RING-type E3 ubiquitin transferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania mexicana

UniProt:

E9ANC4_LEIMU

TriTrypDb:

LmxM.10.1140

Length:

360

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ANC4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANC4

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004842	ubiquitin-protein transferase activity	4	11
GO:0005488	binding	1	11
GO:0016740	transferase activity	2	11
GO:0019787	ubiquitin-like protein transferase activity	3	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0061630	ubiquitin protein ligase activity	5	11
GO:0061659	ubiquitin-like protein ligase activity	4	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	76	78	PF00675	0.546
CLV_PCSK_KEX2_1	76	78	PF00082	0.577
CLV_PCSK_SKI1_1	271	275	PF00082	0.432
CLV_PCSK_SKI1_1	356	360	PF00082	0.358
DOC_CYCLIN_RxL_1	91	102	PF00134	0.337
DOC_CYCLIN_yCln2_LP_2	167	173	PF00134	0.577
DOC_MAPK_gen_1	125	132	PF00069	0.552
DOC_MAPK_gen_1	271	279	PF00069	0.428
DOC_MAPK_gen_1	76	82	PF00069	0.500
DOC_PP2B_LxvP_1	162	165	PF13499	0.530
DOC_PP2B_LxvP_1	243	246	PF13499	0.414
DOC_PP4_FxxP_1	31	34	PF00568	0.543
DOC_USP7_MATH_1	118	122	PF00917	0.385
DOC_USP7_MATH_1	139	143	PF00917	0.599
DOC_USP7_MATH_1	224	228	PF00917	0.589
DOC_USP7_MATH_1	253	257	PF00917	0.656
DOC_USP7_MATH_1	86	90	PF00917	0.457
DOC_WW_Pin1_4	220	225	PF00397	0.697
DOC_WW_Pin1_4	247	252	PF00397	0.470
LIG_14-3-3_CanoR_1	131	138	PF00244	0.600
LIG_14-3-3_CanoR_1	187	191	PF00244	0.432
LIG_14-3-3_CanoR_1	252	258	PF00244	0.596
LIG_14-3-3_CanoR_1	341	349	PF00244	0.302
LIG_14-3-3_CterR_2	356	360	PF00244	0.347
LIG_Actin_WH2_2	119	135	PF00022	0.347
LIG_BRCT_BRCA1_1	34	38	PF00533	0.569
LIG_FHA_1	100	106	PF00498	0.474
LIG_FHA_1	147	153	PF00498	0.501
LIG_FHA_1	157	163	PF00498	0.528
LIG_FHA_1	180	186	PF00498	0.637
LIG_FHA_1	267	273	PF00498	0.505
LIG_FHA_1	320	326	PF00498	0.273
LIG_FHA_1	65	71	PF00498	0.461
LIG_FHA_2	14	20	PF00498	0.580
LIG_FHA_2	239	245	PF00498	0.387
LIG_FHA_2	3	9	PF00498	0.625
LIG_FHA_2	301	307	PF00498	0.469
LIG_FHA_2	64	70	PF00498	0.453
LIG_LIR_Nem_3	189	193	PF02991	0.363
LIG_Pex14_2	27	31	PF04695	0.489
LIG_PTB_Apo_2	278	285	PF02174	0.509
LIG_PTB_Phospho_1	278	284	PF10480	0.508
LIG_SH2_CRK	190	194	PF00017	0.393
LIG_SH2_STAP1	173	177	PF00017	0.582
LIG_SH2_STAP1	49	53	PF00017	0.585
LIG_SH2_STAT5	240	243	PF00017	0.350
LIG_SH2_STAT5	28	31	PF00017	0.479
