DOC_WW_Pin1_4	410	415	PF00397	0.713
DOC_WW_Pin1_4	438	443	PF00397	0.565
DOC_WW_Pin1_4	454	459	PF00397	0.493
DOC_WW_Pin1_4	55	60	PF00397	0.642
DOC_WW_Pin1_4	90	95	PF00397	0.743
LIG_14-3-3_CanoR_1	126	131	PF00244	0.745
LIG_14-3-3_CanoR_1	164	174	PF00244	0.546
LIG_14-3-3_CanoR_1	279	283	PF00244	0.530
LIG_14-3-3_CanoR_1	38	44	PF00244	0.585
LIG_14-3-3_CanoR_1	50	60	PF00244	0.593
LIG_14-3-3_CanoR_1	63	68	PF00244	0.763
LIG_14-3-3_CanoR_1	96	104	PF00244	0.776
LIG_Actin_WH2_2	147	165	PF00022	0.546
LIG_Actin_WH2_2	388	404	PF00022	0.516
LIG_AP2alpha_2	507	509	PF02296	0.744
LIG_BIR_III_4	122	126	PF00653	0.734
LIG_BRCT_BRCA1_1	142	146	PF00533	0.537
LIG_BRCT_BRCA1_1	280	284	PF00533	0.438
LIG_CaM_IQ_9	297	313	PF13499	0.530
LIG_Clathr_ClatBox_1	268	272	PF01394	0.546
LIG_Clathr_ClatBox_1	503	507	PF01394	0.765
LIG_FHA_1	263	269	PF00498	0.511
LIG_FHA_1	3	9	PF00498	0.737
LIG_FHA_1	62	68	PF00498	0.729
LIG_FHA_2	493	499	PF00498	0.789
LIG_FHA_2	82	88	PF00498	0.854
LIG_FHA_2	97	103	PF00498	0.539
LIG_Integrin_RGD_1	376	378	PF01839	0.496
LIG_LIR_Gen_1	510	519	PF02991	0.613
LIG_LIR_Nem_3	510	514	PF02991	0.635
LIG_LIR_Nem_3	516	520	PF02991	0.637
LIG_NRBOX	245	251	PF00104	0.546
LIG_PDZ_Class_2	515	520	PF00595	0.661
LIG_Pex14_1	355	359	PF04695	0.721
LIG_SH2_NCK_1	511	515	PF00017	0.610
LIG_SH2_STAT5	359	362	PF00017	0.549
LIG_SH2_STAT5	511	514	PF00017	0.581
LIG_SH3_1	109	115	PF00018	0.608
LIG_SH3_1	411	417	PF00018	0.717
LIG_SH3_3	107	113	PF00018	0.528
LIG_SH3_3	366	372	PF00018	0.801
LIG_SH3_3	411	417	PF00018	0.717
LIG_SH3_3	452	458	PF00018	0.574
LIG_SH3_3	463	469	PF00018	0.780
LIG_SH3_3	487	493	PF00018	0.712
LIG_SH3_3	64	70	PF00018	0.649
LIG_SH3_3	91	97	PF00018	0.813
LIG_SUMO_SIM_par_1	267	273	PF11976	0.546
LIG_SUMO_SIM_par_1	313	318	PF11976	0.546
LIG_SUMO_SIM_par_1	502	507	PF11976	0.771
LIG_TRAF2_1	219	222	PF00917	0.617
LIG_WRC_WIRS_1	514	519	PF05994	0.567
MOD_CDC14_SPxK_1	93	96	PF00782	0.736
MOD_CDK_SPxK_1	90	96	PF00069	0.745
MOD_CK1_1	118	124	PF00069	0.699
MOD_CK1_1	261	267	PF00069	0.412
MOD_CK1_1	331	337	PF00069	0.787
MOD_CK1_1	364	370	PF00069	0.697
MOD_CK1_1	413	419	PF00069	0.654
MOD_CK2_1	492	498	PF00069	0.797
MOD_CK2_1	81	87	PF00069	0.856
MOD_DYRK1A_RPxSP_1	454	458	PF00069	0.516
MOD_GlcNHglycan	118	121	PF01048	0.811
MOD_GlcNHglycan	131	134	PF01048	0.580
MOD_GlcNHglycan	206	209	PF01048	0.465
MOD_GlcNHglycan	212	215	PF01048	0.497
MOD_GlcNHglycan	23	27	PF01048	0.612
MOD_GlcNHglycan	257	261	PF01048	0.509
MOD_GlcNHglycan	356	359	PF01048	0.786
MOD_GlcNHglycan	363	366	PF01048	0.724
MOD_GlcNHglycan	459	462	PF01048	0.541
MOD_GlcNHglycan	70	73	PF01048	0.752
MOD_GSK3_1	125	132	PF00069	0.720
MOD_GSK3_1	146	153	PF00069	0.488
MOD_GSK3_1	173	180	PF00069	0.433
MOD_GSK3_1	192	199	PF00069	0.295
MOD_GSK3_1	206	213	PF00069	0.418
MOD_GSK3_1	258	265	PF00069	0.419
MOD_GSK3_1	295	302	PF00069	0.411
MOD_GSK3_1	329	336	PF00069	0.722
MOD_GSK3_1	509	516	PF00069	0.561
MOD_GSK3_1	51	58	PF00069	0.601
MOD_GSK3_1	78	85	PF00069	0.706
MOD_LATS_1	124	130	PF00433	0.604
MOD_NEK2_1	103	108	PF00069	0.738
MOD_NEK2_1	116	121	PF00069	0.781
MOD_NEK2_1	278	283	PF00069	0.436
MOD_NEK2_1	296	301	PF00069	0.452
MOD_NEK2_1	315	320	PF00069	0.302
MOD_NEK2_1	328	333	PF00069	0.700
MOD_OFUCOSY	189	196	PF10250	0.338
MOD_PIKK_1	315	321	PF00454	0.389
MOD_PIKK_1	492	498	PF00454	0.787
MOD_PIKK_1	51	57	PF00454	0.653
MOD_PKA_2	125	131	PF00069	0.799
MOD_PKA_2	278	284	PF00069	0.389
MOD_PKA_2	51	57	PF00069	0.591
MOD_PKA_2	62	68	PF00069	0.705
MOD_Plk_1	22	28	PF00069	0.605
MOD_Plk_1	82	88	PF00069	0.854
MOD_Plk_2-3	378	384	PF00069	0.672
MOD_Plk_4	513	519	PF00069	0.452
MOD_ProDKin_1	108	114	PF00069	0.644
MOD_ProDKin_1	258	264	PF00069	0.513
MOD_ProDKin_1	410	416	PF00069	0.714
MOD_ProDKin_1	438	444	PF00069	0.567
MOD_ProDKin_1	454	460	PF00069	0.500
MOD_ProDKin_1	55	61	PF00069	0.649
MOD_ProDKin_1	90	96	PF00069	0.740
MOD_SUMO_for_1	10	13	PF00179	0.735
MOD_SUMO_rev_2	71	81	PF00179	0.556
TRG_DiLeu_BaEn_2	512	518	PF01217	0.553
TRG_DiLeu_LyEn_5	499	504	PF01217	0.494
TRG_ENDOCYTIC_2	511	514	PF00928	0.618
TRG_ER_diArg_1	162	164	PF00400	0.411
TRG_ER_diArg_1	19	21	PF00400	0.752
TRG_ER_diArg_1	278	280	PF00400	0.436
TRG_ER_diArg_1	451	454	PF00400	0.494
TRG_ER_diArg_1	49	52	PF00400	0.387
TRG_Pf-PMV_PEXEL_1	304	308	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCF4	Leptomonas seymouri	40%	100%
A0A3Q8IB69	Leishmania donovani	90%	100%
A4H9T5	Leishmania braziliensis	69%	100%
A4HUT5	Leishmania infantum	89%	100%
Q4QH57	Leishmania major	88%	100%