A_deaminase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AN94_LEIMU

TriTrypDb:

LmxM.10.0840

Length:

720

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AN94

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN94

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006152	purine nucleoside catabolic process	6	1
GO:0006154	adenosine catabolic process	8	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009058	biosynthetic process	2	1
GO:0009116	nucleoside metabolic process	4	1
GO:0009119	ribonucleoside metabolic process	5	1
GO:0009163	nucleoside biosynthetic process	5	1
GO:0009164	nucleoside catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0034404	nucleobase-containing small molecule biosynthetic process	4	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0034656	nucleobase-containing small molecule catabolic process	4	1
GO:0042278	purine nucleoside metabolic process	5	1
GO:0042451	purine nucleoside biosynthetic process	6	1
GO:0042454	ribonucleoside catabolic process	6	1
GO:0042455	ribonucleoside biosynthetic process	6	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0044282	small molecule catabolic process	3	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0046085	adenosine metabolic process	7	1
GO:0046102	inosine metabolic process	7	1
GO:0046103	inosine biosynthetic process	8	1
GO:0046128	purine ribonucleoside metabolic process	6	1
GO:0046129	purine ribonucleoside biosynthetic process	7	1
GO:0046130	purine ribonucleoside catabolic process	7	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0072521	purine-containing compound metabolic process	4	1
GO:0072522	purine-containing compound biosynthetic process	5	1
GO:0072523	purine-containing compound catabolic process	5	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901136	carbohydrate derivative catabolic process	4	1
GO:1901137	carbohydrate derivative biosynthetic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901576	organic substance biosynthetic process	3	1
GO:1901657	glycosyl compound metabolic process	4	1
GO:1901658	glycosyl compound catabolic process	5	1
GO:1901659	glycosyl compound biosynthetic process	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016787	hydrolase activity	2	11
GO:0019239	deaminase activity	3	11
GO:0004000	adenosine deaminase activity	4	1
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	1
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	164	168	PF00656	0.517
CLV_C14_Caspase3-7	402	406	PF00656	0.530
CLV_C14_Caspase3-7	601	605	PF00656	0.618
CLV_C14_Caspase3-7	69	73	PF00656	0.739
CLV_NRD_NRD_1	170	172	PF00675	0.482
CLV_NRD_NRD_1	174	176	PF00675	0.502
CLV_NRD_NRD_1	272	274	PF00675	0.526
CLV_NRD_NRD_1	339	341	PF00675	0.575
CLV_NRD_NRD_1	364	366	PF00675	0.389
CLV_NRD_NRD_1	397	399	PF00675	0.453
CLV_NRD_NRD_1	496	498	PF00675	0.561