LIG_SH2_STAT5	353	356	PF00017	0.384
LIG_SH3_1	226	232	PF00018	0.519
LIG_SH3_2	229	234	PF14604	0.476
LIG_SH3_3	155	161	PF00018	0.474
LIG_SH3_3	226	232	PF00018	0.755
LIG_SH3_3	295	301	PF00018	0.557
LIG_SH3_3	40	46	PF00018	0.622
LIG_SUMO_SIM_par_1	191	196	PF11976	0.333
LIG_SUMO_SIM_par_1	66	71	PF11976	0.472
LIG_TRAF2_1	218	221	PF00917	0.543
LIG_TRAF2_1	245	248	PF00917	0.595
LIG_TRAF2_1	303	306	PF00917	0.497
LIG_TYR_ITIM	188	193	PF00017	0.375
LIG_TYR_ITIM	238	243	PF00017	0.369
LIG_UBA3_1	167	172	PF00899	0.583
MOD_CDK_SPK_2	247	252	PF00069	0.403
MOD_CDK_SPxK_1	220	226	PF00069	0.604
MOD_CK1_1	84	90	PF00069	0.487
MOD_CK2_1	13	19	PF00069	0.598
MOD_CK2_1	2	8	PF00069	0.624
MOD_CK2_1	238	244	PF00069	0.473
MOD_CK2_1	300	306	PF00069	0.528
MOD_GlcNHglycan	134	137	PF01048	0.611
MOD_GlcNHglycan	83	86	PF01048	0.515
MOD_GSK3_1	148	155	PF00069	0.607
MOD_GSK3_1	175	182	PF00069	0.629
MOD_GSK3_1	220	227	PF00069	0.686
MOD_GSK3_1	64	71	PF00069	0.424
MOD_N-GLC_1	2	7	PF02516	0.669
MOD_N-GLC_1	206	211	PF02516	0.733
MOD_N-GLC_2	334	336	PF02516	0.352
MOD_N-GLC_2	345	347	PF02516	0.212
MOD_NEK2_1	132	137	PF00069	0.586
MOD_NEK2_1	180	185	PF00069	0.622
MOD_NEK2_1	68	73	PF00069	0.445
MOD_NEK2_1	99	104	PF00069	0.331
MOD_NMyristoyl	1	7	PF02799	0.622
MOD_PIKK_1	105	111	PF00454	0.507
MOD_PIKK_1	206	212	PF00454	0.704
MOD_PIKK_1	224	230	PF00454	0.772
MOD_PKA_2	186	192	PF00069	0.450
MOD_PKA_2	266	272	PF00069	0.469
MOD_PKA_2	340	346	PF00069	0.406
MOD_Plk_1	320	326	PF00069	0.316
MOD_Plk_2-3	300	306	PF00069	0.554
MOD_Plk_4	153	159	PF00069	0.548
MOD_Plk_4	238	244	PF00069	0.374
MOD_Plk_4	320	326	PF00069	0.275
MOD_ProDKin_1	220	226	PF00069	0.698
MOD_ProDKin_1	247	253	PF00069	0.480
MOD_SUMO_for_1	171	174	PF00179	0.626
TRG_DiLeu_BaLyEn_6	43	48	PF01217	0.453
TRG_ENDOCYTIC_2	190	193	PF00928	0.400
TRG_ENDOCYTIC_2	240	243	PF00928	0.350
TRG_ENDOCYTIC_2	28	31	PF00928	0.588
TRG_ER_diArg_1	113	116	PF00400	0.467
TRG_ER_diArg_1	124	127	PF00400	0.572
TRG_ER_diArg_1	75	77	PF00400	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6A9	Leptomonas seymouri	47%	93%
A0A1X0NRX0	Trypanosomatidae	36%	98%
A0A3R7KAZ9	Trypanosoma rangeli	36%	100%
A0A3S7WRB2	Leishmania donovani	94%	100%
A4H6A2	Leishmania braziliensis	79%	99%
A4HUM6	Leishmania infantum	94%	100%
C9ZVQ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
Q4QHA0	Leishmania major	93%	100%
V5BTV5	Trypanosoma cruzi	37%	99%