Class I SAM-dependent methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methyltransferase domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AND6_LEIMU

TriTrypDb:

LmxM.10.1228

Length:

247

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AND6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AND6

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	1
GO:0032259	methylation	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	185	187	PF00082	0.411
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.411
CLV_PCSK_SKI1_1	49	53	PF00082	0.570
DEG_MDM2_SWIB_1	166	173	PF02201	0.445
DEG_Nend_UBRbox_2	1	3	PF02207	0.626
DOC_CYCLIN_yCln2_LP_2	159	165	PF00134	0.411
DOC_MAPK_gen_1	95	105	PF00069	0.253
DOC_MAPK_MEF2A_6	17	26	PF00069	0.506
DOC_USP7_MATH_1	135	139	PF00917	0.292
DOC_USP7_MATH_1	20	24	PF00917	0.524
DOC_WW_Pin1_4	18	23	PF00397	0.533
LIG_BRCT_BRCA1_1	41	45	PF00533	0.458
LIG_FHA_1	126	132	PF00498	0.227
LIG_FHA_1	151	157	PF00498	0.411
LIG_FHA_1	182	188	PF00498	0.411
LIG_FHA_1	228	234	PF00498	0.530
LIG_FHA_1	236	242	PF00498	0.361
LIG_FHA_2	149	155	PF00498	0.411
LIG_FHA_2	69	75	PF00498	0.339
LIG_LIR_Apic_2	130	135	PF02991	0.405
LIG_LIR_Gen_1	144	155	PF02991	0.506
LIG_LIR_Gen_1	211	222	PF02991	0.410
LIG_LIR_Gen_1	70	81	PF02991	0.432
LIG_LIR_Nem_3	127	132	PF02991	0.411
LIG_LIR_Nem_3	144	150	PF02991	0.411
LIG_LIR_Nem_3	164	169	PF02991	0.426
LIG_LIR_Nem_3	211	217	PF02991	0.410
LIG_LIR_Nem_3	29	35	PF02991	0.383
LIG_LIR_Nem_3	70	76	PF02991	0.458
LIG_Pex14_2	166	170	PF04695	0.483
LIG_PTB_Apo_2	193	200	PF02174	0.411
LIG_PTB_Phospho_1	193	199	PF10480	0.411
LIG_SH2_CRK	147	151	PF00017	0.411
LIG_SH2_STAP1	73	77	PF00017	0.493
LIG_SH2_STAT5	133	136	PF00017	0.352
LIG_SH2_STAT5	199	202	PF00017	0.411
LIG_SH2_STAT5	87	90	PF00017	0.393
LIG_SH3_3	41	47	PF00018	0.425
LIG_SH3_5	83	87	PF00018	0.445
LIG_SUMO_SIM_anti_2	236	241	PF11976	0.433
LIG_TRAF2_1	54	57	PF00917	0.526
LIG_WRC_WIRS_1	126	131	PF05994	0.227
MOD_CK1_1	125	131	PF00069	0.317
MOD_CK1_1	220	226	PF00069	0.529
MOD_CK1_1	3	9	PF00069	0.597
MOD_CK2_1	148	154	PF00069	0.371
MOD_CK2_1	220	226	PF00069	0.445
MOD_CK2_1	50	56	PF00069	0.515
MOD_CK2_1	68	74	PF00069	0.469
MOD_GlcNHglycan	117	120	PF01048	0.393
MOD_GlcNHglycan	53	56	PF01048	0.467
MOD_GlcNHglycan	88	91	PF01048	0.358
MOD_GSK3_1	161	168	PF00069	0.415
MOD_GSK3_1	18	25	PF00069	0.506
MOD_GSK3_1	197	204	PF00069	0.501
MOD_GSK3_1	220	227	PF00069	0.531
MOD_N-GLC_1	122	127	PF02516	0.423
MOD_N-GLC_2	14	16	PF02516	0.468
MOD_NEK2_1	1	6	PF00069	0.616
MOD_NEK2_1	208	213	PF00069	0.445
MOD_NEK2_1	217	222	PF00069	0.366
MOD_NEK2_1	50	55	PF00069	0.481
MOD_NEK2_2	22	27	PF00069	0.516
MOD_Plk_1	1	7	PF00069	0.621
MOD_Plk_1	122	128	PF00069	0.522
MOD_Plk_1	235	241	PF00069	0.261
MOD_Plk_4	161	167	PF00069	0.445
MOD_Plk_4	22	28	PF00069	0.570
MOD_Plk_4	235	241	PF00069	0.342
MOD_Plk_4	39	45	PF00069	0.257
MOD_ProDKin_1	18	24	PF00069	0.530
MOD_SUMO_rev_2	53	60	PF00179	0.493
TRG_DiLeu_BaEn_3	144	150	PF01217	0.227
TRG_ENDOCYTIC_2	147	150	PF00928	0.515
TRG_ENDOCYTIC_2	73	76	PF00928	0.505
TRG_ER_diLys_1	242	247	PF00400	0.481
TRG_ER_FFAT_2	144	154	PF00635	0.504
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.227

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDF1	Leptomonas seymouri	61%	99%
A0A3S7WRE9	Leishmania donovani	87%	79%
A4H6B4	Leishmania braziliensis	74%	100%
A4HUN7	Leishmania infantum	89%	100%
E9ACR1	Leishmania major	89%	100%