DUF3421 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Beta-1,2 mannosyltransferase

Species:

Leishmania mexicana

UniProt:

E9AND7_LEIMU

TriTrypDb:

LmxM.10.1230

Length:

328

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 42

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 42
NetGPI	no	yes: 0, no: 42

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AND7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AND7

PDB structure(s): 2b4w_A , 6q4w_A , 6q4w_B , 6q4x_A , 6q4x_B , 6q4y_A , 6q4y_B , 6q4z_A , 6q4z_B , 6q50_A

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	321	325	PF00656	0.473
CLV_NRD_NRD_1	21	23	PF00675	0.399
CLV_NRD_NRD_1	68	70	PF00675	0.353
CLV_PCSK_KEX2_1	21	23	PF00082	0.484
CLV_PCSK_KEX2_1	68	70	PF00082	0.374
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.509
CLV_PCSK_SKI1_1	148	152	PF00082	0.336
DEG_MDM2_SWIB_1	204	211	PF02201	0.350
DOC_CYCLIN_yCln2_LP_2	99	105	PF00134	0.350
DOC_MAPK_gen_1	148	158	PF00069	0.291
DOC_MAPK_gen_1	275	285	PF00069	0.315
DOC_USP7_UBL2_3	120	124	PF12436	0.318
LIG_AP2alpha_2	101	103	PF02296	0.373
LIG_BIR_III_4	206	210	PF00653	0.342
LIG_BIR_III_4	234	238	PF00653	0.387
LIG_FHA_1	175	181	PF00498	0.330
LIG_FHA_1	217	223	PF00498	0.228
LIG_FHA_1	244	250	PF00498	0.353
LIG_FHA_1	26	32	PF00498	0.321
LIG_FHA_1	42	48	PF00498	0.350
LIG_FHA_1	57	63	PF00498	0.219
LIG_FHA_2	254	260	PF00498	0.196
LIG_FHA_2	319	325	PF00498	0.367
LIG_FHA_2	81	87	PF00498	0.352
LIG_LIR_Gen_1	177	185	PF02991	0.329
LIG_LIR_Gen_1	33	42	PF02991	0.339
LIG_LIR_Gen_1	59	66	PF02991	0.218
LIG_LIR_Gen_1	86	95	PF02991	0.369
LIG_LIR_Nem_3	110	116	PF02991	0.362
LIG_LIR_Nem_3	177	182	PF02991	0.333
LIG_LIR_Nem_3	206	211	PF02991	0.344
LIG_LIR_Nem_3	259	263	PF02991	0.331
LIG_LIR_Nem_3	297	302	PF02991	0.341
LIG_LIR_Nem_3	33	39	PF02991	0.374
LIG_LIR_Nem_3	59	63	PF02991	0.425
LIG_LIR_Nem_3	86	91	PF02991	0.367
LIG_PCNA_yPIPBox_3	170	180	PF02747	0.189
LIG_PDZ_Class_2	323	328	PF00595	0.430
LIG_Pex14_2	204	208	PF04695	0.350
LIG_PTB_Apo_2	310	317	PF02174	0.189
LIG_SH2_CRK	260	264	PF00017	0.409
LIG_SH2_CRK	299	303	PF00017	0.350
LIG_SH2_NCK_1	88	92	PF00017	0.400
LIG_SH2_STAP1	258	262	PF00017	0.309
LIG_SH2_STAT5	128	131	PF00017	0.358
LIG_SH2_STAT5	142	145	PF00017	0.343
LIG_SH2_STAT5	215	218	PF00017	0.360
LIG_SH2_STAT5	230	233	PF00017	0.319
LIG_SH2_STAT5	243	246	PF00017	0.350
LIG_SH2_STAT5	88	91	PF00017	0.365
LIG_SH3_2	270	275	PF14604	0.312
LIG_SH3_3	208	214	PF00018	0.278
LIG_SH3_3	246	252	PF00018	0.350
LIG_SH3_3	267	273	PF00018	0.333
LIG_UBA3_1	155	162	PF00899	0.221
LIG_WRC_WIRS_1	245	250	PF05994	0.350
LIG_WRC_WIRS_1	36	41	PF05994	0.363
MOD_CK1_1	253	259	PF00069	0.189
MOD_CK1_1	3	9	PF00069	0.504
MOD_CK2_1	3	9	PF00069	0.507
MOD_CK2_1	86	92	PF00069	0.365
MOD_GlcNHglycan	125	128	PF01048	0.422
MOD_GlcNHglycan	144	147	PF01048	0.279
MOD_GlcNHglycan	194	197	PF01048	0.334
