MIF4G domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic translation initiation factor 4 gamma 5

Species:

Leishmania mexicana

UniProt:

E9ANB8_LEIMU

TriTrypDb:

LmxM.10.1080

Length:

781

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016281	eukaryotic translation initiation factor 4F complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ANB8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANB8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006412	translation	4	1
GO:0006518	peptide metabolic process	4	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0019538	protein metabolic process	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	1
GO:0043043	peptide biosynthetic process	5	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043603	amide metabolic process	3	1
GO:0043604	amide biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003743	translation initiation factor activity	4	12
GO:0005488	binding	1	12
GO:0008135	translation factor activity, RNA binding	3	12
GO:0045182	translation regulator activity	1	12
GO:0090079	translation regulator activity, nucleic acid binding	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.622
CLV_NRD_NRD_1	112	114	PF00675	0.683
CLV_NRD_NRD_1	165	167	PF00675	0.522
CLV_NRD_NRD_1	328	330	PF00675	0.263
CLV_NRD_NRD_1	403	405	PF00675	0.690
CLV_NRD_NRD_1	705	707	PF00675	0.469
CLV_NRD_NRD_1	739	741	PF00675	0.474
CLV_NRD_NRD_1	779	781	PF00675	0.622
CLV_PCSK_KEX2_1	272	274	PF00082	0.343
CLV_PCSK_KEX2_1	328	330	PF00082	0.255
CLV_PCSK_KEX2_1	377	379	PF00082	0.254
CLV_PCSK_KEX2_1	403	405	PF00082	0.718
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.338
CLV_PCSK_PC1ET2_1	377	379	PF00082	0.298
CLV_PCSK_SKI1_1	161	165	PF00082	0.634
CLV_PCSK_SKI1_1	189	193	PF00082	0.295
CLV_PCSK_SKI1_1	209	213	PF00082	0.261
CLV_PCSK_SKI1_1	273	277	PF00082	0.319
CLV_PCSK_SKI1_1	518	522	PF00082	0.471
CLV_PCSK_SKI1_1	603	607	PF00082	0.611
CLV_PCSK_SKI1_1	702	706	PF00082	0.460
CLV_PCSK_SKI1_1	707	711	PF00082	0.464
CLV_PCSK_SKI1_1	733	737	PF00082	0.488
CLV_PCSK_SKI1_1	740	744	PF00082	0.436
CLV_Separin_Metazoa	251	255	PF03568	0.550
CLV_Separin_Metazoa	703	707	PF03568	0.503
DEG_APCC_DBOX_1	504	512	PF00400	0.418
DEG_APCC_DBOX_1	739	747	PF00400	0.487
DEG_Nend_UBRbox_3	1	3	PF02207	0.735
DOC_CKS1_1	67	72	PF01111	0.641
DOC_CYCLIN_yCln2_LP_2	67	73	PF00134	0.681
DOC_MAPK_gen_1	186	196	PF00069	0.508
DOC_MAPK_gen_1	292	299	PF00069	0.457
DOC_MAPK_MEF2A_6	712	721	PF00069	0.480
DOC_PP1_RVXF_1	207	213	PF00149	0.519
DOC_PP1_RVXF_1	284	290	PF00149	0.481
DOC_PP1_RVXF_1	375	382	PF00149	0.497
