Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Proximal docking complex protein 1

Species:

Leishmania mexicana

UniProt:

E9ANA6_LEIMU

TriTrypDb:

LmxM.10.0960

Length:

806

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	10
GO:0042995	cell projection	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	10
GO:0005815	microtubule organizing center	2	1
GO:0005930	axoneme	2	1
GO:0035253	ciliary rootlet	2	1
GO:0036064	ciliary basal body	3	1
GO:0097542	ciliary tip	2	1

Expansion

Sequence features

E9ANA6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANA6

Function

Biological processes
Term	Name	Level	Count
GO:0003341	cilium movement	4	11
GO:0007017	microtubule-based process	2	11
GO:0007018	microtubule-based movement	3	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0022607	cellular component assembly	4	11
GO:0036158	outer dynein arm assembly	7	11
GO:0043933	protein-containing complex organization	4	11
GO:0065003	protein-containing complex assembly	5	11
GO:0070286	axonemal dynein complex assembly	6	11
GO:0071840	cellular component organization or biogenesis	2	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	436	440	PF00656	0.438
CLV_C14_Caspase3-7	567	571	PF00656	0.727
CLV_C14_Caspase3-7	709	713	PF00656	0.781
CLV_NRD_NRD_1	21	23	PF00675	0.663
CLV_NRD_NRD_1	280	282	PF00675	0.481
CLV_NRD_NRD_1	295	297	PF00675	0.495
CLV_NRD_NRD_1	58	60	PF00675	0.519
CLV_NRD_NRD_1	590	592	PF00675	0.783
CLV_NRD_NRD_1	611	613	PF00675	0.805
CLV_NRD_NRD_1	655	657	PF00675	0.744
CLV_NRD_NRD_1	741	743	PF00675	0.766
CLV_NRD_NRD_1	780	782	PF00675	0.666
CLV_NRD_NRD_1	804	806	PF00675	0.654
CLV_NRD_NRD_1	82	84	PF00675	0.622
CLV_PCSK_FUR_1	739	743	PF00082	0.770
CLV_PCSK_FUR_1	80	84	PF00082	0.657
CLV_PCSK_KEX2_1	279	281	PF00082	0.490
CLV_PCSK_KEX2_1	295	297	PF00082	0.480
CLV_PCSK_KEX2_1	58	60	PF00082	0.512
CLV_PCSK_KEX2_1	590	592	PF00082	0.783
CLV_PCSK_KEX2_1	611	613	PF00082	0.805
CLV_PCSK_KEX2_1	654	656	PF00082	0.745
CLV_PCSK_KEX2_1	741	743	PF00082	0.767
CLV_PCSK_KEX2_1	780	782	PF00082	0.617
CLV_PCSK_KEX2_1	785	787	PF00082	0.539
CLV_PCSK_KEX2_1	80	82	PF00082	0.630
CLV_PCSK_KEX2_1	804	806	PF00082	0.659
CLV_PCSK_PC1ET2_1	279	281	PF00082	0.580
CLV_PCSK_PC1ET2_1	785	787	PF00082	0.533
CLV_PCSK_PC7_1	781	787	PF00082	0.545
CLV_PCSK_SKI1_1	269	273	PF00082	0.498
CLV_PCSK_SKI1_1	329	333	PF00082	0.534
CLV_PCSK_SKI1_1	369	373	PF00082	0.588
CLV_PCSK_SKI1_1	628	632	PF00082	0.737
CLV_PCSK_SKI1_1	749	753	PF00082	0.764
DEG_APCC_DBOX_1	205	213	PF00400	0.546
DEG_APCC_DBOX_1	234	242	PF00400	0.549
DEG_APCC_DBOX_1	328	336	PF00400	0.654
DEG_APCC_DBOX_1	57	65	PF00400	0.629
DEG_Nend_UBRbox_3	1	3	PF02207	0.494
DOC_CYCLIN_RxL_1	233	246	PF00134	0.581
DOC_CYCLIN_RxL_1	528	538	PF00134	0.589
DOC_MAPK_gen_1	131	141	PF00069	0.561
DOC_MAPK_gen_1	194	202	PF00069	0.549
DOC_MAPK_gen_1	233	240	PF00069	0.456
DOC_MAPK_gen_1	292	300	PF00069	0.464
DOC_MAPK_gen_1	419	427	PF00069	0.565
DOC_MAPK_MEF2A_6	516	525	PF00069	0.649
DOC_PP1_RVXF_1	687	694	PF00149	0.753
DOC_PP4_FxxP_1	744	747	PF00568	0.501
DOC_USP7_MATH_1	173	177	PF00917	0.415
DOC_USP7_MATH_1	515	519	PF00917	0.684
DOC_USP7_MATH_1	545	549	PF00917	0.724
DOC_USP7_MATH_1	576	580	PF00917	0.759
DOC_USP7_MATH_1	682	686	PF00917	0.468
DOC_USP7_UBL2_3	190	194	PF12436	0.519
DOC_WW_Pin1_4	550	555	PF00397	0.724
LIG_14-3-3_CanoR_1	248	258	PF00244	0.538
LIG_14-3-3_CanoR_1	329	335	PF00244	0.562
LIG_14-3-3_CanoR_1	432	441	PF00244	0.732
LIG_14-3-3_CanoR_1	59	65	PF00244	0.591
LIG_14-3-3_CanoR_1	611	619	PF00244	0.763
LIG_Actin_WH2_2	57	74	PF00022	0.508
LIG_BIR_III_4	538	542	PF00653	0.629
LIG_BIR_III_4	712	716	PF00653	0.800
LIG_BIR_III_4	722	726	PF00653	0.645
LIG_CaM_IQ_9	255	271	PF13499	0.568
LIG_CaM_IQ_9	287	303	PF13499	0.580
LIG_FHA_1	250	256	PF00498	0.332
LIG_FHA_1	509	515	PF00498	0.667
LIG_FHA_1	518	524	PF00498	0.568
LIG_FHA_1	698	704	PF00498	0.762
LIG_FHA_2	110	116	PF00498	0.588
LIG_FHA_2	142	148	PF00498	0.333
LIG_FHA_2	222	228	PF00498	0.569
LIG_FHA_2	251	257	PF00498	0.560
LIG_FHA_2	349	355	PF00498	0.638
LIG_FHA_2	434	440	PF00498	0.555
LIG_FHA_2	449	455	PF00498	0.456
LIG_FHA_2	61	67	PF00498	0.643
LIG_FHA_2	613	619	PF00498	0.791
LIG_FHA_2	707	713	PF00498	0.547
LIG_LIR_Gen_1	176	184	PF02991	0.374
LIG_LIR_Gen_1	236	244	PF02991	0.329
LIG_LIR_Gen_1	322	331	PF02991	0.382
LIG_LIR_Nem_3	236	240	PF02991	0.314
LIG_LYPXL_SIV_4	250	258	PF13949	0.586
LIG_Rb_pABgroove_1	238	246	PF01858	0.534
LIG_SH2_NCK_1	360	364	PF00017	0.574
LIG_SH2_STAP1	251	255	PF00017	0.513
LIG_SH2_STAP1	360	364	PF00017	0.519
LIG_SH2_STAT3	391	394	PF00017	0.621
LIG_SH2_STAT3	57	60	PF00017	0.602
LIG_SH2_STAT5	178	181	PF00017	0.511
LIG_SH2_STAT5	237	240	PF00017	0.521
LIG_SH2_STAT5	251	254	PF00017	0.318
LIG_SH2_STAT5	399	402	PF00017	0.599
LIG_SH2_STAT5	423	426	PF00017	0.658
LIG_SH3_3	104	110	PF00018	0.684
LIG_SH3_3	500	506	PF00018	0.512
LIG_TRAF2_1	340	343	PF00917	0.476
LIG_Vh1_VBS_1	521	539	PF01044	0.590
LIG_WW_3	746	750	PF00397	0.500
MOD_CDC14_SPxK_1	553	556	PF00782	0.728
MOD_CDK_SPxK_1	550	556	PF00069	0.725
MOD_CK1_1	17	23	PF00069	0.656
MOD_CK1_1	350	356	PF00069	0.684
MOD_CK1_1	549	555	PF00069	0.800
MOD_CK1_1	697	703	PF00069	0.667
MOD_CK1_1	728	734	PF00069	0.704
MOD_CK2_1	109	115	PF00069	0.597
MOD_CK2_1	221	227	PF00069	0.566
MOD_CK2_1	250	256	PF00069	0.523
MOD_CK2_1	41	47	PF00069	0.465
MOD_CK2_1	448	454	PF00069	0.570
MOD_Cter_Amidation	609	612	PF01082	0.807
MOD_Cter_Amidation	739	742	PF01082	0.759
MOD_GlcNHglycan	16	19	PF01048	0.536
MOD_GlcNHglycan	2	5	PF01048	0.754
MOD_GlcNHglycan	212	215	PF01048	0.406
MOD_GlcNHglycan	25	28	PF01048	0.589
MOD_GlcNHglycan	441	444	PF01048	0.690
MOD_GlcNHglycan	572	575	PF01048	0.758
