Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9ANB7_LEIMU

TriTrypDb:

LmxM.10.1070

Length:

592

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ANB7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANB7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	113	117	PF00656	0.710
CLV_C14_Caspase3-7	256	260	PF00656	0.695
CLV_C14_Caspase3-7	263	267	PF00656	0.564
CLV_C14_Caspase3-7	374	378	PF00656	0.453
CLV_NRD_NRD_1	124	126	PF00675	0.716
CLV_NRD_NRD_1	160	162	PF00675	0.680
CLV_NRD_NRD_1	270	272	PF00675	0.589
CLV_NRD_NRD_1	290	292	PF00675	0.339
CLV_NRD_NRD_1	299	301	PF00675	0.523
CLV_NRD_NRD_1	330	332	PF00675	0.659
CLV_NRD_NRD_1	42	44	PF00675	0.661
CLV_NRD_NRD_1	425	427	PF00675	0.619
CLV_NRD_NRD_1	469	471	PF00675	0.662
CLV_NRD_NRD_1	472	474	PF00675	0.689
CLV_NRD_NRD_1	52	54	PF00675	0.634
CLV_NRD_NRD_1	585	587	PF00675	0.424
CLV_PCSK_FUR_1	470	474	PF00082	0.509
CLV_PCSK_KEX2_1	126	128	PF00082	0.704
CLV_PCSK_KEX2_1	270	272	PF00082	0.589
CLV_PCSK_KEX2_1	290	292	PF00082	0.339
CLV_PCSK_KEX2_1	299	301	PF00082	0.523
CLV_PCSK_KEX2_1	330	332	PF00082	0.644
CLV_PCSK_KEX2_1	42	44	PF00082	0.592
CLV_PCSK_KEX2_1	423	425	PF00082	0.606
CLV_PCSK_KEX2_1	471	473	PF00082	0.708
CLV_PCSK_KEX2_1	52	54	PF00082	0.580
CLV_PCSK_KEX2_1	587	589	PF00082	0.441
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.704
CLV_PCSK_PC1ET2_1	423	425	PF00082	0.677
CLV_PCSK_PC1ET2_1	471	473	PF00082	0.708
CLV_PCSK_PC1ET2_1	587	589	PF00082	0.441
CLV_PCSK_PC7_1	286	292	PF00082	0.589
CLV_PCSK_PC7_1	420	426	PF00082	0.564
CLV_PCSK_SKI1_1	145	149	PF00082	0.687
CLV_PCSK_SKI1_1	198	202	PF00082	0.625
CLV_PCSK_SKI1_1	232	236	PF00082	0.686
CLV_PCSK_SKI1_1	273	277	PF00082	0.580
CLV_PCSK_SKI1_1	331	335	PF00082	0.378
CLV_PCSK_SKI1_1	360	364	PF00082	0.650
CLV_PCSK_SKI1_1	42	46	PF00082	0.590
CLV_PCSK_SKI1_1	437	441	PF00082	0.560
CLV_PCSK_SKI1_1	548	552	PF00082	0.591
CLV_PCSK_SKI1_1	558	562	PF00082	0.501
CLV_Separin_Metazoa	515	519	PF03568	0.652
DEG_APCC_DBOX_1	124	132	PF00400	0.605
DEG_APCC_DBOX_1	144	152	PF00400	0.349
DEG_APCC_DBOX_1	197	205	PF00400	0.566
DEG_APCC_DBOX_1	436	444	PF00400	0.554
DEG_APCC_DBOX_1	547	555	PF00400	0.626
DEG_MDM2_SWIB_1	142	149	PF02201	0.689
DEG_Nend_Nbox_1	1	3	PF02207	0.709
DEG_SPOP_SBC_1	103	107	PF00917	0.495
DEG_SPOP_SBC_1	19	23	PF00917	0.783
DOC_ANK_TNKS_1	425	432	PF00023	0.376
DOC_CKS1_1	81	86	PF01111	0.807
DOC_CYCLIN_RxL_1	270	278	PF00134	0.593
DOC_MAPK_gen_1	172	181	PF00069	0.614
DOC_MAPK_gen_1	270	276	PF00069	0.672
DOC_MAPK_MEF2A_6	174	183	PF00069	0.640
DOC_PP1_RVXF_1	34	41	PF00149	0.612
DOC_USP7_MATH_1	103	107	PF00917	0.662
DOC_USP7_MATH_1	19	23	PF00917	0.681
DOC_USP7_MATH_1	253	257	PF00917	0.785
DOC_USP7_MATH_1	439	443	PF00917	0.648
DOC_USP7_MATH_1	6	10	PF00917	0.679
DOC_USP7_MATH_1	62	66	PF00917	0.685
DOC_USP7_UBL2_3	583	587	PF12436	0.414
DOC_WW_Pin1_4	167	172	PF00397	0.771
DOC_WW_Pin1_4	65	70	PF00397	0.785
DOC_WW_Pin1_4	80	85	PF00397	0.811
LIG_14-3-3_CanoR_1	112	116	PF00244	0.716
LIG_14-3-3_CanoR_1	178	184	PF00244	0.706
LIG_14-3-3_CanoR_1	548	554	PF00244	0.550
LIG_14-3-3_CanoR_1	556	565	PF00244	0.623
LIG_14-3-3_CanoR_1	56	60	PF00244	0.671
LIG_14-3-3_CanoR_1	586	591	PF00244	0.447
LIG_Actin_WH2_2	526	543	PF00022	0.647
LIG_BIR_III_4	428	432	PF00653	0.369
LIG_BIR_III_4	574	578	PF00653	0.397
LIG_CSL_BTD_1	94	97	PF09270	0.509
LIG_EVH1_2	72	76	PF00568	0.525
LIG_FHA_1	171	177	PF00498	0.668
LIG_FHA_1	178	184	PF00498	0.540
LIG_FHA_1	231	237	PF00498	0.591
LIG_FHA_1	270	276	PF00498	0.672
LIG_FHA_2	111	117	PF00498	0.690
LIG_FHA_2	194	200	PF00498	0.396
LIG_FHA_2	216	222	PF00498	0.648
LIG_FHA_2	320	326	PF00498	0.668
LIG_FHA_2	372	378	PF00498	0.470
LIG_FHA_2	534	540	PF00498	0.574
LIG_FHA_2	557	563	PF00498	0.646
LIG_LIR_Apic_2	91	97	PF02991	0.613
LIG_LIR_Gen_1	143	151	PF02991	0.592
LIG_LIR_Gen_1	507	517	PF02991	0.573
LIG_LIR_Nem_3	143	149	PF02991	0.533
LIG_LIR_Nem_3	507	512	PF02991	0.585
LIG_MYND_3	516	520	PF01753	0.557
LIG_PCNA_yPIPBox_3	518	531	PF02747	0.570
LIG_Pex14_2	142	146	PF04695	0.593
LIG_RPA_C_Fungi	325	337	PF08784	0.580
LIG_SH2_CRK	509	513	PF00017	0.676
LIG_SH2_GRB2like	485	488	PF00017	0.483
LIG_SH2_SRC	485	488	PF00017	0.483
LIG_SH2_STAP1	398	402	PF00017	0.654
LIG_SH2_STAT5	119	122	PF00017	0.652
LIG_SH3_3	112	118	PF00018	0.593
LIG_SH3_3	66	72	PF00018	0.750
LIG_SH3_3	78	84	PF00018	0.665
LIG_SUMO_SIM_anti_2	549	555	PF11976	0.573
LIG_SUMO_SIM_par_1	528	534	PF11976	0.567
LIG_TRAF2_1	321	324	PF00917	0.661
LIG_TRAF2_1	380	383	PF00917	0.559
LIG_TRAF2_1	407	410	PF00917	0.650
LIG_TRAF2_1	414	417	PF00917	0.545
LIG_TRAF2_1	526	529	PF00917	0.562
LIG_UBA3_1	156	162	PF00899	0.651
MOD_CDK_SPK_2	167	172	PF00069	0.655
MOD_CDK_SPK_2	65	70	PF00069	0.785
MOD_CDK_SPxxK_3	167	174	PF00069	0.762
MOD_CK1_1	104	110	PF00069	0.706
MOD_CK1_1	111	117	PF00069	0.664
MOD_CK1_1	13	19	PF00069	0.674
MOD_CK1_1	170	176	PF00069	0.687
MOD_CK1_1	244	250	PF00069	0.728
MOD_CK1_1	260	266	PF00069	0.528
MOD_CK1_1	549	555	PF00069	0.381
MOD_CK1_1	55	61	PF00069	0.775
MOD_CK1_1	567	573	PF00069	0.564
MOD_CK1_1	65	71	PF00069	0.709
MOD_CK2_1	103	109	PF00069	0.494
MOD_CK2_1	189	195	PF00069	0.590
MOD_CK2_1	224	230	PF00069	0.774
MOD_CK2_1	275	281	PF00069	0.588
MOD_CK2_1	319	325	PF00069	0.569
MOD_CK2_1	523	529	PF00069	0.626
MOD_CK2_1	533	539	PF00069	0.506
MOD_CK2_1	556	562	PF00069	0.646
MOD_Cter_Amidation	40	43	PF01082	0.485
