Endoplasmic reticulum vesicle transporter-domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)/Endoplasmic reticulum vesicle transporter, putative

Species:

Leishmania mexicana

UniProt:

E9ANE8_LEIMU

TriTrypDb:

LmxM.11.0020

Length:

368

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005783	endoplasmic reticulum	5	1
GO:0030134	COPII-coated ER to Golgi transport vesicle	8	1
GO:0030135	coated vesicle	7	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1

Expansion

Sequence features

E9ANE8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANE8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.278
CLV_NRD_NRD_1	211	213	PF00675	0.487
CLV_NRD_NRD_1	231	233	PF00675	0.475
CLV_NRD_NRD_1	277	279	PF00675	0.536
CLV_PCSK_KEX2_1	211	213	PF00082	0.438
CLV_PCSK_KEX2_1	282	284	PF00082	0.358
CLV_PCSK_KEX2_1	298	300	PF00082	0.416
CLV_PCSK_PC1ET2_1	282	284	PF00082	0.341
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.326
CLV_PCSK_PC7_1	278	284	PF00082	0.341
CLV_PCSK_SKI1_1	283	287	PF00082	0.536
DOC_MAPK_gen_1	200	208	PF00069	0.227
DOC_MAPK_gen_1	298	305	PF00069	0.230
DOC_MAPK_MEF2A_6	200	208	PF00069	0.316
DOC_MAPK_MEF2A_6	298	305	PF00069	0.332
DOC_PP4_FxxP_1	2	5	PF00568	0.398
DOC_USP7_MATH_1	148	152	PF00917	0.399
DOC_USP7_MATH_1	23	27	PF00917	0.159
DOC_USP7_MATH_1	285	289	PF00917	0.330
DOC_USP7_UBL2_3	109	113	PF12436	0.348
DOC_USP7_UBL2_3	165	169	PF12436	0.306
DOC_USP7_UBL2_3	257	261	PF12436	0.319
DOC_USP7_UBL2_3	282	286	PF12436	0.348
LIG_14-3-3_CanoR_1	215	220	PF00244	0.176
LIG_14-3-3_CanoR_1	329	339	PF00244	0.239
LIG_14-3-3_CanoR_1	54	62	PF00244	0.141
LIG_APCC_ABBA_1	161	166	PF00400	0.316
LIG_APCC_ABBA_1	60	65	PF00400	0.266
LIG_Clathr_ClatBox_1	313	317	PF01394	0.266
LIG_deltaCOP1_diTrp_1	358	366	PF00928	0.595
LIG_EVH1_2	134	138	PF00568	0.299
LIG_FHA_1	172	178	PF00498	0.221
LIG_FHA_1	22	28	PF00498	0.218
LIG_FHA_1	264	270	PF00498	0.285
LIG_FHA_1	298	304	PF00498	0.230
LIG_FHA_1	90	96	PF00498	0.312
LIG_FHA_2	260	266	PF00498	0.316
LIG_FHA_2	98	104	PF00498	0.287
LIG_GBD_Chelix_1	342	350	PF00786	0.265
LIG_LIR_Nem_3	136	141	PF02991	0.338
LIG_LIR_Nem_3	14	19	PF02991	0.390
LIG_LIR_Nem_3	162	167	PF02991	0.214
LIG_LIR_Nem_3	213	219	PF02991	0.329
LIG_LIR_Nem_3	65	70	PF02991	0.141
LIG_NRP_CendR_1	365	368	PF00754	0.323
LIG_Pex14_1	359	363	PF04695	0.550
LIG_Pex14_2	64	68	PF04695	0.266
LIG_SH2_SRC	290	293	PF00017	0.224
LIG_SH2_STAP1	290	294	PF00017	0.226
LIG_SH2_STAP1	46	50	PF00017	0.277
LIG_SH2_STAT3	176	179	PF00017	0.282
LIG_SH2_STAT3	292	295	PF00017	0.224
LIG_SH2_STAT5	176	179	PF00017	0.316
LIG_SH2_STAT5	268	271	PF00017	0.223
LIG_SH2_STAT5	39	42	PF00017	0.198
LIG_SH2_STAT5	91	94	PF00017	0.449
LIG_SH3_1	129	135	PF00018	0.303
LIG_SH3_3	129	135	PF00018	0.303
LIG_SH3_3	246	252	PF00018	0.203
LIG_SH3_3	63	69	PF00018	0.234
LIG_SH3_5	5	9	PF00018	0.408
LIG_SUMO_SIM_anti_2	24	29	PF11976	0.209
LIG_SUMO_SIM_anti_2	77	84	PF11976	0.240
LIG_SUMO_SIM_par_1	18	24	PF11976	0.242
LIG_SUMO_SIM_par_1	29	35	PF11976	0.242
MOD_CK1_1	21	27	PF00069	0.242
MOD_CK1_1	297	303	PF00069	0.363
MOD_CK2_1	259	265	PF00069	0.316
MOD_CK2_1	285	291	PF00069	0.316
MOD_GlcNHglycan	135	138	PF01048	0.503
MOD_GlcNHglycan	146	149	PF01048	0.589
MOD_GlcNHglycan	188	191	PF01048	0.508
MOD_GlcNHglycan	253	256	PF01048	0.460
MOD_GlcNHglycan	291	295	PF01048	0.463
MOD_GSK3_1	144	151	PF00069	0.387
MOD_GSK3_1	251	258	PF00069	0.306
MOD_GSK3_1	259	266	PF00069	0.254
MOD_GSK3_1	273	280	PF00069	0.163
MOD_GSK3_1	286	293	PF00069	0.218
MOD_N-GLC_1	125	130	PF02516	0.624
MOD_N-GLC_1	89	94	PF02516	0.509
MOD_NEK2_1	225	230	PF00069	0.224
MOD_NEK2_1	259	264	PF00069	0.242
MOD_NEK2_1	89	94	PF00069	0.345
MOD_NEK2_2	108	113	PF00069	0.432
MOD_NEK2_2	91	96	PF00069	0.376
MOD_PKA_2	210	216	PF00069	0.316
MOD_PKA_2	242	248	PF00069	0.218
MOD_PKA_2	277	283	PF00069	0.306
MOD_PKA_2	74	80	PF00069	0.316
MOD_Plk_1	11	17	PF00069	0.430
MOD_Plk_1	48	54	PF00069	0.218
MOD_Plk_4	156	162	PF00069	0.284
MOD_Plk_4	202	208	PF00069	0.306
MOD_Plk_4	23	29	PF00069	0.256
MOD_SUMO_rev_2	196	202	PF00179	0.316
TRG_DiLeu_BaEn_1	265	270	PF01217	0.266
TRG_ENDOCYTIC_2	164	167	PF00928	0.266
TRG_ER_diArg_1	210	212	PF00400	0.302
TRG_ER_diArg_1	40	43	PF00400	0.303
TRG_NLS_MonoExtC_3	277	282	PF00514	0.141
TRG_NLS_MonoExtN_4	278	285	PF00514	0.141
TRG_Pf-PMV_PEXEL_1	54	58	PF00026	0.430

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2S9	Leptomonas seymouri	60%	93%
A0A0N0P4A5	Leptomonas seymouri	24%	90%
A0A0N1I377	Leptomonas seymouri	25%	100%
A0A0S4JE72	Bodo saltans	26%	92%
A0A0S4JXT2	Bodo saltans	37%	87%
A0A1X0NIB7	Trypanosomatidae	24%	94%
A0A1X0NVX1	Trypanosomatidae	44%	93%
A0A3Q8IGE1	Leishmania donovani	25%	79%
A0A3R7KGP9	Trypanosoma rangeli	25%	77%
A0A3R7MPC0	Trypanosoma rangeli	42%	94%
A0A3S5H6H6	Leishmania donovani	90%	100%
A4H9V6	Leishmania braziliensis	76%	100%
A4HJR2	Leishmania braziliensis	26%	100%
A4HL28	Leishmania braziliensis	23%	87%
A4HUR4	Leishmania infantum	90%	100%
A4I779	Leishmania infantum	25%	79%
C9ZMG0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	91%
C9ZWM5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	91%
D0A7P8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	94%
E9B273	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	91%
Q09895	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	94%
Q4Q5Y6	Leishmania major	25%	100%
Q4QH78	Leishmania major	91%	100%
Q4R5C3	Macaca fascicularis	23%	98%
Q4R8X1	Macaca fascicularis	25%	96%
Q54DW2	Dictyostelium discoideum	23%	96%
Q5EAE0	Bos taurus	24%	96%
Q5R8G3	Pongo abelii	25%	96%
Q66KH2	Xenopus laevis	25%	95%
Q6NVS2	Xenopus tropicalis	26%	96%
Q803I2	Danio rerio	26%	96%
Q96RQ1	Homo sapiens	22%	98%
Q9CQE7	Mus musculus	24%	96%
Q9LJU2	Arabidopsis thaliana	22%	76%
Q9Y282	Homo sapiens	25%	96%
V5AS26	Trypanosoma cruzi	25%	91%
V5BGJ7	Trypanosoma cruzi	42%	94%