Putative pteridine transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pteridine transporter, putative

Species:

Leishmania mexicana

UniProt:

E9ANE5_LEIMU

TriTrypDb:

LmxM.10.1310

Length:

659

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 52

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 71
NetGPI	no	yes: 0, no: 71

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	72
GO:0110165	cellular anatomical entity	1	72
GO:0005737	cytoplasm	2	6
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

E9ANE5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANE5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0015877	biopterin transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015224	biopterin transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	651	655	PF00656	0.644
CLV_NRD_NRD_1	260	262	PF00675	0.321
CLV_NRD_NRD_1	298	300	PF00675	0.313
CLV_PCSK_KEX2_1	134	136	PF00082	0.292
CLV_PCSK_KEX2_1	192	194	PF00082	0.250
CLV_PCSK_KEX2_1	298	300	PF00082	0.374
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.292
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.207
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.374
CLV_PCSK_SKI1_1	117	121	PF00082	0.353
CLV_PCSK_SKI1_1	189	193	PF00082	0.207
CLV_PCSK_SKI1_1	588	592	PF00082	0.483
CLV_PCSK_SKI1_1	81	85	PF00082	0.347
DEG_SCF_FBW7_2	17	24	PF00400	0.621
DEG_SCF_TRCP1_1	225	230	PF00400	0.202
DEG_SIAH_1	640	648	PF03145	0.578
DEG_SPOP_SBC_1	559	563	PF00917	0.460
DEG_SPOP_SBC_1	575	579	PF00917	0.246
DOC_ANK_TNKS_1	104	111	PF00023	0.542
DOC_CKS1_1	18	23	PF01111	0.607
DOC_CKS1_1	596	601	PF01111	0.432
DOC_CYCLIN_RxL_1	77	87	PF00134	0.602
DOC_CYCLIN_yCln2_LP_2	398	404	PF00134	0.442
DOC_MAPK_gen_1	134	140	PF00069	0.500
DOC_MAPK_gen_1	261	268	PF00069	0.553
DOC_MAPK_MEF2A_6	228	235	PF00069	0.328
DOC_MAPK_MEF2A_6	499	506	PF00069	0.356
DOC_MAPK_MEF2A_6	64	71	PF00069	0.534
DOC_MAPK_NFAT4_5	64	72	PF00069	0.605
DOC_PP2B_LxvP_1	398	401	PF13499	0.442
DOC_PP2B_PxIxI_1	228	234	PF00149	0.280
DOC_PP4_FxxP_1	596	599	PF00568	0.253
DOC_USP7_MATH_1	277	281	PF00917	0.601
DOC_USP7_MATH_1	310	314	PF00917	0.473
DOC_USP7_MATH_1	333	337	PF00917	0.412
DOC_USP7_MATH_1	559	563	PF00917	0.438
DOC_USP7_MATH_1	575	579	PF00917	0.270
DOC_USP7_UBL2_3	296	300	PF12436	0.408
DOC_USP7_UBL2_3	632	636	PF12436	0.552
DOC_USP7_UBL2_3	646	650	PF12436	0.614
DOC_WW_Pin1_4	17	22	PF00397	0.794
DOC_WW_Pin1_4	306	311	PF00397	0.562
DOC_WW_Pin1_4	42	47	PF00397	0.479
DOC_WW_Pin1_4	576	581	PF00397	0.348
DOC_WW_Pin1_4	595	600	PF00397	0.414
DOC_WW_Pin1_4	637	642	PF00397	0.560
LIG_14-3-3_CanoR_1	299	304	PF00244	0.527
LIG_14-3-3_CanoR_1	351	356	PF00244	0.500
LIG_14-3-3_CanoR_1	476	480	PF00244	0.490
LIG_APCC_ABBAyCdc20_2	31	37	PF00400	0.533
LIG_BIR_III_2	43	47	PF00653	0.614
LIG_BRCT_BRCA1_1	110	114	PF00533	0.407
LIG_BRCT_BRCA1_1	123	127	PF00533	0.426
LIG_BRCT_BRCA1_1	442	446	PF00533	0.317
LIG_BRCT_BRCA1_1	544	548	PF00533	0.492
LIG_EVH1_2	580	584	PF00568	0.360
LIG_FHA_1	118	124	PF00498	0.597
LIG_FHA_1	228	234	PF00498	0.355
LIG_FHA_1	36	42	PF00498	0.578
