Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ANC0_LEIMU

TriTrypDb:

LmxM.10.1100

Length:

425

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ANC0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANC0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	229	231	PF00675	0.521
CLV_NRD_NRD_1	394	396	PF00675	0.686
CLV_NRD_NRD_1	48	50	PF00675	0.641
CLV_NRD_NRD_1	5	7	PF00675	0.724
CLV_NRD_NRD_1	52	54	PF00675	0.624
CLV_NRD_NRD_1	78	80	PF00675	0.559
CLV_PCSK_KEX2_1	194	196	PF00082	0.595
CLV_PCSK_KEX2_1	229	231	PF00082	0.521
CLV_PCSK_KEX2_1	394	396	PF00082	0.686
CLV_PCSK_KEX2_1	48	50	PF00082	0.526
CLV_PCSK_KEX2_1	5	7	PF00082	0.724
CLV_PCSK_KEX2_1	52	54	PF00082	0.624
CLV_PCSK_PC1ET2_1	194	196	PF00082	0.595
CLV_PCSK_PC7_1	190	196	PF00082	0.589
CLV_PCSK_PC7_1	48	54	PF00082	0.496
CLV_PCSK_SKI1_1	195	199	PF00082	0.580
CLV_PCSK_SKI1_1	247	251	PF00082	0.535
CLV_PCSK_SKI1_1	351	355	PF00082	0.543
CLV_PCSK_SKI1_1	382	386	PF00082	0.621
CLV_PCSK_SKI1_1	403	407	PF00082	0.616
CLV_PCSK_SKI1_1	5	9	PF00082	0.715
DEG_APCC_DBOX_1	167	175	PF00400	0.589
DEG_APCC_DBOX_1	229	237	PF00400	0.506
DEG_APCC_DBOX_1	4	12	PF00400	0.706
DEG_APCC_DBOX_1	78	86	PF00400	0.461
DOC_CDC14_PxL_1	279	287	PF14671	0.520
DOC_CKS1_1	252	257	PF01111	0.570
DOC_CYCLIN_RxL_1	244	254	PF00134	0.384
DOC_MAPK_DCC_7	114	122	PF00069	0.678
DOC_MAPK_DCC_7	62	71	PF00069	0.475
DOC_MAPK_gen_1	12	20	PF00069	0.637
DOC_MAPK_gen_1	229	235	PF00069	0.509
DOC_MAPK_gen_1	59	69	PF00069	0.584
DOC_MAPK_MEF2A_6	114	122	PF00069	0.678
DOC_MAPK_MEF2A_6	14	22	PF00069	0.668
DOC_MAPK_MEF2A_6	345	354	PF00069	0.639
DOC_MAPK_MEF2A_6	62	71	PF00069	0.475
DOC_MAPK_RevD_3	67	80	PF00069	0.379
DOC_PP2B_LxvP_1	197	200	PF13499	0.583
DOC_USP7_MATH_2	232	238	PF00917	0.601
DOC_WW_Pin1_4	248	253	PF00397	0.585
DOC_WW_Pin1_4	343	348	PF00397	0.790
DOC_WW_Pin1_4	406	411	PF00397	0.733
LIG_14-3-3_CanoR_1	135	144	PF00244	0.611
LIG_14-3-3_CanoR_1	181	189	PF00244	0.658
LIG_14-3-3_CanoR_1	257	267	PF00244	0.574
LIG_14-3-3_CanoR_1	324	330	PF00244	0.790
LIG_14-3-3_CanoR_1	403	408	PF00244	0.618
LIG_EH1_1	60	68	PF00400	0.426
LIG_eIF4E_1	335	341	PF01652	0.749
LIG_FHA_1	131	137	PF00498	0.652
LIG_FHA_1	17	23	PF00498	0.658
LIG_FHA_1	259	265	PF00498	0.372
LIG_FHA_1	335	341	PF00498	0.827
LIG_FHA_1	58	64	PF00498	0.546
LIG_FHA_2	329	335	PF00498	0.739
LIG_FHA_2	344	350	PF00498	0.657
LIG_LIR_Gen_1	375	385	PF02991	0.626
LIG_LIR_Nem_3	289	294	PF02991	0.647
LIG_LYPXL_yS_3	276	279	PF13949	0.516
LIG_LYPXL_yS_3	294	297	PF13949	0.562
LIG_MYND_1	413	417	PF01753	0.534
LIG_NRBOX	263	269	PF00104	0.502
LIG_Pex14_1	227	231	PF04695	0.508
LIG_PTB_Apo_2	55	62	PF02174	0.663
LIG_PTB_Apo_2	95	102	PF02174	0.374
LIG_PTB_Phospho_1	95	101	PF10480	0.368
LIG_RPA_C_Fungi	311	323	PF08784	0.738
LIG_SH2_SRC	38	41	PF00017	0.384
LIG_SH2_STAP1	109	113	PF00017	0.462
LIG_SH2_STAT5	105	108	PF00017	0.536
