Cilia- and flagella-associated protein 45

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cilia- and flagella-associated protein 45, putative

Species:

Leishmania mexicana

UniProt:

E9ANC5_LEIMU

TriTrypDb:

LmxM.10.1150

Length:

480

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	3
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

E9ANC5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANC5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	16	18	PF00675	0.519
CLV_NRD_NRD_1	192	194	PF00675	0.236
CLV_NRD_NRD_1	211	213	PF00675	0.175
CLV_NRD_NRD_1	24	26	PF00675	0.481
CLV_NRD_NRD_1	240	242	PF00675	0.242
CLV_NRD_NRD_1	246	248	PF00675	0.234
CLV_NRD_NRD_1	274	276	PF00675	0.278
CLV_NRD_NRD_1	299	301	PF00675	0.303
CLV_NRD_NRD_1	329	331	PF00675	0.243
CLV_NRD_NRD_1	340	342	PF00675	0.195
CLV_NRD_NRD_1	405	407	PF00675	0.251
CLV_NRD_NRD_1	427	429	PF00675	0.223
CLV_NRD_NRD_1	440	442	PF00675	0.224
CLV_NRD_NRD_1	456	458	PF00675	0.152
CLV_NRD_NRD_1	472	474	PF00675	0.414
CLV_NRD_NRD_1	82	84	PF00675	0.505
CLV_PCSK_FUR_1	209	213	PF00082	0.320
CLV_PCSK_FUR_1	297	301	PF00082	0.309
CLV_PCSK_FUR_1	327	331	PF00082	0.234
CLV_PCSK_FUR_1	403	407	PF00082	0.320
CLV_PCSK_FUR_1	425	429	PF00082	0.236
CLV_PCSK_KEX2_1	15	17	PF00082	0.579
CLV_PCSK_KEX2_1	153	155	PF00082	0.247
CLV_PCSK_KEX2_1	192	194	PF00082	0.284
CLV_PCSK_KEX2_1	211	213	PF00082	0.251
CLV_PCSK_KEX2_1	240	242	PF00082	0.233
CLV_PCSK_KEX2_1	246	248	PF00082	0.219
CLV_PCSK_KEX2_1	299	301	PF00082	0.303
CLV_PCSK_KEX2_1	329	331	PF00082	0.229
CLV_PCSK_KEX2_1	340	342	PF00082	0.212
CLV_PCSK_KEX2_1	405	407	PF00082	0.320
CLV_PCSK_KEX2_1	425	427	PF00082	0.114
CLV_PCSK_KEX2_1	472	474	PF00082	0.522
CLV_PCSK_KEX2_1	81	83	PF00082	0.517
CLV_PCSK_PC1ET2_1	153	155	PF00082	0.252
CLV_PCSK_SKI1_1	118	122	PF00082	0.521
CLV_PCSK_SKI1_1	472	476	PF00082	0.475
DEG_APCC_DBOX_1	471	479	PF00400	0.547
DOC_MAPK_gen_1	192	200	PF00069	0.418
DOC_MAPK_gen_1	263	271	PF00069	0.448
DOC_MAPK_gen_1	297	306	PF00069	0.520
DOC_MAPK_gen_1	472	478	PF00069	0.587
DOC_MAPK_MEF2A_6	193	202	PF00069	0.439
DOC_PP2B_LxvP_1	465	468	PF13499	0.434
DOC_USP7_MATH_1	34	38	PF00917	0.522
DOC_USP7_UBL2_3	372	376	PF12436	0.507
LIG_14-3-3_CanoR_1	16	24	PF00244	0.568
LIG_BIR_II_1	1	5	PF00653	0.562
LIG_CaM_IQ_9	197	213	PF13499	0.502
LIG_CaM_IQ_9	227	243	PF13499	0.507
LIG_CaM_IQ_9	386	402	PF13499	0.520
LIG_FHA_1	402	408	PF00498	0.507
LIG_FHA_1	6	12	PF00498	0.567
LIG_FHA_2	39	45	PF00498	0.465
LIG_FHA_2	70	76	PF00498	0.654
LIG_FHA_2	98	104	PF00498	0.534
