LeishMANIAdb
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Amidohydrolase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Amidohydrolase
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9ANC2_LEIMU
TriTrypDb:
LmxM.10.1120
Length:
139

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ANC2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANC2

PDB structure(s): 7ane_aw

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 106 110 PF00656 0.662
CLV_NRD_NRD_1 49 51 PF00675 0.523
CLV_NRD_NRD_1 98 100 PF00675 0.733
CLV_PCSK_KEX2_1 30 32 PF00082 0.563
CLV_PCSK_KEX2_1 98 100 PF00082 0.709
CLV_PCSK_PC1ET2_1 30 32 PF00082 0.637
CLV_PCSK_SKI1_1 27 31 PF00082 0.562
CLV_PCSK_SKI1_1 99 103 PF00082 0.696
DOC_MAPK_DCC_7 30 38 PF00069 0.596
DOC_MAPK_gen_1 127 135 PF00069 0.565
DOC_MAPK_gen_1 30 38 PF00069 0.587
DOC_MAPK_MEF2A_6 30 38 PF00069 0.596
DOC_WW_Pin1_4 117 122 PF00397 0.676
LIG_deltaCOP1_diTrp_1 57 65 PF00928 0.585
LIG_FHA_1 9 15 PF00498 0.600
LIG_LIR_Gen_1 57 65 PF02991 0.567
LIG_LIR_Gen_1 78 87 PF02991 0.585
LIG_LIR_Gen_1 93 102 PF02991 0.393
LIG_LIR_Nem_3 120 125 PF02991 0.586
LIG_LIR_Nem_3 57 61 PF02991 0.570
LIG_LIR_Nem_3 78 83 PF02991 0.607
LIG_LIR_Nem_3 93 97 PF02991 0.383
LIG_LYPXL_yS_3 122 125 PF13949 0.589
LIG_SH2_CRK 94 98 PF00017 0.651
LIG_SH2_GRB2like 94 97 PF00017 0.646
LIG_SH2_NCK_1 80 84 PF00017 0.599
LIG_SH2_STAT5 13 16 PF00017 0.548
LIG_SH2_STAT5 80 83 PF00017 0.588
LIG_SH3_3 58 64 PF00018 0.587
MOD_GlcNHglycan 113 116 PF01048 0.663
MOD_NEK2_1 111 116 PF00069 0.637
MOD_NEK2_2 45 50 PF00069 0.531
MOD_ProDKin_1 117 123 PF00069 0.676
TRG_ENDOCYTIC_2 122 125 PF00928 0.554
TRG_ENDOCYTIC_2 80 83 PF00928 0.604
TRG_ENDOCYTIC_2 94 97 PF00928 0.573
TRG_ER_diArg_1 97 99 PF00400 0.708
TRG_NES_CRM1_1 32 46 PF08389 0.631
TRG_NLS_MonoExtC_3 22 27 PF00514 0.652
TRG_NLS_MonoExtN_4 23 28 PF00514 0.655

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5W9 Leptomonas seymouri 79% 75%
A0A0S4IQ26 Bodo saltans 56% 68%
A0A1X0NQG0 Trypanosomatidae 70% 75%
A0A3Q8I8X2 Leishmania donovani 98% 100%
A0A422NGL2 Trypanosoma rangeli 70% 74%
A4H6A0 Leishmania braziliensis 90% 100%
A4HUM4 Leishmania infantum 99% 100%
C9ZVQ5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 68% 76%
Q4QHA2 Leishmania major 99% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS