Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9ANA8_LEIMU

TriTrypDb:

LmxM.10.0980

Length:

614

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ANA8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANA8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	385	389	PF00656	0.474
CLV_NRD_NRD_1	112	114	PF00675	0.806
CLV_NRD_NRD_1	485	487	PF00675	0.636
CLV_NRD_NRD_1	492	494	PF00675	0.562
CLV_NRD_NRD_1	562	564	PF00675	0.602
CLV_PCSK_KEX2_1	112	114	PF00082	0.798
CLV_PCSK_KEX2_1	426	428	PF00082	0.730
CLV_PCSK_KEX2_1	492	494	PF00082	0.597
CLV_PCSK_PC1ET2_1	426	428	PF00082	0.730
CLV_PCSK_SKI1_1	175	179	PF00082	0.507
CLV_PCSK_SKI1_1	370	374	PF00082	0.589
CLV_PCSK_SKI1_1	384	388	PF00082	0.487
CLV_PCSK_SKI1_1	446	450	PF00082	0.660
CLV_PCSK_SKI1_1	604	608	PF00082	0.707
DEG_Nend_UBRbox_3	1	3	PF02207	0.588
DEG_SIAH_1	185	193	PF03145	0.434
DOC_MAPK_DCC_7	185	195	PF00069	0.421
DOC_MAPK_MEF2A_6	194	201	PF00069	0.561
DOC_PP1_RVXF_1	196	202	PF00149	0.454
DOC_PP1_RVXF_1	444	451	PF00149	0.618
DOC_PP1_RVXF_1	602	608	PF00149	0.626
DOC_PP4_FxxP_1	506	509	PF00568	0.596
DOC_USP7_MATH_1	115	119	PF00917	0.717
DOC_USP7_MATH_1	151	155	PF00917	0.519
DOC_USP7_MATH_1	180	184	PF00917	0.464
DOC_USP7_MATH_1	237	241	PF00917	0.660
DOC_USP7_MATH_1	260	264	PF00917	0.667
DOC_USP7_MATH_1	27	31	PF00917	0.457
DOC_USP7_MATH_1	272	276	PF00917	0.543
DOC_USP7_MATH_1	358	362	PF00917	0.584
DOC_USP7_MATH_1	425	429	PF00917	0.710
DOC_USP7_MATH_1	431	435	PF00917	0.799
DOC_USP7_MATH_1	470	474	PF00917	0.571
DOC_USP7_MATH_1	477	481	PF00917	0.692
DOC_USP7_MATH_1	511	515	PF00917	0.512
DOC_USP7_MATH_1	575	579	PF00917	0.581
DOC_USP7_MATH_1	583	587	PF00917	0.623
DOC_USP7_MATH_1	6	10	PF00917	0.747
DOC_USP7_MATH_1	608	612	PF00917	0.691
DOC_WW_Pin1_4	138	143	PF00397	0.756
DOC_WW_Pin1_4	258	263	PF00397	0.754
DOC_WW_Pin1_4	295	300	PF00397	0.668
DOC_WW_Pin1_4	353	358	PF00397	0.586
DOC_WW_Pin1_4	548	553	PF00397	0.790
LIG_14-3-3_CanoR_1	244	250	PF00244	0.666
LIG_14-3-3_CanoR_1	446	451	PF00244	0.616
LIG_Actin_WH2_2	526	542	PF00022	0.506
LIG_APCC_ABBA_1	197	202	PF00400	0.463
LIG_eIF4E_1	371	377	PF01652	0.638
LIG_FHA_1	10	16	PF00498	0.592
LIG_FHA_1	153	159	PF00498	0.536
LIG_FHA_1	317	323	PF00498	0.564
LIG_FHA_1	476	482	PF00498	0.697
LIG_FHA_1	489	495	PF00498	0.531
LIG_FHA_1	500	506	PF00498	0.550
LIG_FHA_2	210	216	PF00498	0.577
LIG_FHA_2	461	467	PF00498	0.664
LIG_FHA_2	549	555	PF00498	0.597
LIG_FHA_2	62	68	PF00498	0.618
LIG_GBD_Chelix_1	444	452	PF00786	0.618
LIG_HCF-1_HBM_1	16	19	PF13415	0.640
LIG_LIR_Apic_2	503	509	PF02991	0.586
LIG_LIR_Gen_1	16	27	PF02991	0.620
LIG_LIR_Gen_1	449	458	PF02991	0.631
LIG_LIR_Nem_3	16	22	PF02991	0.633
LIG_LIR_Nem_3	218	222	PF02991	0.645
LIG_LIR_Nem_3	451	457	PF02991	0.541
LIG_Pex14_2	331	335	PF04695	0.449
LIG_Pex14_2	450	454	PF04695	0.510
LIG_SH2_CRK	91	95	PF00017	0.370
LIG_SH2_NCK_1	91	95	PF00017	0.370
LIG_SH2_SRC	19	22	PF00017	0.616
LIG_SH2_SRC	46	49	PF00017	0.530
LIG_SH2_STAT5	371	374	PF00017	0.544
LIG_SH2_STAT5	462	465	PF00017	0.668
LIG_SH2_STAT5	609	612	PF00017	0.413
LIG_SH2_STAT5	91	94	PF00017	0.377
LIG_SH3_3	259	265	PF00018	0.683
LIG_SH3_3	266	272	PF00018	0.749
LIG_SH3_3	319	325	PF00018	0.562
LIG_SH3_3	333	339	PF00018	0.602
LIG_SH3_3	577	583	PF00018	0.635
LIG_SH3_3	602	608	PF00018	0.626
LIG_SUMO_SIM_anti_2	248	253	PF11976	0.728
LIG_TYR_ITIM	372	377	PF00017	0.633
LIG_WRC_WIRS_1	383	388	PF05994	0.475
LIG_WRC_WIRS_1	559	564	PF05994	0.575
MOD_CK1_1	356	362	PF00069	0.706
MOD_CK1_1	382	388	PF00069	0.366
MOD_CK1_1	410	416	PF00069	0.597
MOD_CK1_1	514	520	PF00069	0.608
MOD_CK1_1	570	576	PF00069	0.650
MOD_CK1_1	9	15	PF00069	0.610
MOD_CK2_1	209	215	PF00069	0.570
MOD_CK2_1	372	378	PF00069	0.523
MOD_CK2_1	460	466	PF00069	0.562
MOD_GlcNHglycan	117	120	PF01048	0.720
MOD_GlcNHglycan	124	127	PF01048	0.646
MOD_GlcNHglycan	133	137	PF01048	0.659
MOD_GlcNHglycan	239	242	PF01048	0.641
MOD_GlcNHglycan	257	261	PF01048	0.550
MOD_GlcNHglycan	287	290	PF01048	0.639
MOD_GlcNHglycan	360	363	PF01048	0.703
MOD_GlcNHglycan	395	399	PF01048	0.604
MOD_GlcNHglycan	408	412	PF01048	0.554
MOD_GlcNHglycan	415	418	PF01048	0.685
MOD_GlcNHglycan	433	436	PF01048	0.509
MOD_GlcNHglycan	506	509	PF01048	0.713
MOD_GlcNHglycan	513	516	PF01048	0.639
MOD_GlcNHglycan	521	524	PF01048	0.503
MOD_GlcNHglycan	70	73	PF01048	0.678
MOD_GlcNHglycan	8	11	PF01048	0.723
MOD_GSK3_1	138	145	PF00069	0.671
MOD_GSK3_1	228	235	PF00069	0.499
MOD_GSK3_1	252	259	PF00069	0.726
MOD_GSK3_1	345	352	PF00069	0.646
MOD_GSK3_1	356	363	PF00069	0.723
MOD_GSK3_1	471	478	PF00069	0.694
MOD_GSK3_1	500	507	PF00069	0.690
MOD_GSK3_1	509	516	PF00069	0.611
MOD_GSK3_1	546	553	PF00069	0.682
MOD_GSK3_1	61	68	PF00069	0.583
MOD_N-GLC_1	6	11	PF02516	0.611
MOD_N-GLC_1	60	65	PF02516	0.518
MOD_N-GLC_1	68	73	PF02516	0.511
MOD_N-GLC_2	83	85	PF02516	0.498
MOD_NEK2_1	239	244	PF00069	0.538
MOD_NEK2_1	316	321	PF00069	0.458
MOD_NEK2_1	329	334	PF00069	0.447
MOD_NEK2_1	347	352	PF00069	0.593
MOD_NEK2_1	394	399	PF00069	0.655
MOD_NEK2_1	453	458	PF00069	0.645
MOD_NEK2_1	471	476	PF00069	0.593
MOD_NEK2_1	499	504	PF00069	0.742
MOD_NEK2_1	65	70	PF00069	0.595
MOD_NEK2_2	180	185	PF00069	0.459
MOD_NEK2_2	583	588	PF00069	0.528
MOD_PIKK_1	27	33	PF00454	0.488
MOD_PKA_2	509	515	PF00069	0.558
MOD_PKA_2	53	59	PF00069	0.715
MOD_Plk_1	180	186	PF00069	0.461
MOD_Plk_1	471	477	PF00069	0.695
MOD_Plk_1	535	541	PF00069	0.627
MOD_Plk_1	6	12	PF00069	0.609
MOD_Plk_1	60	66	PF00069	0.517
MOD_Plk_4	247	253	PF00069	0.727
MOD_Plk_4	307	313	PF00069	0.577
MOD_Plk_4	361	367	PF00069	0.695
MOD_Plk_4	372	378	PF00069	0.583
MOD_Plk_4	382	388	PF00069	0.420
MOD_Plk_4	453	459	PF00069	0.547
MOD_Plk_4	89	95	PF00069	0.488
MOD_ProDKin_1	138	144	PF00069	0.753
MOD_ProDKin_1	258	264	PF00069	0.757
MOD_ProDKin_1	295	301	PF00069	0.673
MOD_ProDKin_1	353	359	PF00069	0.588
MOD_ProDKin_1	548	554	PF00069	0.790
MOD_SUMO_rev_2	56	60	PF00179	0.721
TRG_ENDOCYTIC_2	19	22	PF00928	0.531
TRG_ENDOCYTIC_2	374	377	PF00928	0.622
TRG_ENDOCYTIC_2	609	612	PF00928	0.408
TRG_ENDOCYTIC_2	91	94	PF00928	0.377
TRG_ER_diArg_1	111	113	PF00400	0.807
TRG_ER_diArg_1	492	494	PF00400	0.597

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSV0	Leptomonas seymouri	36%	100%
A0A3S7WRB9	Leishmania donovani	82%	100%
A4HUL1	Leishmania infantum	82%	100%
Q4QHB6	Leishmania major	83%	100%