DOC_SPAK_OSR1_1	610	614	PF12202	0.358
DOC_USP7_MATH_1	118	122	PF00917	0.649
DOC_USP7_MATH_1	218	222	PF00917	0.465
DOC_WW_Pin1_4	275	280	PF00397	0.550
DOC_WW_Pin1_4	618	623	PF00397	0.433
DOC_WW_Pin1_4	66	71	PF00397	0.689
DOC_WW_Pin1_4	665	670	PF00397	0.542
DOC_WW_Pin1_4	675	680	PF00397	0.422
LIG_14-3-3_CanoR_1	19	24	PF00244	0.665
LIG_14-3-3_CanoR_1	197	204	PF00244	0.472
LIG_14-3-3_CanoR_1	257	261	PF00244	0.556
LIG_14-3-3_CanoR_1	273	278	PF00244	0.374
LIG_14-3-3_CanoR_1	494	500	PF00244	0.403
LIG_14-3-3_CanoR_1	761	765	PF00244	0.529
LIG_14-3-3_CanoR_1	8	13	PF00244	0.696
LIG_Actin_WH2_2	690	708	PF00022	0.504
LIG_APCC_ABBAyCdc20_2	147	153	PF00400	0.678
LIG_BRCT_BRCA1_1	683	687	PF00533	0.335
LIG_BRCT_BRCA1_1	730	734	PF00533	0.478
LIG_CaM_IQ_9	284	300	PF13499	0.538
LIG_FHA_1	303	309	PF00498	0.468
LIG_FHA_1	487	493	PF00498	0.370
LIG_FHA_1	568	574	PF00498	0.355
LIG_FHA_1	714	720	PF00498	0.415
LIG_FHA_2	198	204	PF00498	0.479
LIG_FHA_2	214	220	PF00498	0.479
LIG_FHA_2	364	370	PF00498	0.519
LIG_FHA_2	595	601	PF00498	0.640
LIG_FHA_2	636	642	PF00498	0.609
LIG_FHA_2	656	662	PF00498	0.239
LIG_FHA_2	761	767	PF00498	0.488
LIG_HCF-1_HBM_1	101	104	PF13415	0.638
LIG_Integrin_isoDGR_2	427	429	PF01839	0.731
LIG_LIR_Gen_1	107	117	PF02991	0.633
LIG_LIR_Gen_1	220	231	PF02991	0.497
LIG_LIR_Gen_1	333	343	PF02991	0.468
LIG_LIR_Gen_1	452	460	PF02991	0.431
LIG_LIR_Gen_1	510	520	PF02991	0.412
LIG_LIR_Gen_1	540	551	PF02991	0.421
LIG_LIR_Gen_1	651	660	PF02991	0.420
LIG_LIR_Gen_1	684	694	PF02991	0.362
LIG_LIR_Nem_3	107	112	PF02991	0.542
LIG_LIR_Nem_3	220	226	PF02991	0.465
LIG_LIR_Nem_3	333	338	PF02991	0.468
LIG_LIR_Nem_3	452	456	PF02991	0.557
LIG_LIR_Nem_3	510	515	PF02991	0.393
LIG_LIR_Nem_3	540	546	PF02991	0.440
LIG_LIR_Nem_3	609	614	PF02991	0.400
LIG_LIR_Nem_3	651	656	PF02991	0.404
LIG_LIR_Nem_3	684	690	PF02991	0.341
LIG_LIR_Nem_3	699	704	PF02991	0.407
LIG_MLH1_MIPbox_1	683	687	PF16413	0.412
LIG_NRBOX	317	323	PF00104	0.465
LIG_NRBOX	613	619	PF00104	0.479
LIG_PCNA_PIPBox_1	380	389	PF02747	0.538
LIG_PCNA_PIPBox_1	527	536	PF02747	0.284
LIG_PCNA_yPIPBox_3	307	318	PF02747	0.587
LIG_PCNA_yPIPBox_3	377	387	PF02747	0.550
LIG_Pex14_1	491	495	PF04695	0.479
LIG_Pex14_2	734	738	PF04695	0.428
LIG_REV1ctd_RIR_1	209	217	PF16727	0.519
LIG_RPA_C_Fungi	744	756	PF08784	0.513
LIG_SH2_CRK	335	339	PF00017	0.433
LIG_SH2_CRK	620	624	PF00017	0.461
LIG_SH2_GRB2like	495	498	PF00017	0.490
LIG_SH2_GRB2like	652	655	PF00017	0.454
LIG_SH2_PTP2	227	230	PF00017	0.297
LIG_SH2_SRC	356	359	PF00017	0.415
LIG_SH2_STAP1	126	130	PF00017	0.635
LIG_SH2_STAP1	223	227	PF00017	0.433
