RNA-binding protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein-like protein

Species:

Leishmania mexicana

UniProt:

E9ANB3_LEIMU

TriTrypDb:

LmxM.10.1030

Length:

382

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ANB3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANB3

Function

Biological processes
Term	Name	Level	Count
GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0000470	maturation of LSU-rRNA	9	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003723	RNA binding	4	9
GO:0005488	binding	1	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	298	302	PF00656	0.362
CLV_NRD_NRD_1	18	20	PF00675	0.623
CLV_NRD_NRD_1	253	255	PF00675	0.533
CLV_NRD_NRD_1	264	266	PF00675	0.315
CLV_NRD_NRD_1	284	286	PF00675	0.594
CLV_NRD_NRD_1	374	376	PF00675	0.686
CLV_NRD_NRD_1	58	60	PF00675	0.728
CLV_PCSK_FUR_1	206	210	PF00082	0.248
CLV_PCSK_KEX2_1	18	20	PF00082	0.681
CLV_PCSK_KEX2_1	208	210	PF00082	0.259
CLV_PCSK_KEX2_1	252	254	PF00082	0.660
CLV_PCSK_KEX2_1	263	265	PF00082	0.318
CLV_PCSK_KEX2_1	284	286	PF00082	0.525
CLV_PCSK_KEX2_1	333	335	PF00082	0.574
CLV_PCSK_KEX2_1	370	372	PF00082	0.614
CLV_PCSK_KEX2_1	374	376	PF00082	0.596
CLV_PCSK_KEX2_1	78	80	PF00082	0.586
CLV_PCSK_KEX2_1	85	87	PF00082	0.590
CLV_PCSK_KEX2_1	93	95	PF00082	0.633
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.681
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.325
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.574
CLV_PCSK_PC1ET2_1	370	372	PF00082	0.614
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.608
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.602
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.602
CLV_PCSK_SKI1_1	247	251	PF00082	0.525
CLV_PCSK_SKI1_1	264	268	PF00082	0.507
CLV_PCSK_SKI1_1	276	280	PF00082	0.365
CLV_PCSK_SKI1_1	370	374	PF00082	0.628
CLV_PCSK_SKI1_1	79	83	PF00082	0.580
DEG_SPOP_SBC_1	70	74	PF00917	0.609
DOC_CYCLIN_RxL_1	17	28	PF00134	0.605
DOC_MAPK_gen_1	18	24	PF00069	0.619
DOC_MAPK_gen_1	212	221	PF00069	0.516
DOC_MAPK_gen_1	284	291	PF00069	0.525
DOC_MAPK_MEF2A_6	223	231	PF00069	0.516
DOC_MAPK_MEF2A_6	284	293	PF00069	0.517
DOC_PP1_RVXF_1	173	179	PF00149	0.283
DOC_PP1_RVXF_1	18	25	PF00149	0.615
DOC_PP4_FxxP_1	178	181	PF00568	0.445
DOC_PP4_FxxP_1	183	186	PF00568	0.453
DOC_USP7_MATH_1	103	107	PF00917	0.655
DOC_USP7_MATH_1	154	158	PF00917	0.807
DOC_USP7_MATH_1	70	74	PF00917	0.619
DOC_USP7_UBL2_3	352	356	PF12436	0.586
DOC_USP7_UBL2_3	366	370	PF12436	0.729
DOC_USP7_UBL2_3	4	8	PF12436	0.687
DOC_USP7_UBL2_3	46	50	PF12436	0.770
DOC_WW_Pin1_4	156	161	PF00397	0.541
DOC_WW_Pin1_4	365	370	PF00397	0.592
LIG_14-3-3_CanoR_1	175	179	PF00244	0.324
LIG_14-3-3_CanoR_1	19	25	PF00244	0.587
LIG_14-3-3_CanoR_1	206	216	PF00244	0.448
LIG_14-3-3_CanoR_1	247	252	PF00244	0.534
LIG_14-3-3_CanoR_1	336	345	PF00244	0.596
LIG_FHA_1	355	361	PF00498	0.688
LIG_FHA_1	36	42	PF00498	0.598
LIG_FHA_2	296	302	PF00498	0.405
LIG_FHA_2	336	342	PF00498	0.472
LIG_LIR_Apic_2	177	181	PF02991	0.478
LIG_LIR_Apic_2	182	186	PF02991	0.467
LIG_LIR_Nem_3	169	174	PF02991	0.406
LIG_Pex14_2	191	195	PF04695	0.448
LIG_Pex14_2	313	317	PF04695	0.414
LIG_SH2_CRK	171	175	PF00017	0.452
LIG_SH2_CRK	189	193	PF00017	0.504
LIG_SH2_STAT5	218	221	PF00017	0.448
LIG_SH2_STAT5	305	308	PF00017	0.463
LIG_SH3_3	38	44	PF00018	0.586
LIG_SUMO_SIM_anti_2	287	293	PF11976	0.341
LIG_SUMO_SIM_par_1	227	233	PF11976	0.503
LIG_TRAF2_1	95	98	PF00917	0.613
MOD_CDC14_SPxK_1	159	162	PF00782	0.500
MOD_CDC14_SPxK_1	368	371	PF00782	0.601
MOD_CDK_SPK_2	365	370	PF00069	0.693
MOD_CDK_SPxK_1	156	162	PF00069	0.502
MOD_CDK_SPxK_1	365	371	PF00069	0.707
MOD_CK1_1	156	162	PF00069	0.668
MOD_CK1_1	164	170	PF00069	0.582
MOD_CK1_1	207	213	PF00069	0.478
MOD_CK1_1	335	341	PF00069	0.742
MOD_CK2_1	109	115	PF00069	0.582
MOD_CK2_1	138	144	PF00069	0.646
MOD_CK2_1	20	26	PF00069	0.520
MOD_CK2_1	335	341	PF00069	0.470
MOD_Cter_Amidation	16	19	PF01082	0.651
MOD_GlcNHglycan	11	14	PF01048	0.649
MOD_GlcNHglycan	156	159	PF01048	0.670
MOD_GlcNHglycan	224	227	PF01048	0.310
MOD_GlcNHglycan	4	7	PF01048	0.682
MOD_GlcNHglycan	73	76	PF01048	0.670
MOD_GlcNHglycan	86	89	PF01048	0.508
MOD_GSK3_1	152	159	PF00069	0.674
MOD_GSK3_1	20	27	PF00069	0.585
MOD_GSK3_1	317	324	PF00069	0.466
MOD_GSK3_1	337	344	PF00069	0.678
MOD_GSK3_1	355	362	PF00069	0.664
MOD_GSK3_1	65	72	PF00069	0.740
MOD_GSK3_1	9	16	PF00069	0.687
MOD_N-GLC_1	109	114	PF02516	0.602
MOD_N-GLC_1	130	135	PF02516	0.531
MOD_N-GLC_1	164	169	PF02516	0.536
MOD_N-GLC_1	341	346	PF02516	0.654
MOD_NEK2_1	195	200	PF00069	0.531
MOD_NEK2_1	24	29	PF00069	0.579
MOD_NEK2_1	317	322	PF00069	0.455
MOD_NEK2_1	84	89	PF00069	0.587
MOD_NEK2_2	25	30	PF00069	0.534
MOD_PIKK_1	317	323	PF00454	0.461
MOD_PKA_1	20	26	PF00069	0.598
MOD_PKA_1	332	338	PF00069	0.660
MOD_PKA_1	370	376	PF00069	0.690
MOD_PKA_1	66	72	PF00069	0.674
MOD_PKA_2	161	167	PF00069	0.586
MOD_PKA_2	174	180	PF00069	0.243
MOD_PKA_2	335	341	PF00069	0.676
MOD_PKA_2	370	376	PF00069	0.617
MOD_PKB_1	245	253	PF00069	0.506
MOD_Plk_1	25	31	PF00069	0.552
MOD_Plk_2-3	109	115	PF00069	0.573
MOD_Plk_4	174	180	PF00069	0.357
MOD_Plk_4	195	201	PF00069	0.540
MOD_ProDKin_1	156	162	PF00069	0.539
MOD_ProDKin_1	365	371	PF00069	0.598
MOD_SUMO_rev_2	308	315	PF00179	0.365
TRG_ENDOCYTIC_2	171	174	PF00928	0.421
TRG_ENDOCYTIC_2	189	192	PF00928	0.483
TRG_ENDOCYTIC_2	218	221	PF00928	0.448
TRG_ER_diArg_1	244	247	PF00400	0.474
TRG_ER_diArg_1	251	254	PF00400	0.530
TRG_ER_diArg_1	263	265	PF00400	0.345
TRG_ER_diArg_1	283	285	PF00400	0.538
TRG_ER_diLys_1	379	382	PF00400	0.489
TRG_NLS_Bipartite_1	59	81	PF00514	0.632
TRG_NLS_Bipartite_1	8	23	PF00514	0.667
TRG_NLS_MonoCore_2	17	22	PF00514	0.635
TRG_NLS_MonoCore_2	330	335	PF00514	0.629
TRG_NLS_MonoExtC_3	331	336	PF00514	0.640
TRG_NLS_MonoExtN_4	18	23	PF00514	0.619
TRG_NLS_MonoExtN_4	331	337	PF00514	0.646
TRG_NLS_MonoExtN_4	58	63	PF00514	0.613

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9B0	Leptomonas seymouri	60%	92%
A0A3Q8I7S8	Leishmania donovani	91%	100%
A0A3R7KMG8	Trypanosoma rangeli	49%	91%
A4H691	Leishmania braziliensis	75%	100%
A4HUL4	Leishmania infantum	91%	100%
C9ZVP1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	89%
Q4QHB1	Leishmania major	89%	99%