LIG_SH2_STAT5	335	338	PF00017	0.647
LIG_SH2_STAT5	38	41	PF00017	0.384
LIG_SH3_2	252	257	PF14604	0.455
LIG_SH3_3	115	121	PF00018	0.637
LIG_SH3_3	171	177	PF00018	0.403
LIG_SH3_3	249	255	PF00018	0.521
LIG_SH3_3	292	298	PF00018	0.559
LIG_SH3_3	344	350	PF00018	0.766
LIG_SH3_3	405	411	PF00018	0.746
LIG_SUMO_SIM_par_1	18	24	PF11976	0.577
LIG_SUMO_SIM_par_1	231	237	PF11976	0.597
LIG_TRAF2_1	205	208	PF00917	0.636
LIG_TRAF2_1	298	301	PF00917	0.521
LIG_TRAF2_1	331	334	PF00917	0.621
LIG_TRAF2_1	43	46	PF00917	0.462
LIG_TRAF2_1	72	75	PF00917	0.541
LIG_TYR_ITIM	274	279	PF00017	0.626
LIG_WRC_WIRS_1	239	244	PF05994	0.601
LIG_WRC_WIRS_1	354	359	PF05994	0.720
MOD_CDK_SPxK_1	251	257	PF00069	0.448
MOD_CK1_1	157	163	PF00069	0.705
MOD_CK1_1	251	257	PF00069	0.720
MOD_CK1_1	328	334	PF00069	0.524
MOD_CK1_1	418	424	PF00069	0.680
MOD_CK2_1	263	269	PF00069	0.604
MOD_CK2_1	328	334	PF00069	0.524
MOD_CK2_1	40	46	PF00069	0.513
MOD_CK2_1	69	75	PF00069	0.568
MOD_GlcNHglycan	156	159	PF01048	0.737
MOD_GlcNHglycan	200	203	PF01048	0.631
MOD_GlcNHglycan	236	239	PF01048	0.592
MOD_GlcNHglycan	258	261	PF01048	0.597
MOD_GlcNHglycan	417	420	PF01048	0.623
MOD_GSK3_1	130	137	PF00069	0.626
MOD_GSK3_1	234	241	PF00069	0.600
MOD_GSK3_1	324	331	PF00069	0.636
MOD_GSK3_1	368	375	PF00069	0.727
MOD_GSK3_1	418	425	PF00069	0.648
MOD_N-GLC_1	325	330	PF02516	0.519
MOD_N-GLC_1	57	62	PF02516	0.659
MOD_NEK2_1	144	149	PF00069	0.649
MOD_NEK2_1	341	346	PF00069	0.818
MOD_NEK2_1	353	358	PF00069	0.512
MOD_NEK2_2	238	243	PF00069	0.596
MOD_PIKK_1	372	378	PF00454	0.646
MOD_PKA_2	134	140	PF00069	0.626
MOD_PKA_2	256	262	PF00069	0.618
MOD_PKA_2	341	347	PF00069	0.567
MOD_Plk_1	325	331	PF00069	0.520
MOD_Plk_1	57	63	PF00069	0.556
MOD_Plk_4	157	163	PF00069	0.654
MOD_Plk_4	238	244	PF00069	0.513
MOD_Plk_4	263	269	PF00069	0.604
MOD_ProDKin_1	248	254	PF00069	0.591
MOD_ProDKin_1	343	349	PF00069	0.782
MOD_ProDKin_1	406	412	PF00069	0.730
MOD_SUMO_rev_2	72	82	PF00179	0.424
TRG_DiLeu_BaEn_1	301	306	PF01217	0.539
TRG_DiLeu_BaEn_2	2	8	PF01217	0.599
TRG_DiLeu_BaEn_4	269	275	PF01217	0.615
TRG_DiLeu_BaLyEn_6	178	183	PF01217	0.589
TRG_DiLeu_BaLyEn_6	348	353	PF01217	0.654
TRG_ENDOCYTIC_2	276	279	PF00928	0.516
TRG_ENDOCYTIC_2	294	297	PF00928	0.562
TRG_ENDOCYTIC_2	378	381	PF00928	0.612
TRG_ER_diArg_1	229	231	PF00400	0.521
TRG_ER_diArg_1	29	32	PF00400	0.531
TRG_ER_diArg_1	393	395	PF00400	0.680
TRG_ER_diArg_1	47	49	PF00400	0.509
TRG_ER_diArg_1	5	7	PF00400	0.724
TRG_ER_diArg_1	51	53	PF00400	0.610
TRG_ER_diArg_1	61	64	PF00400	0.404
TRG_NES_CRM1_1	215	228	PF08389	0.563
TRG_Pf-PMV_PEXEL_1	181	185	PF00026	0.658
TRG_Pf-PMV_PEXEL_1	394	399	PF00026	0.689

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDA4	Leptomonas seymouri	47%	100%
A0A3Q8IHA3	Leishmania donovani	86%	100%
A4H698	Leishmania braziliensis	68%	100%
A4HUM2	Leishmania infantum	87%	100%
Q4QHA4	Leishmania major	85%	100%