LIG_SH2_STAP1	692	696	PF00017	0.516
LIG_SH2_STAT5	223	226	PF00017	0.315
LIG_SH2_STAT5	227	230	PF00017	0.280
LIG_SH2_STAT5	487	490	PF00017	0.363
LIG_SH2_STAT5	495	498	PF00017	0.372
LIG_SH2_STAT5	501	504	PF00017	0.414
LIG_SH2_STAT5	549	552	PF00017	0.361
LIG_SH2_STAT5	620	623	PF00017	0.465
LIG_SH2_STAT5	652	655	PF00017	0.364
LIG_SH2_STAT5	680	683	PF00017	0.369
LIG_SH2_STAT5	722	725	PF00017	0.361
LIG_SH3_2	74	79	PF14604	0.495
LIG_SH3_3	22	28	PF00018	0.724
LIG_SH3_3	343	349	PF00018	0.433
LIG_SH3_3	431	437	PF00018	0.629
LIG_SH3_3	445	451	PF00018	0.514
LIG_SH3_3	53	59	PF00018	0.693
LIG_SH3_3	69	75	PF00018	0.733
LIG_SH3_3	93	99	PF00018	0.616
LIG_SH3_4	62	69	PF00018	0.584
LIG_SUMO_SIM_anti_2	470	478	PF11976	0.424
LIG_SUMO_SIM_anti_2	482	487	PF11976	0.404
LIG_SUMO_SIM_anti_2	582	587	PF11976	0.316
LIG_SUMO_SIM_anti_2	638	644	PF11976	0.491
LIG_SUMO_SIM_anti_2	766	775	PF11976	0.422
LIG_SUMO_SIM_par_1	470	478	PF11976	0.547
LIG_SUMO_SIM_par_1	715	720	PF11976	0.467
LIG_SUMO_SIM_par_1	766	775	PF11976	0.470
LIG_TRAF2_1	200	203	PF00917	0.433
LIG_TRAF2_1	442	445	PF00917	0.709
LIG_TRAF2_1	537	540	PF00917	0.552
LIG_TRAF2_1	81	84	PF00917	0.768
LIG_TRAF2_2	599	604	PF00917	0.658
LIG_TYR_ITSM	331	338	PF00017	0.433
LIG_UBA3_1	511	518	PF00899	0.439
LIG_UBA3_1	530	536	PF00899	0.357
LIG_UBA3_1	542	548	PF00899	0.485
LIG_UBA3_1	735	741	PF00899	0.347
LIG_WRC_WIRS_1	686	691	PF05994	0.343
MOD_CK1_1	157	163	PF00069	0.570
MOD_CK1_1	221	227	PF00069	0.433
MOD_CK1_1	432	438	PF00069	0.725
MOD_CK1_1	474	480	PF00069	0.516
MOD_CK1_1	567	573	PF00069	0.369
MOD_CK1_1	94	100	PF00069	0.644
MOD_CK2_1	179	185	PF00069	0.409
MOD_CK2_1	196	202	PF00069	0.243
MOD_CK2_1	213	219	PF00069	0.335
MOD_CK2_1	234	240	PF00069	0.433
MOD_CK2_1	260	266	PF00069	0.421
MOD_CK2_1	363	369	PF00069	0.433
MOD_CK2_1	465	471	PF00069	0.448
MOD_CK2_1	534	540	PF00069	0.545
MOD_CK2_1	760	766	PF00069	0.478
MOD_CK2_1	768	774	PF00069	0.447
MOD_CK2_1	94	100	PF00069	0.676
MOD_GlcNHglycan	10	13	PF01048	0.617
MOD_GlcNHglycan	262	265	PF01048	0.438
MOD_GlcNHglycan	289	292	PF01048	0.430
MOD_GlcNHglycan	41	44	PF01048	0.649
MOD_GlcNHglycan	419	422	PF01048	0.786
MOD_GlcNHglycan	536	539	PF01048	0.548
MOD_GlcNHglycan	683	686	PF01048	0.355
MOD_GlcNHglycan	756	759	PF01048	0.474
MOD_GlcNHglycan	82	88	PF01048	0.729
MOD_GSK3_1	157	164	PF00069	0.588
MOD_GSK3_1	256	263	PF00069	0.402
MOD_GSK3_1	471	478	PF00069	0.520
MOD_GSK3_1	495	502	PF00069	0.479
MOD_GSK3_1	62	69	PF00069	0.692
MOD_GSK3_1	665	672	PF00069	0.512
MOD_GSK3_1	681	688	PF00069	0.241
MOD_N-GLC_1	142	147	PF02516	0.695
MOD_N-GLC_1	154	159	PF02516	0.673
