DUF1861 family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Beta-1,2 mannoside phosphorylase

Species:

Leishmania mexicana

UniProt:

E9ANE3_LEIMU

TriTrypDb:

LmxM.10.1290

Length:

311

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 42

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 42
NetGPI	no	yes: 0, no: 42

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ANE3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANE3

PDB structure(s): 2b4w_A , 6q4w_A , 6q4w_B , 6q4x_A , 6q4x_B , 6q4y_A , 6q4y_B , 6q4z_A , 6q4z_B , 6q50_A

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	304	308	PF00656	0.533
CLV_NRD_NRD_1	102	104	PF00675	0.427
CLV_PCSK_KEX2_1	14	16	PF00082	0.441
CLV_PCSK_KEX2_1	53	55	PF00082	0.425
CLV_PCSK_KEX2_1	92	94	PF00082	0.241
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.481
CLV_PCSK_PC1ET2_1	53	55	PF00082	0.418
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.239
CLV_PCSK_SKI1_1	4	8	PF00082	0.473
DEG_COP1_1	71	79	PF00400	0.468
DOC_CDC14_PxL_1	73	81	PF14671	0.298
DOC_CYCLIN_yClb1_LxF_4	256	261	PF00134	0.239
DOC_MAPK_gen_1	14	22	PF00069	0.473
DOC_MAPK_gen_1	152	161	PF00069	0.431
DOC_MAPK_MEF2A_6	15	24	PF00069	0.491
DOC_MAPK_MEF2A_6	154	163	PF00069	0.397
DOC_PP1_RVXF_1	179	186	PF00149	0.279
DOC_PP4_FxxP_1	185	188	PF00568	0.279
DOC_WW_Pin1_4	117	122	PF00397	0.377
LIG_APCC_ABBA_1	62	67	PF00400	0.386
LIG_BIR_II_1	1	5	PF00653	0.508
LIG_BRCT_BRCA1_1	229	233	PF00533	0.461
LIG_BRCT_BRCA1_1	35	39	PF00533	0.402
LIG_FHA_1	171	177	PF00498	0.394
LIG_FHA_1	235	241	PF00498	0.386
LIG_FHA_2	118	124	PF00498	0.418
LIG_FHA_2	127	133	PF00498	0.414
LIG_FHA_2	153	159	PF00498	0.425
LIG_FHA_2	66	72	PF00498	0.402
LIG_LIR_Apic_2	184	188	PF02991	0.466
LIG_LIR_Gen_1	71	79	PF02991	0.419
LIG_LIR_Nem_3	111	116	PF02991	0.420
LIG_LIR_Nem_3	157	163	PF02991	0.387
LIG_LIR_Nem_3	190	194	PF02991	0.396
LIG_LIR_Nem_3	23	27	PF02991	0.428
LIG_LIR_Nem_3	28	33	PF02991	0.414
LIG_LIR_Nem_3	280	285	PF02991	0.393
LIG_LIR_Nem_3	71	76	PF02991	0.419
LIG_MYND_3	259	263	PF01753	0.270
LIG_PDZ_Class_2	306	311	PF00595	0.486
LIG_PTB_Apo_2	225	232	PF02174	0.404
LIG_REV1ctd_RIR_1	37	46	PF16727	0.251
LIG_SH2_CRK	282	286	PF00017	0.402
LIG_SH2_GRB2like	226	229	PF00017	0.402
LIG_SH2_PTP2	226	229	PF00017	0.279
LIG_SH2_SRC	226	229	PF00017	0.396
LIG_SH2_STAP1	17	21	PF00017	0.411
LIG_SH2_STAT5	115	118	PF00017	0.409
LIG_SH2_STAT5	126	129	PF00017	0.392
LIG_SH2_STAT5	160	163	PF00017	0.465
LIG_SH2_STAT5	198	201	PF00017	0.412
LIG_SH2_STAT5	226	229	PF00017	0.402
LIG_SH2_STAT5	87	90	PF00017	0.378
LIG_SH3_2	253	258	PF14604	0.364
LIG_SH3_3	250	256	PF00018	0.385
LIG_TRAF2_1	155	158	PF00917	0.239
LIG_WRC_WIRS_1	21	26	PF05994	0.416
MOD_CK2_1	117	123	PF00069	0.383
MOD_CK2_1	152	158	PF00069	0.422
MOD_GlcNHglycan	201	204	PF01048	0.394
MOD_GlcNHglycan	218	221	PF01048	0.338
MOD_GlcNHglycan	268	271	PF01048	0.402
MOD_GlcNHglycan	282	285	PF01048	0.402
MOD_GSK3_1	148	155	PF00069	0.409
MOD_GSK3_1	16	23	PF00069	0.384
MOD_GSK3_1	161	168	PF00069	0.385
MOD_GSK3_1	247	254	PF00069	0.404
MOD_N-GLC_1	213	218	PF02516	0.452
MOD_N-GLC_1	227	232	PF02516	0.415
MOD_N-GLC_1	33	38	PF02516	0.406
MOD_NEK2_1	199	204	PF00069	0.435
MOD_NEK2_1	65	70	PF00069	0.407
MOD_NEK2_1	97	102	PF00069	0.399
MOD_NEK2_2	247	252	PF00069	0.365
MOD_PKA_2	291	297	PF00069	0.412
MOD_Plk_1	227	233	PF00069	0.400
MOD_Plk_1	33	39	PF00069	0.376
MOD_Plk_1	71	77	PF00069	0.419
MOD_Plk_4	108	114	PF00069	0.425
MOD_Plk_4	16	22	PF00069	0.440
MOD_Plk_4	301	307	PF00069	0.480
MOD_ProDKin_1	117	123	PF00069	0.377
MOD_SUMO_for_1	91	94	PF00179	0.375
TRG_ENDOCYTIC_2	113	116	PF00928	0.443
TRG_ENDOCYTIC_2	160	163	PF00928	0.402
TRG_ENDOCYTIC_2	17	20	PF00928	0.444
TRG_ENDOCYTIC_2	226	229	PF00928	0.445
TRG_ENDOCYTIC_2	282	285	PF00928	0.402
TRG_ENDOCYTIC_2	48	51	PF00928	0.430
TRG_NES_CRM1_1	132	144	PF08389	0.386
TRG_Pf-PMV_PEXEL_1	238	243	PF00026	0.446