MOD_GlcNHglycan	285	288	PF01048	0.350
MOD_GlcNHglycan	299	302	PF01048	0.350
MOD_GSK3_1	164	171	PF00069	0.356
MOD_GSK3_1	52	59	PF00069	0.443
MOD_N-GLC_1	3	8	PF02516	0.507
MOD_N-GLC_1	56	61	PF02516	0.204
MOD_N-GLC_2	173	175	PF02516	0.207
MOD_N-GLC_2	255	257	PF02516	0.346
MOD_N-GLC_2	49	51	PF02516	0.350
MOD_NEK2_1	216	221	PF00069	0.383
MOD_NEK2_1	25	30	PF00069	0.423
MOD_NEK2_1	80	85	PF00069	0.355
MOD_NMyristoyl	1	7	PF02799	0.810
MOD_PIKK_1	187	193	PF00454	0.411
MOD_PIKK_1	302	308	PF00454	0.189
MOD_PKA_2	116	122	PF00069	0.307
MOD_PKA_2	67	73	PF00069	0.224
MOD_Plk_1	14	20	PF00069	0.430
MOD_Plk_1	199	205	PF00069	0.356
MOD_Plk_1	86	92	PF00069	0.366
MOD_Plk_2-3	86	92	PF00069	0.350
MOD_Plk_4	14	20	PF00069	0.483
MOD_Plk_4	199	205	PF00069	0.401
MOD_Plk_4	244	250	PF00069	0.345
MOD_Plk_4	318	324	PF00069	0.423
MOD_Plk_4	86	92	PF00069	0.363
MOD_SUMO_rev_2	253	263	PF00179	0.311
TRG_DiLeu_BaEn_1	100	105	PF01217	0.219
TRG_DiLeu_BaLyEn_6	151	156	PF01217	0.221
TRG_ENDOCYTIC_2	260	263	PF00928	0.415
TRG_ENDOCYTIC_2	299	302	PF00928	0.350
TRG_ENDOCYTIC_2	60	63	PF00928	0.378
TRG_ENDOCYTIC_2	88	91	PF00928	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5W3	Leptomonas seymouri	56%	100%
A0A0N1HYU8	Leptomonas seymouri	53%	100%
A0A0N1I429	Leptomonas seymouri	76%	100%
A0A0N1I5D6	Leptomonas seymouri	51%	100%
A0A0N1I720	Leptomonas seymouri	59%	100%
A0A0N1IL04	Leptomonas seymouri	51%	100%
A0A0N1PCE9	Leptomonas seymouri	56%	100%
A0A0R6XPC0	Leishmania donovani	53%	100%
A0A3Q8IHB3	Leishmania donovani	54%	100%
A0A3S5H6H4	Leishmania donovani	94%	100%
A0A3S5H6H5	Leishmania donovani	56%	100%
A0A3S7WRC9	Leishmania donovani	54%	100%
A0A3S7WRD5	Leishmania donovani	52%	100%
A0A3S7WRE8	Leishmania donovani	51%	100%
A4H6B5	Leishmania braziliensis	81%	100%
A4H6B6	Leishmania braziliensis	52%	100%
A4H6B7	Leishmania braziliensis	53%	98%
A4H6B8	Leishmania braziliensis	51%	100%
A4H6B9	Leishmania braziliensis	57%	100%
A4H6C0	Leishmania braziliensis	54%	100%
A4H6C1	Leishmania braziliensis	52%	100%
A4HUN8	Leishmania infantum	94%	100%
A4HUN9	Leishmania infantum	54%	100%
A4HUP0	Leishmania infantum	53%	100%
A4HUP1	Leishmania infantum	52%	100%
A4HUP2	Leishmania infantum	56%	100%
A4HUP3	Leishmania infantum	53%	100%
A4HUP4	Leishmania infantum	51%	100%
E9AND8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%
E9AND9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E9ANE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
E9ANE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	100%
E9ANE2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	100%
E9ANE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
Q4QH83	Leishmania major	52%	100%
Q4QH84	Leishmania major	53%	98%
Q4QH85	Leishmania major	56%	100%
Q4QH86	Leishmania major	51%	100%
Q4QH87	Leishmania major	53%	100%
Q4QH88	Leishmania major	54%	100%
Q4QH89	Leishmania major	91%	100%