Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AN98_LEIMU

TriTrypDb:

LmxM.10.0880

Length:

1157

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AN98

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN98

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	222	226	PF00656	0.544
CLV_C14_Caspase3-7	641	645	PF00656	0.549
CLV_C14_Caspase3-7	912	916	PF00656	0.582
CLV_C14_Caspase3-7	967	971	PF00656	0.539
CLV_NRD_NRD_1	1138	1140	PF00675	0.461
CLV_NRD_NRD_1	371	373	PF00675	0.450
CLV_NRD_NRD_1	376	378	PF00675	0.441
CLV_NRD_NRD_1	414	416	PF00675	0.568
CLV_NRD_NRD_1	431	433	PF00675	0.489
CLV_NRD_NRD_1	515	517	PF00675	0.555
CLV_NRD_NRD_1	543	545	PF00675	0.595
CLV_NRD_NRD_1	617	619	PF00675	0.540
CLV_NRD_NRD_1	74	76	PF00675	0.565
CLV_NRD_NRD_1	810	812	PF00675	0.564
CLV_NRD_NRD_1	836	838	PF00675	0.571
CLV_NRD_NRD_1	892	894	PF00675	0.585
CLV_NRD_NRD_1	943	945	PF00675	0.555
CLV_NRD_NRD_1	985	987	PF00675	0.519
CLV_PCSK_FUR_1	429	433	PF00082	0.532
CLV_PCSK_FUR_1	811	815	PF00082	0.538
CLV_PCSK_KEX2_1	1137	1139	PF00082	0.440
CLV_PCSK_KEX2_1	237	239	PF00082	0.761
CLV_PCSK_KEX2_1	371	373	PF00082	0.450
CLV_PCSK_KEX2_1	414	416	PF00082	0.568
CLV_PCSK_KEX2_1	431	433	PF00082	0.489
CLV_PCSK_KEX2_1	515	517	PF00082	0.555
CLV_PCSK_KEX2_1	539	541	PF00082	0.587
CLV_PCSK_KEX2_1	543	545	PF00082	0.594
CLV_PCSK_KEX2_1	617	619	PF00082	0.540
CLV_PCSK_KEX2_1	74	76	PF00082	0.565
CLV_PCSK_KEX2_1	810	812	PF00082	0.564
CLV_PCSK_KEX2_1	813	815	PF00082	0.557
CLV_PCSK_KEX2_1	835	837	PF00082	0.574
CLV_PCSK_KEX2_1	922	924	PF00082	0.535
CLV_PCSK_KEX2_1	943	945	PF00082	0.555
CLV_PCSK_KEX2_1	985	987	PF00082	0.478
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.506
CLV_PCSK_PC1ET2_1	539	541	PF00082	0.552
CLV_PCSK_PC1ET2_1	813	815	PF00082	0.538
CLV_PCSK_PC1ET2_1	922	924	PF00082	0.535
CLV_PCSK_PC7_1	1133	1139	PF00082	0.427
CLV_PCSK_PC7_1	367	373	PF00082	0.440
CLV_PCSK_PC7_1	832	838	PF00082	0.561
CLV_PCSK_SKI1_1	1071	1075	PF00082	0.569
CLV_PCSK_SKI1_1	1118	1122	PF00082	0.428
CLV_PCSK_SKI1_1	367	371	PF00082	0.436
CLV_PCSK_SKI1_1	564	568	PF00082	0.568
CLV_PCSK_SKI1_1	952	956	PF00082	0.564
CLV_Separin_Metazoa	368	372	PF03568	0.436
DEG_SPOP_SBC_1	118	122	PF00917	0.561
DEG_SPOP_SBC_1	339	343	PF00917	0.567
