Serine--tRNA ligase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Serine--tRNA ligase

Gene product:

seryl-tRNA synthetase

Species:

Leishmania mexicana

UniProt:

E9ANF6_LEIMU

TriTrypDb:

LmxM.11.0100

Length:

474

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0005829	cytosol	2	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

E9ANF6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANF6

Function

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Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006399	tRNA metabolic process	7	12
GO:0006418	tRNA aminoacylation for protein translation	6	12
GO:0006434	seryl-tRNA aminoacylation	7	12
GO:0006520	amino acid metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12

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Molecular functions
Term	Name	Level	Count
GO:0000049	tRNA binding	5	1
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003824	catalytic activity	1	12
GO:0004812	aminoacyl-tRNA ligase activity	4	12
GO:0004828	serine-tRNA ligase activity	5	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016874	ligase activity	2	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	399	405	PF00089	0.262
CLV_NRD_NRD_1	165	167	PF00675	0.451
CLV_NRD_NRD_1	23	25	PF00675	0.240
CLV_NRD_NRD_1	294	296	PF00675	0.240
CLV_NRD_NRD_1	42	44	PF00675	0.240
CLV_PCSK_FUR_1	40	44	PF00082	0.246
CLV_PCSK_KEX2_1	165	167	PF00082	0.359
CLV_PCSK_KEX2_1	22	24	PF00082	0.240
CLV_PCSK_KEX2_1	39	41	PF00082	0.240
CLV_PCSK_KEX2_1	42	44	PF00082	0.165

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P535	Leptomonas seymouri	86%	100%
A0A0S4JVV1	Bodo saltans	69%	100%
A0A1X0NV86	Trypanosomatidae	75%	100%
A0A3S5H6H8	Leishmania donovani	97%	100%
A0A422MUB7	Trypanosoma rangeli	73%	99%
A0AM81	Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / CIP 8149 / NCTC 11857 / SLCC 5334 / V8)	34%	100%
A0JR71	Arthrobacter sp. (strain FB24)	32%	100%
A0K5F5	Burkholderia cenocepacia (strain HI2424)	35%	100%
A0KWW5	Shewanella sp. (strain ANA-3)	32%	100%
A0L6J8	Magnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1)	34%	100%

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