Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ANB6_LEIMU

TriTrypDb:

LmxM.10.1060

Length:

322

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ANB6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANB6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.665
CLV_NRD_NRD_1	146	148	PF00675	0.610
CLV_PCSK_KEX2_1	146	148	PF00082	0.619
CLV_PCSK_KEX2_1	228	230	PF00082	0.546
CLV_PCSK_PC1ET2_1	228	230	PF00082	0.546
CLV_PCSK_SKI1_1	214	218	PF00082	0.564
DEG_Nend_UBRbox_1	1	4	PF02207	0.539
DOC_MAPK_gen_1	195	204	PF00069	0.516
DOC_MAPK_RevD_3	215	229	PF00069	0.551
DOC_PP4_FxxP_1	21	24	PF00568	0.706
DOC_USP7_MATH_1	141	145	PF00917	0.489
DOC_WW_Pin1_4	126	131	PF00397	0.557
DOC_WW_Pin1_4	20	25	PF00397	0.784
DOC_WW_Pin1_4	57	62	PF00397	0.553
LIG_14-3-3_CanoR_1	229	235	PF00244	0.602
LIG_Actin_WH2_2	215	230	PF00022	0.517
LIG_Clathr_ClatBox_1	312	316	PF01394	0.468
LIG_EH1_1	312	320	PF00400	0.557
LIG_EVH1_2	160	164	PF00568	0.560
LIG_FHA_1	197	203	PF00498	0.598
LIG_FHA_1	231	237	PF00498	0.634
LIG_FHA_1	58	64	PF00498	0.618
LIG_FHA_1	92	98	PF00498	0.605
LIG_FHA_2	24	30	PF00498	0.667
LIG_FHA_2	247	253	PF00498	0.774
LIG_LIR_Gen_1	129	138	PF02991	0.609
LIG_LIR_Gen_1	174	182	PF02991	0.406
LIG_LIR_Nem_3	129	134	PF02991	0.608
LIG_LIR_Nem_3	174	178	PF02991	0.402
LIG_Pex14_2	134	138	PF04695	0.433
LIG_Pex14_2	309	313	PF04695	0.582
LIG_PTB_Apo_2	132	139	PF02174	0.590
LIG_SH2_GRB2like	133	136	PF00017	0.598
LIG_SH2_STAT3	181	184	PF00017	0.539
LIG_SH2_STAT5	133	136	PF00017	0.529
LIG_SH2_STAT5	163	166	PF00017	0.416
LIG_SH2_STAT5	177	180	PF00017	0.407
LIG_SH3_3	111	117	PF00018	0.645
LIG_SUMO_SIM_par_1	50	56	PF11976	0.553
LIG_TRAF2_1	241	244	PF00917	0.721
LIG_TYR_ITIM	116	121	PF00017	0.475
LIG_WRC_WIRS_1	172	177	PF05994	0.418
LIG_WW_1	160	163	PF00397	0.572
MOD_CK1_1	11	17	PF00069	0.576
MOD_CK1_1	136	142	PF00069	0.506
MOD_CK1_1	23	29	PF00069	0.665
MOD_CK1_1	230	236	PF00069	0.613
MOD_CK1_1	278	284	PF00069	0.742
MOD_CK1_1	294	300	PF00069	0.595
MOD_CK1_1	56	62	PF00069	0.437
MOD_CK1_1	91	97	PF00069	0.538
MOD_CK2_1	134	140	PF00069	0.498
MOD_CK2_1	23	29	PF00069	0.714
MOD_CK2_1	246	252	PF00069	0.722
MOD_CK2_1	86	92	PF00069	0.667
MOD_GlcNHglycan	104	107	PF01048	0.550
MOD_GlcNHglycan	122	125	PF01048	0.482
MOD_GlcNHglycan	154	157	PF01048	0.629
MOD_GlcNHglycan	229	232	PF01048	0.503
MOD_GlcNHglycan	277	280	PF01048	0.711
MOD_GlcNHglycan	291	294	PF01048	0.606
MOD_GlcNHglycan	55	58	PF01048	0.411
MOD_GlcNHglycan	77	80	PF01048	0.678
MOD_GlcNHglycan	9	13	PF01048	0.625
MOD_GSK3_1	167	174	PF00069	0.519
MOD_GSK3_1	19	26	PF00069	0.653
MOD_GSK3_1	53	60	PF00069	0.418
MOD_GSK3_1	98	105	PF00069	0.348
MOD_N-GLC_1	134	139	PF02516	0.575
MOD_NEK2_1	134	139	PF00069	0.504
MOD_NEK2_1	152	157	PF00069	0.458
MOD_NEK2_1	227	232	PF00069	0.542
MOD_NEK2_1	53	58	PF00069	0.415
MOD_NEK2_2	141	146	PF00069	0.529
MOD_NEK2_2	40	45	PF00069	0.432
MOD_PIKK_1	246	252	PF00454	0.469
MOD_PIKK_1	28	34	PF00454	0.664
MOD_PIKK_1	91	97	PF00454	0.567
MOD_PKA_2	196	202	PF00069	0.625
MOD_Plk_1	134	140	PF00069	0.504
MOD_Plk_1	141	147	PF00069	0.442
MOD_Plk_1	86	92	PF00069	0.714
MOD_Plk_2-3	171	177	PF00069	0.460
MOD_Plk_4	294	300	PF00069	0.614
MOD_ProDKin_1	126	132	PF00069	0.560
MOD_ProDKin_1	20	26	PF00069	0.781
MOD_ProDKin_1	57	63	PF00069	0.569
TRG_ENDOCYTIC_2	118	121	PF00928	0.578
TRG_ENDOCYTIC_2	131	134	PF00928	0.408
TRG_ENDOCYTIC_2	163	166	PF00928	0.420
TRG_ER_diArg_1	145	147	PF00400	0.598

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5X0	Leptomonas seymouri	49%	95%
A0A1X0NS26	Trypanosomatidae	31%	100%
A0A3S7WRA2	Leishmania donovani	93%	100%
A0A422NGN0	Trypanosoma rangeli	33%	100%
A4H694	Leishmania braziliensis	82%	99%
A4HUL7	Leishmania infantum	93%	100%
C9ZVP4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
Q4QHA8	Leishmania major	93%	100%
V5DKP6	Trypanosoma cruzi	29%	100%