DEG_SPOP_SBC_1	474	478	PF00917	0.537
DEG_SPOP_SBC_1	751	755	PF00917	0.588
DEG_SPOP_SBC_1	843	847	PF00917	0.548
DOC_CKS1_1	397	402	PF01111	0.569
DOC_CKS1_1	535	540	PF01111	0.586
DOC_CKS1_1	580	585	PF01111	0.535
DOC_CKS1_1	6	11	PF01111	0.579
DOC_CKS1_1	997	1002	PF01111	0.509
DOC_MAPK_MEF2A_6	386	395	PF00069	0.536
DOC_MAPK_MEF2A_6	414	423	PF00069	0.546
DOC_MAPK_RevD_3	419	432	PF00069	0.524
DOC_PP1_RVXF_1	993	999	PF00149	0.480
DOC_PP2B_LxvP_1	103	106	PF13499	0.556
DOC_PP2B_LxvP_1	306	309	PF13499	0.535
DOC_PP2B_LxvP_1	652	655	PF13499	0.554
DOC_USP7_MATH_1	1097	1101	PF00917	0.513
DOC_USP7_MATH_1	1150	1154	PF00917	0.513
DOC_USP7_MATH_1	118	122	PF00917	0.561
DOC_USP7_MATH_1	206	210	PF00917	0.532
DOC_USP7_MATH_1	280	284	PF00917	0.571
DOC_USP7_MATH_1	322	326	PF00917	0.541
DOC_USP7_MATH_1	39	43	PF00917	0.581
DOC_USP7_MATH_1	474	478	PF00917	0.537
DOC_USP7_MATH_1	496	500	PF00917	0.571
DOC_USP7_MATH_1	552	556	PF00917	0.585
DOC_USP7_MATH_1	751	755	PF00917	0.588
DOC_USP7_MATH_1	79	83	PF00917	0.553
DOC_USP7_MATH_1	877	881	PF00917	0.579
DOC_USP7_MATH_1	959	963	PF00917	0.589
DOC_WW_Pin1_4	1003	1008	PF00397	0.517
DOC_WW_Pin1_4	1036	1041	PF00397	0.566
DOC_WW_Pin1_4	1082	1087	PF00397	0.565
DOC_WW_Pin1_4	124	129	PF00397	0.553
DOC_WW_Pin1_4	304	309	PF00397	0.562
DOC_WW_Pin1_4	340	345	PF00397	0.554
DOC_WW_Pin1_4	396	401	PF00397	0.567
DOC_WW_Pin1_4	415	420	PF00397	0.504
DOC_WW_Pin1_4	475	480	PF00397	0.573
DOC_WW_Pin1_4	5	10	PF00397	0.580
DOC_WW_Pin1_4	516	521	PF00397	0.541
DOC_WW_Pin1_4	534	539	PF00397	0.578
DOC_WW_Pin1_4	548	553	PF00397	0.551
DOC_WW_Pin1_4	558	563	PF00397	0.550
DOC_WW_Pin1_4	579	584	PF00397	0.536
DOC_WW_Pin1_4	601	606	PF00397	0.566
DOC_WW_Pin1_4	609	614	PF00397	0.560
DOC_WW_Pin1_4	619	624	PF00397	0.494
DOC_WW_Pin1_4	64	69	PF00397	0.541
DOC_WW_Pin1_4	672	677	PF00397	0.552
DOC_WW_Pin1_4	747	752	PF00397	0.577
DOC_WW_Pin1_4	755	760	PF00397	0.567
DOC_WW_Pin1_4	781	786	PF00397	0.559
DOC_WW_Pin1_4	866	871	PF00397	0.584
DOC_WW_Pin1_4	873	878	PF00397	0.563
DOC_WW_Pin1_4	900	905	PF00397	0.584
DOC_WW_Pin1_4	957	962	PF00397	0.591
DOC_WW_Pin1_4	996	1001	PF00397	0.502
LIG_14-3-3_CanoR_1	1052	1059	PF00244	0.563
LIG_14-3-3_CanoR_1	112	119	PF00244	0.569
LIG_14-3-3_CanoR_1	180	185	PF00244	0.561
LIG_14-3-3_CanoR_1	29	39	PF00244	0.526
LIG_14-3-3_CanoR_1	464	474	PF00244	0.582
LIG_14-3-3_CanoR_1	534	538	PF00244	0.582
LIG_14-3-3_CanoR_1	617	623	PF00244	0.516
LIG_14-3-3_CanoR_1	739	743	PF00244	0.532
LIG_14-3-3_CanoR_1	763	769	PF00244	0.562
LIG_14-3-3_CanoR_1	811	817	PF00244	0.573
LIG_14-3-3_CanoR_1	931	936	PF00244	0.541
LIG_14-3-3_CanoR_1	952	961	PF00244	0.590
LIG_Actin_WH2_2	1105	1120	PF00022	0.454
LIG_Actin_WH2_2	583	598	PF00022	0.500
LIG_BIR_III_2	602	606	PF00653	0.568
LIG_BIR_III_4	915	919	PF00653	0.541
LIG_Clathr_ClatBox_1	356	360	PF01394	0.399
LIG_CSL_BTD_1	997	1000	PF09270	0.503
LIG_CtBP_PxDLS_1	108	112	PF00389	0.521
LIG_CtBP_PxDLS_1	394	398	PF00389	0.559
LIG_CtBP_PxDLS_1	932	936	PF00389	0.540
LIG_EVH1_1	652	656	PF00568	0.553
LIG_EVH1_2	1020	1024	PF00568	0.572
LIG_FHA_1	1107	1113	PF00498	0.462
LIG_FHA_1	189	195	PF00498	0.551
LIG_FHA_1	519	525	PF00498	0.535
LIG_FHA_1	565	571	PF00498	0.546
LIG_FHA_1	580	586	PF00498	0.517
LIG_FHA_1	782	788	PF00498	0.515
LIG_FHA_2	43	49	PF00498	0.552
LIG_FHA_2	517	523	PF00498	0.537
LIG_FHA_2	639	645	PF00498	0.548
LIG_FHA_2	846	852	PF00498	0.588
LIG_FHA_2	866	872	PF00498	0.583
LIG_FHA_2	910	916	PF00498	0.583
LIG_Integrin_RGD_1	432	434	PF01839	0.535
LIG_Integrin_RGD_1	913	915	PF01839	0.548
LIG_LIR_Apic_2	557	562	PF02991	0.576
LIG_LIR_Gen_1	1006	1016	PF02991	0.531
LIG_LIR_Gen_1	440	447	PF02991	0.520
LIG_LIR_Gen_1	674	684	PF02991	0.558
LIG_LIR_Nem_3	1006	1011	PF02991	0.528
LIG_LIR_Nem_3	351	355	PF02991	0.415
LIG_LIR_Nem_3	440	444	PF02991	0.520
LIG_LIR_Nem_3	674	680	PF02991	0.560
LIG_MYND_1	260	264	PF01753	0.530
LIG_PDZ_Class_1	1152	1157	PF00595	0.524
LIG_SH2_CRK	1140	1144	PF00017	0.496
LIG_SH2_CRK	559	563	PF00017	0.528
LIG_SH2_NCK_1	559	563	PF00017	0.528
LIG_SH2_STAT3	355	358	PF00017	0.404
LIG_SH2_STAT5	158	161	PF00017	0.444
LIG_SH2_STAT5	355	358	PF00017	0.404
LIG_SH2_STAT5	742	745	PF00017	0.529
LIG_SH3_2	980	985	PF14604	0.531
LIG_SH3_3	102	108	PF00018	0.539
LIG_SH3_3	1078	1084	PF00018	0.554
LIG_SH3_3	179	185	PF00018	0.553
LIG_SH3_3	202	208	PF00018	0.535
LIG_SH3_3	255	261	PF00018	0.546
LIG_SH3_3	290	296	PF00018	0.516
LIG_SH3_3	3	9	PF00018	0.580
LIG_SH3_3	330	336	PF00018	0.580
LIG_SH3_3	650	656	PF00018	0.556
LIG_SH3_3	697	703	PF00018	0.532
LIG_SH3_3	784	790	PF00018	0.505
LIG_SH3_3	977	983	PF00018	0.555
LIG_SUMO_SIM_par_1	657	662	PF11976	0.511
LIG_TRAF2_1	68	71	PF00917	0.578
LIG_WRC_WIRS_1	438	443	PF05994	0.524
LIG_WW_1	263	266	PF00397	0.531
LIG_WW_2	260	263	PF00397	0.533
LIG_WW_3	399	403	PF00397	0.571
MOD_CDC14_SPxK_1	561	564	PF00782	0.572
MOD_CDC14_SPxK_1	758	761	PF00782	0.586
MOD_CDK_SPK_2	534	539	PF00069	0.585
MOD_CDK_SPK_2	873	878	PF00069	0.581
MOD_CDK_SPxK_1	396	402	PF00069	0.569
MOD_CDK_SPxK_1	534	540	PF00069	0.544
MOD_CDK_SPxK_1	558	564	PF00069	0.575
MOD_CDK_SPxK_1	755	761	PF00069	0.589
MOD_CK1_1	1085	1091	PF00069	0.566
MOD_CK1_1	120	126	PF00069	0.549
MOD_CK1_1	141	147	PF00069	0.575
MOD_CK1_1	152	158	PF00069	0.442
MOD_CK1_1	183	189	PF00069	0.565
MOD_CK1_1	314	320	PF00069	0.571
MOD_CK1_1	396	402	PF00069	0.569
MOD_CK1_1	42	48	PF00069	0.623
MOD_CK1_1	440	446	PF00069	0.563
MOD_CK1_1	450	456	PF00069	0.550
MOD_CK1_1	465	471	PF00069	0.543
MOD_CK1_1	528	534	PF00069	0.542
MOD_CK1_1	551	557	PF00069	0.540
MOD_CK1_1	598	604	PF00069	0.552
MOD_CK1_1	62	68	PF00069	0.769
MOD_CK1_1	738	744	PF00069	0.573
MOD_CK1_1	754	760	PF00069	0.549
MOD_CK1_1	866	872	PF00069	0.583
MOD_CK1_1	887	893	PF00069	0.582
MOD_CK1_1	900	906	PF00069	0.549
MOD_CK2_1	345	351	PF00069	0.459
MOD_CK2_1	516	522	PF00069	0.539
MOD_CK2_1	619	625	PF00069	0.534
MOD_CK2_1	64	70	PF00069	0.546
MOD_CK2_1	710	716	PF00069	0.566
MOD_CK2_1	750	756	PF00069	0.553
MOD_CK2_1	845	851	PF00069	0.588
MOD_CK2_1	865	871	PF00069	0.587
MOD_CK2_1	961	967	PF00069	0.542
MOD_DYRK1A_RPxSP_1	516	520	PF00069	0.536
MOD_GlcNHglycan	1040	1043	PF01048	0.566
MOD_GlcNHglycan	1059	1062	PF01048	0.526
MOD_GlcNHglycan	1087	1090	PF01048	0.581
MOD_GlcNHglycan	1099	1102	PF01048	0.500
MOD_GlcNHglycan	1150	1153	PF01048	0.504
MOD_GlcNHglycan	149	152	PF01048	0.519
MOD_GlcNHglycan	208	211	PF01048	0.535
MOD_GlcNHglycan	219	222	PF01048	0.532
MOD_GlcNHglycan	225	228	PF01048	0.508
MOD_GlcNHglycan	313	316	PF01048	0.564
MOD_GlcNHglycan	318	321	PF01048	0.563
MOD_GlcNHglycan	33	36	PF01048	0.573
MOD_GlcNHglycan	450	453	PF01048	0.570
MOD_GlcNHglycan	458	461	PF01048	0.552
MOD_GlcNHglycan	489	493	PF01048	0.578
MOD_GlcNHglycan	496	499	PF01048	0.564
MOD_GlcNHglycan	530	533	PF01048	0.544
MOD_GlcNHglycan	597	600	PF01048	0.541
MOD_GlcNHglycan	646	649	PF01048	0.568
MOD_GlcNHglycan	696	699	PF01048	0.536
MOD_GlcNHglycan	790	793	PF01048	0.549
MOD_GlcNHglycan	816	819	PF01048	0.572
MOD_GlcNHglycan	907	910	PF01048	0.566
MOD_GlcNHglycan	963	966	PF01048	0.542
MOD_GlcNHglycan	98	101	PF01048	0.547
MOD_GSK3_1	1	8	PF00069	0.563
MOD_GSK3_1	1044	1051	PF00069	0.558
MOD_GSK3_1	1053	1060	PF00069	0.556
MOD_GSK3_1	1067	1074	PF00069	0.529
MOD_GSK3_1	107	114	PF00069	0.562
MOD_GSK3_1	1148	1155	PF00069	0.513
MOD_GSK3_1	120	127	PF00069	0.527
MOD_GSK3_1	134	141	PF00069	0.556
MOD_GSK3_1	143	150	PF00069	0.538
MOD_GSK3_1	183	190	PF00069	0.564
MOD_GSK3_1	294	301	PF00069	0.509
MOD_GSK3_1	39	46	PF00069	0.631
MOD_GSK3_1	446	453	PF00069	0.564
MOD_GSK3_1	484	491	PF00069	0.556
MOD_GSK3_1	54	61	PF00069	0.785
MOD_GSK3_1	548	555	PF00069	0.586
MOD_GSK3_1	586	593	PF00069	0.545
MOD_GSK3_1	609	616	PF00069	0.554
MOD_GSK3_1	661	668	PF00069	0.526
MOD_GSK3_1	671	678	PF00069	0.527
MOD_GSK3_1	734	741	PF00069	0.577
MOD_GSK3_1	742	749	PF00069	0.552
MOD_GSK3_1	750	757	PF00069	0.548
MOD_GSK3_1	841	848	PF00069	0.581
MOD_GSK3_1	873	880	PF00069	0.580
MOD_GSK3_1	893	900	PF00069	0.543
MOD_GSK3_1	905	912	PF00069	0.558
MOD_GSK3_1	953	960	PF00069	0.590
MOD_LATS_1	72	78	PF00433	0.534
MOD_N-GLC_1	58	63	PF02516	0.543
MOD_N-GLC_1	884	889	PF02516	0.589
MOD_N-GLC_1	905	910	PF02516	0.547
MOD_N-GLC_1	952	957	PF02516	0.566
MOD_NEK2_1	1	6	PF00069	0.563
MOD_NEK2_1	1108	1113	PF00069	0.454
MOD_NEK2_1	111	116	PF00069	0.574
MOD_NEK2_1	119	124	PF00069	0.538
MOD_NEK2_1	298	303	PF00069	0.520
MOD_NEK2_1	30	35	PF00069	0.568
MOD_NEK2_1	595	600	PF00069	0.548
MOD_NEK2_1	659	664	PF00069	0.562
MOD_NEK2_1	665	670	PF00069	0.544
MOD_NEK2_1	743	748	PF00069	0.564
MOD_NEK2_1	975	980	PF00069	0.555
MOD_NEK2_2	764	769	PF00069	0.541
MOD_PIKK_1	1001	1007	PF00454	0.527
MOD_PIKK_1	1091	1097	PF00454	0.582
MOD_PIKK_1	465	471	PF00454	0.575
MOD_PKA_1	617	623	PF00069	0.516
MOD_PKA_1	74	80	PF00069	0.566
MOD_PKA_1	893	899	PF00069	0.595
MOD_PKA_2	111	117	PF00069	0.573
MOD_PKA_2	465	471	PF00069	0.582
MOD_PKA_2	533	539	PF00069	0.585
MOD_PKA_2	595	601	PF00069	0.525
MOD_PKA_2	617	623	PF00069	0.516
MOD_PKA_2	671	677	PF00069	0.551
MOD_PKA_2	73	79	PF00069	0.573
MOD_PKA_2	738	744	PF00069	0.549
MOD_PKA_2	831	837	PF00069	0.558
MOD_PKA_2	877	883	PF00069	0.585