LIG_REV1ctd_RIR_1	1	11	PF16727	0.644
LIG_SH2_STAT3	161	164	PF00017	0.489
LIG_SH2_STAT3	280	283	PF00017	0.489
LIG_SH2_STAT5	180	183	PF00017	0.520
LIG_SH2_STAT5	206	209	PF00017	0.462
LIG_SH2_STAT5	280	283	PF00017	0.434
LIG_SH2_STAT5	335	338	PF00017	0.520
LIG_SH3_3	8	14	PF00018	0.514
LIG_SUMO_SIM_anti_2	412	417	PF11976	0.434
LIG_SUMO_SIM_anti_2	43	49	PF11976	0.450
LIG_TRAF2_1	100	103	PF00917	0.599
LIG_TRAF2_1	76	79	PF00917	0.575
LIG_WW_3	12	16	PF00397	0.479
MOD_CK1_1	2	8	PF00069	0.396
MOD_CK2_1	38	44	PF00069	0.457
MOD_CK2_1	69	75	PF00069	0.605
MOD_CK2_1	97	103	PF00069	0.617
MOD_GlcNHglycan	350	353	PF01048	0.262
MOD_GlcNHglycan	36	39	PF01048	0.595
MOD_GlcNHglycan	60	63	PF01048	0.601
MOD_GSK3_1	34	41	PF00069	0.499
MOD_GSK3_1	56	63	PF00069	0.672
MOD_NEK2_1	3	8	PF00069	0.539
MOD_NEK2_1	60	65	PF00069	0.621
MOD_PKA_2	34	40	PF00069	0.493
MOD_PKA_2	348	354	PF00069	0.503
MOD_PKB_1	15	23	PF00069	0.582
MOD_Plk_1	156	162	PF00069	0.458
MOD_Plk_1	409	415	PF00069	0.423
MOD_SUMO_rev_2	122	131	PF00179	0.448
MOD_SUMO_rev_2	228	236	PF00179	0.507
MOD_SUMO_rev_2	268	278	PF00179	0.448
TRG_DiLeu_BaEn_1	115	120	PF01217	0.458
TRG_DiLeu_BaEn_3	381	387	PF01217	0.434
TRG_DiLeu_BaEn_4	435	441	PF01217	0.509
TRG_ER_diArg_1	14	17	PF00400	0.582
TRG_ER_diArg_1	185	188	PF00400	0.520
TRG_ER_diArg_1	209	212	PF00400	0.520
TRG_ER_diArg_1	239	241	PF00400	0.444
TRG_ER_diArg_1	246	248	PF00400	0.422
TRG_ER_diArg_1	297	300	PF00400	0.513
TRG_ER_diArg_1	326	329	PF00400	0.453
TRG_ER_diArg_1	403	406	PF00400	0.520
TRG_ER_diArg_1	425	428	PF00400	0.423
TRG_ER_diArg_1	454	457	PF00400	0.386
TRG_ER_diArg_1	471	473	PF00400	0.496
TRG_ER_diArg_1	81	83	PF00400	0.551
TRG_NES_CRM1_1	221	234	PF08389	0.551
TRG_Pf-PMV_PEXEL_1	133	137	PF00026	0.320
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.234
TRG_Pf-PMV_PEXEL_1	385	390	PF00026	0.301
TRG_Pf-PMV_PEXEL_1	405	409	PF00026	0.114
TRG_Pf-PMV_PEXEL_1	457	461	PF00026	0.223

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5W7	Leptomonas seymouri	76%	100%
A0A0S4INS9	Bodo saltans	46%	98%
A0A1X0NS36	Trypanosomatidae	57%	100%
A0A3S7WRD8	Leishmania donovani	97%	100%
A0A422NGP1	Trypanosoma rangeli	55%	100%
A0A480NP79	Sus scrofa	31%	87%
A4H6A3	Leishmania braziliensis	90%	100%
A4HUM7	Leishmania infantum	97%	100%
A8I9E8	Chlamydomonas reinhardtii	44%	96%
C9ZVQ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
Q32LN4	Bos taurus	32%	87%
Q4QH99	Leishmania major	96%	100%
Q9D9U9	Mus musculus	36%	87%
Q9UL16	Homo sapiens	31%	87%
V5BJP2	Trypanosoma cruzi	57%	99%