SpoU_methylase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AND1_LEIMU

TriTrypDb:

LmxM.10.1200

Length:

1062

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	12
GO:0005643	nuclear pore	3	2
GO:0005737	cytoplasm	2	2
GO:0032991	protein-containing complex	1	2
GO:0140513	nuclear protein-containing complex	2	2

Expansion

Sequence features

E9AND1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AND1

Function

Biological processes
Term	Name	Level	Count
GO:0006611	protein export from nucleus	5	2
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0006913	nucleocytoplasmic transport	5	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0033036	macromolecule localization	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051168	nuclear export	6	2
GO:0051169	nuclear transport	4	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2

Molecular functions
Term	Name	Level	Count
GO:0005049	nuclear export signal receptor activity	3	12
GO:0140104	molecular carrier activity	1	12
GO:0140142	nucleocytoplasmic carrier activity	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	497	503	PF00089	0.371
CLV_NRD_NRD_1	119	121	PF00675	0.487
CLV_NRD_NRD_1	238	240	PF00675	0.507
CLV_NRD_NRD_1	542	544	PF00675	0.601
CLV_NRD_NRD_1	714	716	PF00675	0.431
CLV_NRD_NRD_1	987	989	PF00675	0.373
CLV_PCSK_KEX2_1	119	121	PF00082	0.522
CLV_PCSK_KEX2_1	714	716	PF00082	0.403
CLV_PCSK_SKI1_1	1031	1035	PF00082	0.485
CLV_PCSK_SKI1_1	119	123	PF00082	0.609
CLV_PCSK_SKI1_1	148	152	PF00082	0.437
CLV_PCSK_SKI1_1	169	173	PF00082	0.215
CLV_PCSK_SKI1_1	240	244	PF00082	0.514
CLV_PCSK_SKI1_1	439	443	PF00082	0.280
CLV_PCSK_SKI1_1	57	61	PF00082	0.406
CLV_PCSK_SKI1_1	612	616	PF00082	0.431
CLV_PCSK_SKI1_1	644	648	PF00082	0.356
CLV_PCSK_SKI1_1	706	710	PF00082	0.281
CLV_PCSK_SKI1_1	763	767	PF00082	0.451
CLV_PCSK_SKI1_1	970	974	PF00082	0.449
CLV_PCSK_SKI1_1	988	992	PF00082	0.230
DEG_APCC_DBOX_1	438	446	PF00400	0.287
DEG_APCC_DBOX_1	987	995	PF00400	0.421
DEG_SPOP_SBC_1	692	696	PF00917	0.291
DOC_CDC14_PxL_1	214	222	PF14671	0.323
DOC_CYCLIN_RxL_1	261	274	PF00134	0.323
DOC_CYCLIN_yCln2_LP_2	635	641	PF00134	0.373
DOC_CYCLIN_yCln2_LP_2	670	676	PF00134	0.454
DOC_CYCLIN_yCln2_LP_2	911	917	PF00134	0.473
DOC_CYCLIN_yCln2_LP_2	990	996	PF00134	0.348
DOC_MAPK_FxFP_2	727	730	PF00069	0.346
DOC_MAPK_gen_1	132	142	PF00069	0.344
DOC_MAPK_gen_1	166	174	PF00069	0.208
DOC_MAPK_gen_1	786	795	PF00069	0.445
DOC_MAPK_gen_1	988	994	PF00069	0.359
DOC_MAPK_HePTP_8	783	795	PF00069	0.308
DOC_MAPK_MEF2A_6	61	68	PF00069	0.426
DOC_MAPK_MEF2A_6	786	795	PF00069	0.441
DOC_MIT_MIM_1	204	214	PF04212	0.403
DOC_PP1_RVXF_1	208	214	PF00149	0.298
DOC_PP1_RVXF_1	761	767	PF00149	0.398
DOC_PP2B_LxvP_1	990	993	PF13499	0.347
DOC_PP4_FxxP_1	727	730	PF00568	0.346
DOC_USP7_MATH_1	322	326	PF00917	0.344
DOC_USP7_MATH_1	473	477	PF00917	0.504
DOC_USP7_MATH_1	479	483	PF00917	0.491
DOC_WW_Pin1_4	1012	1017	PF00397	0.428
DOC_WW_Pin1_4	299	304	PF00397	0.458
DOC_WW_Pin1_4	803	808	PF00397	0.528
LIG_14-3-3_CanoR_1	1012	1016	PF00244	0.522
LIG_14-3-3_CanoR_1	1031	1039	PF00244	0.536
LIG_14-3-3_CanoR_1	119	125	PF00244	0.489
LIG_14-3-3_CanoR_1	18	27	PF00244	0.495
LIG_14-3-3_CanoR_1	239	243	PF00244	0.507
LIG_14-3-3_CanoR_1	306	312	PF00244	0.447
LIG_14-3-3_CanoR_1	436	442	PF00244	0.381
LIG_14-3-3_CanoR_1	446	454	PF00244	0.370
LIG_14-3-3_CanoR_1	500	508	PF00244	0.468
LIG_14-3-3_CanoR_1	543	552	PF00244	0.495
LIG_14-3-3_CanoR_1	677	683	PF00244	0.474
LIG_14-3-3_CanoR_1	706	716	PF00244	0.356
LIG_Actin_WH2_2	1044	1061	PF00022	0.506
LIG_Actin_WH2_2	224	241	PF00022	0.372
LIG_APCC_ABBA_1	624	629	PF00400	0.442
LIG_APCC_ABBA_1	840	845	PF00400	0.356
LIG_BIR_II_1	1	5	PF00653	0.349
LIG_BRCT_BRCA1_1	11	15	PF00533	0.376
LIG_BRCT_BRCA1_1	909	913	PF00533	0.338
LIG_CaM_NSCaTE_8	465	472	PF13499	0.426
LIG_Clathr_ClatBox_1	994	998	PF01394	0.333
LIG_deltaCOP1_diTrp_1	813	816	PF00928	0.446
LIG_EH1_1	984	992	PF00400	0.472
LIG_EVH1_2	898	902	PF00568	0.326
LIG_FHA_1	231	237	PF00498	0.322
LIG_FHA_1	24	30	PF00498	0.457
LIG_FHA_1	258	264	PF00498	0.326
LIG_FHA_1	322	328	PF00498	0.384
LIG_FHA_1	36	42	PF00498	0.326
LIG_FHA_1	371	377	PF00498	0.458
LIG_FHA_1	501	507	PF00498	0.419
LIG_FHA_1	522	528	PF00498	0.513
LIG_FHA_1	532	538	PF00498	0.434
LIG_FHA_1	605	611	PF00498	0.371
LIG_FHA_1	661	667	PF00498	0.509
LIG_FHA_1	693	699	PF00498	0.391
LIG_FHA_1	745	751	PF00498	0.461
LIG_FHA_1	847	853	PF00498	0.382
LIG_FHA_1	971	977	PF00498	0.336
LIG_FHA_2	1041	1047	PF00498	0.570
LIG_FHA_2	1055	1061	PF00498	0.456
LIG_FHA_2	113	119	PF00498	0.496
LIG_FHA_2	181	187	PF00498	0.603
LIG_FHA_2	191	197	PF00498	0.462
LIG_FHA_2	225	231	PF00498	0.475
LIG_FHA_2	242	248	PF00498	0.521
LIG_FHA_2	667	673	PF00498	0.498
LIG_GBD_Chelix_1	1047	1055	PF00786	0.402
LIG_GBD_Chelix_1	224	232	PF00786	0.319
LIG_LIR_Apic_2	725	730	PF02991	0.358
LIG_LIR_Gen_1	241	250	PF02991	0.587
LIG_LIR_Gen_1	265	274	PF02991	0.448
LIG_LIR_Gen_1	277	286	PF02991	0.254
LIG_LIR_Gen_1	40	50	PF02991	0.419
LIG_LIR_Gen_1	617	626	PF02991	0.379
LIG_LIR_Gen_1	8	19	PF02991	0.367
LIG_LIR_Gen_1	900	908	PF02991	0.468
LIG_LIR_Nem_3	209	215	PF02991	0.331
LIG_LIR_Nem_3	241	246	PF02991	0.593
LIG_LIR_Nem_3	265	270	PF02991	0.447
LIG_LIR_Nem_3	277	282	PF02991	0.293
LIG_LIR_Nem_3	331	336	PF02991	0.306
LIG_LIR_Nem_3	40	45	PF02991	0.372
LIG_LIR_Nem_3	424	430	PF02991	0.434
LIG_LIR_Nem_3	566	571	PF02991	0.388
LIG_LIR_Nem_3	617	623	PF02991	0.463
LIG_LIR_Nem_3	8	14	PF02991	0.356
LIG_LIR_Nem_3	853	859	PF02991	0.447
LIG_LIR_Nem_3	900	905	PF02991	0.477
LIG_MAD2	718	726	PF02301	0.356
LIG_MYND_1	218	222	PF01753	0.385
LIG_MYND_1	726	730	PF01753	0.449
LIG_NRBOX	325	331	PF00104	0.415
LIG_NRBOX	487	493	PF00104	0.439
LIG_NRBOX	847	853	PF00104	0.426
LIG_PCNA_yPIPBox_3	285	296	PF02747	0.468
LIG_PCNA_yPIPBox_3	978	991	PF02747	0.488
LIG_PDZ_Class_3	1057	1062	PF00595	0.419
LIG_Pex14_2	568	572	PF04695	0.439
LIG_Pex14_2	888	892	PF04695	0.463
LIG_Rb_LxCxE_1	704	725	PF01857	0.440
LIG_SH2_CRK	11	15	PF00017	0.342
LIG_SH2_CRK	253	257	PF00017	0.322
LIG_SH2_CRK	620	624	PF00017	0.471
LIG_SH2_CRK	717	721	PF00017	0.322
LIG_SH2_NCK_1	11	15	PF00017	0.342
LIG_SH2_NCK_1	843	847	PF00017	0.299
LIG_SH2_SRC	253	256	PF00017	0.377
LIG_SH2_SRC	72	75	PF00017	0.299
LIG_SH2_SRC	843	846	PF00017	0.340
LIG_SH2_SRC	996	999	PF00017	0.467
LIG_SH2_STAP1	11	15	PF00017	0.399
LIG_SH2_STAP1	253	257	PF00017	0.322
LIG_SH2_STAP1	620	624	PF00017	0.377
LIG_SH2_STAP1	74	78	PF00017	0.438
LIG_SH2_STAP1	843	847	PF00017	0.446
LIG_SH2_STAT3	342	345	PF00017	0.507
LIG_SH2_STAT5	1008	1011	PF00017	0.487
LIG_SH2_STAT5	361	364	PF00017	0.411
LIG_SH2_STAT5	538	541	PF00017	0.557
LIG_SH2_STAT5	571	574	PF00017	0.410
LIG_SH2_STAT5	620	623	PF00017	0.372
LIG_SH2_STAT5	645	648	PF00017	0.411
LIG_SH2_STAT5	779	782	PF00017	0.334
LIG_SH2_STAT5	996	999	PF00017	0.467
LIG_SH3_3	804	810	PF00018	0.450
LIG_SUMO_SIM_anti_2	227	234	PF11976	0.412
LIG_SUMO_SIM_anti_2	323	331	PF11976	0.427
LIG_SUMO_SIM_anti_2	455	462	PF11976	0.312
LIG_SUMO_SIM_anti_2	494	499	PF11976	0.336
LIG_SUMO_SIM_par_1	111	118	PF11976	0.403
LIG_SUMO_SIM_par_1	227	234	PF11976	0.368
LIG_SUMO_SIM_par_1	254	260	PF11976	0.343
LIG_SUMO_SIM_par_1	323	331	PF11976	0.435
LIG_SUMO_SIM_par_1	37	43	PF11976	0.333
LIG_SUMO_SIM_par_1	698	704	PF11976	0.376
LIG_UBA3_1	1054	1059	PF00899	0.487
LIG_UBA3_1	282	287	PF00899	0.292
LIG_WRC_WIRS_1	121	126	PF05994	0.547
LIG_WRC_WIRS_1	308	313	PF05994	0.290
MOD_CDK_SPxxK_3	299	306	PF00069	0.314
MOD_CK1_1	1011	1017	PF00069	0.452
MOD_CK1_1	156	162	PF00069	0.491
MOD_CK1_1	234	240	PF00069	0.427
MOD_CK1_1	241	247	PF00069	0.459
MOD_CK1_1	307	313	PF00069	0.475
MOD_CK1_1	325	331	PF00069	0.291
MOD_CK1_1	341	347	PF00069	0.355
MOD_CK1_1	447	453	PF00069	0.507
MOD_CK1_1	606	612	PF00069	0.368
MOD_CK1_1	660	666	PF00069	0.510
MOD_CK1_1	691	697	PF00069	0.551
MOD_CK1_1	797	803	PF00069	0.533
MOD_CK1_1	88	94	PF00069	0.523
MOD_CK1_1	9	15	PF00069	0.406
MOD_CK2_1	1040	1046	PF00069	0.459
MOD_CK2_1	1054	1060	PF00069	0.528
MOD_CK2_1	112	118	PF00069	0.465
MOD_CK2_1	180	186	PF00069	0.512
MOD_CK2_1	190	196	PF00069	0.404
MOD_CK2_1	224	230	PF00069	0.478
MOD_CK2_1	241	247	PF00069	0.528
MOD_CK2_1	37	43	PF00069	0.316
MOD_CK2_1	666	672	PF00069	0.455
MOD_CK2_1	687	693	PF00069	0.546
MOD_CK2_1	707	713	PF00069	0.314
MOD_CK2_1	737	743	PF00069	0.442
MOD_DYRK1A_RPxSP_1	1012	1016	PF00069	0.427
MOD_GlcNHglycan	276	279	PF01048	0.291
MOD_GlcNHglycan	383	386	PF01048	0.524
MOD_GlcNHglycan	449	452	PF01048	0.573
MOD_GlcNHglycan	470	473	PF01048	0.497
MOD_GlcNHglycan	481	484	PF01048	0.496
MOD_GlcNHglycan	545	548	PF01048	0.523
MOD_GlcNHglycan	584	587	PF01048	0.466
MOD_GlcNHglycan	658	662	PF01048	0.429
MOD_GlcNHglycan	690	693	PF01048	0.503
MOD_GlcNHglycan	769	772	PF01048	0.423
MOD_GlcNHglycan	786	789	PF01048	0.327
MOD_GlcNHglycan	797	800	PF01048	0.463
MOD_GlcNHglycan	8	11	PF01048	0.384
MOD_GlcNHglycan	802	805	PF01048	0.567
MOD_GlcNHglycan	874	877	PF01048	0.196
MOD_GlcNHglycan	998	1002	PF01048	0.512
MOD_GSK3_1	1008	1015	PF00069	0.502
MOD_GSK3_1	1050	1057	PF00069	0.392
MOD_GSK3_1	119	126	PF00069	0.565
MOD_GSK3_1	14	21	PF00069	0.356
MOD_GSK3_1	190	197	PF00069	0.603
MOD_GSK3_1	230	237	PF00069	0.325
MOD_GSK3_1	321	328	PF00069	0.425
MOD_GSK3_1	431	438	PF00069	0.421
MOD_GSK3_1	5	12	PF00069	0.460
MOD_GSK3_1	507	514	PF00069	0.454
MOD_GSK3_1	529	536	PF00069	0.511
MOD_GSK3_1	538	545	PF00069	0.516
MOD_GSK3_1	602	609	PF00069	0.466
MOD_GSK3_1	614	621	PF00069	0.396
MOD_GSK3_1	662	669	PF00069	0.426
MOD_GSK3_1	684	691	PF00069	0.613
MOD_GSK3_1	692	699	PF00069	0.548
MOD_GSK3_1	81	88	PF00069	0.478
MOD_GSK3_1	846	853	PF00069	0.338
MOD_GSK3_1	868	875	PF00069	0.371
MOD_N-GLC_1	447	452	PF02516	0.452
MOD_N-GLC_1	627	632	PF02516	0.419
MOD_N-GLC_2	937	939	PF02516	0.445
MOD_NEK2_1	1054	1059	PF00069	0.499
MOD_NEK2_1	112	117	PF00069	0.406
MOD_NEK2_1	238	243	PF00069	0.409
MOD_NEK2_1	257	262	PF00069	0.314
MOD_NEK2_1	37	42	PF00069	0.390
MOD_NEK2_1	4	9	PF00069	0.412
MOD_NEK2_1	491	496	PF00069	0.334
MOD_NEK2_1	507	512	PF00069	0.350
MOD_NEK2_1	531	536	PF00069	0.427
MOD_NEK2_1	584	589	PF00069	0.543
MOD_NEK2_1	614	619	PF00069	0.450
MOD_NEK2_1	657	662	PF00069	0.445
MOD_NEK2_1	736	741	PF00069	0.449
MOD_NEK2_1	795	800	PF00069	0.673
MOD_NEK2_1	851	856	PF00069	0.380
MOD_NEK2_1	868	873	PF00069	0.363
MOD_NEK2_1	907	912	PF00069	0.293
MOD_NEK2_1	956	961	PF00069	0.362
MOD_NEK2_1	976	981	PF00069	0.441
MOD_NEK2_2	23	28	PF00069	0.486
MOD_NEK2_2	463	468	PF00069	0.380
MOD_PIKK_1	32	38	PF00454	0.442
MOD_PIKK_1	341	347	PF00454	0.366
MOD_PIKK_1	551	557	PF00454	0.398
MOD_PIKK_1	676	682	PF00454	0.501
MOD_PIKK_1	744	750	PF00454	0.442
MOD_PK_1	533	539	PF00069	0.509
MOD_PKA_1	119	125	PF00069	0.598
MOD_PKA_1	543	549	PF00069	0.537
MOD_PKA_2	1011	1017	PF00069	0.431
MOD_PKA_2	119	125	PF00069	0.519
MOD_PKA_2	238	244	PF00069	0.508
MOD_PKA_2	435	441	PF00069	0.534
MOD_PKA_2	499	505	PF00069	0.478
MOD_PKA_2	542	548	PF00069	0.498
MOD_PKA_2	676	682	PF00069	0.467
MOD_Plk_1	126	132	PF00069	0.456
MOD_Plk_1	272	278	PF00069	0.358
MOD_Plk_1	32	38	PF00069	0.479
MOD_Plk_1	447	453	PF00069	0.583
MOD_Plk_1	627	633	PF00069	0.512
MOD_Plk_1	657	663	PF00069	0.474
MOD_Plk_1	742	748	PF00069	0.366
MOD_Plk_1	976	982	PF00069	0.488
MOD_Plk_4	1050	1056	PF00069	0.402
MOD_Plk_4	138	144	PF00069	0.449
MOD_Plk_4	224	230	PF00069	0.371
MOD_Plk_4	23	29	PF00069	0.474
MOD_Plk_4	231	237	PF00069	0.323
MOD_Plk_4	238	244	PF00069	0.326
MOD_Plk_4	322	328	PF00069	0.370
MOD_Plk_4	37	43	PF00069	0.289
MOD_Plk_4	491	497	PF00069	0.336
MOD_Plk_4	533	539	PF00069	0.520
MOD_Plk_4	606	612	PF00069	0.493
MOD_Plk_4	618	624	PF00069	0.491
MOD_Plk_4	662	668	PF00069	0.525
MOD_Plk_4	851	857	PF00069	0.314
MOD_Plk_4	9	15	PF00069	0.397
MOD_Plk_4	956	962	PF00069	0.398
MOD_ProDKin_1	1012	1018	PF00069	0.422
MOD_ProDKin_1	299	305	PF00069	0.453
MOD_ProDKin_1	803	809	PF00069	0.519
TRG_DiLeu_BaEn_1	411	416	PF01217	0.339
TRG_DiLeu_BaEn_2	374	380	PF01217	0.361
TRG_DiLeu_BaEn_3	424	430	PF01217	0.347
TRG_DiLeu_BaEn_4	405	411	PF01217	0.375
TRG_DiLeu_BaLyEn_6	278	283	PF01217	0.427
TRG_DiLeu_BaLyEn_6	332	337	PF01217	0.414
TRG_DiLeu_BaLyEn_6	609	614	PF01217	0.428
TRG_ENDOCYTIC_2	11	14	PF00928	0.393
TRG_ENDOCYTIC_2	253	256	PF00928	0.497
TRG_ENDOCYTIC_2	42	45	PF00928	0.442
TRG_ENDOCYTIC_2	620	623	PF00928	0.466
TRG_ENDOCYTIC_2	645	648	PF00928	0.364
TRG_ENDOCYTIC_2	717	720	PF00928	0.311
TRG_ER_diArg_1	101	104	PF00400	0.482
TRG_ER_diArg_1	119	121	PF00400	0.450
TRG_ER_diArg_1	714	716	PF00400	0.428
TRG_NES_CRM1_1	137	152	PF08389	0.334
TRG_NES_CRM1_1	363	375	PF08389	0.320
TRG_Pf-PMV_PEXEL_1	266	271	PF00026	0.331
TRG_Pf-PMV_PEXEL_1	612	616	PF00026	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKL7	Leptomonas seymouri	64%	96%
A0A1X0NQX8	Trypanosomatidae	27%	100%
A0A3R7NI03	Trypanosoma rangeli	28%	100%
A0A3S7WRC3	Leishmania donovani	96%	100%
A4H6A9	Leishmania braziliensis	89%	100%
A4HUN3	Leishmania infantum	96%	100%
C9ZVR7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
Q4Q902	Leishmania major	21%	87%
Q4QH93	Leishmania major	95%	100%
V5BTW0	Trypanosoma cruzi	28%	100%