Inorganic diphosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acidocalcisomal pyrophosphatase

Species:

Leishmania mexicana

UniProt:

E9ANG7_LEIMU

TriTrypDb:

LmxM.11.0210

Length:

443

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	16
GO:0110165	cellular anatomical entity	1	16
GO:0005829	cytosol	2	1

Expansion

Sequence features

E9ANG7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANG7

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	16
GO:0006796	phosphate-containing compound metabolic process	4	16
GO:0008152	metabolic process	1	16
GO:0009987	cellular process	1	16
GO:0044237	cellular metabolic process	2	16

Molecular functions
Term	Name	Level	Count
GO:0000287	magnesium ion binding	5	16
GO:0003824	catalytic activity	1	16
GO:0004427	inorganic diphosphate phosphatase activity	6	16
GO:0005488	binding	1	16
GO:0016462	pyrophosphatase activity	5	16
GO:0016787	hydrolase activity	2	16
GO:0016817	hydrolase activity, acting on acid anhydrides	3	16
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	16
GO:0043167	ion binding	2	16
GO:0043169	cation binding	3	16
GO:0046872	metal ion binding	4	16
GO:0005509	calcium ion binding	5	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	73	77	PF00656	0.610
CLV_MEL_PAP_1	223	229	PF00089	0.442
CLV_NRD_NRD_1	106	108	PF00675	0.460
CLV_NRD_NRD_1	11	13	PF00675	0.743
CLV_NRD_NRD_1	225	227	PF00675	0.508
CLV_NRD_NRD_1	434	436	PF00675	0.395
CLV_PCSK_KEX2_1	106	108	PF00082	0.571
CLV_PCSK_KEX2_1	224	226	PF00082	0.532
CLV_PCSK_SKI1_1	371	375	PF00082	0.211
CLV_PCSK_SKI1_1	407	411	PF00082	0.269
CLV_PCSK_SKI1_1	435	439	PF00082	0.556
DEG_SPOP_SBC_1	65	69	PF00917	0.411
DOC_CKS1_1	205	210	PF01111	0.368
DOC_MAPK_DCC_7	335	344	PF00069	0.557
DOC_MAPK_gen_1	12	19	PF00069	0.747
DOC_MAPK_gen_1	128	136	PF00069	0.530
DOC_MAPK_gen_1	415	423	PF00069	0.463
DOC_MAPK_MEF2A_6	128	136	PF00069	0.463
DOC_PP4_FxxP_1	188	191	PF00568	0.433
DOC_USP7_MATH_1	142	146	PF00917	0.335
DOC_USP7_UBL2_3	213	217	PF12436	0.480
DOC_USP7_UBL2_3	279	283	PF12436	0.454
DOC_USP7_UBL2_3	436	440	PF12436	0.452
DOC_WW_Pin1_4	138	143	PF00397	0.507
DOC_WW_Pin1_4	204	209	PF00397	0.365
DOC_WW_Pin1_4	225	230	PF00397	0.337
DOC_WW_Pin1_4	41	46	PF00397	0.587
LIG_14-3-3_CanoR_1	111	118	PF00244	0.374
LIG_BIR_II_1	1	5	PF00653	0.644
LIG_BRCT_BRCA1_1	109	113	PF00533	0.454
LIG_BRCT_BRCA1_1	184	188	PF00533	0.418
LIG_deltaCOP1_diTrp_1	162	168	PF00928	0.366
LIG_deltaCOP1_diTrp_1	294	302	PF00928	0.497
LIG_FHA_1	158	164	PF00498	0.511
LIG_FHA_1	178	184	PF00498	0.606
LIG_FHA_1	307	313	PF00498	0.456
LIG_FHA_1	44	50	PF00498	0.673
LIG_FHA_1	67	73	PF00498	0.718
LIG_FHA_1	82	88	PF00498	0.577
LIG_FHA_1	99	105	PF00498	0.461
LIG_FHA_2	168	174	PF00498	0.560
LIG_FHA_2	241	247	PF00498	0.450
LIG_FHA_2	71	77	PF00498	0.642
LIG_LIR_Apic_2	185	191	PF02991	0.426
LIG_LIR_Apic_2	4	10	PF02991	0.732
LIG_LIR_Gen_1	110	121	PF02991	0.469
LIG_LIR_Gen_1	146	155	PF02991	0.522
LIG_LIR_Gen_1	179	188	PF02991	0.508
LIG_LIR_Gen_1	228	237	PF02991	0.362
LIG_LIR_Nem_3	110	116	PF02991	0.455
LIG_LIR_Nem_3	146	152	PF02991	0.610
LIG_LIR_Nem_3	160	164	PF02991	0.357
LIG_LIR_Nem_3	179	184	PF02991	0.518
LIG_LIR_Nem_3	228	233	PF02991	0.364
LIG_LIR_Nem_3	272	278	PF02991	0.457
LIG_LIR_Nem_3	357	361	PF02991	0.445
LIG_LIR_Nem_3	392	397	PF02991	0.476
LIG_PCNA_yPIPBox_3	359	373	PF02747	0.464
LIG_PDZ_Class_3	438	443	PF00595	0.514
LIG_Pex14_1	167	171	PF04695	0.462
LIG_Pex14_1	393	397	PF04695	0.469
LIG_Pex14_2	161	165	PF04695	0.349
LIG_Pex14_2	302	306	PF04695	0.512
LIG_PTAP_UEV_1	50	55	PF05743	0.561
LIG_SH2_CRK	253	257	PF00017	0.268
LIG_SH2_CRK	7	11	PF00017	0.739
LIG_SH2_SRC	123	126	PF00017	0.464
LIG_SH2_STAP1	419	423	PF00017	0.510
LIG_SH2_STAT3	192	195	PF00017	0.391
LIG_SH2_STAT5	123	126	PF00017	0.370
LIG_SH2_STAT5	135	138	PF00017	0.389
LIG_SH2_STAT5	215	218	PF00017	0.366
LIG_SH2_STAT5	236	239	PF00017	0.399
LIG_SH3_2	274	279	PF14604	0.504
LIG_SH3_3	234	240	PF00018	0.541
LIG_SH3_3	271	277	PF00018	0.493
LIG_SH3_3	362	368	PF00018	0.537
LIG_SH3_3	39	45	PF00018	0.678
LIG_SH3_3	48	54	PF00018	0.693
LIG_TYR_ITIM	121	126	PF00017	0.461
LIG_UBA3_1	148	153	PF00899	0.569
MOD_CDK_SPxxK_3	204	211	PF00069	0.360
MOD_CK1_1	182	188	PF00069	0.460
MOD_CK1_1	2	8	PF00069	0.662
MOD_CK1_1	35	41	PF00069	0.602
MOD_CK2_1	240	246	PF00069	0.438
MOD_CK2_1	35	41	PF00069	0.568
MOD_CMANNOS	165	168	PF00535	0.362
MOD_GlcNHglycan	113	116	PF01048	0.365
MOD_GlcNHglycan	184	187	PF01048	0.466
MOD_GlcNHglycan	317	320	PF01048	0.339
MOD_GlcNHglycan	34	37	PF01048	0.574
MOD_GlcNHglycan	51	54	PF01048	0.606
MOD_GSK3_1	107	114	PF00069	0.465
MOD_GSK3_1	138	145	PF00069	0.523
MOD_GSK3_1	167	174	PF00069	0.510
MOD_GSK3_1	182	189	PF00069	0.471
MOD_GSK3_1	240	247	PF00069	0.338
MOD_GSK3_1	302	309	PF00069	0.447
MOD_GSK3_1	54	61	PF00069	0.527
MOD_GSK3_1	66	73	PF00069	0.522
MOD_LATS_1	105	111	PF00433	0.476
MOD_N-GLC_1	138	143	PF02516	0.514
MOD_NEK2_1	100	105	PF00069	0.483
MOD_NEK2_1	116	121	PF00069	0.399
MOD_NEK2_1	19	24	PF00069	0.720
MOD_PIKK_1	116	122	PF00454	0.425
MOD_PIKK_1	98	104	PF00454	0.488
MOD_PK_1	244	250	PF00069	0.292
MOD_Plk_1	116	122	PF00069	0.440
MOD_Plk_1	186	192	PF00069	0.477
MOD_Plk_1	19	25	PF00069	0.655
MOD_Plk_1	2	8	PF00069	0.522
MOD_Plk_1	415	421	PF00069	0.533
MOD_Plk_1	424	430	PF00069	0.472
MOD_Plk_1	70	76	PF00069	0.617
MOD_Plk_2-3	268	274	PF00069	0.360
MOD_Plk_2-3	76	82	PF00069	0.760
MOD_ProDKin_1	138	144	PF00069	0.507
MOD_ProDKin_1	204	210	PF00069	0.355
MOD_ProDKin_1	225	231	PF00069	0.338
MOD_ProDKin_1	41	47	PF00069	0.585
MOD_SUMO_for_1	199	202	PF00179	0.543
MOD_SUMO_for_1	265	268	PF00179	0.469
MOD_SUMO_rev_2	145	155	PF00179	0.531
MOD_SUMO_rev_2	352	361	PF00179	0.469
MOD_SUMO_rev_2	44	52	PF00179	0.680
TRG_ENDOCYTIC_2	123	126	PF00928	0.472
TRG_ENDOCYTIC_2	253	256	PF00928	0.298
TRG_ENDOCYTIC_2	299	302	PF00928	0.455
TRG_ER_diArg_1	106	108	PF00400	0.469
TRG_ER_diArg_1	223	226	PF00400	0.536
TRG_ER_diLys_1	438	443	PF00400	0.558
TRG_NES_CRM1_1	355	367	PF08389	0.557
TRG_NLS_MonoExtC_3	434	439	PF00514	0.479
TRG_Pf-PMV_PEXEL_1	371	375	PF00026	0.256

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDG0	Leptomonas seymouri	80%	99%
A0A0S4JW75	Bodo saltans	64%	100%
A0A1X0NVA1	Trypanosomatidae	67%	100%
A0A1X0NVH4	Trypanosomatidae	72%	100%
A0A1X0NWW9	Trypanosomatidae	67%	100%
A0A3R7KMZ3	Trypanosoma rangeli	65%	100%
A0A3S7WRH5	Leishmania donovani	97%	100%
A4H3Q3	Leishmania braziliensis	38%	100%
A4H9T7	Leishmania braziliensis	92%	100%
A4HUT3	Leishmania infantum	96%	100%
D0A7N0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
D0A7N2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
Q4QH59	Leishmania major	96%	100%
V5BB26	Trypanosoma cruzi	65%	100%