RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ANF4_LEIMU

TriTrypDb:

LmxM.11.0080

Length:

217

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ANF4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANF4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	176	178	PF00675	0.599
CLV_NRD_NRD_1	181	183	PF00675	0.579
CLV_NRD_NRD_1	32	34	PF00675	0.614
CLV_NRD_NRD_1	73	75	PF00675	0.666
CLV_NRD_NRD_1	77	79	PF00675	0.686
CLV_PCSK_KEX2_1	3	5	PF00082	0.557
CLV_PCSK_KEX2_1	30	32	PF00082	0.616
CLV_PCSK_KEX2_1	84	86	PF00082	0.610
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.572
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.638
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.635
CLV_PCSK_PC7_1	27	33	PF00082	0.624
CLV_PCSK_SKI1_1	104	108	PF00082	0.263
CLV_PCSK_SKI1_1	154	158	PF00082	0.574
CLV_PCSK_SKI1_1	177	181	PF00082	0.557
CLV_PCSK_SKI1_1	79	83	PF00082	0.645
DOC_PP4_FxxP_1	93	96	PF00568	0.586
DOC_USP7_MATH_1	213	217	PF00917	0.561
DOC_USP7_UBL2_3	174	178	PF12436	0.637
DOC_USP7_UBL2_3	75	79	PF12436	0.621
LIG_14-3-3_CanoR_1	78	82	PF00244	0.719
LIG_FHA_1	64	70	PF00498	0.738
LIG_FHA_2	103	109	PF00498	0.488
LIG_LIR_Gen_1	128	135	PF02991	0.474
LIG_LIR_Nem_3	105	110	PF02991	0.474
LIG_LIR_Nem_3	128	133	PF02991	0.474
LIG_Pex14_2	202	206	PF04695	0.487
LIG_WRC_WIRS_1	132	137	PF05994	0.466
MOD_CK1_1	64	70	PF00069	0.684
MOD_CK2_1	102	108	PF00069	0.505
MOD_Cter_Amidation	1	4	PF01082	0.693
MOD_GlcNHglycan	211	214	PF01048	0.684
MOD_GSK3_1	166	173	PF00069	0.677
MOD_GSK3_1	209	216	PF00069	0.455
MOD_GSK3_1	53	60	PF00069	0.642
MOD_GSK3_1	63	70	PF00069	0.598
MOD_N-GLC_1	125	130	PF02516	0.276
MOD_NEK2_1	125	130	PF00069	0.493
MOD_NEK2_1	148	153	PF00069	0.488
MOD_NEK2_1	157	162	PF00069	0.563
MOD_NEK2_1	166	171	PF00069	0.453
MOD_NEK2_1	69	74	PF00069	0.477
MOD_NEK2_2	102	107	PF00069	0.505
MOD_NEK2_2	131	136	PF00069	0.463
MOD_NEK2_2	158	163	PF00069	0.668
MOD_PIKK_1	125	131	PF00454	0.500
MOD_PKA_1	74	80	PF00069	0.717
MOD_PKA_2	77	83	PF00069	0.739
MOD_Plk_1	125	131	PF00069	0.476
MOD_SUMO_for_1	112	115	PF00179	0.488
MOD_SUMO_rev_2	108	114	PF00179	0.472
TRG_DiLeu_BaEn_1	189	194	PF01217	0.625
TRG_DiLeu_BaEn_2	197	203	PF01217	0.560
TRG_DiLeu_BaEn_4	195	201	PF01217	0.582
TRG_ER_diArg_1	31	33	PF00400	0.683
TRG_ER_diLys_1	214	217	PF00400	0.467
TRG_NLS_MonoCore_2	29	34	PF00514	0.679
TRG_NLS_MonoCore_2	81	86	PF00514	0.631
TRG_NLS_MonoExtC_3	181	187	PF00514	0.540
TRG_NLS_MonoExtC_3	81	87	PF00514	0.549
TRG_NLS_MonoExtN_4	27	34	PF00514	0.643
TRG_NLS_MonoExtN_4	79	86	PF00514	0.613
TRG_Pf-PMV_PEXEL_1	4	9	PF00026	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4P3	Leptomonas seymouri	76%	100%
A0A0S4JVA8	Bodo saltans	54%	96%
A0A1X0NV88	Trypanosomatidae	56%	96%
A0A3R7KAH2	Trypanosoma rangeli	55%	100%
A0A3S7WRD9	Leishmania donovani	92%	96%
A4H9V0	Leishmania braziliensis	83%	100%
A4HUS0	Leishmania infantum	92%	96%
D0A7P3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	99%
Q4QH72	Leishmania major	88%	100%
V5BRH6	Trypanosoma cruzi	56%	79%