LIG_FHA_1	361	367	PF00498	0.348
LIG_FHA_1	376	382	PF00498	0.256
LIG_FHA_1	393	399	PF00498	0.356
LIG_FHA_1	480	486	PF00498	0.325
LIG_FHA_1	5	11	PF00498	0.725
LIG_FHA_1	54	60	PF00498	0.564
LIG_FHA_1	596	602	PF00498	0.417
LIG_FHA_1	97	103	PF00498	0.412
LIG_FHA_2	18	24	PF00498	0.689
LIG_GBD_Chelix_1	71	79	PF00786	0.230
LIG_LIR_Apic_2	15	21	PF02991	0.759
LIG_LIR_Apic_2	30	36	PF02991	0.640
LIG_LIR_Gen_1	100	109	PF02991	0.516
LIG_LIR_Gen_1	124	132	PF02991	0.521
LIG_LIR_Gen_1	184	195	PF02991	0.520
LIG_LIR_Gen_1	203	214	PF02991	0.499
LIG_LIR_Gen_1	263	273	PF02991	0.547
LIG_LIR_Gen_1	377	386	PF02991	0.294
LIG_LIR_Gen_1	395	405	PF02991	0.273
LIG_LIR_Gen_1	445	454	PF02991	0.325
LIG_LIR_Gen_1	490	497	PF02991	0.333
LIG_LIR_Gen_1	545	554	PF02991	0.510
LIG_LIR_Gen_1	583	592	PF02991	0.264
LIG_LIR_Gen_1	86	96	PF02991	0.547
LIG_LIR_Nem_3	100	106	PF02991	0.498
LIG_LIR_Nem_3	124	130	PF02991	0.496
LIG_LIR_Nem_3	184	190	PF02991	0.526
LIG_LIR_Nem_3	203	209	PF02991	0.310
LIG_LIR_Nem_3	263	268	PF02991	0.532
LIG_LIR_Nem_3	377	382	PF02991	0.289
LIG_LIR_Nem_3	395	400	PF02991	0.368
LIG_LIR_Nem_3	417	421	PF02991	0.383
LIG_LIR_Nem_3	445	450	PF02991	0.299
LIG_LIR_Nem_3	490	495	PF02991	0.336
LIG_LIR_Nem_3	498	503	PF02991	0.289
LIG_LIR_Nem_3	545	551	PF02991	0.472
LIG_LIR_Nem_3	583	587	PF02991	0.259
LIG_LIR_Nem_3	86	92	PF02991	0.438
LIG_NRBOX	586	592	PF00104	0.223
LIG_Pex14_1	633	637	PF04695	0.479
LIG_Pex14_2	170	174	PF04695	0.365
LIG_Pex14_2	242	246	PF04695	0.299
LIG_Pex14_2	247	251	PF04695	0.285
LIG_Pex14_2	409	413	PF04695	0.360
LIG_Pex14_2	442	446	PF04695	0.305
LIG_Pex14_2	466	470	PF04695	0.364
LIG_REV1ctd_RIR_1	265	274	PF16727	0.382
LIG_SH2_CRK	103	107	PF00017	0.508
LIG_SH2_CRK	137	141	PF00017	0.377
LIG_SH2_CRK	152	156	PF00017	0.377
LIG_SH2_CRK	18	22	PF00017	0.618
LIG_SH2_CRK	187	191	PF00017	0.514
LIG_SH2_CRK	358	362	PF00017	0.345
LIG_SH2_CRK	379	383	PF00017	0.309
LIG_SH2_CRK	447	451	PF00017	0.299
LIG_SH2_NCK_1	18	22	PF00017	0.613
LIG_SH2_NCK_1	447	451	PF00017	0.300
LIG_SH2_PTP2	33	36	PF00017	0.630
LIG_SH2_PTP2	418	421	PF00017	0.349
LIG_SH2_PTP2	503	506	PF00017	0.399
LIG_SH2_SRC	33	36	PF00017	0.636
LIG_SH2_STAP1	132	136	PF00017	0.500
LIG_SH2_STAP1	187	191	PF00017	0.486
LIG_SH2_STAP1	520	524	PF00017	0.405
LIG_SH2_STAP1	89	93	PF00017	0.536
LIG_SH2_STAT5	132	135	PF00017	0.502
LIG_SH2_STAT5	265	268	PF00017	0.468
LIG_SH2_STAT5	33	36	PF00017	0.627
LIG_SH2_STAT5	418	421	PF00017	0.340
LIG_SH2_STAT5	464	467	PF00017	0.289
LIG_SH2_STAT5	503	506	PF00017	0.302
LIG_SH2_STAT5	512	515	PF00017	0.293
LIG_SH2_STAT5	73	76	PF00017	0.518
LIG_SH3_3	153	159	PF00018	0.299
LIG_SH3_3	434	440	PF00018	0.286
LIG_SH3_3	57	63	PF00018	0.519
LIG_SH3_3	605	611	PF00018	0.390
LIG_SH3_3	615	621	PF00018	0.493
LIG_SH3_4	646	653	PF00018	0.634
LIG_SUMO_SIM_anti_2	493	498	PF11976	0.315
LIG_SUMO_SIM_par_1	365	370	PF11976	0.297
LIG_SUMO_SIM_par_1	493	498	PF11976	0.347
LIG_TRAF2_1	21	24	PF00917	0.653
LIG_TYR_ITIM	150	155	PF00017	0.379
LIG_TYR_ITIM	381	386	PF00017	0.374
LIG_TYR_ITIM	416	421	PF00017	0.333
LIG_TYR_ITSM	443	450	PF00017	0.404
LIG_UBA3_1	266	270	PF00899	0.522