MOD_GlcNHglycan	578	581	PF01048	0.755
MOD_GlcNHglycan	624	627	PF01048	0.709
MOD_GlcNHglycan	648	651	PF01048	0.701
MOD_GlcNHglycan	657	660	PF01048	0.717
MOD_GlcNHglycan	704	707	PF01048	0.730
MOD_GlcNHglycan	727	730	PF01048	0.758
MOD_GSK3_1	221	228	PF00069	0.418
MOD_GSK3_1	343	350	PF00069	0.679
MOD_GSK3_1	426	433	PF00069	0.647
MOD_GSK3_1	444	451	PF00069	0.533
MOD_GSK3_1	504	511	PF00069	0.575
MOD_GSK3_1	545	552	PF00069	0.750
MOD_GSK3_1	694	701	PF00069	0.673
MOD_GSK3_1	702	709	PF00069	0.661
MOD_N-GLC_1	173	178	PF02516	0.446
MOD_N-GLC_1	23	28	PF02516	0.608
MOD_N-GLC_1	263	268	PF02516	0.609
MOD_N-GLC_1	67	72	PF02516	0.599
MOD_NEK2_1	243	248	PF00069	0.533
MOD_NEK2_1	287	292	PF00069	0.449
MOD_NEK2_1	335	340	PF00069	0.690
MOD_NEK2_1	6	11	PF00069	0.768
MOD_NEK2_1	646	651	PF00069	0.720
MOD_NEK2_2	173	178	PF00069	0.404
MOD_PIKK_1	119	125	PF00454	0.599
MOD_PIKK_1	287	293	PF00454	0.479
MOD_PIKK_1	30	36	PF00454	0.395
MOD_PIKK_1	338	344	PF00454	0.585
MOD_PKA_1	654	660	PF00069	0.746
MOD_PKA_1	785	791	PF00069	0.575
MOD_PKA_2	335	341	PF00069	0.613
MOD_PKA_2	654	660	PF00069	0.724
MOD_PKA_2	785	791	PF00069	0.617
MOD_PKB_1	430	438	PF00069	0.684
MOD_Plk_1	141	147	PF00069	0.331
MOD_Plk_1	173	179	PF00069	0.437
MOD_Plk_1	263	269	PF00069	0.554
MOD_Plk_1	67	73	PF00069	0.512
MOD_Plk_2-3	109	115	PF00069	0.657
MOD_Plk_4	221	227	PF00069	0.562
MOD_Plk_4	330	336	PF00069	0.625
MOD_Plk_4	395	401	PF00069	0.529
MOD_Plk_4	448	454	PF00069	0.536
MOD_ProDKin_1	550	556	PF00069	0.725
MOD_SUMO_rev_2	562	571	PF00179	0.714
MOD_SUMO_rev_2	777	787	PF00179	0.676
TRG_DiLeu_BaEn_2	455	461	PF01217	0.610
TRG_DiLeu_BaEn_3	305	311	PF01217	0.633
TRG_DiLeu_BaEn_4	306	312	PF01217	0.574
TRG_DiLeu_BaEn_4	463	469	PF01217	0.583
TRG_ENDOCYTIC_2	178	181	PF00928	0.511
TRG_ENDOCYTIC_2	237	240	PF00928	0.302
TRG_ENDOCYTIC_2	323	326	PF00928	0.376
TRG_ER_diArg_1	10	13	PF00400	0.706
TRG_ER_diArg_1	295	297	PF00400	0.497
TRG_ER_diArg_1	57	59	PF00400	0.609
TRG_ER_diArg_1	590	592	PF00400	0.750
TRG_ER_diArg_1	611	614	PF00400	0.811
TRG_ER_diArg_1	653	656	PF00400	0.743
TRG_ER_diArg_1	739	742	PF00400	0.774
TRG_ER_diArg_1	779	781	PF00400	0.671
TRG_ER_diArg_1	791	794	PF00400	0.452
TRG_ER_diArg_1	80	83	PF00400	0.624
TRG_ER_diArg_1	804	806	PF00400	0.598
TRG_Pf-PMV_PEXEL_1	134	138	PF00026	0.587
TRG_Pf-PMV_PEXEL_1	62	66	PF00026	0.578
TRG_Pf-PMV_PEXEL_1	689	694	PF00026	0.740
TRG_Pf-PMV_PEXEL_1	72	76	PF00026	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P488	Leptomonas seymouri	50%	89%
A0A1X0NQB6	Trypanosomatidae	26%	100%
A0A3Q8I8W1	Leishmania donovani	87%	100%
A0A422NCY5	Trypanosoma rangeli	28%	100%
A4H684	Leishmania braziliensis	70%	99%
A4HUK9	Leishmania infantum	86%	100%
C9ZVN6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
Q4QHB8	Leishmania major	85%	100%
V5BJM8	Trypanosoma cruzi	28%	100%