Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinetoplastid kinetochore protein 20

Species:

Leishmania mexicana

UniProt:

E9AND5_LEIMU

TriTrypDb:

LmxM.10.1227

Length:

245

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000776	kinetochore	3	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AND5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AND5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	16	20	PF00656	0.534
CLV_C14_Caspase3-7	68	72	PF00656	0.559
CLV_MEL_PAP_1	138	144	PF00089	0.497
CLV_NRD_NRD_1	140	142	PF00675	0.425
CLV_PCSK_KEX2_1	140	142	PF00082	0.412
CLV_PCSK_KEX2_1	243	245	PF00082	0.584
CLV_PCSK_PC1ET2_1	243	245	PF00082	0.584
DOC_CYCLIN_yCln2_LP_2	149	155	PF00134	0.361
DOC_CYCLIN_yCln2_LP_2	31	37	PF00134	0.476
DOC_MAPK_gen_1	4	13	PF00069	0.466
DOC_MAPK_MEF2A_6	151	159	PF00069	0.535
DOC_MIT_MIM_1	137	145	PF04212	0.534
DOC_PP2B_LxvP_1	31	34	PF13499	0.538
DOC_USP7_MATH_1	214	218	PF00917	0.582
DOC_USP7_MATH_1	99	103	PF00917	0.538
DOC_WW_Pin1_4	53	58	PF00397	0.473
LIG_14-3-3_CanoR_1	132	142	PF00244	0.484
LIG_Actin_WH2_2	59	77	PF00022	0.506
LIG_BRCT_BRCA1_1	138	142	PF00533	0.527
LIG_BRCT_BRCA1_1	63	67	PF00533	0.512
LIG_FHA_1	159	165	PF00498	0.552
LIG_FHA_1	178	184	PF00498	0.560
LIG_FHA_1	227	233	PF00498	0.375
LIG_FHA_2	119	125	PF00498	0.476
LIG_FHA_2	204	210	PF00498	0.487
LIG_FHA_2	39	45	PF00498	0.462
LIG_LIR_Gen_1	139	150	PF02991	0.536
LIG_LIR_Gen_1	170	179	PF02991	0.451
LIG_LIR_Gen_1	190	198	PF02991	0.489
LIG_LIR_Nem_3	116	122	PF02991	0.458
LIG_LIR_Nem_3	139	145	PF02991	0.536
LIG_LIR_Nem_3	170	175	PF02991	0.423
LIG_LIR_Nem_3	190	195	PF02991	0.481
LIG_LIR_Nem_3	56	61	PF02991	0.425
LIG_NRBOX	230	236	PF00104	0.447
LIG_SH2_CRK	192	196	PF00017	0.431
LIG_SH2_STAP1	192	196	PF00017	0.470
LIG_SH2_STAT5	120	123	PF00017	0.389
LIG_SH2_STAT5	21	24	PF00017	0.415
LIG_SH2_STAT5	45	48	PF00017	0.519
LIG_SH2_STAT5	55	58	PF00017	0.500
LIG_SH3_3	160	166	PF00018	0.476
LIG_SUMO_SIM_par_1	9	14	PF11976	0.451
LIG_UBA3_1	231	238	PF00899	0.447
MOD_CK1_1	126	132	PF00069	0.578
MOD_CK1_1	217	223	PF00069	0.620
MOD_CK1_1	226	232	PF00069	0.456
MOD_CK2_1	118	124	PF00069	0.510
MOD_CK2_1	203	209	PF00069	0.521
MOD_CK2_1	213	219	PF00069	0.531
MOD_CK2_1	221	227	PF00069	0.477
MOD_CK2_1	234	240	PF00069	0.405
MOD_GlcNHglycan	58	61	PF01048	0.430
MOD_GSK3_1	132	139	PF00069	0.551
MOD_GSK3_1	213	220	PF00069	0.504
MOD_GSK3_1	61	68	PF00069	0.400
MOD_GSK3_1	74	81	PF00069	0.316
MOD_N-GLC_1	99	104	PF02516	0.493
MOD_NEK2_1	131	136	PF00069	0.545
MOD_NEK2_1	234	239	PF00069	0.482
MOD_NEK2_1	61	66	PF00069	0.450
MOD_PIKK_1	190	196	PF00454	0.450
MOD_PIKK_1	66	72	PF00454	0.554
MOD_PIKK_1	88	94	PF00454	0.472
MOD_PK_1	123	129	PF00069	0.580
MOD_PKA_1	140	146	PF00069	0.500
MOD_PKA_2	131	137	PF00069	0.535
MOD_PKA_2	140	146	PF00069	0.467
MOD_PKA_2	74	80	PF00069	0.475
MOD_Plk_4	61	67	PF00069	0.407
MOD_ProDKin_1	53	59	PF00069	0.469
MOD_SUMO_rev_2	124	131	PF00179	0.579
TRG_DiLeu_BaEn_1	227	232	PF01217	0.525
TRG_DiLeu_BaLyEn_6	230	235	PF01217	0.487
TRG_ENDOCYTIC_2	192	195	PF00928	0.468
TRG_ENDOCYTIC_2	55	58	PF00928	0.507
TRG_ENDOCYTIC_2	6	9	PF00928	0.348
TRG_ER_diArg_1	140	142	PF00400	0.436

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5W4	Leptomonas seymouri	55%	100%
A0A0S4JKW0	Bodo saltans	28%	70%
A0A1X0NQF7	Trypanosomatidae	29%	100%
A0A3S7WRE7	Leishmania donovani	95%	100%
A0A422NBU0	Trypanosoma rangeli	34%	100%
A4H6B3	Leishmania braziliensis	80%	100%
A4HUN6	Leishmania infantum	95%	100%
C9ZVS5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	93%
E9ACR0	Leishmania major	95%	100%
V5BPA9	Trypanosoma cruzi	30%	100%