LIG_UBA3_1	534	541	PF00899	0.222
LIG_Vh1_VBS_1	367	385	PF01044	0.447
LIG_WRC_WIRS_1	551	556	PF05994	0.225
MOD_CDK_SPxxK_3	42	49	PF00069	0.311
MOD_CK1_1	422	428	PF00069	0.380
MOD_CK1_1	431	437	PF00069	0.406
MOD_CK1_1	471	477	PF00069	0.351
MOD_CK1_1	560	566	PF00069	0.357
MOD_CK2_1	17	23	PF00069	0.583
MOD_CK2_1	310	316	PF00069	0.298
MOD_GlcNHglycan	106	109	PF01048	0.322
MOD_GlcNHglycan	11	14	PF01048	0.630
MOD_GlcNHglycan	160	163	PF01048	0.361
MOD_GlcNHglycan	216	219	PF01048	0.362
MOD_GlcNHglycan	225	228	PF01048	0.374
MOD_GlcNHglycan	235	238	PF01048	0.371
MOD_GlcNHglycan	421	424	PF01048	0.434
MOD_GSK3_1	104	111	PF00069	0.410
MOD_GSK3_1	117	124	PF00069	0.352
MOD_GSK3_1	223	230	PF00069	0.392
MOD_GSK3_1	290	297	PF00069	0.437
MOD_GSK3_1	306	313	PF00069	0.392
MOD_GSK3_1	347	354	PF00069	0.459
MOD_GSK3_1	442	449	PF00069	0.372
MOD_GSK3_1	471	478	PF00069	0.363
MOD_GSK3_1	557	564	PF00069	0.374
MOD_GSK3_1	648	655	PF00069	0.812
MOD_GSK3_1	79	86	PF00069	0.383
MOD_N-GLC_1	351	356	PF02516	0.519
MOD_N-GLC_1	84	89	PF02516	0.399
MOD_NEK2_1	112	117	PF00069	0.377
MOD_NEK2_1	130	135	PF00069	0.346
MOD_NEK2_1	138	143	PF00069	0.347
MOD_NEK2_1	223	228	PF00069	0.360
MOD_NEK2_1	332	337	PF00069	0.511
MOD_NEK2_1	375	380	PF00069	0.296
MOD_NEK2_1	392	397	PF00069	0.289
MOD_NEK2_1	442	447	PF00069	0.355
MOD_NEK2_1	479	484	PF00069	0.362
MOD_NEK2_1	533	538	PF00069	0.302
MOD_NEK2_1	557	562	PF00069	0.353
MOD_NEK2_1	569	574	PF00069	0.351
MOD_NEK2_1	79	84	PF00069	0.363
MOD_NEK2_2	543	548	PF00069	0.222
MOD_PIKK_1	440	446	PF00454	0.222
MOD_PK_1	351	357	PF00069	0.222
MOD_PKA_1	298	304	PF00069	0.188
MOD_PKA_2	104	110	PF00069	0.325
MOD_PKA_2	227	233	PF00069	0.224
MOD_PKA_2	298	304	PF00069	0.189
MOD_PKA_2	475	481	PF00069	0.349
MOD_Plk_1	333	339	PF00069	0.321
MOD_Plk_1	351	357	PF00069	0.443
MOD_Plk_1	431	437	PF00069	0.391
MOD_Plk_1	543	549	PF00069	0.296
MOD_Plk_1	84	90	PF00069	0.423
MOD_Plk_4	367	373	PF00069	0.314
MOD_Plk_4	400	406	PF00069	0.421
MOD_Plk_4	414	420	PF00069	0.370
MOD_Plk_4	442	448	PF00069	0.451
MOD_Plk_4	475	481	PF00069	0.337
MOD_Plk_4	487	493	PF00069	0.321
MOD_Plk_4	543	549	PF00069	0.372
MOD_Plk_4	569	575	PF00069	0.347
MOD_Plk_4	625	631	PF00069	0.571
MOD_ProDKin_1	17	23	PF00069	0.762
MOD_ProDKin_1	306	312	PF00069	0.436
MOD_ProDKin_1	42	48	PF00069	0.317
MOD_ProDKin_1	576	582	PF00069	0.417
MOD_ProDKin_1	595	601	PF00069	0.414
MOD_ProDKin_1	637	643	PF00069	0.443
MOD_SUMO_for_1	269	272	PF00179	0.418
MOD_SUMO_rev_2	617	624	PF00179	0.408
TRG_DiLeu_BaEn_1	254	259	PF01217	0.453
TRG_DiLeu_BaLyEn_6	186	191	PF01217	0.276
TRG_DiLeu_BaLyEn_6	596	601	PF01217	0.320
TRG_ENDOCYTIC_2	103	106	PF00928	0.345
TRG_ENDOCYTIC_2	137	140	PF00928	0.346
TRG_ENDOCYTIC_2	152	155	PF00928	0.377
TRG_ENDOCYTIC_2	187	190	PF00928	0.337
TRG_ENDOCYTIC_2	265	268	PF00928	0.444
TRG_ENDOCYTIC_2	358	361	PF00928	0.346
TRG_ENDOCYTIC_2	379	382	PF00928	0.359
TRG_ENDOCYTIC_2	383	386	PF00928	0.358
TRG_ENDOCYTIC_2	418	421	PF00928	0.355
TRG_ENDOCYTIC_2	447	450	PF00928	0.352
TRG_ENDOCYTIC_2	503	506	PF00928	0.482
TRG_ENDOCYTIC_2	89	92	PF00928	0.369
TRG_NLS_MonoExtN_4	296	302	PF00514	0.186