CLV_NRD_NRD_1	528	530	PF00675	0.419
CLV_NRD_NRD_1	95	97	PF00675	0.548
CLV_PCSK_KEX2_1	170	172	PF00082	0.482
CLV_PCSK_KEX2_1	174	176	PF00082	0.502
CLV_PCSK_KEX2_1	271	273	PF00082	0.495
CLV_PCSK_KEX2_1	339	341	PF00082	0.575
CLV_PCSK_KEX2_1	364	366	PF00082	0.417
CLV_PCSK_KEX2_1	397	399	PF00082	0.459
CLV_PCSK_KEX2_1	495	497	PF00082	0.558
CLV_PCSK_KEX2_1	528	530	PF00082	0.418
CLV_PCSK_KEX2_1	94	96	PF00082	0.599
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.599
CLV_PCSK_PC7_1	166	172	PF00082	0.479
CLV_PCSK_PC7_1	267	273	PF00082	0.278
CLV_PCSK_SKI1_1	132	136	PF00082	0.362
CLV_PCSK_SKI1_1	273	277	PF00082	0.474
CLV_PCSK_SKI1_1	281	285	PF00082	0.428
CLV_PCSK_SKI1_1	290	294	PF00082	0.312
CLV_PCSK_SKI1_1	297	301	PF00082	0.379
CLV_PCSK_SKI1_1	566	570	PF00082	0.399
CLV_PCSK_SKI1_1	575	579	PF00082	0.442
DEG_APCC_DBOX_1	272	280	PF00400	0.484
DEG_APCC_DBOX_1	623	631	PF00400	0.337
DEG_Kelch_Keap1_1	205	210	PF01344	0.237
DEG_Nend_UBRbox_2	1	3	PF02207	0.691
DEG_SCF_FBW7_1	100	107	PF00400	0.509
DEG_SPOP_SBC_1	356	360	PF00917	0.436
DOC_CDC14_PxL_1	33	41	PF14671	0.386
DOC_CYCLIN_RxL_1	286	294	PF00134	0.420
DOC_CYCLIN_yCln2_LP_2	633	639	PF00134	0.438
DOC_MAPK_DCC_7	6	14	PF00069	0.659
DOC_MAPK_gen_1	94	102	PF00069	0.462
DOC_MAPK_HePTP_8	283	295	PF00069	0.324
DOC_MAPK_MEF2A_6	286	295	PF00069	0.320
DOC_PP1_RVXF_1	36	42	PF00149	0.345
DOC_PP2B_LxvP_1	259	262	PF13499	0.426
DOC_PP2B_LxvP_1	433	436	PF13499	0.446
DOC_PP2B_LxvP_1	633	636	PF13499	0.341
DOC_PP4_FxxP_1	444	447	PF00568	0.476
DOC_PP4_FxxP_1	631	634	PF00568	0.296
DOC_USP7_MATH_1	104	108	PF00917	0.723
DOC_USP7_MATH_1	214	218	PF00917	0.524
DOC_USP7_MATH_1	262	266	PF00917	0.476
DOC_USP7_MATH_1	356	360	PF00917	0.506
DOC_USP7_MATH_1	545	549	PF00917	0.605
DOC_USP7_MATH_1	651	655	PF00917	0.674
DOC_WW_Pin1_4	100	105	PF00397	0.641
DOC_WW_Pin1_4	112	117	PF00397	0.493
DOC_WW_Pin1_4	344	349	PF00397	0.607
DOC_WW_Pin1_4	606	611	PF00397	0.497
DOC_WW_Pin1_4	687	692	PF00397	0.493
DOC_WW_Pin1_4	694	699	PF00397	0.429
LIG_14-3-3_CanoR_1	162	166	PF00244	0.342
LIG_14-3-3_CanoR_1	170	174	PF00244	0.401
LIG_14-3-3_CanoR_1	253	259	PF00244	0.320
LIG_14-3-3_CanoR_1	281	289	PF00244	0.455
LIG_14-3-3_CanoR_1	290	296	PF00244	0.373
LIG_14-3-3_CanoR_1	297	305	PF00244	0.383
LIG_14-3-3_CanoR_1	3	13	PF00244	0.699
LIG_14-3-3_CanoR_1	365	375	PF00244	0.309
LIG_14-3-3_CanoR_1	410	417	PF00244	0.369
LIG_14-3-3_CanoR_1	592	600	PF00244	0.460
LIG_14-3-3_CanoR_1	624	634	PF00244	0.295
LIG_14-3-3_CanoR_1	682	688	PF00244	0.380
LIG_Actin_WH2_2	154	172	PF00022	0.358
LIG_APCC_ABBA_1	559	564	PF00400	0.211
LIG_BIR_III_4	501	505	PF00653	0.480
LIG_deltaCOP1_diTrp_1	437	444	PF00928	0.368
LIG_deltaCOP1_diTrp_1	673	680	PF00928	0.497
LIG_deltaCOP1_diTrp_1	707	715	PF00928	0.343
LIG_FHA_1	206	212	PF00498	0.353
LIG_FHA_1	367	373	PF00498	0.334
LIG_FHA_1	406	412	PF00498	0.511
LIG_FHA_1	512	518	PF00498	0.528
LIG_FHA_1	532	538	PF00498	0.406
LIG_FHA_1	551	557	PF00498	0.476
LIG_FHA_1	610	616	PF00498	0.391
LIG_FHA_2	101	107	PF00498	0.637
LIG_FHA_2	113	119	PF00498	0.495
LIG_FHA_2	123	129	PF00498	0.334
LIG_FHA_2	148	154	PF00498	0.340
LIG_FHA_2	188	194	PF00498	0.390
LIG_FHA_2	371	377	PF00498	0.305
LIG_FHA_2	5	11	PF00498	0.565
LIG_FHA_2	599	605	PF00498	0.684
LIG_GBD_Chelix_1	157	165	PF00786	0.459
LIG_LIR_Apic_2	552	557	PF02991	0.486
LIG_LIR_Apic_2	628	634	PF02991	0.328
LIG_LIR_Gen_1	125	134	PF02991	0.346
LIG_LIR_Gen_1	252	263	PF02991	0.322
LIG_LIR_Gen_1	679	688	PF02991	0.489
LIG_LIR_Gen_1	707	715	PF02991	0.466
LIG_LIR_Nem_3	125	130	PF02991	0.368
LIG_LIR_Nem_3	252	258	PF02991	0.381
LIG_LIR_Nem_3	277	283	PF02991	0.370
LIG_LIR_Nem_3	437	442	PF02991	0.338
LIG_LIR_Nem_3	676	680	PF02991	0.479
LIG_LIR_Nem_3	707	711	PF02991	0.412
LIG_LIR_Nem_3	712	718	PF02991	0.413
LIG_NRBOX	480	486	PF00104	0.497
LIG_NRBOX	56	62	PF00104	0.429
LIG_Pex14_1	247	251	PF04695	0.321
LIG_Pex14_2	618	622	PF04695	0.386
LIG_PTB_Apo_2	133	140	PF02174	0.301
LIG_SH2_CRK	255	259	PF00017	0.425
LIG_SH2_NCK_1	251	255	PF00017	0.455
LIG_SH2_NCK_1	648	652	PF00017	0.632
LIG_SH2_PTP2	554	557	PF00017	0.309
LIG_SH2_STAP1	251	255	PF00017	0.455
LIG_SH2_STAT5	122	125	PF00017	0.346
LIG_SH2_STAT5	187	190	PF00017	0.327
LIG_SH2_STAT5	255	258	PF00017	0.363
LIG_SH2_STAT5	274	277	PF00017	0.435
LIG_SH2_STAT5	554	557	PF00017	0.309
LIG_SH3_3	347	353	PF00018	0.628
LIG_SH3_3	533	539	PF00018	0.554
LIG_SUMO_SIM_anti_2	153	160	PF11976	0.404
LIG_SUMO_SIM_par_1	10	16	PF11976	0.570
LIG_SUMO_SIM_par_1	98	103	PF11976	0.485
LIG_TRAF2_1	151	154	PF00917	0.346
LIG_TRAF2_1	178	181	PF00917	0.627
LIG_TRAF2_1	238	241	PF00917	0.493
MOD_CDK_SPxxK_3	112	119	PF00069	0.488
MOD_CK1_1	324	330	PF00069	0.450
MOD_CK1_1	349	355	PF00069	0.671
MOD_CK1_1	540	546	PF00069	0.609
MOD_CK1_1	547	553	PF00069	0.537
MOD_CK1_1	560	566	PF00069	0.343
MOD_CK1_1	591	597	PF00069	0.394
MOD_CK1_1	649	655	PF00069	0.652
MOD_CK2_1	112	118	PF00069	0.572
MOD_CK2_1	147	153	PF00069	0.310
MOD_CK2_1	187	193	PF00069	0.393
MOD_CK2_1	204	210	PF00069	0.440
MOD_CK2_1	4	10	PF00069	0.626
MOD_CK2_1	487	493	PF00069	0.591
MOD_CK2_1	497	503	PF00069	0.458
MOD_CK2_1	687	693	PF00069	0.543
MOD_CK2_1	701	707	PF00069	0.242
MOD_CMANNOS	674	677	PF00535	0.500
MOD_GlcNHglycan	150	153	PF01048	0.311
MOD_GlcNHglycan	199	202	PF01048	0.451
MOD_GlcNHglycan	216	219	PF01048	0.516
MOD_GlcNHglycan	376	380	PF01048	0.316
MOD_GlcNHglycan	49	52	PF01048	0.467
MOD_GlcNHglycan	505	508	PF01048	0.587
MOD_GlcNHglycan	538	542	PF01048	0.724
MOD_GlcNHglycan	68	71	PF01048	0.474
MOD_GlcNHglycan	74	77	PF01048	0.694
MOD_GSK3_1	100	107	PF00069	0.696
MOD_GSK3_1	187	194	PF00069	0.383
MOD_GSK3_1	210	217	PF00069	0.436
MOD_GSK3_1	351	358	PF00069	0.665
MOD_GSK3_1	366	373	PF00069	0.233
MOD_GSK3_1	405	412	PF00069	0.451