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5W3	Leptomonas seymouri	59%	98%
A0A0N1HYU8	Leptomonas seymouri	58%	98%
A0A0N1I429	Leptomonas seymouri	51%	95%
A0A0N1I5D6	Leptomonas seymouri	64%	99%
A0A0N1I720	Leptomonas seymouri	54%	99%
A0A0N1IL04	Leptomonas seymouri	76%	100%
A0A0N1PCE9	Leptomonas seymouri	52%	97%
A0A0R6XPC0	Leishmania donovani	56%	98%
A0A3Q8IHB3	Leishmania donovani	50%	97%
A0A3S5H6H4	Leishmania donovani	50%	95%
A0A3S5H6H5	Leishmania donovani	54%	99%
A0A3S7WRC9	Leishmania donovani	63%	98%
A0A3S7WRD5	Leishmania donovani	68%	99%
A0A3S7WRE8	Leishmania donovani	92%	100%
A4H6B5	Leishmania braziliensis	52%	100%
A4H6B6	Leishmania braziliensis	49%	100%
A4H6B7	Leishmania braziliensis	58%	100%
A4H6B8	Leishmania braziliensis	69%	100%
A4H6B9	Leishmania braziliensis	55%	100%
A4H6C0	Leishmania braziliensis	61%	100%
A4H6C1	Leishmania braziliensis	83%	100%
A4HUN8	Leishmania infantum	50%	95%
A4HUN9	Leishmania infantum	50%	97%
A4HUP0	Leishmania infantum	57%	98%
A4HUP1	Leishmania infantum	68%	99%
A4HUP2	Leishmania infantum	54%	99%
A4HUP3	Leishmania infantum	63%	98%
A4HUP4	Leishmania infantum	92%	100%
E9AND7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E9AND8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E9AND9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	100%
E9ANE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
E9ANE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	99%
E9ANE2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	100%
Q4QH83	Leishmania major	90%	100%
Q4QH84	Leishmania major	64%	100%
Q4QH85	Leishmania major	55%	99%
Q4QH86	Leishmania major	71%	100%
Q4QH87	Leishmania major	57%	100%
Q4QH88	Leishmania major	49%	100%
Q4QH89	Leishmania major	50%	100%