MOD_GlcNHglycan	22	25	PF01048	0.616
MOD_GlcNHglycan	226	229	PF01048	0.604
MOD_GlcNHglycan	255	258	PF01048	0.759
MOD_GlcNHglycan	351	354	PF01048	0.653
MOD_GlcNHglycan	479	482	PF01048	0.788
MOD_GlcNHglycan	486	490	PF01048	0.714
MOD_GlcNHglycan	499	502	PF01048	0.466
MOD_GlcNHglycan	547	551	PF01048	0.586
MOD_GlcNHglycan	569	572	PF01048	0.520
MOD_GlcNHglycan	76	79	PF01048	0.766
MOD_GlcNHglycan	8	11	PF01048	0.744
MOD_GSK3_1	101	108	PF00069	0.615
MOD_GSK3_1	14	21	PF00069	0.618
MOD_GSK3_1	189	196	PF00069	0.387
MOD_GSK3_1	253	260	PF00069	0.733
MOD_GSK3_1	275	282	PF00069	0.549
MOD_GSK3_1	6	13	PF00069	0.676
MOD_GSK3_1	86	93	PF00069	0.709
MOD_N-GLC_1	349	354	PF02516	0.655
MOD_NEK2_1	101	106	PF00069	0.692
MOD_NEK2_1	110	115	PF00069	0.618
MOD_NEK2_1	179	184	PF00069	0.513
MOD_NEK2_1	18	23	PF00069	0.668
MOD_NEK2_1	193	198	PF00069	0.489
MOD_NEK2_1	235	240	PF00069	0.789
MOD_NEK2_1	275	280	PF00069	0.587
MOD_NEK2_1	496	501	PF00069	0.676
MOD_NEK2_1	533	538	PF00069	0.409
MOD_NEK2_1	74	79	PF00069	0.667
MOD_NEK2_2	257	262	PF00069	0.541
MOD_PIKK_1	279	285	PF00454	0.547
MOD_PK_1	586	592	PF00069	0.458
MOD_PKA_1	52	58	PF00069	0.780
MOD_PKA_1	586	592	PF00069	0.458
MOD_PKA_2	111	117	PF00069	0.710
MOD_PKA_2	177	183	PF00069	0.695
MOD_PKA_2	269	275	PF00069	0.671
MOD_PKA_2	419	425	PF00069	0.664
MOD_PKA_2	52	58	PF00069	0.695
MOD_PKA_2	540	546	PF00069	0.656
MOD_Plk_1	189	195	PF00069	0.679
MOD_Plk_1	349	355	PF00069	0.658
MOD_Plk_1	546	552	PF00069	0.585
MOD_Plk_1	62	68	PF00069	0.650
MOD_Plk_1	90	96	PF00069	0.626
MOD_Plk_4	189	195	PF00069	0.388
MOD_Plk_4	549	555	PF00069	0.360
MOD_ProDKin_1	167	173	PF00069	0.766
MOD_ProDKin_1	65	71	PF00069	0.783
MOD_ProDKin_1	80	86	PF00069	0.809
MOD_SUMO_rev_2	227	234	PF00179	0.602
TRG_DiLeu_BaEn_4	528	534	PF01217	0.567
TRG_DiLeu_BaLyEn_6	152	157	PF01217	0.685
TRG_DiLeu_BaLyEn_6	270	275	PF01217	0.596
TRG_DiLeu_BaLyEn_6	33	38	PF01217	0.620
TRG_ENDOCYTIC_2	509	512	PF00928	0.676
TRG_ER_diArg_1	125	128	PF00400	0.611
TRG_ER_diArg_1	171	174	PF00400	0.644
TRG_ER_diArg_1	269	271	PF00400	0.588
TRG_ER_diArg_1	330	332	PF00400	0.644
TRG_ER_diArg_1	424	426	PF00400	0.684
TRG_ER_diArg_1	469	472	PF00400	0.594
TRG_NLS_MonoCore_2	469	474	PF00514	0.506
TRG_NLS_MonoExtC_3	470	475	PF00514	0.709
TRG_NLS_MonoExtN_4	470	475	PF00514	0.515
TRG_Pf-PMV_PEXEL_1	202	206	PF00026	0.592
TRG_Pf-PMV_PEXEL_1	262	266	PF00026	0.620
TRG_Pf-PMV_PEXEL_1	305	310	PF00026	0.424
TRG_Pf-PMV_PEXEL_1	43	48	PF00026	0.499

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL10	Leptomonas seymouri	34%	100%
A0A3S7WRC5	Leishmania donovani	88%	100%
A4H695	Leishmania braziliensis	71%	100%
A4HUL8	Leishmania infantum	88%	100%
Q4QHA7	Leishmania major	87%	100%