LsmAD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PAB1-binding protein , putative

Species:

Leishmania mexicana

UniProt:

E9ANC1_LEIMU

TriTrypDb:

LmxM.10.1110

Length:

527

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0010494	cytoplasmic stress granule	5	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ANC1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANC1

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0034063	stress granule assembly	7	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0140694	non-membrane-bounded organelle assembly	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	41	45	PF00656	0.380
CLV_C14_Caspase3-7	482	486	PF00656	0.852
CLV_NRD_NRD_1	229	231	PF00675	0.689
CLV_NRD_NRD_1	502	504	PF00675	0.821
CLV_PCSK_KEX2_1	223	225	PF00082	0.761
CLV_PCSK_KEX2_1	502	504	PF00082	0.808
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.753
CLV_PCSK_SKI1_1	179	183	PF00082	0.469
CLV_PCSK_SKI1_1	308	312	PF00082	0.626
CLV_PCSK_SKI1_1	93	97	PF00082	0.639
DEG_Nend_Nbox_1	1	3	PF02207	0.757
DEG_SCF_FBW7_1	244	251	PF00400	0.632
DEG_SPOP_SBC_1	234	238	PF00917	0.777
DOC_CYCLIN_yClb5_NLxxxL_5	190	196	PF00134	0.469
DOC_MAPK_MEF2A_6	12	20	PF00069	0.357
DOC_PP1_RVXF_1	115	122	PF00149	0.612
DOC_PP2B_LxvP_1	277	280	PF13499	0.794
DOC_PP4_FxxP_1	303	306	PF00568	0.721
DOC_PP4_MxPP_1	421	424	PF00568	0.771
DOC_SPAK_OSR1_1	148	152	PF12202	0.475
DOC_USP7_MATH_1	219	223	PF00917	0.691
DOC_USP7_MATH_1	235	239	PF00917	0.733
DOC_USP7_MATH_1	283	287	PF00917	0.820
DOC_USP7_MATH_1	296	300	PF00917	0.629
DOC_USP7_MATH_1	306	310	PF00917	0.615
DOC_USP7_MATH_1	4	8	PF00917	0.667
DOC_USP7_MATH_1	483	487	PF00917	0.764
DOC_USP7_UBL2_3	523	527	PF12436	0.703
DOC_WW_Pin1_4	244	249	PF00397	0.725
DOC_WW_Pin1_4	292	297	PF00397	0.716
DOC_WW_Pin1_4	298	303	PF00397	0.713
DOC_WW_Pin1_4	431	436	PF00397	0.828
DOC_WW_Pin1_4	98	103	PF00397	0.690
LIG_14-3-3_CanoR_1	449	459	PF00244	0.748
LIG_BIR_III_4	218	222	PF00653	0.729
LIG_deltaCOP1_diTrp_1	330	337	PF00928	0.708
LIG_eIF4E_1	15	21	PF01652	0.357
LIG_EVH1_1	277	281	PF00568	0.794
LIG_FHA_1	159	165	PF00498	0.357
LIG_FHA_1	187	193	PF00498	0.375
LIG_FHA_1	201	207	PF00498	0.373
LIG_FHA_1	22	28	PF00498	0.475
LIG_FHA_1	299	305	PF00498	0.725
LIG_FHA_1	496	502	PF00498	0.745
LIG_FHA_2	152	158	PF00498	0.366
LIG_FHA_2	160	166	PF00498	0.344
LIG_FHA_2	178	184	PF00498	0.357
LIG_FHA_2	227	233	PF00498	0.758
LIG_FHA_2	41	47	PF00498	0.369
LIG_LIR_Apic_2	301	306	PF02991	0.724
LIG_LIR_Apic_2	322	328	PF02991	0.624
LIG_LIR_Apic_2	343	348	PF02991	0.763
LIG_LIR_Gen_1	137	145	PF02991	0.590
LIG_LIR_Gen_1	14	25	PF02991	0.383
LIG_LIR_Nem_3	137	143	PF02991	0.601
LIG_LIR_Nem_3	14	20	PF02991	0.383
LIG_PAM2_1	294	306	PF00658	0.659
LIG_RPA_C_Fungi	37	49	PF08784	0.469
LIG_SH2_CRK	325	329	PF00017	0.633
LIG_SH2_CRK	345	349	PF00017	0.779
LIG_SH2_CRK	360	364	PF00017	0.568
LIG_SH2_GRB2like	17	20	PF00017	0.357
LIG_SH2_NCK_1	325	329	PF00017	0.691
