LeishMANIAdb
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Serine--tRNA ligase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Serine--tRNA ligase
Gene product:
seryl-tRNA synthetase
Species:
Leishmania mexicana
UniProt:
E9ANF6_LEIMU
TriTrypDb:
LmxM.11.0100
Length:
474

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 5
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
TermNameLevelCount
GO:0005737 cytoplasm 2 1
GO:0005739 mitochondrion 5 1
GO:0005829 cytosol 2 1
GO:0005929 cilium 4 1
GO:0042995 cell projection 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1
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Expansion

Sequence features

E9ANF6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANF6

Function

Biological processes
TermNameLevelCount
GO:0006082 organic acid metabolic process 3 12
GO:0006139 nucleobase-containing compound metabolic process 3 12
GO:0006399 tRNA metabolic process 7 12
GO:0006418 tRNA aminoacylation for protein translation 6 12
GO:0006434 seryl-tRNA aminoacylation 7 12
GO:0006520 amino acid metabolic process 3 12
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009987 cellular process 1 12
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Molecular functions
TermNameLevelCount
GO:0000049 tRNA binding 5 1
GO:0000166 nucleotide binding 3 12
GO:0003676 nucleic acid binding 3 1
GO:0003723 RNA binding 4 1
GO:0003824 catalytic activity 1 12
GO:0004812 aminoacyl-tRNA ligase activity 4 12
GO:0004828 serine-tRNA ligase activity 5 12
GO:0005488 binding 1 12
GO:0005524 ATP binding 5 12
GO:0016874 ligase activity 2 12
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_MEL_PAP_1 399 405 PF00089 0.262
CLV_NRD_NRD_1 165 167 PF00675 0.451
CLV_NRD_NRD_1 23 25 PF00675 0.240
CLV_NRD_NRD_1 294 296 PF00675 0.240
CLV_NRD_NRD_1 42 44 PF00675 0.240
CLV_PCSK_FUR_1 40 44 PF00082 0.246
CLV_PCSK_KEX2_1 165 167 PF00082 0.359
CLV_PCSK_KEX2_1 22 24 PF00082 0.240
CLV_PCSK_KEX2_1 39 41 PF00082 0.240
CLV_PCSK_KEX2_1 42 44 PF00082 0.165
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P535 Leptomonas seymouri 86% 100%
A0A0S4JVV1 Bodo saltans 69% 100%
A0A1X0NV86 Trypanosomatidae 75% 100%
A0A3S5H6H8 Leishmania donovani 97% 100%
A0A422MUB7 Trypanosoma rangeli 73% 99%
A0AM81 Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / CIP 8149 / NCTC 11857 / SLCC 5334 / V8) 34% 100%
A0JR71 Arthrobacter sp. (strain FB24) 32% 100%
A0K5F5 Burkholderia cenocepacia (strain HI2424) 35% 100%
A0KWW5 Shewanella sp. (strain ANA-3) 32% 100%
A0L6J8 Magnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1) 34% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS