A very simple single-pass membrane protein restricted to Kinetoplastids. Might be mitochondrial.. A transit peptide cannot be excluded in the sequence.. Localization: Mitochondrial (by feature)
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 9 |
| NetGPI | no | yes: 0, no: 9 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0005739 | mitochondrion | 5 | 1 |
| GO:0005741 | mitochondrial outer membrane | 5 | 1 |
| GO:0005742 | mitochondrial outer membrane translocase complex | 4 | 1 |
| GO:0016020 | membrane | 2 | 4 |
| GO:0019867 | outer membrane | 3 | 1 |
| GO:0031090 | organelle membrane | 3 | 1 |
| GO:0031966 | mitochondrial membrane | 4 | 1 |
| GO:0031968 | organelle outer membrane | 4 | 1 |
| GO:0032991 | protein-containing complex | 1 | 1 |
| GO:0043226 | organelle | 2 | 1 |
| GO:0043227 | membrane-bounded organelle | 3 | 1 |
| GO:0043229 | intracellular organelle | 3 | 1 |
| GO:0043231 | intracellular membrane-bounded organelle | 4 | 1 |
| GO:0098588 | bounding membrane of organelle | 4 | 1 |
| GO:0098796 | membrane protein complex | 2 | 1 |
| GO:0098798 | mitochondrial protein-containing complex | 2 | 1 |
| GO:0098799 | outer mitochondrial membrane protein complex | 3 | 1 |
| GO:0110165 | cellular anatomical entity | 1 | 4 |
Related structures:
AlphaFold database: E9ANA4
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0006605 | protein targeting | 5 | 1 |
| GO:0006626 | protein targeting to mitochondrion | 5 | 1 |
| GO:0006810 | transport | 3 | 1 |
| GO:0006839 | mitochondrial transport | 4 | 1 |
| GO:0006886 | intracellular protein transport | 4 | 1 |
| GO:0008104 | protein localization | 4 | 1 |
| GO:0009987 | cellular process | 1 | 1 |
| GO:0015031 | protein transport | 4 | 1 |
| GO:0030150 | protein import into mitochondrial matrix | 4 | 1 |
| GO:0033036 | macromolecule localization | 2 | 1 |
| GO:0033365 | protein localization to organelle | 5 | 1 |
| GO:0044743 | protein transmembrane import into intracellular organelle | 4 | 1 |
| GO:0045184 | establishment of protein localization | 3 | 1 |
| GO:0046907 | intracellular transport | 3 | 1 |
| GO:0051179 | localization | 1 | 1 |
| GO:0051234 | establishment of localization | 2 | 1 |
| GO:0051641 | cellular localization | 2 | 1 |
| GO:0051649 | establishment of localization in cell | 3 | 1 |
| GO:0055085 | transmembrane transport | 2 | 1 |
| GO:0065002 | intracellular protein transmembrane transport | 4 | 1 |
| GO:0070585 | protein localization to mitochondrion | 6 | 1 |
| GO:0070727 | cellular macromolecule localization | 3 | 1 |
| GO:0071702 | organic substance transport | 4 | 1 |
| GO:0071705 | nitrogen compound transport | 4 | 1 |
| GO:0071806 | protein transmembrane transport | 3 | 1 |
| GO:0072594 | establishment of protein localization to organelle | 4 | 1 |
| GO:0072655 | establishment of protein localization to mitochondrion | 5 | 1 |
| GO:1990542 | mitochondrial transmembrane transport | 3 | 1 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_C14_Caspase3-7 | 8 | 12 | PF00656 | 0.673 |
| CLV_NRD_NRD_1 | 18 | 20 | PF00675 | 0.346 |
| CLV_NRD_NRD_1 | 92 | 94 | PF00675 | 0.584 |
| CLV_PCSK_KEX2_1 | 18 | 20 | PF00082 | 0.371 |
| CLV_PCSK_KEX2_1 | 91 | 93 | PF00082 | 0.573 |
| DEG_APCC_DBOX_1 | 58 | 66 | PF00400 | 0.341 |
| DEG_Nend_Nbox_1 | 1 | 3 | PF02207 | 0.663 |
| DOC_PP4_FxxP_1 | 38 | 41 | PF00568 | 0.266 |
| LIG_14-3-3_CanoR_1 | 91 | 100 | PF00244 | 0.458 |
| LIG_BRCT_BRCA1_1 | 56 | 60 | PF00533 | 0.386 |
| LIG_LIR_Apic_2 | 37 | 41 | PF02991 | 0.266 |
| LIG_LIR_Nem_3 | 77 | 83 | PF02991 | 0.431 |
| LIG_PDZ_Class_1 | 102 | 107 | PF00595 | 0.304 |
| LIG_Pex14_2 | 60 | 64 | PF04695 | 0.348 |
| LIG_RPA_C_Fungi | 88 | 100 | PF08784 | 0.585 |
| LIG_SH2_SRC | 83 | 86 | PF00017 | 0.510 |
| LIG_SH2_STAT5 | 27 | 30 | PF00017 | 0.432 |
| LIG_SH2_STAT5 | 35 | 38 | PF00017 | 0.241 |
| LIG_SH2_STAT5 | 66 | 69 | PF00017 | 0.577 |
| MOD_CK1_1 | 26 | 32 | PF00069 | 0.453 |
| MOD_CK2_1 | 95 | 101 | PF00069 | 0.585 |
| MOD_GlcNHglycan | 86 | 89 | PF01048 | 0.526 |
| MOD_GlcNHglycan | 97 | 100 | PF01048 | 0.564 |
| MOD_GSK3_1 | 79 | 86 | PF00069 | 0.611 |
| MOD_GSK3_1 | 91 | 98 | PF00069 | 0.541 |
| MOD_NEK2_1 | 23 | 28 | PF00069 | 0.442 |
| MOD_NEK2_1 | 65 | 70 | PF00069 | 0.493 |
| MOD_NEK2_2 | 66 | 71 | PF00069 | 0.554 |
| MOD_PK_1 | 5 | 11 | PF00069 | 0.607 |
| MOD_PKA_1 | 91 | 97 | PF00069 | 0.530 |
| MOD_PKA_2 | 91 | 97 | PF00069 | 0.585 |
| MOD_Plk_4 | 23 | 29 | PF00069 | 0.474 |
| MOD_SUMO_rev_2 | 72 | 81 | PF00179 | 0.460 |
| TRG_DiLeu_BaLyEn_6 | 38 | 43 | PF01217 | 0.399 |
| TRG_ENDOCYTIC_2 | 35 | 38 | PF00928 | 0.266 |
| TRG_ER_diArg_1 | 18 | 20 | PF00400 | 0.426 |
| TRG_ER_diArg_1 | 91 | 93 | PF00400 | 0.504 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N1HVG0 | Leptomonas seymouri | 77% | 100% |
| A0A0S4JL52 | Bodo saltans | 39% | 100% |
| A0A1X0NS16 | Trypanosomatidae | 47% | 100% |
| A0A3S7WR90 | Leishmania donovani | 96% | 100% |
| A0A422NCR7 | Trypanosoma rangeli | 54% | 100% |
| A4HUK7 | Leishmania infantum | 96% | 100% |
| C9ZVN4 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 50% | 100% |
| Q4QHC0 | Leishmania major | 93% | 100% |