LIG_SH2_NCK_1	345	349	PF00017	0.791
LIG_SH2_SRC	84	87	PF00017	0.469
LIG_SH2_STAP1	160	164	PF00017	0.357
LIG_SH2_STAP1	338	342	PF00017	0.671
LIG_SH2_STAP1	84	88	PF00017	0.469
LIG_SH2_STAT5	15	18	PF00017	0.357
LIG_SH2_STAT5	160	163	PF00017	0.357
LIG_SH2_STAT5	205	208	PF00017	0.475
LIG_SH3_3	238	244	PF00018	0.768
LIG_SH3_3	262	268	PF00018	0.810
LIG_SH3_3	272	278	PF00018	0.684
LIG_SH3_3	290	296	PF00018	0.651
LIG_SH3_3	299	305	PF00018	0.738
LIG_SH3_3	361	367	PF00018	0.748
LIG_SH3_3	421	427	PF00018	0.747
LIG_SH3_3	453	459	PF00018	0.700
LIG_SUMO_SIM_par_1	23	29	PF11976	0.475
LIG_TRAF2_1	270	273	PF00917	0.686
LIG_TYR_ITIM	13	18	PF00017	0.357
LIG_UBA3_1	87	93	PF00899	0.475
LIG_WRC_WIRS_1	307	312	PF05994	0.642
MOD_CDC14_SPxK_1	434	437	PF00782	0.760
MOD_CDK_SPxK_1	431	437	PF00069	0.768
MOD_CK1_1	134	140	PF00069	0.700
MOD_CK1_1	167	173	PF00069	0.357
MOD_CK1_1	222	228	PF00069	0.778
MOD_CK1_1	343	349	PF00069	0.650
MOD_CK1_1	451	457	PF00069	0.678
MOD_CK1_1	73	79	PF00069	0.470
MOD_CK2_1	151	157	PF00069	0.357
MOD_CK2_1	177	183	PF00069	0.469
MOD_CK2_1	226	232	PF00069	0.756
MOD_Cter_Amidation	521	524	PF01082	0.788
MOD_GlcNHglycan	185	189	PF01048	0.431
MOD_GlcNHglycan	224	227	PF01048	0.693
MOD_GlcNHglycan	237	240	PF01048	0.757
MOD_GlcNHglycan	254	257	PF01048	0.609
MOD_GlcNHglycan	286	289	PF01048	0.814
MOD_GlcNHglycan	298	301	PF01048	0.566
MOD_GlcNHglycan	481	484	PF01048	0.783
MOD_GlcNHglycan	485	489	PF01048	0.736
MOD_GSK3_1	196	203	PF00069	0.380
MOD_GSK3_1	222	229	PF00069	0.745
MOD_GSK3_1	244	251	PF00069	0.696
MOD_GSK3_1	292	299	PF00069	0.706
MOD_GSK3_1	459	466	PF00069	0.847
MOD_GSK3_1	479	486	PF00069	0.549
MOD_N-GLC_1	4	9	PF02516	0.659
MOD_NEK2_1	159	164	PF00069	0.367
MOD_NEK2_1	38	43	PF00069	0.418
MOD_PIKK_1	451	457	PF00454	0.796
MOD_PKA_2	219	225	PF00069	0.728
MOD_PKA_2	448	454	PF00069	0.728
MOD_Plk_1	340	346	PF00069	0.630
MOD_Plk_1	76	82	PF00069	0.390
MOD_Plk_2-3	115	121	PF00069	0.698
MOD_Plk_4	21	27	PF00069	0.475
MOD_Plk_4	289	295	PF00069	0.855
MOD_Plk_4	306	312	PF00069	0.524
MOD_Plk_4	313	319	PF00069	0.566
MOD_ProDKin_1	244	250	PF00069	0.726
MOD_ProDKin_1	292	298	PF00069	0.714
MOD_ProDKin_1	431	437	PF00069	0.828
MOD_ProDKin_1	98	104	PF00069	0.688
MOD_SUMO_rev_2	109	119	PF00179	0.721
MOD_SUMO_rev_2	165	170	PF00179	0.469
MOD_SUMO_rev_2	85	95	PF00179	0.469
TRG_DiLeu_BaEn_2	50	56	PF01217	0.469
TRG_DiLeu_BaEn_4	272	278	PF01217	0.795
TRG_ENDOCYTIC_2	15	18	PF00928	0.357
TRG_ENDOCYTIC_2	84	87	PF00928	0.357
TRG_ER_diArg_1	501	503	PF00400	0.807
TRG_ER_diLys_1	523	527	PF00400	0.856
TRG_NLS_MonoExtC_3	498	503	PF00514	0.806
TRG_NLS_MonoExtN_4	496	503	PF00514	0.747

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I433	Leptomonas seymouri	68%	100%
A0A1X0NQC5	Trypanosomatidae	35%	95%
A0A3S5H6H2	Leishmania donovani	96%	100%
A0A422NGM0	Trypanosoma rangeli	37%	96%
A4H699	Leishmania braziliensis	87%	100%
A4HUM3	Leishmania infantum	96%	100%
Q4QHA3	Leishmania major	94%	100%
V5DKQ2	Trypanosoma cruzi	37%	96%