Peptidylprolyl isomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

FKBP-type peptidyl-prolyl cis-trans isomerase, putative

Species:

Leishmania mexicana

UniProt:

E9AN99_LEIMU

TriTrypDb:

LmxM.10.0890

Length:

155

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AN99

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN99

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	1
GO:0006457	protein folding	2	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018208	peptidyl-proline modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0061077	chaperone-mediated protein folding	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	7
GO:0003824	catalytic activity	1	7
GO:0016853	isomerase activity	2	7
GO:0016859	cis-trans isomerase activity	3	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	30	32	PF00675	0.272
CLV_PCSK_SKI1_1	126	130	PF00082	0.262
DEG_Nend_UBRbox_3	1	3	PF02207	0.353
DOC_SPAK_OSR1_1	26	30	PF12202	0.341
DOC_USP7_MATH_1	14	18	PF00917	0.378
DOC_USP7_MATH_1	42	46	PF00917	0.256
DOC_USP7_UBL2_3	28	32	PF12436	0.365
DOC_WW_Pin1_4	38	43	PF00397	0.398
LIG_BIR_III_2	13	17	PF00653	0.341
LIG_CtBP_PxDLS_1	101	105	PF00389	0.283
LIG_FHA_1	82	88	PF00498	0.283
LIG_FHA_2	149	155	PF00498	0.434
LIG_LIR_Apic_2	97	102	PF02991	0.283
LIG_LIR_Gen_1	149	155	PF02991	0.386
LIG_LIR_Nem_3	149	155	PF02991	0.386
LIG_LIR_Nem_3	94	99	PF02991	0.283
LIG_SH2_SRC	99	102	PF00017	0.283
LIG_SH2_STAT5	99	102	PF00017	0.283
LIG_SH3_3	111	117	PF00018	0.439
LIG_SH3_3	41	47	PF00018	0.256
LIG_SH3_3	95	101	PF00018	0.284
LIG_UBA3_1	127	135	PF00899	0.398
MOD_CK1_1	38	44	PF00069	0.283
MOD_GlcNHglycan	22	25	PF01048	0.396
MOD_GSK3_1	38	45	PF00069	0.291
MOD_N-GLC_1	117	122	PF02516	0.214
MOD_N-GLC_1	42	47	PF02516	0.283
MOD_NEK2_1	148	153	PF00069	0.381
MOD_Plk_1	117	123	PF00069	0.214
MOD_Plk_1	62	68	PF00069	0.283
MOD_Plk_4	117	123	PF00069	0.214
MOD_ProDKin_1	38	44	PF00069	0.300
MOD_SUMO_rev_2	11	17	PF00179	0.414
TRG_DiLeu_BaLyEn_6	123	128	PF01217	0.262
TRG_ENDOCYTIC_2	152	155	PF00928	0.410

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTT4	Leptomonas seymouri	79%	100%
A0A0N1HUP7	Leptomonas seymouri	38%	100%
A0A0N1II12	Leptomonas seymouri	33%	78%
A0A0N1PEA6	Leptomonas seymouri	39%	100%
A0A0S4KLH1	Bodo saltans	38%	100%
A0A1X0NUY2	Trypanosomatidae	37%	100%
A0A1X0P7N1	Trypanosomatidae	49%	73%
A0A1X0P8C6	Trypanosomatidae	40%	100%
A0A3Q8IB31	Leishmania donovani	92%	97%
A0A3Q8ICF9	Leishmania donovani	38%	100%
A0A3R7LCV9	Trypanosoma rangeli	41%	100%
A0A3S5H764	Leishmania donovani	29%	77%
A0A3S5H813	Leishmania donovani	39%	100%
A0A3S5IR72	Trypanosoma rangeli	43%	77%
A0A422N485	Trypanosoma rangeli	36%	100%
A4H677	Leishmania braziliensis	87%	100%
A4HA48	Leishmania braziliensis	31%	76%
A4HCI1	Leishmania braziliensis	38%	82%
A4HNN1	Leishmania braziliensis	41%	100%
A4HUK1	Leishmania infantum	92%	97%
A4HYB4	Leishmania infantum	28%	77%
A4I002	Leishmania infantum	38%	100%
A4ICW4	Leishmania infantum	39%	100%
A5IGB8	Legionella pneumophila (strain Corby)	48%	67%
D0A0P0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	79%
E9AS47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	76%
E9ASE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9AVX5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
O22870	Arabidopsis thaliana	29%	70%
O42993	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	100%
P0A9L3	Escherichia coli (strain K12)	45%	75%
P0A9L4	Shigella flexneri	45%	75%
P0C1J5	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	41%	74%
P0CP96	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	41%	100%
P0CP97	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	41%	100%
P30417	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	37%	68%
P51752	Coxiella burnetii (strain RSA 493 / Nine Mile phase I)	48%	67%
P53605	Legionella longbeachae	49%	67%
Q09734	Trypanosoma cruzi	46%	79%
Q2U316	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	36%	100%
Q2UPT7	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	38%	100%
Q38936	Arabidopsis thaliana	39%	95%
Q4HZB8	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	37%	100%
Q4IN00	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	36%	79%
Q4Q255	Leishmania major	40%	100%
Q4QBK4	Leishmania major	38%	100%
Q4QDB9	Leishmania major	28%	77%
Q4QHC5	Leishmania major	91%	100%
Q54SR7	Dictyostelium discoideum	40%	100%
Q5ZXE0	Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)	48%	67%
Q6BP84	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	42%	100%
Q6CGG3	Yarrowia lipolytica (strain CLIB 122 / E 150)	38%	100%
Q6FSC1	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	44%	100%
Q6M981	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	36%	100%
Q70YI1	Legionella pneumophila	48%	67%
Q86ZF2	Podospora anserina	39%	84%
Q9M2S7	Arabidopsis thaliana	34%	82%
V5BA38	Trypanosoma cruzi	40%	100%