PUA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ANG4_LEIMU

TriTrypDb:

LmxM.11.0180

Length:

195

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E9ANG4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANG4

Function

Biological processes
Term	Name	Level	Count
GO:0001731	formation of translation preinitiation complex	7	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	8	12	PF00082	0.226
DOC_MAPK_gen_1	50	56	PF00069	0.415
DOC_USP7_MATH_1	19	23	PF00917	0.471
DOC_USP7_MATH_1	49	53	PF00917	0.427
DOC_USP7_UBL2_3	90	94	PF12436	0.415
LIG_APCC_ABBA_1	140	145	PF00400	0.404
LIG_BRCT_BRCA1_1	51	55	PF00533	0.458
LIG_LIR_Apic_2	180	186	PF02991	0.440
LIG_LIR_Gen_1	41	49	PF02991	0.411
LIG_LIR_Nem_3	35	40	PF02991	0.407
LIG_LIR_Nem_3	41	47	PF02991	0.408
LIG_LIR_Nem_3	5	10	PF02991	0.337
LIG_LYPXL_yS_3	37	40	PF13949	0.415
LIG_LYPXL_yS_3	95	98	PF13949	0.442
LIG_PDZ_Class_2	190	195	PF00595	0.572
LIG_SH2_SRC	111	114	PF00017	0.494
LIG_SH2_SRC	143	146	PF00017	0.447
LIG_SH2_SRC	85	88	PF00017	0.399
LIG_SH2_STAT5	111	114	PF00017	0.412
LIG_SH2_STAT5	143	146	PF00017	0.429
LIG_SH2_STAT5	85	88	PF00017	0.399
LIG_SH3_3	81	87	PF00018	0.415
LIG_TRAF2_1	159	162	PF00917	0.385
LIG_TRAF2_1	39	42	PF00917	0.381
MOD_CK2_1	156	162	PF00069	0.429
MOD_CK2_1	19	25	PF00069	0.443
MOD_CK2_1	68	74	PF00069	0.458
MOD_GlcNHglycan	113	116	PF01048	0.204
MOD_GlcNHglycan	124	127	PF01048	0.232
MOD_GlcNHglycan	188	191	PF01048	0.432
MOD_GlcNHglycan	2	5	PF01048	0.381
MOD_GSK3_1	152	159	PF00069	0.439
MOD_GSK3_1	64	71	PF00069	0.471
MOD_NEK2_1	188	193	PF00069	0.408
MOD_NEK2_1	68	73	PF00069	0.455
MOD_PIKK_1	68	74	PF00454	0.471
MOD_PKA_1	8	14	PF00069	0.404
MOD_Plk_4	152	158	PF00069	0.432
MOD_SUMO_rev_2	20	29	PF00179	0.473
TRG_ENDOCYTIC_2	37	40	PF00928	0.406
TRG_ENDOCYTIC_2	95	98	PF00928	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4P0	Leptomonas seymouri	83%	99%
A0A0S4JUH4	Bodo saltans	72%	94%
A0A1X0NV76	Trypanosomatidae	72%	99%
A0A3B3IRV3	Homo sapiens	44%	100%
A0A3S5H6H9	Leishmania donovani	97%	99%
A0A3S5ISC7	Trypanosoma rangeli	75%	99%
A4H9U0	Leishmania braziliensis	92%	100%
A4HUT0	Leishmania infantum	97%	99%
D0A7N4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	96%
P87313	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	100%
P89886	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	44%	100%
Q2KIE4	Bos taurus	44%	100%
Q4G009	Rattus norvegicus	44%	100%
Q4QH62	Leishmania major	96%	100%
Q58827	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	33%	100%
Q5PPY1	Xenopus laevis	44%	100%
Q5ZI42	Gallus gallus	43%	100%
Q6DER1	Xenopus tropicalis	44%	100%
Q6NRJ7	Xenopus laevis	44%	100%
Q75AA8	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	41%	100%
Q7ZV34	Danio rerio	43%	100%
Q86KL4	Dictyostelium discoideum	44%	100%
Q9CQ21	Mus musculus	43%	100%
Q9DB27	Mus musculus	44%	100%
Q9ULC4	Homo sapiens	44%	100%
Q9W445	Drosophila melanogaster	44%	100%
V5BWL1	Trypanosoma cruzi	71%	99%