TRG_Pf-PMV_PEXEL_1	256	260	PF00026	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U2	Leptomonas seymouri	44%	94%
A0A0N1HY49	Leptomonas seymouri	46%	98%
A0A0N1HZ06	Leptomonas seymouri	38%	100%
A0A0N1IHL1	Leptomonas seymouri	40%	92%
A0A0N1PAY4	Leptomonas seymouri	41%	75%
A0A0N1PB77	Leptomonas seymouri	40%	100%
A0A0N1PBZ2	Leptomonas seymouri	45%	98%
A0A0N1PCC1	Leptomonas seymouri	42%	99%
A0A0S4INN8	Bodo saltans	30%	100%
A0A381MBI0	Leishmania infantum	94%	100%
A0A3Q8I8X7	Leishmania donovani	94%	100%
A0A3Q8IAZ0	Leishmania donovani	45%	94%
A0A3Q8IH50	Leishmania donovani	48%	91%
A0A3Q8IVN0	Leishmania donovani	39%	100%
A0A3R7M4J1	Trypanosoma rangeli	41%	100%
A0A3S5H5P4	Leishmania donovani	46%	97%
A0A3S5H5V2	Leishmania donovani	45%	100%
A0A3S5H6F6	Leishmania donovani	44%	94%
A0A3S5H763	Leishmania donovani	48%	98%
A0A3S7WR10	Leishmania donovani	41%	88%
A0A3S7WR14	Leishmania donovani	47%	96%
A0A3S7WR15	Leishmania donovani	44%	78%
A0A3S7WR24	Leishmania donovani	44%	94%
A4H4T8	Leishmania braziliensis	44%	100%
A4H5Y4	Leishmania braziliensis	84%	100%
A4H617	Leishmania braziliensis	45%	100%
A4H618	Leishmania braziliensis	45%	100%
A4H619	Leishmania braziliensis	46%	100%
A4H620	Leishmania braziliensis	51%	100%
A4H6C3	Leishmania braziliensis	84%	100%
A4HNH7	Leishmania braziliensis	38%	97%
A4HSS2	Leishmania infantum	46%	97%
A4HUE4	Leishmania infantum	41%	88%
A4HUE5	Leishmania infantum	44%	95%
A4HUE6	Leishmania infantum	47%	96%
A4HUE7	Leishmania infantum	45%	94%
A4HUE8	Leishmania infantum	45%	94%
A4HUF4	Leishmania infantum	44%	94%
A4HUF5	Leishmania infantum	49%	100%
A4HYA9	Leishmania infantum	47%	98%
A4IC33	Leishmania infantum	38%	100%
C9ZIK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
C9ZIK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
C9ZVE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
C9ZVE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
C9ZVF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
D0A423	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E8NHQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AG72	Leishmania infantum	45%	100%
E9AI40	Leishmania braziliensis	46%	100%
E9AJY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9AKQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AL06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AN44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9AN45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AN46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9AN47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
E9AS42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	98%
E9B741	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
Q4QDC4	Leishmania major	47%	100%
Q4QH81	Leishmania major	94%	100%
Q4QHH7	Leishmania major	48%	100%
Q4QHH8	Leishmania major	43%	100%
Q4QHH9	Leishmania major	43%	100%
Q4QHI0	Leishmania major	44%	100%
Q4QHI1	Leishmania major	46%	100%
Q4QHI2	Leishmania major	43%	100%
Q4QIU9	Leishmania major	44%	100%
Q4QJ48	Leishmania major	46%	100%
Q7KIP2	Leishmania major	39%	100%