Putative carrier protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

carrier protein, putative

Species:

Leishmania mexicana

UniProt:

E9ANB2_LEIMU

TriTrypDb:

LmxM.10.1020

Length:

395

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 32
NetGPI	no	yes: 0, no: 32

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	33
GO:0110165	cellular anatomical entity	1	33
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9ANB2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANB2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	6
GO:0006862	nucleotide transport	6	6
GO:0009987	cellular process	1	6
GO:0015748	organophosphate ester transport	5	6
GO:0015931	nucleobase-containing compound transport	5	6
GO:0051179	localization	1	6
GO:0051234	establishment of localization	2	6
GO:0055085	transmembrane transport	2	6
GO:0071702	organic substance transport	4	6
GO:0071705	nitrogen compound transport	4	6
GO:0035352	NAD transmembrane transport	4	1
GO:0043132	NAD transport	7	1
GO:1901679	nucleotide transmembrane transport	3	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015215	nucleotide transmembrane transporter activity	4	1
GO:0015605	organophosphate ester transmembrane transporter activity	3	1
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:0051724	NAD transmembrane transporter activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	24	28	PF00656	0.586
CLV_NRD_NRD_1	114	116	PF00675	0.295
CLV_PCSK_SKI1_1	102	106	PF00082	0.283
CLV_PCSK_SKI1_1	142	146	PF00082	0.291
CLV_PCSK_SKI1_1	206	210	PF00082	0.242
CLV_PCSK_SKI1_1	232	236	PF00082	0.206
CLV_PCSK_SKI1_1	260	264	PF00082	0.471
DEG_APCC_DBOX_1	141	149	PF00400	0.578
DEG_Nend_Nbox_1	1	3	PF02207	0.677
DEG_SCF_FBW7_1	333	340	PF00400	0.471
DOC_CKS1_1	334	339	PF01111	0.439
DOC_CYCLIN_yCln2_LP_2	105	111	PF00134	0.514
DOC_CYCLIN_yCln2_LP_2	322	328	PF00134	0.305
DOC_MAPK_MEF2A_6	194	202	PF00069	0.428
DOC_USP7_MATH_1	20	24	PF00917	0.760
DOC_USP7_MATH_1	375	379	PF00917	0.284
DOC_WW_Pin1_4	208	213	PF00397	0.506
DOC_WW_Pin1_4	333	338	PF00397	0.436
DOC_WW_Pin1_4	54	59	PF00397	0.719
LIG_14-3-3_CanoR_1	206	213	PF00244	0.423
LIG_14-3-3_CanoR_1	215	220	PF00244	0.422
LIG_14-3-3_CanoR_1	229	235	PF00244	0.501
LIG_14-3-3_CanoR_1	273	280	PF00244	0.462
LIG_Actin_WH2_2	218	234	PF00022	0.527
LIG_BRCT_BRCA1_1	131	135	PF00533	0.467
LIG_CtBP_PxDLS_1	108	112	PF00389	0.471
LIG_CtBP_PxDLS_1	150	154	PF00389	0.356
LIG_deltaCOP1_diTrp_1	289	297	PF00928	0.429
LIG_FHA_1	125	131	PF00498	0.510
LIG_FHA_1	238	244	PF00498	0.301
LIG_FHA_1	317	323	PF00498	0.285
LIG_FHA_1	343	349	PF00498	0.439
LIG_FHA_1	61	67	PF00498	0.636
LIG_FHA_1	74	80	PF00498	0.604
LIG_FHA_2	22	28	PF00498	0.723
LIG_FHA_2	297	303	PF00498	0.404
LIG_FHA_2	375	381	PF00498	0.256
LIG_IBAR_NPY_1	324	326	PF08397	0.439
LIG_LIR_Apic_2	289	295	PF02991	0.471
LIG_LIR_Gen_1	159	166	PF02991	0.455
LIG_LIR_Gen_1	378	386	PF02991	0.259
LIG_LIR_Gen_1	82	91	PF02991	0.517
LIG_LIR_LC3C_4	240	244	PF02991	0.436
LIG_LIR_Nem_3	126	131	PF02991	0.505
LIG_LIR_Nem_3	138	144	PF02991	0.605
LIG_LIR_Nem_3	218	222	PF02991	0.464
LIG_LIR_Nem_3	233	238	PF02991	0.311
LIG_LIR_Nem_3	378	384	PF02991	0.228
LIG_LIR_Nem_3	82	86	PF02991	0.521
LIG_Pex14_1	252	256	PF04695	0.231
LIG_SH2_CRK	256	260	PF00017	0.343
LIG_SH2_CRK	358	362	PF00017	0.329
LIG_SH2_SRC	15	18	PF00017	0.603
LIG_SH2_SRC	264	267	PF00017	0.276
LIG_SH2_SRC	379	382	PF00017	0.219
LIG_SH2_STAP1	187	191	PF00017	0.515
LIG_SH2_STAP1	381	385	PF00017	0.228
LIG_SH2_STAT5	162	165	PF00017	0.472
LIG_SH2_STAT5	326	329	PF00017	0.447
LIG_SH3_3	193	199	PF00018	0.500
LIG_SH3_3	23	29	PF00018	0.777
LIG_WRC_WIRS_1	259	264	PF05994	0.333
MOD_CDK_SPxxK_3	208	215	PF00069	0.387
MOD_CK1_1	218	224	PF00069	0.469
MOD_CK1_1	275	281	PF00069	0.410
MOD_CK1_1	296	302	PF00069	0.312
MOD_CK1_1	312	318	PF00069	0.256
MOD_CK1_1	49	55	PF00069	0.742
MOD_CK2_1	3	9	PF00069	0.728
MOD_CK2_1	374	380	PF00069	0.280
MOD_GlcNHglycan	16	20	PF01048	0.480
MOD_GlcNHglycan	265	269	PF01048	0.566
MOD_GlcNHglycan	315	318	PF01048	0.245
MOD_GlcNHglycan	358	361	PF01048	0.317
MOD_GlcNHglycan	49	52	PF01048	0.568
MOD_GSK3_1	293	300	PF00069	0.348
MOD_GSK3_1	309	316	PF00069	0.243
MOD_GSK3_1	32	39	PF00069	0.722
MOD_GSK3_1	333	340	PF00069	0.468
MOD_GSK3_1	49	56	PF00069	0.713
MOD_GSK3_1	75	82	PF00069	0.604
MOD_N-GLC_1	79	84	PF02516	0.370
MOD_N-GLC_2	366	368	PF02516	0.407
MOD_NEK2_1	192	197	PF00069	0.539
MOD_NEK2_1	2	7	PF00069	0.687
MOD_NEK2_1	238	243	PF00069	0.317
MOD_NEK2_1	361	366	PF00069	0.302
MOD_NEK2_1	374	379	PF00069	0.232
MOD_NEK2_2	230	235	PF00069	0.414
MOD_PIKK_1	278	284	PF00454	0.510
MOD_PKA_1	115	121	PF00069	0.535
MOD_PKA_2	272	278	PF00069	0.467
MOD_Plk_1	275	281	PF00069	0.338
MOD_Plk_1	3	9	PF00069	0.698
MOD_Plk_1	79	85	PF00069	0.523
MOD_Plk_4	198	204	PF00069	0.403
MOD_Plk_4	238	244	PF00069	0.313
MOD_Plk_4	258	264	PF00069	0.191
MOD_Plk_4	275	281	PF00069	0.341
MOD_Plk_4	3	9	PF00069	0.711
MOD_Plk_4	337	343	PF00069	0.514
MOD_ProDKin_1	208	214	PF00069	0.506
MOD_ProDKin_1	333	339	PF00069	0.436
MOD_ProDKin_1	54	60	PF00069	0.716
TRG_DiLeu_BaEn_4	67	73	PF01217	0.727
TRG_ENDOCYTIC_2	162	165	PF00928	0.472
TRG_ENDOCYTIC_2	205	208	PF00928	0.525
TRG_ENDOCYTIC_2	256	259	PF00928	0.242
TRG_ENDOCYTIC_2	326	329	PF00928	0.453
TRG_ENDOCYTIC_2	358	361	PF00928	0.285
TRG_ENDOCYTIC_2	381	384	PF00928	0.228
TRG_ENDOCYTIC_2	83	86	PF00928	0.498
TRG_Pf-PMV_PEXEL_1	142	146	PF00026	0.305

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8S5	Leptomonas seymouri	31%	100%
A0A0N1IBB8	Leptomonas seymouri	23%	82%
A0A0N1IHK9	Leptomonas seymouri	64%	100%
A0A0S4JF45	Bodo saltans	29%	96%
A0A0S4JH99	Bodo saltans	43%	78%
A0A0S4JIT1	Bodo saltans	30%	100%
A0A1X0NN16	Trypanosomatidae	31%	100%
A0A1X0NQB5	Trypanosomatidae	53%	100%
A0A1X0P6Z0	Trypanosomatidae	26%	99%
A0A3Q8IC78	Leishmania donovani	94%	100%
A0A3Q8IS12	Leishmania donovani	30%	100%
A0A3R7L1P3	Trypanosoma rangeli	28%	100%
A0A3S7WUZ5	Leishmania donovani	24%	88%
A0A422NGL1	Trypanosoma rangeli	52%	100%
A0A422P0Q3	Trypanosoma rangeli	27%	100%
A4H690	Leishmania braziliensis	79%	100%
A4H9K7	Leishmania braziliensis	24%	100%
A4HQI4	Leishmania braziliensis	31%	100%
A4HUL3	Leishmania infantum	94%	100%
A4HXX3	Leishmania infantum	24%	88%
C9ZVP0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
C9ZZS9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	99%
E9AHZ3	Leishmania infantum	30%	100%
E9ARN7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AU97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
Q4Q094	Leishmania major	30%	100%
Q4QDU2	Leishmania major	26%	100%
Q4QHB2	Leishmania major	88%	99%
Q54VX4	Dictyostelium discoideum	22%	100%
V5BTU3	Trypanosoma cruzi	51%	100%
V5DDT9	Trypanosoma cruzi	29%	100%
V5DN72	Trypanosoma cruzi	27%	100%