Putative ARP2/3 complex subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ARP2/3 complex subunit, putative

Species:

Leishmania mexicana

UniProt:

E9ANB0_LEIMU

TriTrypDb:

LmxM.10.1000

Length:

400

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	6
GO:0005885	Arp2/3 protein complex	2	6
GO:0032991	protein-containing complex	1	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9ANB0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANB0

Function

Biological processes
Term	Name	Level	Count
GO:0007015	actin filament organization	5	6
GO:0008064	regulation of actin polymerization or depolymerization	6	6
GO:0008154	actin polymerization or depolymerization	6	6
GO:0009987	cellular process	1	6
GO:0016043	cellular component organization	3	6
GO:0022607	cellular component assembly	4	6
GO:0030041	actin filament polymerization	7	6
GO:0030832	regulation of actin filament length	5	6
GO:0030833	regulation of actin filament polymerization	7	6
GO:0032271	regulation of protein polymerization	6	6
GO:0032535	regulation of cellular component size	4	6
GO:0032956	regulation of actin cytoskeleton organization	5	6
GO:0032970	regulation of actin filament-based process	4	6
GO:0033043	regulation of organelle organization	5	6
GO:0034314	Arp2/3 complex-mediated actin nucleation	7	6
GO:0043254	regulation of protein-containing complex assembly	5	6
GO:0043933	protein-containing complex organization	4	6
GO:0044087	regulation of cellular component biogenesis	4	6
GO:0045010	actin nucleation	6	6
GO:0050789	regulation of biological process	2	6
GO:0050794	regulation of cellular process	3	6
GO:0051128	regulation of cellular component organization	4	6
GO:0051258	protein polymerization	6	6
GO:0051493	regulation of cytoskeleton organization	6	6
GO:0065003	protein-containing complex assembly	5	6
GO:0065007	biological regulation	1	6
GO:0065008	regulation of biological quality	2	6
GO:0071840	cellular component organization or biogenesis	2	6
GO:0090066	regulation of anatomical structure size	3	6
GO:0097435	supramolecular fiber organization	4	6
GO:0110053	regulation of actin filament organization	6	6
GO:1902903	regulation of supramolecular fiber organization	5	6

Molecular functions
Term	Name	Level	Count
GO:0003779	actin binding	4	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0008092	cytoskeletal protein binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	290	294	PF00656	0.329
CLV_NRD_NRD_1	298	300	PF00675	0.607
CLV_PCSK_KEX2_1	298	300	PF00082	0.607
CLV_PCSK_KEX2_1	308	310	PF00082	0.520
CLV_PCSK_PC1ET2_1	308	310	PF00082	0.608
CLV_PCSK_SKI1_1	199	203	PF00082	0.551
DEG_APCC_DBOX_1	198	206	PF00400	0.547
DEG_SIAH_1	255	263	PF03145	0.565
DEG_SPOP_SBC_1	262	266	PF00917	0.619
DOC_CYCLIN_yClb5_NLxxxL_5	128	136	PF00134	0.617
DOC_MAPK_gen_1	308	316	PF00069	0.567
DOC_MAPK_gen_1	85	95	PF00069	0.609
DOC_MAPK_MEF2A_6	308	316	PF00069	0.637
DOC_PP1_RVXF_1	359	366	PF00149	0.497
DOC_PP2B_LxvP_1	172	175	PF13499	0.504
DOC_PP2B_LxvP_1	219	222	PF13499	0.669
DOC_PP2B_LxvP_1	347	350	PF13499	0.287
DOC_PP2B_PxIxI_1	110	116	PF00149	0.640
DOC_PP4_FxxP_1	117	120	PF00568	0.714
DOC_USP7_MATH_1	106	110	PF00917	0.664
DOC_USP7_MATH_1	163	167	PF00917	0.600
DOC_USP7_MATH_1	262	266	PF00917	0.689
DOC_USP7_MATH_2	156	162	PF00917	0.667
DOC_WW_Pin1_4	176	181	PF00397	0.661
DOC_WW_Pin1_4	250	255	PF00397	0.618
DOC_WW_Pin1_4	258	263	PF00397	0.682
DOC_WW_Pin1_4	59	64	PF00397	0.668
LIG_14-3-3_CanoR_1	208	214	PF00244	0.564
LIG_14-3-3_CanoR_1	24	29	PF00244	0.653
LIG_14-3-3_CanoR_1	58	63	PF00244	0.558
LIG_14-3-3_CanoR_1	71	78	PF00244	0.516
LIG_Actin_WH2_2	186	201	PF00022	0.527
LIG_Actin_WH2_2	349	366	PF00022	0.511
LIG_APCC_ABBA_1	375	380	PF00400	0.489
LIG_BIR_II_1	1	5	PF00653	0.662
LIG_BRCT_BRCA1_1	271	275	PF00533	0.454
LIG_FHA_1	146	152	PF00498	0.677
LIG_FHA_1	277	283	PF00498	0.451
LIG_FHA_1	343	349	PF00498	0.381
LIG_FHA_2	15	21	PF00498	0.517
LIG_FHA_2	177	183	PF00498	0.651
LIG_HCF-1_HBM_1	337	340	PF13415	0.630
LIG_LIR_Apic_2	148	152	PF02991	0.690
LIG_LIR_Gen_1	302	312	PF02991	0.562
LIG_LIR_Nem_3	302	307	PF02991	0.541
LIG_NRBOX	201	207	PF00104	0.506
LIG_Pex14_1	342	346	PF04695	0.548
LIG_Rb_LxCxE_1	90	112	PF01857	0.586
LIG_SH2_CRK	123	127	PF00017	0.485
LIG_SH2_CRK	149	153	PF00017	0.630
LIG_SH2_SRC	300	303	PF00017	0.467
LIG_SH2_STAP1	395	399	PF00017	0.525
LIG_SH2_STAT5	26	29	PF00017	0.641
LIG_SH2_STAT5	300	303	PF00017	0.471
LIG_SH2_STAT5	340	343	PF00017	0.368
LIG_SH3_2	19	24	PF14604	0.703
LIG_SH3_3	16	22	PF00018	0.716
LIG_SH3_3	253	259	PF00018	0.583
LIG_SH3_3	48	54	PF00018	0.739
LIG_SUMO_SIM_anti_2	216	222	PF11976	0.650
LIG_SUMO_SIM_par_1	277	283	PF11976	0.478
LIG_SUMO_SIM_par_1	312	319	PF11976	0.624
LIG_TRAF2_1	179	182	PF00917	0.552
LIG_TRAF2_1	37	40	PF00917	0.495
LIG_TRFH_1	346	350	PF08558	0.573
LIG_TYR_ITIM	121	126	PF00017	0.495
LIG_WRC_WIRS_1	25	30	PF05994	0.642
MOD_CDK_SPxxK_3	176	183	PF00069	0.657
MOD_CK1_1	109	115	PF00069	0.626
MOD_CK1_1	166	172	PF00069	0.635
MOD_CK1_1	176	182	PF00069	0.553
MOD_CK1_1	209	215	PF00069	0.589
MOD_CK1_1	241	247	PF00069	0.557
MOD_CK1_1	261	267	PF00069	0.789
MOD_CK1_1	355	361	PF00069	0.532
MOD_CK1_1	57	63	PF00069	0.754
MOD_CK1_1	73	79	PF00069	0.549
MOD_CK2_1	14	20	PF00069	0.510
MOD_CK2_1	176	182	PF00069	0.655
MOD_CK2_1	34	40	PF00069	0.677
MOD_CK2_1	73	79	PF00069	0.688
MOD_CK2_1	93	99	PF00069	0.614
MOD_GlcNHglycan	152	155	PF01048	0.623
MOD_GlcNHglycan	160	163	PF01048	0.578
MOD_GlcNHglycan	208	211	PF01048	0.559
MOD_GlcNHglycan	238	241	PF01048	0.613
MOD_GlcNHglycan	243	246	PF01048	0.569
MOD_GlcNHglycan	266	269	PF01048	0.751
MOD_GlcNHglycan	271	274	PF01048	0.632
MOD_GlcNHglycan	276	279	PF01048	0.506
MOD_GlcNHglycan	318	321	PF01048	0.529
MOD_GlcNHglycan	331	334	PF01048	0.499
MOD_GlcNHglycan	73	76	PF01048	0.697
MOD_GSK3_1	105	112	PF00069	0.682
MOD_GSK3_1	221	228	PF00069	0.688
MOD_GSK3_1	248	255	PF00069	0.544
MOD_GSK3_1	258	265	PF00069	0.634
MOD_GSK3_1	274	281	PF00069	0.524
MOD_GSK3_1	351	358	PF00069	0.440
MOD_GSK3_1	54	61	PF00069	0.685
MOD_GSK3_1	69	76	PF00069	0.600
MOD_NEK2_1	206	211	PF00069	0.609
MOD_NEK2_1	248	253	PF00069	0.453
MOD_NEK2_1	280	285	PF00069	0.314
MOD_NEK2_1	70	75	PF00069	0.589
MOD_NEK2_2	191	196	PF00069	0.543
MOD_PIKK_1	230	236	PF00454	0.717
MOD_PIKK_1	49	55	PF00454	0.681
MOD_PKA_2	316	322	PF00069	0.647
MOD_PKA_2	369	375	PF00069	0.503
MOD_PKA_2	57	63	PF00069	0.565
MOD_PKA_2	70	76	PF00069	0.515
MOD_Plk_1	191	197	PF00069	0.617
MOD_Plk_1	33	39	PF00069	0.686
MOD_Plk_2-3	34	40	PF00069	0.677
MOD_Plk_4	109	115	PF00069	0.643
MOD_Plk_4	238	244	PF00069	0.678
MOD_Plk_4	342	348	PF00069	0.397
MOD_ProDKin_1	176	182	PF00069	0.655
MOD_ProDKin_1	250	256	PF00069	0.629
MOD_ProDKin_1	258	264	PF00069	0.684
MOD_ProDKin_1	59	65	PF00069	0.667
MOD_SUMO_for_1	334	337	PF00179	0.373
MOD_SUMO_rev_2	302	310	PF00179	0.563
TRG_DiLeu_BaEn_1	216	221	PF01217	0.642
TRG_ENDOCYTIC_2	123	126	PF00928	0.633
TRG_ENDOCYTIC_2	129	132	PF00928	0.657
TRG_ER_diArg_1	297	299	PF00400	0.597

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P323	Leptomonas seymouri	34%	95%
A0A3Q8I8S8	Leishmania donovani	86%	100%
A4H688	Leishmania braziliensis	64%	100%
E9AGA0	Leishmania infantum	86%	100%
Q4QHB4	Leishmania major	84%	100%