Putative small GTP-binding protein Rab11

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

small GTP-binding protein Rab11, putative

Species:

Leishmania mexicana

UniProt:

E9ANA1_LEIMU

TriTrypDb:

LmxM.10.0910

Length:

208

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0000331	contractile vacuole	6	1
GO:0005773	vacuole	5	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

E9ANA1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANA1

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0003924	GTPase activity	7	12
GO:0005488	binding	1	12
GO:0005525	GTP binding	5	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0017076	purine nucleotide binding	4	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	128	132	PF00082	0.301
CLV_PCSK_SKI1_1	47	51	PF00082	0.301
CLV_PCSK_SKI1_1	54	58	PF00082	0.301
CLV_PCSK_SKI1_1	9	13	PF00082	0.442
DEG_Nend_UBRbox_2	1	3	PF02207	0.555
DEG_SCF_TRCP1_1	15	21	PF00400	0.301
DOC_CKS1_1	172	177	PF01111	0.698
DOC_CKS1_1	34	39	PF01111	0.301
DOC_CYCLIN_yClb1_LxF_4	141	147	PF00134	0.301
DOC_MAPK_gen_1	137	146	PF00069	0.301

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Z9	Leptomonas seymouri	29%	88%
A0A0N0P3A0	Leptomonas seymouri	37%	77%
A0A0N0P3G2	Leptomonas seymouri	27%	100%
A0A0N0P3Q3	Leptomonas seymouri	30%	100%
A0A0N0P6K4	Leptomonas seymouri	31%	96%
A0A0N0P6P8	Leptomonas seymouri	42%	99%
A0A0N0P8G7	Leptomonas seymouri	35%	96%
A0A0N0P8I1	Leptomonas seymouri	34%	94%
A0A0N0P971	Leptomonas seymouri	33%	97%
A0A0N1HU31	Leptomonas seymouri	31%	84%

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