Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AND2_LEIMU

TriTrypDb:

LmxM.10.1210

Length:

567

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AND2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AND2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	81	85	PF00656	0.431
CLV_C14_Caspase3-7	87	91	PF00656	0.490
CLV_MEL_PAP_1	260	266	PF00089	0.434
CLV_NRD_NRD_1	140	142	PF00675	0.399
CLV_NRD_NRD_1	286	288	PF00675	0.498
CLV_NRD_NRD_1	341	343	PF00675	0.529
CLV_NRD_NRD_1	427	429	PF00675	0.510
CLV_NRD_NRD_1	436	438	PF00675	0.472
CLV_NRD_NRD_1	52	54	PF00675	0.563
CLV_PCSK_FUR_1	425	429	PF00082	0.566
CLV_PCSK_KEX2_1	25	27	PF00082	0.549
CLV_PCSK_KEX2_1	341	343	PF00082	0.616
CLV_PCSK_KEX2_1	381	383	PF00082	0.491
CLV_PCSK_KEX2_1	427	429	PF00082	0.477
CLV_PCSK_KEX2_1	436	438	PF00082	0.502
CLV_PCSK_KEX2_1	449	451	PF00082	0.614
CLV_PCSK_KEX2_1	52	54	PF00082	0.498
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.445
CLV_PCSK_PC1ET2_1	381	383	PF00082	0.487
CLV_PCSK_PC1ET2_1	449	451	PF00082	0.637
CLV_PCSK_PC7_1	432	438	PF00082	0.523
CLV_PCSK_SKI1_1	102	106	PF00082	0.470
CLV_PCSK_SKI1_1	26	30	PF00082	0.532
CLV_PCSK_SKI1_1	42	46	PF00082	0.428
CLV_PCSK_SKI1_1	61	65	PF00082	0.492
DEG_COP1_1	219	226	PF00400	0.394
DEG_Nend_UBRbox_1	1	4	PF02207	0.565
DEG_SPOP_SBC_1	124	128	PF00917	0.485
DEG_SPOP_SBC_1	488	492	PF00917	0.564
DOC_CKS1_1	158	163	PF01111	0.701
DOC_CKS1_1	227	232	PF01111	0.358
DOC_CYCLIN_RxL_1	99	106	PF00134	0.427
DOC_MAPK_gen_1	447	457	PF00069	0.476
DOC_MAPK_MEF2A_6	235	243	PF00069	0.399
DOC_MAPK_RevD_3	274	288	PF00069	0.431
DOC_PP1_RVXF_1	198	204	PF00149	0.391
DOC_PP1_RVXF_1	380	387	PF00149	0.522
DOC_PP1_RVXF_1	561	567	PF00149	0.424
DOC_USP7_MATH_1	124	128	PF00917	0.522
DOC_USP7_MATH_1	159	163	PF00917	0.670
DOC_USP7_MATH_1	206	210	PF00917	0.542
DOC_USP7_MATH_1	295	299	PF00917	0.433
DOC_USP7_MATH_1	318	322	PF00917	0.458
DOC_USP7_MATH_1	33	37	PF00917	0.423
DOC_USP7_MATH_1	488	492	PF00917	0.550
DOC_USP7_MATH_1	553	557	PF00917	0.585
DOC_USP7_UBL2_3	25	29	PF12436	0.564
DOC_WW_Pin1_4	157	162	PF00397	0.665
DOC_WW_Pin1_4	226	231	PF00397	0.489
DOC_WW_Pin1_4	534	539	PF00397	0.470
LIG_14-3-3_CanoR_1	2	10	PF00244	0.527
LIG_14-3-3_CanoR_1	200	204	PF00244	0.490
LIG_14-3-3_CanoR_1	263	271	PF00244	0.488
LIG_14-3-3_CanoR_1	290	297	PF00244	0.496
LIG_14-3-3_CanoR_1	302	308	PF00244	0.378
LIG_14-3-3_CanoR_1	358	364	PF00244	0.575
LIG_14-3-3_CanoR_1	467	473	PF00244	0.477
LIG_14-3-3_CanoR_1	497	502	PF00244	0.665
LIG_Actin_WH2_2	220	237	PF00022	0.374
LIG_Actin_WH2_2	273	289	PF00022	0.452
LIG_BRCT_BRCA1_1	161	165	PF00533	0.526
LIG_FHA_1	234	240	PF00498	0.413
LIG_FHA_1	303	309	PF00498	0.365
LIG_FHA_2	147	153	PF00498	0.480
LIG_FHA_2	200	206	PF00498	0.298
LIG_FHA_2	227	233	PF00498	0.539
LIG_FHA_2	349	355	PF00498	0.365
LIG_LIR_Gen_1	185	193	PF02991	0.422
LIG_LIR_Gen_1	351	357	PF02991	0.436
LIG_LIR_Gen_1	495	506	PF02991	0.531
LIG_LIR_Nem_3	185	189	PF02991	0.356
LIG_LIR_Nem_3	351	356	PF02991	0.440
LIG_LIR_Nem_3	495	501	PF02991	0.515
LIG_LYPXL_S_1	267	271	PF13949	0.523
LIG_LYPXL_yS_3	268	271	PF13949	0.522
LIG_NRBOX	100	106	PF00104	0.425
LIG_PCNA_PIPBox_1	462	471	PF02747	0.477
LIG_PCNA_yPIPBox_3	458	469	PF02747	0.479
LIG_RPA_C_Fungi	285	297	PF08784	0.488
LIG_SH2_CRK	498	502	PF00017	0.573
LIG_SH2_CRK	526	530	PF00017	0.529
LIG_SH2_STAP1	353	357	PF00017	0.590
LIG_SH2_STAP1	498	502	PF00017	0.641
LIG_SH2_STAT3	396	399	PF00017	0.416
LIG_SH2_STAT3	435	438	PF00017	0.525
LIG_SH2_STAT5	498	501	PF00017	0.609
LIG_SH3_3	224	230	PF00018	0.409
LIG_SH3_3	266	272	PF00018	0.512
LIG_TRAF2_1	202	205	PF00917	0.545
LIG_TRAF2_1	209	212	PF00917	0.385
LIG_TRAF2_1	362	365	PF00917	0.372
LIG_TRAF2_1	417	420	PF00917	0.470
LIG_TYR_ITSM	349	356	PF00017	0.307
LIG_UBA3_1	454	461	PF00899	0.449
MOD_CDK_SPxxK_3	534	541	PF00069	0.426
MOD_CK1_1	11	17	PF00069	0.563
MOD_CK1_1	222	228	PF00069	0.397
MOD_CK1_1	253	259	PF00069	0.416
MOD_CK1_1	306	312	PF00069	0.502
MOD_CK1_1	492	498	PF00069	0.566
MOD_CK2_1	146	152	PF00069	0.508
MOD_CK2_1	160	166	PF00069	0.522
MOD_CK2_1	199	205	PF00069	0.384
MOD_CK2_1	206	212	PF00069	0.385
MOD_CK2_1	306	312	PF00069	0.483
MOD_CK2_1	33	39	PF00069	0.558
MOD_CK2_1	348	354	PF00069	0.416
MOD_CK2_1	359	365	PF00069	0.501
MOD_CK2_1	43	49	PF00069	0.472
MOD_Cter_Amidation	50	53	PF01082	0.472
MOD_GlcNHglycan	12	16	PF01048	0.628
MOD_GlcNHglycan	128	131	PF01048	0.660
MOD_GlcNHglycan	162	165	PF01048	0.521
MOD_GlcNHglycan	208	211	PF01048	0.580
MOD_GlcNHglycan	251	255	PF01048	0.471
MOD_GlcNHglycan	26	29	PF01048	0.470
MOD_GlcNHglycan	264	267	PF01048	0.392
MOD_GlcNHglycan	272	275	PF01048	0.507
MOD_GlcNHglycan	312	315	PF01048	0.527
MOD_GlcNHglycan	400	403	PF01048	0.400
MOD_GlcNHglycan	491	494	PF01048	0.684
MOD_GlcNHglycan	5	8	PF01048	0.649
MOD_GlcNHglycan	550	553	PF01048	0.569
MOD_GlcNHglycan	97	101	PF01048	0.597
MOD_GSK3_1	103	110	PF00069	0.487
MOD_GSK3_1	126	133	PF00069	0.613
MOD_GSK3_1	222	229	PF00069	0.477
MOD_GSK3_1	302	309	PF00069	0.502
MOD_GSK3_1	344	351	PF00069	0.557
MOD_GSK3_1	488	495	PF00069	0.541
MOD_GSK3_1	497	504	PF00069	0.529
MOD_GSK3_1	84	91	PF00069	0.646
MOD_N-GLC_1	303	308	PF02516	0.420
MOD_NEK2_1	1	6	PF00069	0.670
MOD_NEK2_1	189	194	PF00069	0.434
MOD_NEK2_1	250	255	PF00069	0.542
MOD_NEK2_1	300	305	PF00069	0.492
MOD_NEK2_1	486	491	PF00069	0.567
MOD_NEK2_1	501	506	PF00069	0.548
MOD_NEK2_1	96	101	PF00069	0.531
MOD_NEK2_2	33	38	PF00069	0.493
MOD_PIKK_1	103	109	PF00454	0.591
MOD_PIKK_1	290	296	PF00454	0.597
MOD_PKA_1	24	30	PF00069	0.573
MOD_PKA_2	1	7	PF00069	0.542
MOD_PKA_2	199	205	PF00069	0.436
MOD_PKA_2	262	268	PF00069	0.556
MOD_PKA_2	359	365	PF00069	0.590
MOD_PKA_2	442	448	PF00069	0.514
MOD_PKA_2	486	492	PF00069	0.587
MOD_PKA_2	496	502	PF00069	0.631
MOD_PKA_2	548	554	PF00069	0.510
MOD_Plk_1	211	217	PF00069	0.424
MOD_Plk_1	219	225	PF00069	0.440
MOD_Plk_1	303	309	PF00069	0.406
MOD_Plk_1	348	354	PF00069	0.622
MOD_Plk_1	78	84	PF00069	0.578
MOD_Plk_1	96	102	PF00069	0.352
MOD_Plk_2-3	84	90	PF00069	0.456
MOD_Plk_4	303	309	PF00069	0.463
MOD_Plk_4	501	507	PF00069	0.524
MOD_ProDKin_1	157	163	PF00069	0.665
MOD_ProDKin_1	226	232	PF00069	0.488
MOD_ProDKin_1	534	540	PF00069	0.463
TRG_DiLeu_BaEn_1	312	317	PF01217	0.533
TRG_ENDOCYTIC_2	268	271	PF00928	0.416
TRG_ENDOCYTIC_2	353	356	PF00928	0.596
TRG_ENDOCYTIC_2	498	501	PF00928	0.587
TRG_ENDOCYTIC_2	526	529	PF00928	0.529
TRG_ER_diArg_1	333	336	PF00400	0.581
TRG_ER_diArg_1	357	360	PF00400	0.414
TRG_ER_diArg_1	389	392	PF00400	0.410
TRG_ER_diArg_1	425	428	PF00400	0.580
TRG_ER_diArg_1	435	437	PF00400	0.535
TRG_ER_diArg_1	521	524	PF00400	0.552
TRG_NES_CRM1_1	232	245	PF08389	0.445
TRG_Pf-PMV_PEXEL_1	290	294	PF00026	0.440
TRG_Pf-PMV_PEXEL_1	408	412	PF00026	0.486
TRG_Pf-PMV_PEXEL_1	42	47	PF00026	0.648

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5W6	Leptomonas seymouri	54%	100%
A0A1X0NRY0	Trypanosomatidae	30%	97%
A0A3Q8I7T8	Leishmania donovani	92%	100%
A0A3R7MBP9	Trypanosoma rangeli	28%	97%
A4H6B0	Leishmania braziliensis	79%	100%
A4HUN4	Leishmania infantum	92%	100%
C9ZVR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	98%
Q4QH92	Leishmania major	92%	100%
V5BJP6	Trypanosoma cruzi	30%	92%