MOD_GSK3_1	45	52	PF00069	0.383
MOD_GSK3_1	463	470	PF00069	0.375
MOD_GSK3_1	487	494	PF00069	0.505
MOD_GSK3_1	540	547	PF00069	0.639
MOD_GSK3_1	604	611	PF00069	0.420
MOD_GSK3_1	683	690	PF00069	0.462
MOD_N-GLC_1	281	286	PF02516	0.527
MOD_N-GLC_1	344	349	PF02516	0.736
MOD_N-GLC_1	448	453	PF02516	0.381
MOD_N-GLC_1	45	50	PF02516	0.294
MOD_NEK2_1	137	142	PF00069	0.320
MOD_NEK2_1	147	152	PF00069	0.280
MOD_NEK2_1	169	174	PF00069	0.436
MOD_NEK2_1	291	296	PF00069	0.354
MOD_NEK2_1	366	371	PF00069	0.407
MOD_NEK2_1	375	380	PF00069	0.404
MOD_NEK2_1	4	9	PF00069	0.621
MOD_NEK2_1	45	50	PF00069	0.313
MOD_NEK2_1	462	467	PF00069	0.353
MOD_NEK2_1	487	492	PF00069	0.515
MOD_NEK2_1	569	574	PF00069	0.353
MOD_NEK2_1	625	630	PF00069	0.357
MOD_NEK2_2	122	127	PF00069	0.369
MOD_NEK2_2	413	418	PF00069	0.484
MOD_NEK2_2	557	562	PF00069	0.342
MOD_PIKK_1	226	232	PF00454	0.480
MOD_PIKK_1	311	317	PF00454	0.479
MOD_PIKK_1	625	631	PF00454	0.355
MOD_PIKK_1	88	94	PF00454	0.589
MOD_PKA_1	339	345	PF00069	0.586
MOD_PKA_2	161	167	PF00069	0.351
MOD_PKA_2	169	175	PF00069	0.404
MOD_PKA_2	339	345	PF00069	0.721
MOD_PKA_2	366	372	PF00069	0.337
MOD_PKA_2	409	415	PF00069	0.373
MOD_PKA_2	5	11	PF00069	0.656
MOD_PKA_2	591	597	PF00069	0.539
MOD_PKA_2	623	629	PF00069	0.295
MOD_PKA_2	701	707	PF00069	0.542
MOD_PKB_1	495	503	PF00069	0.500
MOD_Plk_1	224	230	PF00069	0.296
MOD_Plk_1	263	269	PF00069	0.591
MOD_Plk_1	404	410	PF00069	0.335
MOD_Plk_1	448	454	PF00069	0.386
MOD_Plk_4	187	193	PF00069	0.329
MOD_Plk_4	254	260	PF00069	0.404
MOD_Plk_4	28	34	PF00069	0.403
MOD_Plk_4	448	454	PF00069	0.239
MOD_Plk_4	49	55	PF00069	0.451
MOD_Plk_4	550	556	PF00069	0.557
MOD_Plk_4	676	682	PF00069	0.526
MOD_ProDKin_1	100	106	PF00069	0.647
MOD_ProDKin_1	112	118	PF00069	0.488
MOD_ProDKin_1	344	350	PF00069	0.608
MOD_ProDKin_1	606	612	PF00069	0.480
MOD_ProDKin_1	687	693	PF00069	0.503
MOD_ProDKin_1	694	700	PF00069	0.414
TRG_DiLeu_BaLyEn_6	287	292	PF01217	0.351
TRG_DiLeu_BaLyEn_6	56	61	PF01217	0.378
TRG_ENDOCYTIC_2	131	134	PF00928	0.333
TRG_ENDOCYTIC_2	251	254	PF00928	0.381
TRG_ENDOCYTIC_2	255	258	PF00928	0.353
TRG_ENDOCYTIC_2	386	389	PF00928	0.490
TRG_ER_diArg_1	169	171	PF00400	0.473
TRG_ER_diArg_1	173	175	PF00400	0.462
TRG_ER_diArg_1	271	273	PF00400	0.441
TRG_ER_diArg_1	364	367	PF00400	0.404
TRG_ER_diArg_1	495	497	PF00400	0.476
TRG_ER_diArg_1	527	529	PF00400	0.422
TRG_Pf-PMV_PEXEL_1	317	321	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	364	368	PF00026	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6F9	Leptomonas seymouri	50%	97%
A0A1X0NRU3	Trypanosomatidae	32%	98%
A0A3S5IS54	Trypanosoma rangeli	37%	100%
A0A3S7WR98	Leishmania donovani	90%	98%
A4H672	Leishmania braziliensis	74%	100%
A4HUJ6	Leishmania infantum	90%	98%
C9ZVM1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
Q4QHD0	Leishmania major	88%	100%
V5BTS5	Trypanosoma cruzi	36%	100%