J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9ANB5_LEIMU

TriTrypDb:

LmxM.10.1050

Length:

251

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ANB5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANB5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	204	206	PF00675	0.561
CLV_NRD_NRD_1	227	229	PF00675	0.419
CLV_NRD_NRD_1	32	34	PF00675	0.395
CLV_PCSK_KEX2_1	204	206	PF00082	0.559
CLV_PCSK_KEX2_1	227	229	PF00082	0.392
CLV_PCSK_KEX2_1	34	36	PF00082	0.292
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.317
CLV_PCSK_SKI1_1	126	130	PF00082	0.656
CLV_PCSK_SKI1_1	245	249	PF00082	0.580
CLV_PCSK_SKI1_1	53	57	PF00082	0.410
CLV_PCSK_SKI1_1	70	74	PF00082	0.521
DEG_APCC_KENBOX_2	171	175	PF00400	0.489
DEG_Nend_Nbox_1	1	3	PF02207	0.539
DOC_ANK_TNKS_1	8	15	PF00023	0.416
DOC_CYCLIN_RxL_1	67	74	PF00134	0.306
DOC_MAPK_gen_1	147	155	PF00069	0.422
DOC_MAPK_gen_1	33	39	PF00069	0.311
DOC_MAPK_MEF2A_6	147	155	PF00069	0.455
DOC_MIT_MIM_1	31	39	PF04212	0.391
DOC_PP1_RVXF_1	16	23	PF00149	0.496
DOC_PP4_FxxP_1	116	119	PF00568	0.529
DOC_PP4_FxxP_1	128	131	PF00568	0.604
DOC_PP4_FxxP_1	22	25	PF00568	0.416
DOC_USP7_MATH_1	119	123	PF00917	0.664
DOC_USP7_MATH_1	151	155	PF00917	0.558
DOC_USP7_MATH_1	87	91	PF00917	0.787
DOC_USP7_MATH_1	92	96	PF00917	0.721
LIG_14-3-3_CanoR_1	126	131	PF00244	0.620
LIG_14-3-3_CanoR_1	134	141	PF00244	0.583
LIG_deltaCOP1_diTrp_1	106	116	PF00928	0.633
LIG_LIR_Apic_2	115	119	PF02991	0.549
LIG_LIR_Gen_1	106	116	PF02991	0.577
LIG_LIR_Gen_1	154	162	PF02991	0.463
LIG_LIR_Gen_1	192	202	PF02991	0.592
LIG_LIR_Gen_1	63	73	PF02991	0.410
LIG_LIR_Nem_3	106	112	PF02991	0.634
LIG_LIR_Nem_3	154	158	PF02991	0.403
LIG_LIR_Nem_3	192	197	PF02991	0.497
LIG_LIR_Nem_3	239	244	PF02991	0.476
LIG_LIR_Nem_3	63	69	PF02991	0.311
LIG_NRBOX	68	74	PF00104	0.357
LIG_Pex14_2	128	132	PF04695	0.608
LIG_SH2_CRK	66	70	PF00017	0.279
LIG_SH2_PTP2	246	249	PF00017	0.471
LIG_SH2_STAP1	161	165	PF00017	0.469
LIG_SH2_STAT5	193	196	PF00017	0.526
LIG_SH2_STAT5	246	249	PF00017	0.427
LIG_SH2_STAT5	66	69	PF00017	0.355
LIG_TYR_ITIM	244	249	PF00017	0.471
MOD_CK1_1	121	127	PF00069	0.641
MOD_CK1_1	139	145	PF00069	0.539
MOD_CK2_1	139	145	PF00069	0.587
MOD_Cter_Amidation	225	228	PF01082	0.423
MOD_GlcNHglycan	200	203	PF01048	0.518
MOD_GlcNHglycan	90	93	PF01048	0.667
MOD_GlcNHglycan	94	97	PF01048	0.670
MOD_GSK3_1	132	139	PF00069	0.639
MOD_GSK3_1	183	190	PF00069	0.487
MOD_GSK3_1	212	219	PF00069	0.607
MOD_GSK3_1	236	243	PF00069	0.493
MOD_GSK3_1	60	67	PF00069	0.415
MOD_GSK3_1	88	95	PF00069	0.618
MOD_N-GLC_1	151	156	PF02516	0.517
MOD_N-GLC_1	183	188	PF02516	0.385
MOD_NEK2_2	193	198	PF00069	0.346
MOD_NEK2_2	240	245	PF00069	0.501
MOD_PKA_1	204	210	PF00069	0.679
MOD_PKA_2	133	139	PF00069	0.638
MOD_PKA_2	168	174	PF00069	0.571
MOD_PKA_2	204	210	PF00069	0.679
MOD_PKA_2	87	93	PF00069	0.755
MOD_Plk_1	151	157	PF00069	0.425
MOD_Plk_4	136	142	PF00069	0.556
MOD_SUMO_rev_2	139	148	PF00179	0.506
MOD_SUMO_rev_2	46	55	PF00179	0.282
TRG_DiLeu_BaLyEn_6	15	20	PF01217	0.251
TRG_ENDOCYTIC_2	246	249	PF00928	0.427
TRG_ENDOCYTIC_2	66	69	PF00928	0.279
TRG_ER_diArg_1	227	230	PF00400	0.444
TRG_ER_diArg_1	32	35	PF00400	0.399
TRG_Pf-PMV_PEXEL_1	163	168	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	18	23	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	70	74	PF00026	0.470

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRV7	Leptomonas seymouri	59%	100%
A0A0S4JQU3	Bodo saltans	31%	99%
A0A1X0NRW0	Trypanosomatidae	36%	100%
A0A3Q8IB40	Leishmania donovani	90%	91%
A0A3R7ND09	Trypanosoma rangeli	33%	100%
A4H693	Leishmania braziliensis	78%	100%
A4HUL6	Leishmania infantum	90%	91%
C9ZVP3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
Q4QHA9	Leishmania major	90%	100%