MOD_N-GLC_1	212	217	PF02516	0.333
MOD_N-GLC_1	417	422	PF02516	0.727
MOD_NEK2_1	212	217	PF00069	0.313
MOD_NEK2_1	234	239	PF00069	0.343
MOD_NEK2_1	260	265	PF00069	0.439
MOD_NEK2_1	302	307	PF00069	0.332
MOD_NEK2_1	370	375	PF00069	0.340
MOD_NEK2_1	386	391	PF00069	0.433
MOD_NEK2_1	463	468	PF00069	0.437
MOD_NEK2_1	511	516	PF00069	0.484
MOD_NEK2_1	681	686	PF00069	0.407
MOD_NEK2_1	696	701	PF00069	0.390
MOD_NEK2_1	728	733	PF00069	0.513
MOD_NEK2_1	760	765	PF00069	0.513
MOD_NEK2_2	218	223	PF00069	0.315
MOD_PIKK_1	62	68	PF00454	0.763
MOD_PIKK_1	696	702	PF00454	0.504
MOD_PKA_2	196	202	PF00069	0.323
MOD_PKA_2	256	262	PF00069	0.441
MOD_PKA_2	363	369	PF00069	0.415
MOD_PKA_2	402	408	PF00069	0.712
MOD_PKA_2	7	13	PF00069	0.699
MOD_PKA_2	760	766	PF00069	0.516
MOD_Plk_1	142	148	PF00069	0.693
MOD_Plk_1	154	160	PF00069	0.675
MOD_Plk_1	218	224	PF00069	0.333
MOD_Plk_1	333	339	PF00069	0.415
MOD_Plk_1	503	509	PF00069	0.533
MOD_Plk_1	648	654	PF00069	0.480
MOD_Plk_1	765	771	PF00069	0.536
MOD_Plk_1	94	100	PF00069	0.687
MOD_Plk_2-3	142	148	PF00069	0.693
MOD_Plk_4	256	262	PF00069	0.418
MOD_Plk_4	27	33	PF00069	0.774
MOD_Plk_4	317	323	PF00069	0.433
MOD_Plk_4	333	339	PF00069	0.415
MOD_Plk_4	419	425	PF00069	0.671
MOD_Plk_4	471	477	PF00069	0.488
MOD_Plk_4	511	517	PF00069	0.533
MOD_Plk_4	552	558	PF00069	0.475
MOD_Plk_4	559	565	PF00069	0.491
MOD_Plk_4	635	641	PF00069	0.597
MOD_Plk_4	648	654	PF00069	0.356
MOD_Plk_4	713	719	PF00069	0.429
MOD_Plk_4	765	771	PF00069	0.461
MOD_ProDKin_1	275	281	PF00069	0.433
MOD_ProDKin_1	618	624	PF00069	0.445
MOD_ProDKin_1	66	72	PF00069	0.686
MOD_ProDKin_1	665	671	PF00069	0.533
MOD_ProDKin_1	675	681	PF00069	0.415
MOD_SUMO_for_1	187	190	PF00179	0.297
MOD_SUMO_for_1	77	80	PF00179	0.747
MOD_SUMO_rev_2	160	168	PF00179	0.532
MOD_SUMO_rev_2	592	599	PF00179	0.566
MOD_SUMO_rev_2	600	607	PF00179	0.541
TRG_DiLeu_BaEn_3	242	248	PF01217	0.415
TRG_ENDOCYTIC_2	223	226	PF00928	0.312
TRG_ENDOCYTIC_2	227	230	PF00928	0.283
TRG_ENDOCYTIC_2	335	338	PF00928	0.313
TRG_ENDOCYTIC_2	453	456	PF00928	0.549
TRG_ENDOCYTIC_2	701	704	PF00928	0.483
TRG_ER_diArg_1	505	508	PF00400	0.407
TRG_NES_CRM1_1	185	198	PF08389	0.357

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEC9	Leptomonas seymouri	71%	100%
A0A0S4J374	Bodo saltans	28%	90%
A0A1X0NQC6	Trypanosomatidae	45%	100%
A0A3R7KDY4	Trypanosoma rangeli	40%	100%
A0A3S7WRD0	Leishmania donovani	97%	100%
A4H696	Leishmania braziliensis	90%	100%
A4HUL9	Leishmania infantum	97%	100%
C9ZVP6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
Q4QHA6	Leishmania major	95%	100%
V5BTU8	Trypanosoma cruzi	39%	100%