MOD_PKB_1	1065	1073	PF00069	0.564
MOD_PKB_1	891	899	PF00069	0.572
MOD_PKB_1	929	937	PF00069	0.542
MOD_Plk_1	42	48	PF00069	0.545
MOD_Plk_2-3	236	242	PF00069	0.516
MOD_Plk_2-3	43	49	PF00069	0.532
MOD_Plk_2-3	710	716	PF00069	0.542
MOD_Plk_4	1029	1035	PF00069	0.562
MOD_Plk_4	1108	1114	PF00069	0.447
MOD_Plk_4	165	171	PF00069	0.409
MOD_Plk_4	322	328	PF00069	0.542
MOD_Plk_4	345	351	PF00069	0.459
MOD_Plk_4	590	596	PF00069	0.530
MOD_Plk_4	738	744	PF00069	0.529
MOD_ProDKin_1	1003	1009	PF00069	0.521
MOD_ProDKin_1	1036	1042	PF00069	0.565
MOD_ProDKin_1	1082	1088	PF00069	0.568
MOD_ProDKin_1	124	130	PF00069	0.551
MOD_ProDKin_1	304	310	PF00069	0.556
MOD_ProDKin_1	340	346	PF00069	0.542
MOD_ProDKin_1	396	402	PF00069	0.569
MOD_ProDKin_1	415	421	PF00069	0.501
MOD_ProDKin_1	475	481	PF00069	0.572
MOD_ProDKin_1	5	11	PF00069	0.580
MOD_ProDKin_1	516	522	PF00069	0.543
MOD_ProDKin_1	534	540	PF00069	0.580
MOD_ProDKin_1	548	554	PF00069	0.551
MOD_ProDKin_1	558	564	PF00069	0.550
MOD_ProDKin_1	579	585	PF00069	0.537
MOD_ProDKin_1	601	607	PF00069	0.571
MOD_ProDKin_1	609	615	PF00069	0.559
MOD_ProDKin_1	619	625	PF00069	0.488
MOD_ProDKin_1	64	70	PF00069	0.542
MOD_ProDKin_1	672	678	PF00069	0.554
MOD_ProDKin_1	747	753	PF00069	0.579
MOD_ProDKin_1	755	761	PF00069	0.568
MOD_ProDKin_1	781	787	PF00069	0.559
MOD_ProDKin_1	866	872	PF00069	0.583
MOD_ProDKin_1	873	879	PF00069	0.563
MOD_ProDKin_1	900	906	PF00069	0.585
MOD_ProDKin_1	957	963	PF00069	0.592
MOD_ProDKin_1	996	1002	PF00069	0.505
MOD_SUMO_for_1	538	541	PF00179	0.588
MOD_SUMO_rev_2	89	95	PF00179	0.507
TRG_DiLeu_BaLyEn_6	1101	1106	PF01217	0.530
TRG_DiLeu_BaLyEn_6	581	586	PF01217	0.536
TRG_ENDOCYTIC_2	1140	1143	PF00928	0.493
TRG_ER_diArg_1	1137	1139	PF00400	0.440
TRG_ER_diArg_1	370	372	PF00400	0.447
TRG_ER_diArg_1	401	404	PF00400	0.581
TRG_ER_diArg_1	428	431	PF00400	0.533
TRG_ER_diArg_1	556	559	PF00400	0.586
TRG_ER_diArg_1	73	75	PF00400	0.569
TRG_ER_diArg_1	775	778	PF00400	0.527
TRG_ER_diArg_1	835	837	PF00400	0.574
TRG_ER_diArg_1	929	932	PF00400	0.539
TRG_Pf-PMV_PEXEL_1	354	358	PF00026	0.409
TRG_Pf-PMV_PEXEL_1	897	902	PF00026	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8I7S0	Leishmania donovani	83%	99%
A4HUK0	Leishmania infantum	83%	99%
Q4QHC6	Leishmania major	80%	99%